KEGG   PATHWAY: mmu00350
Entry
mmu00350                    Pathway                                
Name
Tyrosine metabolism - Mus musculus (house mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
mmu00350  Tyrosine metabolism
mmu00350

Module
mmu_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:mmu00350]
mmu_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:mmu00350]
mmu_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:mmu00350]
Other DBs
GO: 0006570
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100328588  Il4i1b; interleukin 4 induced 1B [KO:K03334] [EC:1.4.3.2]
100470  Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
109731  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
11522  Adh1; alcohol dehydrogenase 1 (class I) [KO:K13951] [EC:1.1.1.1]
11529  Adh7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
11532  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
11670  Aldh3a1; aldehyde dehydrogenase family 3, subfamily A1 [KO:K00129] [EC:1.2.1.5]
11754  Aoc3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
11761  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
12846  Comt; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
13166  Dbh; dopamine beta hydroxylase [KO:K00503] [EC:1.14.17.1]
13190  Dct; dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
13195  Ddc; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
14085  Fah; fumarylacetoacetate hydrolase [KO:K01555] [EC:3.7.1.2]
14204  Il4i1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
14718  Got1; glutamic-oxaloacetic transaminase 1, soluble [KO:K14454] [EC:2.6.1.1]
14719  Got2; glutamatic-oxaloacetic transaminase 2, mitochondrial [KO:K14455] [EC:2.6.1.1]
14874  Gstz1; glutathione transferase zeta 1 (maleylacetoacetate isomerase) [KO:K01800] [EC:5.2.1.2]
15233  Hgd; homogentisate 1, 2-dioxygenase [KO:K00451] [EC:1.13.11.5]
15445  Hpd; 4-hydroxyphenylpyruvic acid dioxygenase [KO:K00457] [EC:1.13.11.27]
17161  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
17319  Mif; macrophage migration inhibitory factor (glycosylation-inhibiting factor) [KO:K07253] [EC:5.3.2.1]
18948  Pnmt; phenylethanolamine-N-methyltransferase [KO:K00553] [EC:2.1.1.28]
213043  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
21823  Th; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
22018  Tpo; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
22173  Tyr; tyrosinase [KO:K00505] [EC:1.14.18.1]
22178  Tyrp1; tyrosinase-related protein 1 [KO:K00506] [EC:1.14.18.-]
234724  Tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
237940  Aoc2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]
26876  Adh4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
621603  Aldh3b2; aldehyde dehydrogenase 3 family, member B2 [KO:K00129] [EC:1.2.1.5]
67689  Aldh3b1; aldehyde dehydrogenase 3 family, member B1 [KO:K00129] [EC:1.2.1.5]
68636  Fahd1; fumarylacetoacetate hydrolase domain containing 1 [KO:K01557] [EC:3.7.1.5]
71724  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
71872  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
73458  Aldh3b3; aldehyde dehydrogenase 3 family, member B3 [KO:K00129] [EC:1.2.1.5]
73988  4930438A08Rik; RIKEN cDNA 4930438A08 gene [KO:K03334] [EC:1.4.3.2]
76615  Got1l1; glutamic-oxaloacetic transaminase 1-like 1 [KO:K14454] [EC:2.6.1.1]
791260  Tomt; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00360  Phenylalanine metabolism
mmu00400  Phenylalanine, tyrosine and tryptophan biosynthesis
mmu00620  Pyruvate metabolism
mmu00650  Butanoate metabolism
KO pathway
ko00350   

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