Transcription Machinery

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 Eukaryotic type
   RNA polymerase II system
     RNA polymerase II
     Basal transcription factors
     Mediator complex
     Coactivators
       SAGA/TFTC/STAGA complex
       BAF/PBAF complex
         K11647  SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:5.6.2.-]
         K11648  SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
         K11649  SMARCC; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C
         K11650  SMARCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D
         K11651  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
         K05692  ACTB_G1; actin beta/gamma 1
         K11340  ACTL6A, INO80K; actin-like protein 6A
         K11652  ACTL6B; actin-like protein 6B
         K11653  ARID1; AT-rich interactive domain-containing protein 1
         K11765  ARID2; AT-rich interactive domain-containing protein 2
         K11757  PBRM1, PB1; protein polybromo-1
       SWI/SNF complex
         K11771  SWI1, ADR6; SWI/SNF chromatin-remodeling complex subunit SWI1
         K11786  STH1_SNF2; ATP-dependent helicase STH1/SNF2 [EC:5.6.2.-]
         K11648  SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
         K11772  SWI3; SWI/SNF complex subunit SWI3
         K11773  SNF6; SWI/SNF complex component SNF6
         K11774  SNF11; SWI/SNF complex component SNF11
         K11775  SNF12, SWP73; SWI/SNF complex component SWP73
         K11776  SWP82; SWI/SNF complex component SWP82
         K11767  ARP7, SWP61; actin-related protein 7
         K11768  ARP9, SWP59; actin-related protein 9
         K03140  TAF14; transcription initiation factor TFIID/TFIIF subunit
       RSC complex
         K11756  RSC1_2; chromatin structure-remodeling complex subunit RSC1/2
         K11758  RSC3_30; chromatin structure-remodeling complex subunit RSC3/30
         K11759  RSC4; chromatin structure-remodeling complex subunit RSC4
         K11760  RSC6; chromatin structure-remodeling complex subunit RSC6
         K11761  NPL6, RSC7; chromatin structure-remodeling complex protein RSC7
         K11762  RSC8, SWH3, SSR2; chromatin structure-remodeling complex subunit RSC8
         K11763  RSC9; chromatin structure-remodeling complex subunit RSC9
         K11764  LDB7, RSC14; chromatin structure-remodeling complex protein RSC14
         K11766  RSC58; chromatin structure-remodeling complex subunit RSC58
         K11767  ARP7, SWP61; actin-related protein 7
         K11768  ARP9, SWP59; actin-related protein 9
         K11769  HTL1; chromatin structure-remodeling complex protein HTL1
         K11770  SFH1; chromatin structure-remodeling complex subunit SFH1
         K11786  STH1_SNF2; ATP-dependent helicase STH1/SNF2 [EC:5.6.2.-]
       Others
     Other transcription-related factors
       Transcription elongation factors
       Transcription termination factor
         K15173  TTF2; transcription termination factor 2 [EC:5.6.2.-]
         K14400  PCF11; pre-mRNA cleavage complex 2 protein Pcf11
         K14401  CPSF1, CFT1; cleavage and polyadenylation specificity factor subunit 1
         K14403  CPSF3, YSH1; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
         K14404  CPSF4, YTH1; cleavage and polyadenylation specificity factor subunit 4
         K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
         K06100  SYMPK; symplekin
         K15544  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
         K12619  XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
         K14845  RAI1, DOM3Z; RAT1-interacting protein
         K15559  RTT103; regulator of Ty1 transposition protein 103
         K13219  SFPQ, PSF; splicing factor, proline- and glutamine-rich
         K15560  NRD1; protein NRD1
         K13191  RBM16, SCAF8; RNA-binding protein 16
         K13167  SCAF4, SFRS15; SR-related and CTD-associated factor 4
         K15561  NAB3; nuclear polyadenylated RNA-binding protein 3
         K10706  SETX, ALS4, SEN1; ATP-dependent RNA/DNA helicase, senataxin [EC:5.6.2.5 5.6.2.3]
         K09578  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
       PAF1 complex
       NELF complex
       Super elongation complex (SEC)
       Little elongation complex (LEC)
       Brd4/P-TEFb complex
       BUR kinase complex
       CTDK-I complex
       7SK RNP complex
         K15189  HEXIM1_2; protein HEXIM1/2
         K15190  MEPCE, BCDIN3; 7SK snRNA methylphosphate capping enzyme [EC:2.1.1.-]
         K15191  LARP7; La-related protein 7
         K15188  CCNT; cyclin T
         K02211  CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
       DBIRD complex
       Others
   RNA polymerase III system
     RNA polymerase III
     Basal transcription factors
     Other transcription-related factors
       snRNA-activating protein complex (SNAPc)
         K15208  SNAPC1; snRNA-activating protein complex subunit 1
         K15209  SNAPC2; snRNA-activating protein complex subunit 2
         K15210  SNAPC3; snRNA-activating protein complex subunit 3
         K09453  SNAPC4; snRNA-activating protein complex subunit 4
         K15211  SNAPC5; snRNA-activating protein complex subunit 5
       Octamer transcription factors
         K09364  POU2F, OTF; POU domain transcription factor, class 2
         K09367  POU5F; POU domain transcription factor, class 5
       Others
         K20828  ZNF143_76, STAF; zinc finger protein 143/76
         K25817  MAF1; repressor of RNA polymerase III transcription MAF1
   RNA polymerase I system
     RNA polymerase I
     Basal transcription factors
     Other transcription-related factors
       UBF
       Transcription initiation factors
       Transcription elongation factors
       NoRC (nucleolar remodeling complex)
         K11654  SMARCA5, SNF2H, ISWI; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [EC:5.6.2.-]
         K15224  BAZ2A, TIP5; bromodomain adjacent to zinc finger domain protein 2A
       CTDK-I complex
       Transcription termination factors
       Others
 
 Prokaryotic type
   Bacterial type
     RNA polymerase
     Other transcription-related factors
       RNA polymerase-associated proteins
         K03580  hepA; ATP-dependent helicase HepA [EC:5.6.2.-]
         K02600  nusA; transcription termination/antitermination protein NusA
         K03625  nusB; transcription antitermination protein NusB
         K02601  nusG; transcription termination/antitermination protein NusG
         K03599  sspA, mglA; stringent starvation protein A
         K03600  sspB; stringent starvation protein B
         K17752  rsbT; serine/threonine-protein kinase RsbT [EC:2.7.11.1]
         K17762  rsbS; rsbT antagonist protein RsbS
         K17763  rsbR; rsbT co-antagonist protein RsbR
         K07315  rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3]
         K19707  rsbQ; sigma-B regulation protein RsbQ
         K05518  rsbX; phosphoserine phosphatase RsbX [EC:3.1.3.3]
         K04749  rsbV, rsfB; anti-sigma B/F factor antagonist
         K04757  rsbW; serine/threonine-protein kinase RsbW (anti-sigma-B/F factor) [EC:2.7.11.1]
         K06378  spoIIAA; stage II sporulation protein AA (anti-sigma F factor antagonist)
         K06379  spoIIAB; stage II sporulation protein AB (anti-sigma F factor) [EC:2.7.11.1]
         K03597  rseA; sigma-E factor negative regulatory protein RseA
         K03598  rseB; sigma-E factor negative regulatory protein RseB
         K03803  rseC; sigma-E factor negative regulatory protein RseC
         K29217  rseA; anti-sigma-E factor RseA
         K29218  rshA; anti-sigma-H factor RshA
         K29219  rskA; anti-sigma-K factor RskA
         K29220  rslA; anti-sigma-L factor RslA
       Transcription elongation factors
         K06204  dksA; RNA polymerase-binding transcription factor
         K03624  greA; transcription elongation factor GreA
         K04760  greB; transcription elongation factor GreB
       Transcription termination factor
         K03628  rho; transcription termination factor Rho
         K19000  rof; Rho-binding antiterminator
   Archaeal type

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Last updated: September 17, 2026