KEGG   ORTHOLOGY: K10627
Entry
K10627                      KO                                     
Symbol
RAD18
Name
E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10627  RAD18; E3 ubiquitin-protein ligase RAD18
   03400 DNA repair and recombination proteins
    K10627  RAD18; E3 ubiquitin-protein ligase RAD18
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10627  RAD18; E3 ubiquitin-protein ligase RAD18
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10627  RAD18; E3 ubiquitin-protein ligase RAD18
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  TLS (translesion DNA synthesis) factors
   Rad6 epistasis group
    K10627  RAD18; E3 ubiquitin-protein ligase RAD18
Genes
HSA: 56852(RAD18)
PTR: 460144(RAD18)
PPS: 100987535(RAD18)
GGO: 101128422(RAD18)
PON: 100172537(RAD18)
PPYG: 129033703(RAD18)
NLE: 100591424(RAD18)
HMH: 116466696(RAD18)
SSYN: 129471047(RAD18)
MCC: 704708(RAD18)
MCF: 102135261(RAD18)
MTHB: 126947696
MNI: 105477646(RAD18)
CSAB: 103227963(RAD18)
CATY: 105585742(RAD18)
PANU: 101009263(RAD18)
TGE: 112618531(RAD18)
MLEU: 105554253(RAD18)
RRO: 104667475(RAD18)
RBB: 108530948(RAD18)
TFN: 117083196(RAD18)
PTEH: 111546963(RAD18)
CANG: 105525601(RAD18)
CJC: 100395032(RAD18)
SBQ: 101050326(RAD18)
CIMI: 108284702(RAD18)
ANAN: 105730025(RAD18)
CSYR: 103273843(RAD18)
MMUR: 105869090(RAD18)
LCAT: 123623152(RAD18)
ERUF: 138387021(RAD18)
PCOQ: 105812123(RAD18)
OGA: 100959302(RAD18)
MMU: 58186(Rad18)
MCAL: 110296281(Rad18)
MPAH: 110316714(Rad18)
RNO: 362412(Rad18)
MCOC: 116099378(Rad18)
ANU: 117714648(Rad18)
ASYL: 127679023(Rad18)
MUN: 110548314(Rad18)
CGE: 100758311(Rad18) 100759084
MAUA: 101831818(Rad18)
PROB: 127236159(Rad18)
PLEU: 114689588(Rad18)
PMAV: 102920684(Rad18)
MORG: 121437754(Rad18) 121442694
MFOT: 126505497
AAMP: 119808097(Rad18)
CNL: 130885068(Rad18)
NGI: 103751408(Rad18)
HGL: 101700755 101717786(Rad18)
CPOC: 100720939(Rad18)
CCAN: 109688340(Rad18)
DORD: 105981395(Rad18)
DSP: 122107936(Rad18)
PLOP: 125358773(Rad18)
NCAR: 124971036
MMMA: 107150050(Rad18)
ITI: 101965365(Rad18)
OCU: 100345274
OPI: 101528857(RAD18)
OCZ: 121166072(RAD18)
TUP: 102480989(RAD18)
GVR: 103605949(RAD18)
CFA: 476544(RAD18)
CLUD: 112662297(RAD18)
VVP: 112933720(RAD18)
VLG: 121495924(RAD18)
NPO: 129521332(RAD18)
AML: 100473633(RAD18)
UMR: 103669584(RAD18)
UAH: 113257127(RAD18)
UAR: 123799177(RAD18)
ELK: 111144077
LLV: 125109252
MPUF: 101685431(RAD18)
MNP: 132009878(RAD18)
MLK: 131824182(RAD18)
NVS: 122909241(RAD18)
ORO: 101379847(RAD18)
EJU: 114207734(RAD18)
ZCA: 113917249(RAD18)
MLX: 118005149(RAD18)
NSU: 110584879(RAD18)
LWW: 102725700(RAD18)
FCA: 101081963(RAD18)
PYU: 121041308(RAD18)
PCOO: 112858606(RAD18)
PBG: 122487469(RAD18)
PVIV: 125161231(RAD18)
LRUF: 124524018
LGF: 123605933(RAD18)
AJU: 106972348
PTG: 102952118(RAD18)
PPAD: 109254402(RAD18)
PUC: 125929601
PLEZ: 122203333(RAD18)
HHV: 120231273(RAD18)
BTA: 514440(RAD18)
BOM: 102271579(RAD18)
BIU: 109576438(RAD18)
BBUB: 102401679(RAD18)
BKE: 129634814(RAD18)
BBIS: 104979858(RAD18)
CHX: 102189249(RAD18)
OAS: 101106800(RAD18)
BTAX: 128055066(RAD18)
CSUM: 138087518(RAD18)
ODA: 120867685(RAD18)
CCAD: 122424358(RAD18)
MREE: 136167761(RAD18)
OVR: 110140225(RAD18)
MBEZ: 129548047(RAD18)
SSC: 100217383(RAD18)
CFR: 102509822(RAD18)
CBAI: 105067424(RAD18)
CDK: 105093146(RAD18)
VPC: 102545564(RAD18)
BACU: 103014713(RAD18)
BMUS: 118904428(RAD18)
LVE: 103083149(RAD18)
OOR: 101285956(RAD18)
LALB: 132527832(RAD18)
GMF: 115844040(RAD18)
DDP: 132432480(RAD18)
DLE: 111169968(RAD18)
PCAD: 102992348(RAD18)
PSIU: 116762857(RAD18)
PPHC: 136129382(RAD18)
NASI: 112396785(RAD18)
ECB: 100052645(RAD18)
EPZ: 103559118(RAD18)
EAI: 106841766(RAD18)
MYB: 102241055(RAD18)
MYD: 102766796(RAD18)
MMYO: 118668023(RAD18)
MLF: 102429758(RAD18)
MDT: 132215354(RAD18)
MYUM: 138992674(RAD18)
PKL: 118715177(RAD18)
EFUS: 103295282(RAD18)
MNA: 107534792(RAD18)
DRO: 112301145(RAD18)
SHON: 118993360(RAD18)
AJM: 119041413(RAD18)
PDIC: 114502065(RAD18)
PHAS: 123814588(RAD18)
MMF: 118633400(RAD18)
PPAM: 129087887(RAD18)
HAI: 109387264(RAD18)
RFQ: 117037315(RAD18)
PALE: 102879933(RAD18)
PGIG: 120621428(RAD18)
PVP: 105299066(RAD18)
RAY: 107505034(RAD18)
MJV: 108397670(RAD18)
TOD: 119255148(RAD18)
SARA: 101541542(RAD18)
SFUM: 130037269(RAD18)
SETR: 125998065(RAD18)
LAV: 100658955(RAD18)
TMU: 101345493
ETF: 101646036(RAD18)
DNM: 101439013(RAD18)
MDO: 100023569(RAD18)
GAS: 123247177(RAD18)
SHR: 100928699(RAD18)
AFZ: 127551587
PCW: 110199088(RAD18)
TVP: 118831244(RAD18)
PBRV: 138158087(RAD18)
MLAO: 141496282(RAD18)
OAA: 103170251(RAD18)
TACU: 119919498(RAD18)
GGA: 416114(RAD18)
PCOC: 116236635(RAD18)
MGP: 100544303(RAD18)
CJO: 107319987(RAD18)
TPAI: 128078474(RAD18)
LMUT: 125698771(RAD18)
NMEL: 110404855(RAD18)
APLA: 101795815(RAD18)
AACU: 137862353(RAD18)
ACYG: 106036732(RAD18)
CATA: 118248199(RAD18)
AFUL: 116493260(RAD18)
TGU: 100224321(RAD18)
LSR: 110477119(RAD18)
SCAN: 103824134(RAD18)
PMOA: 120514113(RAD18)
OTC: 121347308(RAD18)
PRUF: 121350533(RAD18)
ATRC: 139595725(RAD18)
GFR: 102035408(RAD18)
FAB: 101814043(RAD18)
OMA: 130258375(RAD18)
PHI: 102104638(RAD18)
PMAJ: 107210127(RAD18)
CCAE: 111934913(RAD18)
CCW: 104683519(RAD18)
CBRC: 103616321(RAD18)
ACOE: 138117423(RAD18)
ETL: 114070952(RAD18)
ZAB: 102063139(RAD18)
ZLE: 135453255(RAD18)
ACHL: 103797578(RAD18)
SVG: 106851771(RAD18)
MMEA: 130585466(RAD18)
HRT: 120758200(RAD18)
SATI: 136366223(RAD18)
CCIC: 134048735(RAD18)
FPG: 101921579(RAD18)
FCH: 102057190(RAD18)
CCRI: 104165406(RAD18)
NNT: 104405912(RAD18)
SHAB: 115614554(RAD18)
ACUN: 113484972(RAD18)
ACHC: 115333365(RAD18)
HALD: 104319953(RAD18)
HLE: 104833572(RAD18)
AGEN: 126049800
HHAR: 128137120(RAD18)
BBUT: 142042677(RAD18)
GCL: 127021563
CSTI: 104559311(RAD18)
LDI: 104353033(RAD18)
MNB: 103769878(RAD18)
PPUS: 135182268(RAD18)
AVIT: 104273802(RAD18)
BRHI: 104494284(RAD18)
EGZ: 104121774(RAD18)
NNI: 104016953(RAD18)
PCRI: 104032674(RAD18)
PCAO: 104041441
PARX: 142058433(RAD18)
PADL: 103913593(RAD18)
AFOR: 103902620(RAD18)
FGA: 104069422(RAD18)
CBOR: 142086068(RAD18)
GSTE: 104250419(RAD18)
CBOY: 140658172(RAD18)
MAME: 142415749(RAD18)
CLV: 102086124(RAD18)
CNIC: 135993055(RAD18)
MUI: 104540512(RAD18)
PGUU: 104469421(RAD18)
PLET: 104617150(RAD18)
EHS: 104504602(RAD18)
CMAC: 104484029(RAD18)
CUCA: 104063592(RAD18)
TEO: 104375514(RAD18)
BREG: 104636208(RAD18)
OHA: 104334376(RAD18)
ACAR: 104523682(RAD18)
CPEA: 104393834(RAD18)
CVF: 104284522(RAD18)
RTD: 128915820(RAD18)
CRID: 134521668(RAD18)
LMIC: 141749467(RAD18)
AAM: 106494835(RAD18)
AROW: 112970462(RAD18)
NPD: 112958719(RAD18)
TGT: 104577214(RAD18)
DNE: 112982908(RAD18)
SCAM: 104148112(RAD18)
ASN: 102375130(RAD18)
AMJ: 102563738(RAD18)
CPOO: 109311140(RAD18)
GGN: 109288936(RAD18)
PSS: 102444322(RAD18)
CIZ: 142019069(RAD18)
CMY: 102941266(RAD18)
CCAY: 125639320(RAD18)
LKP: 140914114(RAD18)
NDS: 141990412(RAD18)
DCC: 119859189(RAD18)
CPIC: 101939710(RAD18)
TST: 117880368(RAD18)
CABI: 116827054(RAD18)
MRV: 120368921(RAD18)
ACS: 100557402 103279877(rad18)
ASAO: 132769373(RAD18)
PVT: 110077861(RAD18)
SUND: 121923849(RAD18)
PBI: 103056943(RAD18)
PMUR: 107301565(RAD18)
CTIG: 120318320(RAD18)
TSR: 106549709(RAD18)
PGUT: 117673912(RAD18)
PCAE: 139309499(RAD18)
APRI: 131190855(RAD18)
PTEX: 113451323(RAD18)
NSS: 113419385(RAD18)
VKO: 123034549(RAD18)
PMUA: 114591798(RAD18)
PRAF: 128408425(RAD18)
ZVI: 118080795(RAD18)
HCG: 128346294(RAD18)
GJA: 107114124(RAD18)
STOW: 125429867(RAD18)
EMC: 129328551(RAD18)
XLA: 108714633(rad18.L)
XTR: 100494054(rad18)
NPR: 108786007(RAD18)
RTEM: 120945013(RAD18)
ACAT: 141102757(RAD18)
PADS: 140336982(RAD18)
BBUF: 120978831(RAD18)
BGAR: 122943856(RAD18)
DTC: 141088780(RAD18)
PWL: 138258975(RAD18)
MUO: 115472829(RAD18)
GSH: 117351187(RAD18)
DRE: 393106(rad18)
SRX: 107712119 107750256(rad18)
LROH: 127166880(rad18)
GRF: 141347386(rad18)
OMC: 131542226(rad18)
PPRM: 120470200(rad18)
RKG: 130087456(rad18)
MAMB: 125273825(rad18)
CIDE: 127514701
CERY: 137011212(rad18)
TROS: 130557059(rad18)
TDW: 130424760(rad18)
MANU: 129450161(rad18)
PDAB: 135770149(rad18)
IPU: 108272121
IFU: 128614614(rad18)
SMEO: 124386983(rad18)
TFD: 113643157(rad18)
TVC: 132844482(rad18)
CGAR: 128526616(rad18)
NGRA: 132885183(rad18)
TRN: 134316583(rad18)
AMEX: 103028794(rad18)
CMAO: 118808350(rad18)
EEE: 113569672(rad18)
CHAR: 105904641(rad18)
SPIL: 134092328(rad18)
ASAD: 121706913(rad18)
TFS: 130524462(rad18)
LCO: 104930494(rad18)
TBEN: 117489863(rad18)
CGOB: 115008923(rad18)
PGEO: 117447423(rad18)
GACU: 117551171(rad18)
EMAC: 134882381(rad18)
ELY: 117256339(rad18)
EFO: 125896451(rad18)
PLEP: 121956161(rad18)
SLUC: 116041692(rad18)
ECRA: 117943757(rad18)
ESP: 116688106(rad18)
PFLV: 114554810(rad18)
GAT: 120835246(rad18)
PPUG: 119194100(rad18)
AFB: 129105581(rad18)
CLUM: 117730616(rad18)
PSWI: 130208628(rad18)
CANA: 137796535(rad18)
CVE: 137873642(rad18)
MSAM: 119886291(rad18)
SCHU: 122863876(rad18)
EARM: 139283040(rad18)
CUD: 121528059(rad18)
SPUL: 138606437(rad18)
LMIX: 132977384(rad18)
HTC: 141788705(rad18)
ALAT: 119021589(rad18)
ASTR: 137596027(rad18)
PKLU: 139214409(rad18)
MZE: 101483336(rad18)
ONL: 100694313(rad18)
OAU: 116333794(rad18)
OLA: 101171403(rad18)
OML: 112145737(rad18)
CSAI: 133448511(rad18)
XMA: 102225004(rad18)
XCO: 114135760(rad18)
XHE: 116710646(rad18)
PRET: 103465214(rad18)
PFOR: 103150695(rad18)
PLAI: 106950368(rad18)
PMEI: 106903981(rad18)
GAF: 122834175(rad18)
PPRL: 129355740(rad18)
CVG: 107093339(rad18)
CTUL: 119776647
GMU: 124857420(rad18)
NFU: 107385741(rad18)
KMR: 108235555(rad18)
ALIM: 106517983(rad18)
NWH: 119412520(rad18)
AOCE: 111575522(rad18)
EJA: 138200902(rad18)
BFRE: 138636922(rad18)
MCEP: 125007328(rad18)
CSEM: 103385898(rad18)
POV: 109629025(rad18)
SSEN: 122767606(rad18)
SSOE: 131461080(rad18)
HHIP: 117761810(rad18)
HSP: 118104990(rad18)
PPLT: 128462124(rad18)
SMAU: 118309687(rad18)
LCF: 108886444
SDU: 111222142(rad18)
SLAL: 111651709
XGL: 120806947(rad18)
HCQ: 109522657(rad18)
SSCV: 125977831(rad18)
SBIA: 133508055(rad18)
PEE: 133408872(rad18)
PTAO: 133483813(rad18)
BPEC: 110168675(rad18)
ENY: 140365670(rad18)
MALB: 109964516(rad18)
BSPL: 114856102(rad18)
SJO: 128355738(rad18)
SSCO: 133977431(rad18)
TTY: 137181587(rad18)
GMH: 115557036(rad18)
SASA: 106565582(rad18) 106583181
STRU: 115150525 115207892(rad18)
OTW: 112217042(rad18) 112254648
OMY: 110494263(rad18) 110528165
OGO: 124003105(rad18) 124031245
ONE: 115140152 115143126(rad18)
ELS: 105017026(rad18)
OEP: 134028963(rad18)
SFM: 108923333(rad18)
PKI: 111835902(rad18)
AANG: 118208106 118210688(rad18)
CCOG: 133110440(rad18) 133139016
LOC: 102695914(rad18)
PSPA: 121298399(rad18)
PSEX: 120541476(rad18)
LCM: 102346340(RAD18)
CMK: 103176811(rad18)
RTP: 109930318(rad18)
CPLA: 122559168(rad18)
CPUN: 140483883(rad18)
HOC: 132822162(rad18)
SCAU: 119973150(rad18)
LERI: 129704560(rad18)
HAKA: 140741918(rad18)
BFO: 118415212
BBEL: 109468764
SPU: 579478
AJJ: 139960856
APLC: 110986390
ARUN: 117304796
AAMU: 139954248
AFIL: 140171236
SKO: 100369548
PFLL: 139135983
AME: 725208
ACER: 107995678
ALAB: 122719909
ADR: 102678498
AFLR: 100867571
BIM: 100742796
BBIF: 117204043
BVK: 117230880
BVAN: 117155923
BHUN: 126867696
BTER: 100651875
BAFF: 126914030
BPYO: 122566808
BPAS: 132910013
FVI: 122538796
CCAL: 108629581
OBB: 114874316
OLG: 117607735
MGEN: 117227274
NMEA: 116427854
CGIG: 122405429
SOC: 105198206
MPHA: 105834212
AEC: 105149831
ACEP: 105621567
ACOC: 108690999
MZT: 108720334
CCOA: 108771491
TCZ: 108760298
TSEP: 108752869
PBAR: 105425326
VEM: 105568444
COBS: 139105871
TLN: 139816103
TAME: 143904095
HST: 105187943
DQU: 106745820
CFO: 105250065
FEX: 115235186
PMEC: 138941639
LHU: 105668230
PGC: 109857968
OBO: 105287573
PCF: 106792375
PFUC: 122518633
VPS: 122631966
VCRB: 124426831
VVE: 124952274
NVI: 100123126
CSOL: 105363891
TPRE: 106650929
MDL: 103575092
CGLO: 123270615
FAS: 105270117
DAM: 107035831
AGIF: 122852392
VCAN: 122408172
CCIN: 107265053
AROA: 105685016
BTAB: 109035035
DCI: 103514678
CLEC: 106665107
HHAL: 106687557
LDA: 142330308
HVI: 124362492
FOC: 113214733
TPAL: 117654400
ZNE: 110833542
CSEC: 111872829
PAME: 138700276
BROR: 134542963
IEL: 124161469
HAMR: 139701068
DMK: 116932812
DPZ: 124349613
PVM: 113823358
PJA: 122260476
PCHN: 125034405
HAME: 121860982
PCLA: 123773967
CQD: 128684322
MRJ: 136852986
PORN: 139753240
EAF: 111697964
TCF: 131885349
ABRU: 129975642
SDM: 118186911
LPOL: 106466648
MYI: 110443107
PMAX: 117331922
NVE: 5511158
EPA: 110240273
ATEN: 116287617
AMIL: 114962183
MCAZ: 138056838
MFOO: 138011602
PDAM: 113677252
SPIS: 111330769
DGT: 114530664
XEN: 124434325
HMG: 101241243
CCLM: 134197332
SCE: YCR066W(RAD18)
SEUB: DI49_0811
ERC: Ecym_2490
KMX: KLMA_30501(RAD18)
CGR: 2889701(GVI51_J03421)
NCS: NCAS_0D04540(NCAS0D04540)
NDI: NDAI_0I00400(NDAI0I00400)
TPF: TPHA_0D03910(TPHA0D03910)
TBL: TBLA_0I02360(TBLA0I02360)
TDL: TDEL_0A07470(TDEL0A07470)
KAF: KAFR_0F02840(KAFR0F02840)
KNG: KNAG_0I02880(KNAG0I02880)
PIC: PICST_31983(RAD18)
LEL: PVL30_005492(RAD18)
LBG: 92209426(LODBEIA_P42300)
CAL: CAALFM_C601770WA(RAD18)
CTEN: 18247974(RAD18)
ASAU: 88175517(PUMCH_004457)
YLI: 2905883(YALI2_A00131g)
SLB: AWJ20_1767(RAD18)
NCR: NCU05210(uvs-2)
NTE: NEUTE1DRAFT80563(NEUTE1DRAFT_80563)
SMP: 10804756(SMAC4_07188)
PBEL: QC761_124110(RAD18)
PPSD: QC762_124110(RAD18)
PPSP: QC763_124110(RAD18)
PPSA: QC764_124110(RAD18)
RTHE: 98125311(VTJ83DRAFT_4203)
MGR: MGG_04175
PGRI: PgNI_06712
SSCK: SPSK_07447
TATV: 25777184(TrAtP1_005831)
TASP: 36610891(TrAFT101_005149)
MAW: 19252495(RAD18_1)
MAJ: MAA_02723
MBRN: 26241776(rad18)
UVI: 66060919(UV8b_00141)
CMT: CCM_00425
PLJ: 28891008(PLICBS_004672)
PTKZ: JDV02_006489(RAD18)
DCON: 63715781(DCS_03138)
CDET: 87942015(CDEST_05512)
MBE: MBM_00796
ALUC: AKAW2_30191S(RAD18)
ACHE: ACHE_60321S(RAD18)
APUU: APUU_20258S(RAD18)
PPSF: 300793695(PFLUO_LOCUS7519)
CPW: 9692836(RAD18_1)
ABE: ARB_03261
TVE: TRV_02491
PTE: PTT_14923
PTRR: 6347112(PtrM4_032880)
ADAC: 96083075(ACET3X_002753)
SPO: 2539686(rhp18)
SOM: SOMG_01391(rhp18)
CNE: CNH01875
CNB: CNBL1870
CDEU: CNBG_4334
CDEC: 89992350(IAS62_005580)
CTEG: 91992726(I308_105871)
CBAS: 91985776(I312_105731)
CDEP: 91089825(L203_105616)
KMG: 30162352(I203_100899)
KNE: 92179384(IAR55_002125)
KDJ: 28966223(I303_102510)
KBI: 30204761(I302_101685)
KPIN: 30171610(I206_102891)
KSH: 87954488(IL334_002357)
KER: 91105522(V865_006721)
KSN: 43590750(CI109_101223)
KEP: 91093115(L201_002443)
TASA: A1Q1_04286
CCAC: CcaHIS019_0107200(RAD18)
SCM: SCHCO_02482875(SCHCODRAFT_02482875)
MGL: MGL_2236
MRT: MRET_0274
DFA: DFA_00638
SPAR: SPRG_00931
 » show all
Reference
  Authors
Masuda Y, Suzuki M, Kawai H, Suzuki F, Kamiya K
  Title
Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex.
  Journal
Nucleic Acids Res 40:1065-76 (2012)
DOI:10.1093/nar/gkr805
  Sequence
[hsa:56852]
Reference
  Authors
Xiao W, Chow BL, Broomfield S, Hanna M
  Title
The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways.
  Journal
Genetics 155:1633-41 (2000)
  Sequence
[sce:YCR066W]
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