 Eukaryotic type
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 Basic leucine zipper (bZIP)
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Basic helix-loop-helix (bHLH)
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Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
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Other basic domains
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Zinc finger
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Cys4 thyroid hormone receptor-like
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Cys4 hepatocyte nuclear factor 4-like
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Cys4 estrogen receptor-like
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Cys4 nerve growth factor IB-like
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Cys4 Fushi tarazu-F1-like
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Cys4 germ cell nuclear factor
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Cys4 Knirps/DAX1-like
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Cys4 GATA-factors
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Cys2His2 SP/KLF family and related proteins
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Cys2His2 GLI-like
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Cys2His2 Snail
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Cys2His2 BTB-ZF factors
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Cys2His2 BED
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Cys2His2 PRDM
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Cys2His2 metabolic regulators in fungi
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Cys2His2 others
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Cys2HisCys zinc factors
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Cys3His zinc factors
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Cys2CysHis zinc factors
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CXXC CpG-binding proteins
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Cys6 metabolic regulators in fungi
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 K09240 CAT8; transcriptional regulatory protein CAT8
K27389 RDS2, ERT1, GSM1; transcription activator of gluconeogenesis
K09241 GAL4; transcriptional regulatory protein GAL4
K09242 LEU3; transcriptional regulatory protein LEU3
K09243 UME6; transcriptional regulatory protein UME6
K09244 AMDR; transcriptional regulatory protein AMDR
K09245 UGA3; transcriptional activator protein UGA3
K09246 ARG81, ARGR2; arginine metabolism regulation protein II
K09247 CYP1, HAP1; heme activator protein 1
K09248 PUT3; proline utilization trans-activator
K21641 RGT1; glucose transport transcription regulator RGT1
K21546 GLIZ; C6 transcription factor GliZ
K21450 ARAR; arabinolytic transcriptional activator AraR
K23629 ASAR; C6 transcription factor AsaR
K21547 PRO1, NOSA; C6 transcription factor Pro1
K21632 WOR2; white-opaque regulator 2
K21633 CZF1; zinc cluster transcription factor CZF1
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Other zinc fingers
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Helix-turn-helix
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beta-Scaffold factors with minor groove contacts
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RHR (Rel homology region) Rel/Ankyrin
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RHR (Rel homology region) Ankyrin only
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RHR (Rel homology region) NF-AT
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STAT
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p53
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MADS-box regulators of differentiation, MEF-2
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MADS-box regulators of differentiation, Homeotic genes
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MADS-box regulators of differentiation, Yeast regulators
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K12412 MCM1; pheromone receptor transcription factor
K19808 ARG80, ARGR1; arginine metabolism regulation protein I
K09265 RLM1; transcription factor RLM1
K19807 SMP1; transcription factor SMP1
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MADS-box responders to external signals
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SAND domain-containing proteins
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TATA-binding proteins
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HMG SOX
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HMG TCF-1
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HMG TOX
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HMG2-related
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UBF
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Other HMG box factors
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Heteromeric CCAAT factors
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Grainyhead
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Cold-shock domain factors, DbpA-like
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Cold-shock domain factors, YB-1/DbpB-like
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Cold-shock domain factors, FRG Y2-like
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Runt
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MYRF
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Other transcription factors
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Prokaryotic type
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Helix-turn-helix
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AraC family
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LysR family
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DeoR family
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LacI family
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GntR family
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K02103 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor
K03482 yidP; GntR family transcriptional regulator, glv operon transcriptional regulator
K03486 treR2, treR; GntR family transcriptional regulator, trehalose operon transcriptional repressor
K03489 yydK; GntR family transcriptional regulator, transcriptional regulator of bglA
K03492 gmuR; GntR family transcriptional regulator, regulator of glucomannan utilization
K02043 phnF; GntR family transcriptional regulator, phosphonate transport system regulatory protein
K05836 hutC; GntR family transcriptional regulator, histidine utilization repressor
K10711 frlR; GntR family transcriptional regulator, frlABCD operon transcriptional regulator
K11922 mngR, farR; GntR family transcriptional regulator, mannosyl-D-glycerate transport/metabolism system repressor
K24966 gamR; GntR family transcriptional regulator, amino sugar utilization regulator
K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator
K24968 phnF; GntR family transcriptional regulator, repressor of the phnDCE operon
K24969 dasR; GntR family transcriptional regulator, nutrient-sensing system regulator
K03710 K03710; GntR family transcriptional regulator
K03603 fadR; GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA
K05799 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex
K11474 glcC; GntR family transcriptional regulator, glc operon transcriptional activator
K13637 uxuR; GntR family transcriptional regulator, uxu operon transcriptional repressor
K19775 exuR; GntR family transcriptional regulator, hexuronate regulon transcriptional repressor
K14348 lldR; GntR family transcriptional regulator, L-lactate dehydrogenase operon regulator
K19776 dgoR; GntR family transcriptional regulator, galactonate operon transcriptional repressor
K22104 nanR; GntR family transcriptional regulator, sialic acid-inducible nan operon repressor
K00375 K00375; GntR family transcriptional regulator / MocR family aminotransferase
K18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC
K07978 plmA; GntR family transcriptional regulator
K07979 ytrA; GntR family transcriptional regulator
K11476 gntR; GntR family transcriptional regulator, gluconate operon transcriptional repressor
K11475 vanR; GntR family transcriptional regulator, vanillate catabolism transcriptional regulator
K13654 mcbR; GntR family transcriptional regulator, colanic acid and biofilm gene transcriptional regulator
K15735 csiR; GntR family transcriptional regulator, carbon starvation induced regulator
K22293 rspR; GntR family transcriptional regulator, rspAB operon transcriptional repressor
K23015 lgoR; GntR family transcriptional regulator, transcriptional activator for L-galactonate catabolism
K23466 tgnR; GntR family transcriptional regulator, trigonelline degradation regulator
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TetR/AcrR family
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K18476 tetR; TetR/AcrR family transcriptional regulator, tetracycline repressor protein
K19047 tetC; TetR/AcrR family transcriptional regulator, repressor of tetCD
K02167 betI; TetR/AcrR family transcriptional regulator, transcriptional repressor of bet genes
K03577 acrR, smeT; TetR/AcrR family transcriptional regulator, acrAB operon repressor
K18136 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor
K05501 slmA, ttk; TetR/AcrR family transcriptional regulator
K09017 rutR; TetR/AcrR family transcriptional regulator
K10913 hapR, luxR, litR; TetR/AcrR family transcriptional regulator, hemagglutinin/protease regulatory protein
K19736 aefR; TetR/AcrR family transcriptional regulator, regulator of autoinduction and epiphytic fitness
K13770 ysiA, fadR; TetR/AcrR family transcriptional regulator, fatty acid metabolism regulator protein
K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon
K16138 uidR; TetR/AcrR family transcriptional regulator, repressor for uid operon
K18301 mexL; TetR/AcrR family transcriptional regulator, mexJK operon transcriptional repressor
K18129 mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
K18130 nalC; TetR/AcrR family transcriptional regulator, transcriptional repressor NalC
K18135 nalD; TetR/AcrR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
K18137 adeN; TetR/AcrR family transcriptional regulator, repressor of the adeIJK operon
K18140 envR, acrS; TetR/AcrR family transcriptional regulator, acrEF/envCD operon repressor
K18294 nfxB; TetR/AcrR family transcriptional regulator, mexCD-oprJ operon repressor
K18905 ameR, rmiR; TetR/AcrR family transcriptional regulator, repressor of the ameABC operon
K18937 lfrR; TetR/AcrR family transcriptional regulator, repressor for lfrA
K18938 qacR; TetR/AcrR family transcriptional regulator, repressor for qacA
K18939 lmrA, yxaF; TetR/AcrR family transcriptional regulator, lmrAB and yxaGH operons repressor
K18992 cmeR; TetR/AcrR family transcriptional regulator, cmeABC operon repressor
K19060 mphR; TetR/AcrR family transcriptional regulator, macrolide resistance operon repressor
K19335 bdcR; TetR/AcrR family transcriptional regulator, repressor for divergent bdcA
K20325 fhrR; TetR/AcrR family transcriptional regulator, Clp-modulated transcription factor
K21453 icaR; TetR/AcrR family transcriptional regulator, biofilm operon repressor
K21961 ethR, etaR; TetR/AcrR family transcriptional regulator, ethionamide resistance regulator
K21962 acnR; TetR/AcrR family transcriptional regulator, transcriptional repressor of aconitase
K22041 comR; TetR/AcrR family transcriptional regulator, copper-responsive repressor
K22105 fabR; TetR/AcrR family transcriptional regulator, fatty acid biosynthesis regulator
K22106 fatR, bscR; TetR/AcrR family transcriptional regulator, repressor of fatR-cypB operon
K22107 kstR; TetR/AcrR family transcriptional regulator, cholesterol catabolism regulator
K22108 kstR2; TetR/AcrR family transcriptional regulator, cholesterol catabolism regulator
K22294 nicS; TetR/AcrR family transcriptional regulator, upper aerobic nicotinate degradation pathway regulator
K23777 cecR; TetR/AcrR family transcriptional regulator, regulator of cefoperazone and chloramphenicol sensitivity
K24699 mftR; TetR/AcrR family transcriptional regulator, regulator of mycofactocin system
K27107 mce3R; TetR/AcrR family transcriptional regulator, mce3 operon repressor
K22295 K22295; TetR/AcrR family transcriptional regulator, repressor for neighboring sulfatase
K23778 rcdA; TetR/AcrR family transcriptional regulator, regulator of biofilm formation and stress response
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Lrp/AsnC family
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LuxR family
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K15852 luxR, vanR; LuxR family transcriptional regulator, transcriptional activator of the bioluminescence operon
K18304 lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR
K18099 rhlR, phzR; LuxR family transcriptional regulator, quorum-sensing system regulator RhlR
K18098 bjaR1, rpaR, rhiR; LuxR family transcriptional regulator, quorum-sensing system regulator BjaR1
K07782 sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA
K19666 solR, cepR, tofR; LuxR family transcriptional regulator, quorum-sensing system regulator SolR
K20540 cepR2; LuxR family transcriptional regulator, quorum-sensing system regulator CepR2
K19731 cciR; LuxR family transcriptional regulator, quorum-sensing system regulator CciR
K19732 traR; LuxR family transcriptional regulator, activator of conjugal transfer of Ti plasmids
K19733 sinR, avsR; LuxR family transcriptional regulator, quorum-sensing system regulator SinR
K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
K20252 cinR; LuxR family transcriptional regulator, quorum-sensing system regulator CinR
K20253 bisR; LuxR family transcriptional regulator, quorum-sensing system regulator BisR
K21697 vjbR; LuxR family transcriptional regulator, quorum-sensing system regulator VjbR
K21963 ecpR, matA; LuxR family transcriptional regulator, Mat/Ecp fimbriae transcriptional regulator
K25873 raiR; LuxR family transcriptional regulator, quorum-sensing system regulator RaiR
K07781 rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor
K04333 csgD; LuxR family transcriptional regulator, csgAB operon transcriptional regulatory protein
K01994 gerE; LuxR family transcriptional regulator, transcriptional regulator of spore coat protein
K20330 toxJ; LuxR family transcriptional regulator, activator of tox operons
K20334 cviR; LuxR family transcriptional regulator, quorum-sensing system regulator CviR
K20918 vpsT; LuxR family transcriptional regulator, positive regulator of biofilm formation
K21685 ramA; LuxR family transcriptional regulator, regulator of acetate metabolism
K21901 dctR; LuxR family transcriptional regulator, dicarboxylate transport regulator
K22650 bglJ; LuxR family transcriptional regulator, regulator of transport and utilization of aryl beta-glucosides
K24912 ramR, amfR; LuxR family transcriptional regulator, transcriptional activator for aerial hyphae formation
K03556 malT; LuxR family transcriptional regulator, maltose regulon positive regulatory protein
K21748 alkS; LuxR family transcriptional regulator, alkane degradation pathway regulator
K16247 gutR; LuxR family transcriptional regulator, glucitol operon activator
K21907 gadE; LuxR family transcriptional regulator, glutamate-dependent acid resistance regulator
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MarR family
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MerR family
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Fur family
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IclR family
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CRP/FNR family
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Rrf2 family
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K13643 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor
K13771 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor
K13772 rirA; Rrf2 family transcriptional regulator, iron-responsive regulator
K17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor
K19587 oqxR; Rrf2 family transcriptional regulator, repressor of oqxAB
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ArsR family
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XRE family
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PadR family
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Other families
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Ribbon-helix-helix
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Other transcription factors
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BglG family
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Others
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K18955 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator
K18956 whiB5; WhiB family transcriptional regulator, redox-sensing transcriptional regulator
K18957 whiB6; WhiB family transcriptional regulator, redox-sensing transcriptional regulator
K18958 whiB7; WhiB family transcriptional regulator, redox-sensing transcriptional regulator
K19339 nosR; NosR/NirI family transcriptional regulator, nitrous oxide reductase regulator
K19343 nirI; NosR/NirI family transcriptional regulator, nitrite reductase regulator
K21559 cprC; NosR/NirI family transcriptional regulator, putative reductive dehalogenation system regulator
K23239 frmR; FrmR/RcnR family transcriptional regulator, repressor of frmRAB operon
K23240 rcnR; FrmR/RcnR family transcriptional regulator, repressor of rcnA expression
K21600 csoR, ricR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor
K09684 pucR; PucR family transcriptional regulator, purine catabolism regulatory protein
K23253 putR; PucR family transcriptional regulator, proline-responsive transcriptional activator
K06284 abrB, abh; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes
K04769 spoVT; AbrB family transcriptional regulator, stage V sporulation protein T
K21696 rcoM; LytTR family transcriptional regulator, CO-responsive transcriptional regulator RcoM
K05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator
K22894 embR; SARP family transcriptional regulator, regulator of embCAB operon
K03497 parB, spo0J; ParB family transcriptional regulator, chromosome partitioning protein
K23371 sbnI; L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive regulator [EC:2.7.1.225]
K07736 carD; CarD family transcriptional regulator, regulator of rRNA transcription
K25884 mucR, rosR; MucR family transcriptional regulator, transcriptional regulator of exopolysaccharide biosynthesis
K02443 glpP; glycerol uptake operon antiterminator
K02531 lacT; transcriptional antiterminator
K05785 rfaH; transcriptional antiterminator RfaH
K03402 argR, ahrC; transcriptional regulator of arginine metabolism
K02565 nagC; N-acetylglucosamine repressor
K15545 mlc; transcriptional regulator of PTS gene
K02562 mtlR; mannitol operon repressor
K03705 hrcA; heat-inducible transcriptional repressor
K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
K10810 tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10]
K03708 ctsR; transcriptional regulator of stress and heat shock response
K03721 tyrR; transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport
K03765 cadC; transcriptional activator of cad operon
K22486 hilA; transcriptional regulator HilA, main transcriptional regulator of SPI1
K03567 gcvR; glycine cleavage system transcriptional repressor
K02616 paaX; phenylacetic acid degradation operon negative regulatory protein
K03974 pspF; psp operon transcriptional activator
K03973 pspC; phage shock protein C
K05311 cggR; central glycolytic genes regulator
K05346 deoR; deoxyribonucleoside regulator
K11531 lsrR; lsr operon transcriptional repressor
K05519 med; transcriptional activator of comK gene
K05880 dhaR; transcriptional activator for dhaKLM operon
K06140 rnk; regulator of nucleoside diphosphate kinase
K06285 mtrB; transcription attenuation protein (tryptophan RNA-binding attenuator protein)
K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
K06314 rsfA; prespore-specific regulator
K06315 splA; transcriptional regulator of the spore photoproduct lyase operon
K07733 alpA; prophage regulatory protein
K07734 paiB; transcriptional regulator
K07735 algH; putative transcriptional regulator
K08277 caiF; transcriptional activator CaiF
K06204 dksA; RNA polymerase-binding transcription factor
K07738 nrdR; transcriptional repressor NrdR
K09683 hutP; hut operon positive regulatory protein
K11926 crl; sigma factor-binding protein Crl
K12296 comX1_2; competence protein ComX
K02250 comK; competence protein ComK
K14414 rtcR; transcriptional regulatory protein RtcR
K19667 xpsR; transcriptional activator of eps genes
K22302 dicC; transcriptional repressor of cell division inhibition gene dicB
K23306 brz; bacteriorhodopsin-regulating zinc finger protein
K03925 mraZ; transcriptional regulator MraZ
K08088 fimY; fimbrial regulator
K25885 exoR; exopolysaccharide production negative regulator
K07471 ygiV; probable transcriptional regulator
K26991 yvrL; membrane-bound negative regulator
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Transcription Factors