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Name |
Description |
Object |
Legend |
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mmu04728
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Dopaminergic synapse |
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where i... |
C03758 (Dopamine) C00355 (3,4-Dihydroxy-L-phenylalanine) C03758 (Dopamine) C03758 (Dopamine) C00575 ... |
DOPAMINERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) DAT VMAT ... |
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mmu05030
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Cocaine addiction |
...onsequences.There is strong evidence that the dopaminergic system that projects from the ventral teg... |
...00355 (3,4-Dihydroxy-L-phenylalanine) C03758 (Dopamine) C03758 (Dopamine) C01161 (3,4-Dihydroxypheny... |
...inal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synapse VMAT Synaptic cleft mGluR2/3 D2R ... |
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mmu05034
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Alcoholism |
...ediators of the rewarding effects of alcohol, dopaminergic ventral tegmental area (VTA) projections ... |
...00355 (3,4-Dihydroxy-L-phenylalanine) C03758 (Dopamine) C03758 (Dopamine) C01161 (3,4-Dihydroxypheny... |
...inal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synapse VMAT Synaptic cleft D1R DAT NMDA-... |
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mmu05012
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Parkinson disease |
...rder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars... |
... C00008 (ADP) C00009 (Orthophosphate) C03758 (Dopamine) C00704 (Superoxide), C00027 (Hydrogen peroxi... |
... CytC Cx I Cx II Cx III Cx IV Cx V HTRA2 mPTP Dopaminergic neuron Disrupted synaptic vesicle func... |
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mmu05032
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Morphine addiction |
... most important brain-reward circuit involves dopamine (DA) -containing neurons in the ventral tegme... |
...obutanoate) C00334 (4-Aminobutanoate) C03758 (Dopamine) C00238 (Potassium cation) C00238 (Potassium ... |
...MP GABA 5'-AMP Adenosine PDE Disinhibition of dopamine cell firing Drug abuse Increase in IPSCs Enha... |
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mmu05033
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Nicotine addiction |
...gs, including nicotine, is that they increase dopamine (DA) release in the nucleus accumbens (NAc). ... |
C00334 (4-Aminobutanoate) C01330 (Sodium cation), C00076 (Calcium cation) C00076 (Calcium cation) C0... |
...ing effects of nicotine VGAT VGAT vGLUT vGLUT Dopaminergic synapse Ca / Na Ca / Na GABA Glu GABA G... |
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mmu05031
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Amphetamine addiction |
...rugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial pr... |
...00355 (3,4-Dihydroxy-L-phenylalanine) C03758 (Dopamine) C03758 (Dopamine) C03758 (Dopamine) C01161 (... |
...inal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synapse VMAT Synaptic cleft High [Ca ] ... |
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mmu04080
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Neuroactive ligand-receptor interaction |
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...nolamide) C11695 (Anandamide) C12272 (N-Oleoyldopamine) C12271 (N-Arachidonyldopamine) C00245 (Tauri... |
...ns Palmitoyl-ethanolamide Anandamide N-Oleoyl-dopamine N-Arachidonoyl-dopamine Taurine β-Alanine Gly... |
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mmu04721
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Synaptic vesicle cycle |
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles ... |
...lcium cation) C00080 (H+) C00080 (H+) C03758 (Dopamine), C01996 (Acetylcholine), C00334 (4-Aminobuta... |
... opens Serotonergic synapse GABAergic synapse Dopaminergic synapse Endocytosis α-SNAP NSF Early endo... |
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mmu04917
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Prolactin signaling pathway |
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological function... |
...phatidylinositol-3,4,5-trisphosphate) C03758 (Dopamine) C00355 (3,4-Dihydroxy-L-phenylalanine) C0008... |
... lymphocytes, macrophages, fibroblasts) IRF-1 Dopaminergic synapse (Tuberoinfundibular neurons) Dopa... |
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mmu00350
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Tyrosine metabolism |
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...045 (3-(3,4-Dihydroxyphenyl)pyruvate) C03758 (Dopamine) C05587 (3-Methoxytyramine) C04043 (3,4-Dihyd... |
...inone L-DOPA 3-(3,4-Dihydroxy-phenyl)pyruvate Dopamine 3-Methoxy-tyramine 3,4-Dihydroxy-phenylacet-a... |
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mmu04024
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cAMP signaling pathway |
cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... |
...ssium cation) C00076 (Calcium cation) C03758 (Dopamine) C01312 (Prostaglandin I2) C00780 (Serotonin)... |
... PLCε JNK CREB CNGC Rho ROCK MYPT1 CaMKs GPCR Dopamine PGI2 5-HT Ach GABA Epinephrine Adenosine AF6 ... |
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mmu04540
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Gap junction |
Gap junctions contain intercellular channels that allow direct communication between the cytosolic c... |
...0780 (Serotonin) C00025 (L-Glutamate) C03758 (Dopamine) C00547 (L-Noradrenaline) 104318 (Csnk1d) 187... |
... Connexin Connexin Connexin Connexin Connexin Dopamine Noradrenaline ERK5 MEKK2 MEK5 PKG HTR2 Cdc2 E... |
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mmu01100
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Metabolic pathways |
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...lone) C01227 (Dehydroepiandrosterone) C03758 (Dopamine) C00547 (L-Noradrenaline) C05577 (3,4-Dihydro... |
Monoterpenoid biosynthesis One carbon pool by folate Flavonoid biosynthesis Starch and sucrose metab... |
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mmu04750
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Inflammatory mediator regulation of TRP channels |
The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs.... |
...C09179 (Resiniferatoxin) C12271 (N-Arachidonyldopamine) C11695 (Anandamide) C00469 (Ethanol) C09155 ... |
Mast cell INFLAMMATORY MEDIATOR REGULATION OF TRP CHANNELS P2YR B1/B2 5HTR TRPV1 ASIC IL1R TrkA I... |
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mmu04976
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Bile secretion |
Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins i... |
...ne (JP18/USP/INN)), C00114 (Choline), C03758 (Dopamine), D00318 (Famotidine (JP18/USP/INN)), D00333 ... |
AQP9 BILE SECRETION Tight junction Hepatocyte NHE1 HCO Cholangiocyte AE2 ATP CFTR HCO cAMP NBC1 2HC... |