KEGG   PATHWAY: sty02010
Entry
sty02010                    Pathway                                
Name
ABC transporters - Salmonella enterica subsp. enterica serovar Typhi CT18
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
sty02010  ABC transporters
sty02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Salmonella enterica subsp. enterica serovar Typhi CT18 [GN:sty]
Gene
STY0123  yabJ; thiamine ABC transporter ATP-binding protein [KO:K02062] [EC:7.6.2.15]
STY0124  yabK; thiamine ABC transporter permease [KO:K02063]
STY0125  tbpA; thiamine ABC transporter substrate-binding protein [KO:K02064]
STY0219  fhuC; ferrichrome transport ATP-binding protein FhuC [KO:K10829] [EC:7.2.2.16]
STY0220  fhuD; ferrichrome-binding periplasmic protein [KO:K23227]
STY0221  fhuB; ferrichrome transport protein FhuB [KO:K23228]
STY0228  btuF; vitamin B12-transporter protein BtuF [KO:K06858]
STY0272  yaeC; lipoprotein [KO:K02073]
STY0273  yaeE; ABC transporter permease [KO:K02072]
STY0274  abc; ABC transporter ATP-binding protein [KO:K02071]
STY0465  phnV; 2-aminoethylphosphonate transport system permease PhnV [KO:K11082]
STY0466  phnU; 2-aminoethylphosphonate transport system permease PhnU [KO:K11083]
STY0467  phnT; 2-aminoethylphosphonate import ATP-binding protein PhnT [KO:K11084]
STY0468  phnS; 2-aminoethylphosphonate transporter substrate-binding protein PhnS [KO:K11081]
STY0503  mdlA; ABC transporter ATP-binding protein [KO:K18889]
STY0504  mdlB; ABC transporter ATP-binding protein [KO:K18890]
STY0558  sfbA; iron-binding lipoprotein [KO:K02073]
STY0559  sfbB; ABC transporter ATP-binding protein [KO:K02071]
STY0560  sfbC; ABC transporter permease [KO:K02072]
STY0634  fepC; ferric enterobactin ABC transporter ATP-binding protein FepC [KO:K23188]
STY0635  fepG; ferric enterobactin ABC transporter permease FepG [KO:K23187]
STY0636  fepD; ferric enterobactin ABC transporter permease FepD [KO:K23186]
STY0638  fepB; ferric enterobactin ABC transporter substrate-binding protein [KO:K23185]
STY0707  gltL; glutamate/aspartate transport ATP-binding protein GltL [KO:K10004] [EC:7.4.2.1]
STY0708  gltK; glutamate/aspartate transport system permease GltK [KO:K10002]
STY0709  gltJ; glutamate/aspartate transport system permease GltJ [KO:K10003]
STY0710  ybeJ; ABC transporter substrate-binding protein [KO:K10001]
STY0764  [KO:K09691] [EC:7.5.2.14]
STY0811  modF; molybdenum transport ATP-binding protein ModF [KO:K05776]
STY0814  modA; molybdenum ABC transporter substrate-binding protein ModA [KO:K02020]
STY0815  modB; molybdate ABC transporter permease ModB [KO:K02018]
STY0816  modC; molybdenum ABC transporter ATP-binding protein ModC [KO:K02017] [EC:7.3.2.5]
STY0866  glnQ; glutamine transport ATP-binding protein GlnQ [KO:K10038] [EC:7.4.2.1]
STY0867  glnP; glutamine transport system permease GlnP [KO:K10037]
STY0868  glnH; glutamine-binding periplasmic protein [KO:K10036]
STY0887  [KO:K13892]
STY0888  yliB; ABC transporter substrate-binding protein [KO:K13889]
STY0889  yliC; ABC transporter permease [KO:K13890]
STY0890  yliD; ABC transporter permease [KO:K13891]
STY0910  potF; putrescine ABC transporter substrate-binding protein PotF [KO:K11073]
STY0911  potG; putrescine ABC transporter ATP-binding protein PotG [KO:K11076] [EC:7.6.2.16]
STY0912  potH; putrescine ABC transporter permease PotH [KO:K11075]
STY0913  potI; putrescine transport system permease PotI [KO:K11074]
STY0920  artJ; arginine/ornithine ABC transporter substrate-binding protein [KO:K09996]
STY0921  artM; arginine ABC transporter permease ArtM [KO:K09998]
STY0922  artQ; arginine ABC transporter permease ArtQ [KO:K09999]
STY0923  artI; arginine/ornithine ABC transporter substrate-binding protein [KO:K09997]
STY0924  artP; arginine ABC transporter ATP-binding protein ArtP [KO:K10000] [EC:7.4.2.1]
STY0938  ybjZ; macrolide transporter ATP-binding protein/permease [KO:K05685] [EC:7.6.2.-]
STY0954  cydC; cysteine/glutathione ABC transporter membrane protein/ATP-binding protein CydC [KO:K16012]
STY0955  cydD; cysteine/glutathione ABC transporter ATP-binding protein CydD [KO:K16013]
STY0985  msbA; lipid transporter ATP-binding protein/permease [KO:K11085] [EC:7.5.2.6]
STY1257  [KO:K09808]
STY1258  [KO:K09810] [EC:7.6.2.-]
STY1259  [KO:K09808]
STY1262  potD; putrescine/spermidine ABC transporter substrate-binding protein PotD [KO:K11069]
STY1263  potC; putrescine/spermidine ABC transporter permease PotC [KO:K11070]
STY1265  potB; putrescine/spermidine ABC transporter permease PotB [KO:K11071]
STY1266  potA; spermidine/putrescine ABC transporter ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
STY1304  oppA; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580]
STY1305  oppB; oligopeptide ABC transporter permease OppB [KO:K15581]
STY1308  oppD; oligopeptide ABC transporter ATP-binding protein OppD [KO:K15583]
STY1309  oppF; oligopeptide ABC transporter ATP-binding protein OppF [KO:K10823]
STY1355  sapF; peptide ABC transporter ATP-binding protein SapF [KO:K19230]
STY1356  sapD; peptide ABC transporter ATP-binding protein SapD [KO:K19229]
STY1357  sapC; peptide ABC transporter permease SapC [KO:K19228]
STY1368  sapB; peptide ABC transporter permease SapB [KO:K19227]
STY1369  sapA; peptide ABC transporter substrate-binding protein SapA [KO:K19226]
STY1384  mppA; periplasmic murein peptide-binding protein MppA [KO:K15580]
STY1570  [KO:K05846]
STY1571  [KO:K05845]
STY1572  [KO:K05846]
STY1573  [KO:K05847] [EC:7.6.2.9]
STY1768  btuD; vitamin B12 ABC transporter ATP-binding protein [KO:K06074] [EC:7.6.2.8]
STY1770  btuC; vitamin B12 ABC transporter permease [KO:K06073]
STY2099  yebL; high-affinity zinc ABC transporter substrate-binding protein [KO:K09815]
STY2100  znuC; high-affinity zinc ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
STY2101  yebI; high-affinity zinc ABC transporter permease [KO:K09816]
STY2159  [KO:K10010] [EC:7.4.2.1]
STY2160  yecS; ABC transporter permease [KO:K10009]
STY2162  fliY; cystine-binding periplasmic protein [KO:K02424]
STY2223  cbiO; cobalt transport ATP-binding protein CbiO [KO:K02006]
STY2224  cbiQ; cobalt transport protein CbiQ [KO:K02008]
STY2225  cbiN; cobalt transport protein CbiN [KO:K02009]
STY2392  yehW; ABC transporter permease [KO:K05846]
STY2393  yehX; ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
STY2394  yehY; ABC transporter permease [KO:K05846]
STY2395  yehZ; ABC transporter substrate-binding protein [KO:K05845]
STY2421  mglC; galactoside transport system permease MglC [KO:K10541]
STY2424  mglB; D-galactose-binding periplasmic protein [KO:K10540]
STY2452  yejA; transport system periplasmic binding protein [KO:K13893]
STY2453  yejB; binding-protein-dependent transporter [KO:K13894]
STY2454  yejE; binding-protein-dependent transporter [KO:K13895]
STY2455  yejF; ABC transporter ATP-binding protein [KO:K13896]
STY2477  ccmD1; heme exporter protein D1 [KO:K02196]
STY2478  ccmC1; heme exporter protein C1 [KO:K02195]
STY2479  ccmB1; heme exporter protein B1 [KO:K02194]
STY2480  ccmA1; heme exporter protein A1 [KO:K02193] [EC:7.6.2.5]
STY2489  yojI; ABC transporter ATP-binding protein [KO:K06159]
STY2581  hisP; histidine ABC transporter ATP-binding protein [KO:K10017] [EC:7.4.2.1]
STY2582  hisM; histidine ABC transporter permease [KO:K10015]
STY2583  hisQ; histidine ABC transporter permease [KO:K10016]
STY2584  hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014]
STY2585  argT; lysine/arginine/ornithine ABC transporter substrate-binding protein [KO:K10013]
STY2678  cysA; sulfate ABC transporter ATP-binding protein CysA [KO:K02045] [EC:7.3.2.3]
STY2679  cysW; sulfate ABC transporter permease CysW [KO:K02047]
STY2680  cysU; sulfate ABC transporter permease CysT [KO:K02046]
STY2681  cysP; sulfate ABC transporter substrate-binding protein [KO:K02048]
STY2877  [KO:K12541]
STY2891  iroC; ABC transporter ATP-binding protein/permease [KO:K18895]
STY2936  proW; glycine betaine/L-proline transport system permease P [KO:K02001]
STY2937  proX; glycine betaine-binding periplasmic protein [KO:K02002]
STY2983  sitA; iron transporter substrate-binding protein [KO:K11604]
STY2984  sitB; iron transporter ATP-binding protein [KO:K11607]
STY2985  sitC; iron transporter inner membrane protein [KO:K11605]
STY2986  sitD; iron transporter inner membrane protein [KO:K11606]
STY3231  [KO:K16785]
STY3232  [KO:K16786] [EC:7.-.-.-]
STY3233  [KO:K16787] [EC:7.-.-.-]
STY3312  [KO:K02020]
STY3488  [KO:K07122]
STY3489  [KO:K07323]
STY3490  [KO:K02067]
STY3491  [KO:K02066]
STY3492  [KO:K02065]
STY3498  [KO:K06861] [EC:7.5.2.5]
STY3793  [KO:K10555]
STY3794  ydeZ; ABC transporter permease [KO:K10557]
STY3795  [KO:K10556]
STY3796  [KO:K10558]
STY3808  sbp; periplasmic sulfate binding protein [KO:K23163]
STY3894  rbsB; D-ribose-binding periplasmic protein [KO:K10439]
STY3895  rbsC; high affinity ribose transport protein [KO:K10440]
STY3896  rbsA; high affinity ribose transport protein [KO:K10441] [EC:7.5.2.7]
STY3897  rbsD; high affinity ribose transport protein RbsD [KO:K06726] [EC:5.4.99.62]
STY3926  pstS; phosphate ABC transporter substrate-binding protein [KO:K02040]
STY3927  pstC; phosphate ABC transporter permease [KO:K02037]
STY3928  pstA; phosphate ABC transporter permease [KO:K02038]
STY3929  pstB; phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
STY3959  ccmA2; heme exporter protein A2 [KO:K02193] [EC:7.6.2.5]
STY3960  ccmB2; heme exporter protein B2 [KO:K02194]
STY3961  ccmC2; heme exporter protein C2 [KO:K02195]
STY3962  ccmD2; heme exporter protein D2 [KO:K02196]
STY4168  dppA; periplasmic dipeptide transport protein [KO:K12368]
STY4169  dppB; dipeptide ABC transporter permease DppB [KO:K12369]
STY4170  dppC; dipeptide ABC transporter permease DppC [KO:K12370]
STY4171  dppD; dipeptide ABC transporter ATP-binding protein DppD [KO:K12371]
STY4172  dppF; dipeptide ABC transporter ATP-binding protein DppF [KO:K12372]
STY4241  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
STY4242  ftsX; cell division protein FtsX [KO:K09811]
STY4248  livK; high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
STY4249  livH; high-affinity branched-chain amino acid ABC transporter permease [KO:K01997]
STY4250  livM; high-affinity branched-chain amino acid ABC transporter permease [KO:K01998]
STY4251  livG; ABC transporter ATP-binding protein [KO:K01995]
STY4252  livF; ABC transporter ATP-binding protein [KO:K01996]
STY4254  ugpB; glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
STY4255  ugpA; glycerol-3-phosphate ABC transporter permease [KO:K05814]
STY4256  ugpE; glycerol-3-phosphate ABC transporter permease [KO:K05815]
STY4257  ugpC; glycerol-3-phosphate ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
STY4423  malG; maltose transport system permease MalG [KO:K10110]
STY4424  malF; maltose transport system permease MalF [KO:K10109]
STY4425  malE; maltose/maltodextrin-binding protein MalE [KO:K10108]
STY4426  malK; maltose transport system ATP-binding protein MalK [KO:K10111] [EC:7.5.2.-]
STY4460  [KO:K12541]
STY4652  vexD; Vi polysaccharide exporter inner-membrane protein [KO:K22922]
STY4653  vexC; Vi polysaccharide exporter ATP-binding protein [KO:K22923]
STY4654  vexB; Vi polysaccharide exporter inner-membrane protein [KO:K22921]
STY4711  artJ; arginine-binding protein [KO:K09996]
STY4817  [KO:K07091]
STY4818  [KO:K11720]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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