KEGG   PATHWAY: spo00740
Entry
spo00740                    Pathway                                
Name
Riboflavin metabolism - Schizosaccharomyces pombe (fission yeast)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
spo00740  Riboflavin metabolism
spo00740

Module
spo_M00911  Riboflavin biosynthesis, fungi, GTP => riboflavin/FMN/FAD [PATH:spo00740]
Other DBs
GO: 0006771
Organism
Schizosaccharomyces pombe (fission yeast) [GN:spo]
Gene
2541490  rib1; GTP cyclohydrolase [KO:K01497] [EC:3.5.4.25]
2540625  rib7; 5-amino-6-(5-phosphoribosylamino) uracil reductase [KO:K14654] [EC:1.1.1.302]
2539515  rib2; bifunctional CMP deaminase family methyltransferase/riboflavin-specific deaminase [KO:K14655] [EC:5.4.99.28]
2540577  rib3; 3,4-dihydroxy-2-butanone 4-phosphate synthase [KO:K02858] [EC:4.1.99.12]
2541125  rib4; 6,7-dimethyl-8-ribityllumazine synthase [KO:K00794] [EC:2.5.1.78]
2539183  rib5; riboflavin synthase Rib5 [KO:K00793] [EC:2.5.1.9]
2539192  fmn1; riboflavin kinase Fmn1 [KO:K00861] [EC:2.7.1.26]
90818466  pho1; extracellular acid phosphatase Pho1 [KO:K01078] [EC:3.1.3.2]
2540652  SPOM_SPBC4.06; acid phosphatase [KO:K01078] [EC:3.1.3.2]
2540606  pho4; thiamine-repressible acid phosphatase Pho4 [KO:K01078] [EC:3.1.3.2]
2540420  SPOM_SPBC21H7.03C; multiple inositol polyphosphate phosphatase [KO:K01078] [EC:3.1.3.2]
3361433  stp1; protein tyrosine phosphatase Stp1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
2539270  nad1; FAD synthetase Nad1 [KO:K00953] [EC:2.7.7.2]
2541356  ysa1; subfamily NudF ADP-ribose diphosphatase Ysa1 [KO:K01515] [EC:3.6.1.13 3.6.1.-]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00235  Dimethylallyl diphosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01390  Prenol
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
C21214  Dimethylallyl phosphate
C21215  Prenylated FMNH2
Reference
PMID:12136096
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
PMID:11856310
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
PMID:12867427
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
PMID:16042598
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
spo00030  Pentose phosphate pathway
spo00040  Pentose and glucuronate interconversions
spo00230  Purine metabolism
spo00860  Porphyrin metabolism
spo00900  Terpenoid backbone biosynthesis
KO pathway
ko00740   
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