KEGG   PATHWAY: mmu04728
Entry
mmu04728                    Pathway                                
Name
Dopaminergic synapse - Mus musculus (house mouse)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
mmu04728  Dopaminergic synapse
mmu04728

Other DBs
GO: 0001963
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100039815  Gm2436; predicted gene 2436 [KO:K11583]
100039830  Gm2446; predicted gene 2446 [KO:K11583]
100043318  Gng5c; G protein subunit gamma 5C [KO:K04542]
100503710  Gng14; G protein subunit gamma 14 [KO:K04347]
102633809  Gm3785; predicted gene 3785 [KO:K04542]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
109689  Arrb1; arrestin, beta 1 [KO:K04439]
109731  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
110877  Slc18a1; solute carrier family 18 (vesicular monoamine), member 1 [KO:K08155]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11865  Bmal1; basic helix-loop-helix ARNT like 1 [KO:K02296]
11909  Atf2; activating transcription factor 2 [KO:K04450]
11911  Atf4; activating transcription factor 4 [KO:K04374]
12286  Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
12287  Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
12288  Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12753  Clock; clock circadian regulator [KO:K02223] [EC:2.3.1.48]
12846  Comt; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12913  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
12915  Atf6b; activating transcription factor 6 beta [KO:K09049]
13162  Slc6a3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [KO:K05036]
13195  Ddc; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
13488  Drd1; dopamine receptor D1 [KO:K04144]
13489  Drd2; dopamine receptor D2 [KO:K04145]
13490  Drd3; dopamine receptor D3 [KO:K04146]
13491  Drd4; dopamine receptor D4 [KO:K04147]
13492  Drd5; dopamine receptor D5 [KO:K05840]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
14677  Gnai1; G protein subunit alpha i1 [KO:K04630]
14678  Gnai2; G protein subunit alpha i2 [KO:K04630]
14679  Gnai3; G protein subunit alpha i3 [KO:K04630]
14680  Gnal; guanine nucleotide binding protein, alpha stimulating, olfactory type [KO:K04633]
14681  Gnao1; guanine nucleotide binding protein, alpha O [KO:K04534]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14683  Gnas; GNAS complex locus [KO:K04632]
14688  Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536]
14693  Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537]
14695  Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825]
14696  Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538]
14697  Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
14699  Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
14700  Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
14701  Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
14702  Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
14704  Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
14706  Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
14707  Gng5; G protein subunit gamma 5 [KO:K04542]
14708  Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
14709  Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
14710  Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
14799  Gria1; glutamate receptor, ionotropic, AMPA1 (alpha 1) [KO:K05197]
14800  Gria2; glutamate receptor, ionotropic, AMPA2 (alpha 2) [KO:K05198]
14802  Gria4; glutamate receptor, ionotropic, AMPA4 (alpha 4) [KO:K05200]
14811  Grin2a; glutamate receptor, ionotropic, NMDA2A (epsilon 1) [KO:K05209]
14812  Grin2b; glutamate receptor, ionotropic, NMDA2B (epsilon 2) [KO:K05210]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
16519  Kcnj3; potassium inwardly-rectifying channel, subfamily J, member 3 [KO:K04997]
16521  Kcnj5; potassium inwardly-rectifying channel, subfamily J, member 5 [KO:K04999]
16522  Kcnj6; potassium inwardly-rectifying channel, subfamily J, member 6 [KO:K05000]
16524  Kcnj9; potassium inwardly-rectifying channel, subfamily J, member 9 [KO:K05002]
16572  Kif5a; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
16573  Kif5b; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
16574  Kif5c; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
17161  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
19045  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
19046  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
19047  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
19049  Ppp1r1b; protein phosphatase 1, regulatory inhibitor subunit 1B [KO:K15494]
19052  Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382] [EC:3.1.3.16]
19053  Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382] [EC:3.1.3.16]
19054  Ppp2r3d; protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [KO:K11583]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
20265  Scn1a; sodium channel, voltage-gated, type I, alpha [KO:K04833]
208647  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
208677  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
214084  Slc18a2; solute carrier family 18 (vesicular monoamine), member 2 [KO:K08155]
216869  Arrb2; arrestin, beta 2 [KO:K04439]
21770  Ppp2r5d; protein phosphatase 2, regulatory subunit B', delta [KO:K11584]
21823  Th; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
225849  Ppp2r5b; protein phosphatase 2, regulatory subunit B', beta [KO:K11584]
226849  Ppp2r5a; protein phosphatase 2, regulatory subunit B', alpha [KO:K11584]
231991  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
235542  Ppp2r3a; protein phosphatase 2, regulatory subunit B'', alpha [KO:K11583]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26427  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
26931  Ppp2r5c; protein phosphatase 2, regulatory subunit B', gamma [KO:K11584]
26932  Ppp2r5e; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
269643  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
434233  Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B [KO:K06269] [EC:3.1.3.16]
494124  Calm5; calmodulin 5 [KO:K02183]
51792  Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
52432  Ppp2r2d; protein phosphatase 2, regulatory subunit B, delta [KO:K04354]
53623  Gria3; glutamate receptor, ionotropic, AMPA3 (alpha 3) [KO:K05199]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
59032  Ppp2r3c; protein phosphatase 2, regulatory subunit B'', gamma [KO:K11583]
606496  Gsk3a; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
64337  Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
66066  Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
68566  Caly; calcyon neuron-specific vesicular protein [KO:K15493]
70405  Calml3; calmodulin-like 3 [KO:K02183]
71978  Ppp2r2a; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
72930  Ppp2r2b; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
73699  Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
75600  Calml4; calmodulin-like 4 [KO:K02183]
78284  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
791260  Tomt; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
80796  Calm4; calmodulin 4 [KO:K02183]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
mmu00350  Tyrosine metabolism
mmu04020  Calcium signaling pathway
mmu04721  Synaptic vesicle cycle
mmu04724  Glutamatergic synapse
mmu05012  Parkinson disease
KO pathway
ko04728   

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