PATHWAY: mmu04728 Help
Entry
Name
Dopaminergic synapse - Mus musculus (house mouse)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
110877 Slc18a1; solute carrier family 18 (vesicular monoamine), member 1 [KO:K08155 ]
214084 Slc18a2; solute carrier family 18 (vesicular monoamine), member 2 [KO:K08155 ]
68566 Caly; calcyon neuron-specific vesicular protein [KO:K15493 ]
14682 Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634 ]
16438 Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958 ]
16439 Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959 ]
16440 Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960 ]
19057 Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
14680 Gnal; guanine nucleotide binding protein, alpha stimulating, olfactory type [KO:K04633 ]
12912 Creb1; cAMP responsive element binding protein 1 [KO:K05870 ]
11909 Atf2; activating transcription factor 2 [KO:K04450 ]
11911 Atf4; activating transcription factor 4 [KO:K04374 ]
12913 Creb3; cAMP responsive element binding protein 3 [KO:K09048 ]
26427 Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048 ]
208647 Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048 ]
208677 Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048 ]
78284 Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048 ]
231991 Creb5; cAMP responsive element binding protein 5 [KO:K09047 ]
12915 Atf6b; activating transcription factor 6 beta [KO:K09049 ]
19049 Ppp1r1b; protein phosphatase 1, regulatory inhibitor subunit 1B [KO:K15494 ]
20265 Scn1a; sodium channel, voltage-gated, type I, alpha [KO:K04833 ]
12288 Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850 ]
12289 Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851 ]
12286 Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344 ]
12287 Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849 ]
16519 Kcnj3; potassium inwardly-rectifying channel, subfamily J, member 3 [KO:K04997 ]
16522 Kcnj6; potassium inwardly-rectifying channel, subfamily J, member 6 [KO:K05000 ]
16524 Kcnj9; potassium inwardly-rectifying channel, subfamily J, member 9 [KO:K05002 ]
16521 Kcnj5; potassium inwardly-rectifying channel, subfamily J, member 5 [KO:K04999 ]
14681 Gnao1; guanine nucleotide binding protein, alpha O [KO:K04534 ]
14688 Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536 ]
14693 Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537 ]
14695 Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825 ]
14696 Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538 ]
14697 Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539 ]
14702 Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826 ]
14704 Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540 ]
14706 Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541 ]
14708 Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543 ]
14709 Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544 ]
14700 Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545 ]
66066 Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546 ]
14701 Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347 ]
64337 Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547 ]
14699 Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548 ]
14710 Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549 ]
19052 Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
19053 Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
51792 Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456 ]
73699 Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456 ]
52432 Ppp2r2d; protein phosphatase 2, regulatory subunit B, delta [KO:K04354 ]
72930 Ppp2r2b; protein phosphatase 2, regulatory subunit B, beta [KO:K04354 ]
269643 Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354 ]
71978 Ppp2r2a; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354 ]
59032 Ppp2r3c; protein phosphatase 2, regulatory subunit B'', gamma [KO:K11583 ]
235542 Ppp2r3a; protein phosphatase 2, regulatory subunit B'', alpha [KO:K11583 ]
19054 Ppp2r3d; protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [KO:K11583 ]
225849 Ppp2r5b; protein phosphatase 2, regulatory subunit B', beta [KO:K11584 ]
26931 Ppp2r5c; protein phosphatase 2, regulatory subunit B', gamma [KO:K11584 ]
21770 Ppp2r5d; protein phosphatase 2, regulatory subunit B', delta [KO:K11584 ]
26932 Ppp2r5e; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584 ]
226849 Ppp2r5a; protein phosphatase 2, regulatory subunit B', alpha [KO:K11584 ]
14811 Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209 ]
14812 Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210 ]
14799 Gria1; glutamate receptor, ionotropic, AMPA1 (alpha 1) [KO:K05197 ]
14800 Gria2; glutamate receptor, ionotropic, AMPA2 (alpha 2) [KO:K05198 ]
53623 Gria3; glutamate receptor, ionotropic, AMPA3 (alpha 3) [KO:K05199 ]
14802 Gria4; glutamate receptor, ionotropic, AMPA4 (alpha 4) [KO:K05200 ]
11865 Bmal1; basic helix-loop-helix ARNT like 1 [KO:K02296 ]
13162 Slc6a3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [KO:K05036 ]
Compound
C00355 3,4-Dihydroxy-L-phenylalanine
C01161 3,4-Dihydroxyphenylacetate
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Beaulieu JM, Gainetdinov RR
Title
The physiology, signaling, and pharmacology of dopamine receptors.
Journal
Reference
Authors
Neve KA, Seamans JK, Trantham-Davidson H
Title
Dopamine receptor signaling.
Journal
Reference
Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
Journal
Reference
Authors
Knab AM, Lightfoot JT
Title
Does the difference between physically active and couch potato lie in the dopamine system?
Journal
Reference
Authors
Greengard P, Allen PB, Nairn AC
Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
Journal
Reference
Authors
Hu XT, Dong Y, Zhang XF, White FJ
Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
Journal
Reference
Authors
Beaulieu JM, Gainetdinov RR, Caron MG
Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
Journal
Reference
Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
Journal
Reference
Authors
Seamans JK, Yang CR
Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
Journal
Reference
Authors
Yao WD, Spealman RD, Zhang J
Title
Dopaminergic signaling in dendritic spines.
Journal
Reference
Authors
Li YC, Gao WJ
Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
Journal
Reference
Authors
Tang TS, Bezprozvanny I
Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
Journal
Reference
Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
Journal
Reference
Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
Title
Dopamine receptors: from structure to function.
Journal
Reference
Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
Journal
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