KEGG   PATHWAY: stm00290
Entry
stm00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Salmonella enterica subsp. enterica serovar Typhimurium LT2
Class
Metabolism; Amino acid metabolism
Pathway map
stm00290  Valine, leucine and isoleucine biosynthesis
stm00290

Module
stm_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:stm00290]
stm_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:stm00290]
stm_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:stm00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Salmonella enterica subsp. enterica serovar Typhimurium LT2 [GN:stm]
Gene
STM3244  tdcB; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
STM3905  ilvA; PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STM0329  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
STM0111  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
STM0330  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
STM0110  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
STM0112  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
STM0116  ilvI; valine sensitive acetolactate synthase III, large subunit [KO:K01652] [EC:2.2.1.6]
STM3796  ilvB; acetolactate synthase I large subunit [KO:K01652] [EC:2.2.1.6]
STM3901  ilvG; acetolactate synthase 2 catalytic subunit [KO:K01652] [EC:2.2.1.6]
STM0117  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
STM3795  ilvN; acetolactate synthase I small subunit [KO:K01653] [EC:2.2.1.6]
STM3902  ilvM; acetolactate synthase II, small subunit [KO:K11258] [EC:2.2.1.6]
STM3909  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
STM3531  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
STM3904  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
STM3903  ilvE; branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
STM3665  avtA; valine--pyruvate transaminase [KO:K00835] [EC:2.6.1.66]
STM2331  yfbQ; aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
STM0113  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
stm00260  Glycine, serine and threonine metabolism
stm00280  Valine, leucine and isoleucine degradation
stm00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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