KEGG   PATHWAY: srim01055
Entry
srim01055                   Pathway                                
Name
Biosynthesis of vancomycin group antibiotics - Streptomyces rimosus
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
srim01055  Biosynthesis of vancomycin group antibiotics
srim01055

Organism
Streptomyces rimosus [GN:srim]
Gene
CP984_06500  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K16421] [EC:1.13.11.46]
CP984_39205  alpha-hydroxy-acid oxidizing protein [KO:K16422] [EC:1.1.3.46]
CP984_06505  alpha-hydroxy-acid oxidizing protein [KO:K16422] [EC:1.1.3.46]
CP984_27455  alpha-hydroxy-acid oxidizing protein [KO:K16422] [EC:1.1.3.46]
CP984_06495  PLP-dependent aminotransferase family protein [KO:K16423] [EC:2.6.1.103]
CP984_06525  FAD-dependent oxidoreductase [KO:K16431] [EC:1.14.19.-]
CP984_01885  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
CP984_08335  SDR family oxidoreductase [KO:K01710] [EC:4.2.1.46]
CP984_10780  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
CP984_10770  NDP-hexose 2,3-dehydratase [KO:K16435] [EC:4.2.1.159]
CP984_10775  DegT/DnrJ/EryC1/StrS family aminotransferase [KO:K16436] [EC:2.6.1.- 2.6.1.106]
CP984_10765  methyltransferase domain-containing protein [KO:K16437]
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
srim00400  Phenylalanine, tyrosine and tryptophan biosynthesis
srim00520  Amino sugar and nucleotide sugar metabolism
srim00620  Pyruvate metabolism
KO pathway
ko01055   
LinkDB

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