Entry Name Protein export - Xenopus laevis (African clawed frog)
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Other DBs Organism Xenopus laevis (African clawed frog) [GN:
xla ]
Gene 100049747 spcs2.S; probable signal peptidase complex subunit 2 isoform X1 [KO:K12947 ] [EC:3.4.-.-]
100101323 srp68.L; signal recognition particle 68kDa L homeolog [KO:K03107 ]
108696415 srpra.L; signal recognition particle receptor subunit alpha [KO:K13431 ]
108706624 spcs3.S; signal peptidase complex subunit 3 [KO:K12948 ] [EC:3.4.-.-]
108707646 spcs2.L; probable signal peptidase complex subunit 2 isoform X1 [KO:K12947 ] [EC:3.4.-.-]
108713810 immp1l.L; mitochondrial inner membrane protease subunit 1 [KO:K09647 ] [EC:3.4.21.-]
108714662 sec61a1.L; protein transport protein Sec61 subunit alpha [KO:K10956 ]
108715214 immp1l.S; mitochondrial inner membrane protease subunit 1 [KO:K09647 ] [EC:3.4.21.-]
108717692 srp9.S; signal recognition particle 9 kDa protein isoform X2 [KO:K03109 ]
108718204 srprb.S; signal recognition particle receptor subunit beta [KO:K12272 ]
379698 bag6.L; large proline-rich protein bag6-A [KO:K23390 ]
379756 hspa5.S; heat shock protein family A (Hsp70) member 5 S homeolog precursor [KO:K09490 ] [EC:3.6.4.10 ]
379848 sec61b.L; SEC61 translocon beta subunit L homeolog [KO:K09481 ]
379936 sec61a1.S; Sec61 translocon alpha 1 subunit S homeolog [KO:K10956 ]
380540 srprb.L; SRP receptor subunit beta L homeolog [KO:K12272 ]
394424 sec61g.L; protein transport protein Sec61 subunit gamma [KO:K07342 ]
398926 bag6.S; large proline-rich protein bag6-B [KO:K23390 ]
414520 sgta.S; uncharacterized protein LOC414520 [KO:K16365 ]
431835 get4.L; Golgi to ER traffic protein 4 homolog A [KO:K23387 ]
432311 spcs3.L; signal peptidase complex subunit 3 L homeolog [KO:K12948 ] [EC:3.4.-.-]
443902 sec63.S; SEC63 homolog, protein translocation regulator S homeolog [KO:K09540 ]
444393 srp72.S; signal recognition particle 72kDa S homeolog [KO:K03108 ]
444741 get4.S; Golgi to ER traffic protein 4 homolog B [KO:K23387 ]
446595 srp9.L; signal recognition particle 9kDa L homeolog [KO:K03109 ]
446660 sec62.L; SEC62 homolog, preprotein translocation factor L homeolog [KO:K12275 ]
446676 sec62.S; SEC62 homolog, preprotein translocation factor S homeolog [KO:K12275 ]
447179 get1.S; guided entry of tail-anchored proteins factor 1 S homeolog precursor [KO:K22384 ]
495049 srp19.L; signal recognition particle 19kDa L homeolog [KO:K03105 ]
495416 sec63.L; SEC63 homolog, protein translocation regulator L homeolog [KO:K09540 ]
495969 immp2l.L; mitochondrial inner membrane protease subunit 2 [KO:K09648 ] [EC:3.4.21.-]
496044 spcs1.L; signal peptidase complex subunit 1 L homeolog [KO:K12946 ] [EC:3.4.-.-]
496358 sgta.L; small glutamine rich tetratricopeptide repeat co-chaperone alpha L homeolog [KO:K16365 ]
734467 get1.L; guided entry of tail-anchored proteins factor 1 L homeolog precursor [KO:K22384 ]
779186 srp14.S; signal recognition particle 14kDa S homeolog [KO:K03104 ]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway
