KEGG ORTHOLOGY: K20777

ORTHOLOGY: K20777

Entry

K20777                      KO

Symbol

EXD2

Name

exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K20777  EXD2; exonuclease 3'-5' domain-containing protein 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.11.1  exodeoxyribonuclease I
     K20777  EXD2; exonuclease 3'-5' domain-containing protein 2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     K20777  EXD2; exonuclease 3'-5' domain-containing protein 2

Other DBs

GO:	0008852 0008310

Genes

HSA:	55218(EXD2)

PTR:	452996(EXD2)

PPS:	100981128(EXD2)

GGO:	101141719(EXD2)

PON:	100454609(EXD2)

NLE:	100598564(EXD2)

HMH:	116484498(EXD2)

MCC:	712296(EXD2)

MCF:	102132077(EXD2)

MTHB:

126958774

MNI:	105472888(EXD2)

CSAB:

103229241(EXD2)

CATY:

105582883(EXD2)

PANU:

101007812(EXD2)

TGE:	112628857(EXD2)

MLEU:

105554422(EXD2)

RRO:	104659636(EXD2)

RBB:	108533736(EXD2)

TFN:	117069411(EXD2)

PTEH:

111520162(EXD2)

CANG:

105517229(EXD2)

CJC:	100408563(EXD2)

SBQ:	101042550(EXD2)

CIMI:

108284346(EXD2)

CSYR:

103250425(EXD2)

MMUR:

105880261(EXD2)

LCAT:

123647446(EXD2)

PCOQ:

105819927(EXD2)

OGA:	100961030(EXD2)

MMU:	97827(Exd2)

MCAL:

110307376(Exd2)

MPAH:

110324346(Exd2)

RNO:	362759(Exd2)

MCOC:

116080049(Exd2)

ANU:	117697374(Exd2)

MUN:	110546606(Exd2)

CGE:	100765115(Exd2)

MAUA:

101823551(Exd2)

PROB:

127230914(Exd2)

PLEU:

114697784(Exd2)

MORG:

121452578(Exd2)

MFOT:

126511475

AAMP:

119818867(Exd2)

NGI:	103744214(Exd2)

HGL:	101710627(Exd2)

CPOC:

100721998(Exd2)

CCAN:

109685990(Exd2)

DORD:

105986534(Exd2)

DSP:	122118783(Exd2)

PLOP:

125363171(Exd2)

NCAR:

124978210

MMMA:

107146421(Exd2)

OCU:

100348519

OPI:	101520170(EXD2)

TUP:	102502137(EXD2)

GVR:	103591291(EXD2)

CFA:	490750(EXD2)

CLUD:

112657070(EXD2)

VVP:	112927208(EXD2)

VLG:	121493219(EXD2)

NPO:	129496067(EXD2)

AML:	100469494(EXD2)

UMR:	103671636(EXD2)

UAH:	113270396(EXD2)

UAR:	123799045(EXD2)

ELK:

111148561

LLV:

125104042

MPUF:

101676440(EXD2)

MNP:	132000065(EXD2)

MLK:	131836730(EXD2)

NVS:	122893061(EXD2)

ORO:	101369710(EXD2)

EJU:	114204769(EXD2)

ZCA:	113909548(EXD2)

MLX:	118002668(EXD2)

NSU:	110571611(EXD2)

LWW:	102741186(EXD2) 102750126

FCA:	101098798(EXD2)

PYU:	121031967(EXD2)

PCOO:

112856130(EXD2)

PBG:	122467782(EXD2)

PVIV:

125167279(EXD2)

LRUF:

124512080

PTG:	102956146(EXD2)

PPAD:

109268264(EXD2)

PUC:

125909408

AJU:

106971566

HHV:	120237427(EXD2)

BTA:	539532(EXD2)

BOM:	102264899(EXD2)

BIU:	109565284(EXD2)

BBUB:

102400738(EXD2)

BBIS:

104993442(EXD2)

CHX:	102175029(EXD2)

OAS:	101117589(EXD2)

BTAX:

128054011(EXD2)

ODA:	120852778(EXD2)

CCAD:

122443793(EXD2)

MBEZ:

129562950(EXD2)

SSC:	100155300(EXD2)

CFR:	102514478(EXD2)

CBAI:

105074705(EXD2)

CDK:	105086157(EXD2)

VPC:	102539500(EXD2)

BACU:

103011846(EXD2)

BMUS:

118890942(EXD2)

LVE:	103087906(EXD2)

OOR:	101285736(EXD2)

DLE:	111173028(EXD2)

PCAD:

102976562(EXD2)

PSIU:

116749371(EXD2)

NASI:

112396109(EXD2)

ECB:	100053111(EXD2)

EPZ:	103547166(EXD2)

EAI:	106847741(EXD2)

MYB:	102262743(EXD2)

MYD:	102762340(EXD2)

MMYO:

118657110(EXD2)

MLF:

102420442

PKL:	118716266(EXD2)

EFUS:

103283629(EXD2)

MNA:	107545711(EXD2)

DRO:	112311533(EXD2)

SHON:

118976702(EXD2)

AJM:	119035638(EXD2)

PDIC:

114492308(EXD2)

PHAS:

123808477(EXD2)

MMF:	118638376(EXD2)

PPAM:

129065935(EXD2)

HAI:	109382107(EXD2)

RFQ:	117023960(EXD2)

PALE:

102888910(EXD2)

PGIG:

120612786(EXD2)

PVP:	105308026(EXD2)

RAY:	107503278(EXD2)

MJV:	108391823(EXD2)

TOD:	119239223(EXD2)

SARA:

101549291(EXD2)

SETR:

126004003(EXD2)

LAV:	100661708(EXD2)

TMU:

101360551

ETF:	101652989(EXD2)

DNM:	101442472(EXD2)

MDO:	100028590(EXD2)

GAS:

123237715

SHR:	100925474(EXD2)

AFZ:

127549674

PCW:	110220661(EXD2)

OAA:	100074346(EXD2)

GGA:	423264(EXD2)

PCOC:

116229275(EXD2)

MGP:	100549672(EXD2)

CJO:	107314902(EXD2)

TPAI:

128087383(EXD2)

LMUT:

125694644(EXD2)

NMEL:

110400986(EXD2)

APLA:

101795979(EXD2)

ACYG:

106031659(EXD2)

CATA:

118244433(EXD2)

AFUL:

116490266(EXD2)

TGU:	100222893(EXD2)

LSR:	110479661(EXD2)

SCAN:

103826608(EXD2)

PMOA:

120500232(EXD2)

OTC:	121331499(EXD2) 121339448

PRUF:

121349422(EXD2)

GFR:	102042773(EXD2)

FAB:	101813352(EXD2)

OMA:	130253716(EXD2)

PHI:	102100000(EXD2)

PMAJ:

107206031(EXD2)

CCAE:

111930277(EXD2)

CCW:	104683675(EXD2)

CBRC:

103620803(EXD2)

ETL:	114055503(EXD2)

ZAB:	102061766(EXD2)

ACHL:

103808677(EXD2)

SVG:	106849037(EXD2)

MMEA:

130574139(EXD2)

HRT:	120754415(EXD2)

FPG:	101912429(EXD2)

FCH:	102049018(EXD2)

CLV:	102087628(EXD2)

EGZ:	104122109(EXD2)

NNI:	104020312(EXD2)

PCRI:

104025146(EXD2)

PLET:

104623384(EXD2)

EHS:	104509877(EXD2)

PCAO:

104049203(EXD2)

ACUN:

113480620(EXD2)

TALA:

104368645(EXD2)

PADL:

103918286(EXD2)

AFOR:

103898908(EXD2)

ACHC:

115338671(EXD2)

HALD:

104314178(EXD2)

HLE:	104835913(EXD2)

AGEN:

126049251

GCL:

127016358

CCRI:

104154567(EXD2)

CSTI:

104556467(EXD2)

CMAC:

104482907(EXD2)

MUI:	104537917(EXD2)

BREG:

104629080

FGA:	104081653(EXD2)

GSTE:

104264779(EXD2)

LDI:	104354674(EXD2)

MNB:	103781142(EXD2)

OHA:	104326939(EXD2)

NNT:	104408197(EXD2)

SHAB:

115607720(EXD2)

DPUB:

104300350(EXD2)

ACAR:

104521919(EXD2)

CPEA:

104397675(EXD2)

AVIT:

104276443(EXD2)

CVF:	104285094(EXD2)

RTD:	128908805(EXD2)

CUCA:

104062787(EXD2)

TEO:	104377164(EXD2)

BRHI:

104492322(EXD2)

AAM:

106498359

AROW:

112963672(EXD2)

NPD:	112946405(EXD2)

TGT:	104577014(EXD2)

DNE:	112980698(EXD2)

SCAM:

104153836(EXD2)

ASN:	102380497(EXD2)

AMJ:	102569788(EXD2)

CPOO:

109321403(EXD2)

GGN:	109298848(EXD2)

PSS:	102463492(EXD2)

CMY:	102931960(EXD2)

CCAY:

125638452(EXD2)

DCC:	119858017(EXD2)

CPIC:

101947243(EXD2)

TST:	117876866(EXD2)

CABI:

116821506(EXD2)

MRV:	120403723(EXD2)

ACS:	100553135(exd2)

ASAO:

132767293(EXD2)

PVT:	110076422(EXD2)

SUND:

121919198(EXD2)

PBI:	103053120(EXD2)

PMUR:

107285830(EXD2)

CTIG:

120299313(EXD2)

TSR:	106539602(EXD2)

PGUT:

117665581(EXD2)

APRI:

131187523(EXD2)

PTEX:

113441675(EXD2)

NSS:	113414303(EXD2)

VKO:	123026814(EXD2)

PMUA:

114595002(EXD2)

PRAF:

128412205(EXD2)

ZVI:	118084182(EXD2)

HCG:	128341042(EXD2)

GJA:	107112202(EXD2)

STOW:

125426774(EXD2)

EMC:	129325204(EXD2)

XLA:	100158397(exd2.S) 398805(exd2.L)

XTR:	549208(exd2)

NPR:	108794106(EXD2)

RTEM:

120921063(EXD2)

BBUF:

120982173(EXD2)

BGAR:

122922058(EXD2)

MUO:	115477525(EXD2)

GSH:	117363423(EXD2)

DRE:	334455(exd2)

SRX:	107753346 107758720

SANH:

107687840 107687943

SGH:	107558452 107589756

CCAR:

109071131 109087859

CAUA:

113116974(exd2)

CGIB:

127976596

PTET:

122362203(exd2)

LROH:

127179591(exd2)

OMC:	131523417(exd2)

PPRM:

120481165(exd2)

RKG:	130088881(exd2)

MAMB:

125268369(exd2)

CIDE:

127498751

MASI:

127410951 127455370

TROS:

130560199(exd2)

TDW:	130436822(exd2)

MANU:

129417927(exd2)

IPU:

108269970

IFU:	128612866(exd2)

PHYP:

113538766(exd2)

SMEO:

124390136(exd2)

TFD:	113659681(exd2)

TVC:	132852481(exd2)

AMEX:

103044057(exd2)

CMAO:

118823902(exd2)

EEE:	113589877(exd2)

CHAR:

105899115(exd2)

TRU:	101079715(exd2)

TFS:	130539779(exd2)

TNG:	GSTEN00004438G001

LCO:	104935352(exd2)

TBEN:

117493796(exd2)

CGOB:

115027797(exd2)

PGEO:

117468089(exd2)

GACU:

117556756(exd2)

EMAC:

134881983(exd2)

ELY:	117267553(exd2)

EFO:	125901223(exd2)

PLEP:

121953892(exd2)

SLUC:

116057679(exd2)

ECRA:

117935967(exd2)

ESP:	116686123(exd2)

PFLV:

114547313(exd2)

GAT:	120833078(exd2)

PPUG:

119227319(exd2)

AFB:	129103462(exd2)

CLUM:

117725362(exd2)

PSWI:

130201287(exd2)

MSAM:

119910186(exd2)

SCHU:

122862195(exd2)

CUD:	121526702(exd2)

ALAT:

119004865(exd2)

MZE:	101486647(exd2)

ONL:	100697775(exd2)

OAU:	116318161(exd2)

OLA:	101175217(exd2)

OML:	112148307(exd2)

CSAI:

133462092(exd2)

XMA:	102219587(exd2)

XCO:	114134601(exd2)

XHE:	116708431(exd2)

PRET:

103458220(exd2)

PFOR:

103150043(exd2)

PLAI:

106951979(exd2)

PMEI:

106921676(exd2)

GAF:	122846103(exd2)

PPRL:

129377232(exd2)

CVG:	107099428(exd2)

CTUL:

119794926(exd2)

GMU:	124855205(exd2)

NFU:	107391858(exd2)

KMR:	108235343(exd2)

ALIM:

106535886(exd2)

NWH:	119427045(exd2)

AOCE:

111573546(exd2)

MCEP:

125023850(exd2)

CSEM:

103381622(exd2)

POV:	109646202(exd2)

SSEN:

122782801(exd2)

HHIP:

117756417(exd2)

HSP:	118116312(exd2)

SMAU:

118285876(exd2)

LCF:

108876609

SDU:	111225958(exd2)

SLAL:

111646824(exd2)

XGL:	120795823(exd2)

HCQ:	109517280(exd2)

SSCV:

125980995

SBIA:

133512944(exd2)

PEE:	133412585(exd2)

PTAO:

133487388(exd2)

BPEC:

110157470(exd2)

MALB:

109962471(exd2)

BSPL:

114848801(exd2)

SJO:	128374859(exd2)

SASA:

106577206(exd2) 106591874 106594271

STRU:

115161834 115173030

OTW:	112236358(exd2) 112255832

OMY:	110498418 110505945(exd2)

OGO:	124001689 124046803(exd2)

ONE:

115120394

OKI:	109882482 109904624

OKE:	118362110 118369108 127922412

SALP:

112072896 112076611(exd2)

SNH:	120023216 120060101

CCLU:

121539125 121544531

ELS:	105015906(exd2)

SFM:	108919375(exd2)

PKI:	111852028(exd2)

AANG:

118209621(exd2)

LOC:	102695465(exd2)

PSPA:

121323757 121329975(exd2)

ARUT:

117422043(exd2)

PSEX:

120518448(exd2)

LCM:	102361044(EXD2)

CMK:	103178441(exd2)

RTP:	109919570(exd2)

CPLA:

122553819(exd2)

HOC:	132817823(exd2)

LERI:

129700407(exd2)

PMRN:

116947754(EXD2)

LRJ:	133341410(EXD2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG6744(Exd2)

DER:

6553858

DSE:

6606823

DSI:	Dsimw501_GD20659(Dsim_GD20659)

DYA:	Dyak_GE24622

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22458

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119664403 119676174 119686024

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119638693 119638694 119638696 119642760 119642762 119643811 119643847

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ010215 CpipJ_CPIJ010267

CPII:

120423875 120432451

CNS:	116342857 116346857 116346858 116349325

BCOO:

119066709 119069009 119074874 119075879

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100120121(Exdl2)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202169

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

113367358 113367360 113367361

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

109036461 109036533 109043590

DCI:

103524369

NLU:	111058434 111060504

MQU:	128991071 128993499

PHU:	Phum_PHUM002160

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_325251 DAPPUDRAFT_325261 DAPPUDRAFT_341412

DMK:

116927368

DPZ:

124325935

PVM:	113805241 113825786 113825787 113829633

PJA:	122243118 122264449 122264469

PCHN:

125032854 125039564 125039577

PMOO:

119572226 119586388 119586390 119586391

HAME:

121871454 121871456

PCLA:

123768933 123769241

CQD:	128687639 128687641

PTRU:

123513142 123518030

ESN:	126997859 127006980

MNZ:	135194981 135226695

HAZT:

EAF:

TCF:

PPOI:

DSV:

RSAN:

VDE:	111243736 111245006 111254230

VJA:	111261288 111265261 111270175

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

TSP:

HRO:	HELRODRAFT_190612

LGI:	LOTGIDRAFT_119943

PVUL:

126815358

BGT:

106071181

GAE:	121383573 121384250

HRF:	124146063 124149180

HRJ:	124271671 124282872

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:	107329907 107329909 107330735 107348847 107348848 107348849 107356323

AMIL:

114965899 114965915 114973205

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

CRE:	CHLRE_10g451250v5 CHLRE_10g451300v5

VCN:	VOLCADRAFT_104579 VOLCADRAFT_99000

CSL:	COCSUDRAFT_65906

FGR:	FGSG_06820

FPU:	FPSE_11845

FVR:	FVEG_05166

FOX:	FOXG_02005

NHE:	NECHADRAFT_48479

TRE:	TRIREDRAFT_52956

TRR:	M419DRAFT_84787

CMT:

CCM_03151

DSQ:	DICSQDRAFT_94692

PSQ:	PUNSTDRAFT_48565

LBC:	LACBIDRAFT_301746

CPUT:

CONPUDRAFT_46607

MBR:	MONBRDRAFT_37441

DDI:	DDB_G0278079(exdl2A)

DPP:	DICPUDRAFT_146576 DICPUDRAFT_154097

DFA:	DFA_00645(exdl2A) DFA_05468

PTM:	GSPATT00020313001 GSPATT00023558001

SMIN:

v1.2.014490.t1(symbB.v1.2.014490.t1)

FCY:	FRACYDRAFT_149334

GTT:	GUITHDRAFT_146260

NGR:	NAEGRDRAFT_68365

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Reference

PMID:26807646

Authors

Broderick R, Nieminuszczy J, Baddock HT, Deshpande RA, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W

Title

EXD2 promotes homologous recombination by facilitating DNA end resection.

Journal

Nat Cell Biol 18:271-80 (2016)
DOI:10.1038/ncb3303

Sequence

[hsa:55218]

LinkDB

DBGET integrated database retrieval system