DNA Repair and Recombination Proteins

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 Eukaryotic type
   SSBR (single strand breaks repair)
   DSBR (double strand breaks repair)
     HR (homologous recombination)
       MRN(MRX) complex
       BRCA1-core complex
       BRCA1-A complex
       BRCA1-B complex
       BRCA1-C complex
       BRCA complex
       RecA family proteins
       Rad52 family proteins
       Rad54 family proteins
       RecQ family DNA helicases
       Bloom's syndrome complex (BTR)
       RPA (replication factor A)
       Protein phosphatase 4
       AP-5 complex
       SMC5-SMC6 complex
       Other HR factors
         K10882  EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
         K10883  EME2; crossover junction endonuclease EME2
         K20777  EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
         K08991  MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
         K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
         K10991  SWI5, SAE3; DNA repair protein Swi5/Sae3
         K10992  SFR1; Swi5-dependent recombination DNA repair protein 1
         K15078  SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
         K10484  BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
         K15079  SLX4; structure-specific endonuclease subunit SLX4
         K15338  GEN1, YEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
         K19026  SPG11; spatacsin
         K19027  ZFYVE26; zinc finger FYVE domain-containing protein 26
         K20778  RAD51AP1; RAD51-associated protein 1
         K28888  NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
         K11339  MORF4L1, MRG15, EAF3; mortality factor 4-like protein 1
         K22544  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
         K22766  FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
         K22806  SPIDR; DNA repair-scaffolding protein
         K22810  FAM84B; protein FAM84B
         K23112  BRAT1; BRCA1-associated ATM activator 1
         K23456  CFAP410, C21ORF2; cilla- and flagella-associated protein
         K25065  HDGFL2; hepatoma-derived growth factor-related protein 2
         K25770  ZSWIM7, SWS1; zinc finger SWIM domain-containing protein 7
         K25771  SWSAP1; ATPase SWSAP1
         K25790  EMSY; BRCA2-interacting transcriptional repressor EMSY
         K25791  HSF2BP; heat shock factor 2-binding protein
         K26125  MMS22L; protein MMS22-like
         K09257  NFKBIL2; NF-kappa-B inhibitor-like protein 2
         K27262  BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
         K27412  PARPBP; PCNA-interacting partner
         K27803  HROB; homologous recombination OB-fold protein
         K10737  MCM8; DNA helicase MCM8 [EC:5.6.2.4]
         K10738  MCM9; DNA helicase MCM9 [EC:5.6.2.4]
         K15047  HNRNPUL1, E1BAP5; heterogeneous nuclear ribonucleoprotein U-like protein 1
         K28611  HNRNPUL2; heterogeneous nuclear ribonucleoprotein U-like protein 2
         K28623  MRNIP; MRN complex-interacting protein
         K29002  RADX; RPA-related protein RADX
         K29038  RBM6; RNA-binding protein 6
         K22807  WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
         K22685  WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
         K26559  WHY1; single-stranded DNA-binding protein WHY1
         K26561  WHY2; single-stranded DNA-binding protein WHY2
         K26560  WHY3; single-stranded DNA-binding protein WHY3
         K14635  MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
         K15080  SAW1; single-strand annealing weakened protein 1
         K26124  RTT101, CUL8; cullin 8
         K26122  MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
         K26123  MMS1; E3 ubiquitin-protein ligase linker protein MMS1
     NHEJ (non-homologous end-joining)
     FA (Fanconi anemia) pathway
     Other DSBR factors
   TLS (translesion DNA synthesis) factors
     Y-family DNA polymerases
     B-family DNA polymerases
     A-family DNA polymerase
     Rad6 epistasis group
       K10573  UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
       K10574  UBE2B, RAD6B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
       K10627  RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
       K15505  RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
       K15711  SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
       K10704  UBE2V; ubiquitin-conjugating enzyme E2 variant
       K10580  UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
     Other TLS factors
   Check point factors
   Other factors with a suspected DNA repair function
 
 Prokaryotic type
   SSBR (single strand breaks repair)
   DSBR (double strand breaks repair)
     HR (homologous recombination)
       RecBC pathway proteins
       RecFOR pathway proteins
       AddAB pathway proteins
       Other HR factor
       Archaeal homologous recombinant proteins
         K04483  radA; DNA repair protein RadA
         K04484  radB; DNA repair protein RadB
         K03552  hjr, hjc, hje; holliday junction resolvase [EC:3.1.21.10]
         K03546  sbcC, rad50; DNA repair protein SbcC/Rad50
         K03547  sbcD, mre11; DNA repair protein SbcD/Mre11
         K06915  herA; DNA double-strand break repair helicase HerA and related ATPase
         K25510  nurA; DNA double-strand break repair nuclease NurA [EC:3.1.-.-]
         K03726  helS; ATP-dependent DNA helicase [EC:5.6.2.4]
     NHEJ (non-homologous end-joining)
   TLS (translesion DNA synthesis) factors
   Other factors with a suspected DNA repair function

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Last updated: June 23, 2026