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map01521
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EGFR tyrosine kinase inhibitor resistance |
...nt of the EGFR-TKIs-mediated apoptosis pathway (BCL2-like 11/BIM deletion polymorphism), histologic ... |
...92 (STAT3) K11217 (JAK1), K04447 (JAK2) K02161 (BCL2) K02159 (BAX) K04570 (BCL2L1) K16341 (BCL2L11) ... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
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map04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
...Sphingosine) C00027 (Hydrogen peroxide) K04570 (BCL2L1) K02310 (DFFA) K04728 (ATM) K04451 (TP53) K01... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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map05200
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Pathways in cancer |
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...158 (BAD) K06643 (MDM2) K06624 (CDKN1B) K04570 (BCL2L1) K04692 (STAT3) K11220 (STAT1) K04364 (GRB2) ... |
PATHWAYS IN CANCER DCC CASP3 CASP9 CASP3 ECAD β-catenin Wnt α-catenin β-catenin ITGB Dvl ECM ITGA ... |
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map04064
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NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...-trisphosphate) C00076 (Calcium cation) K04570 (BCL2L1) K02161 (BCL2) K16060 (BIRC2_3) K04734 (NFKBI... |
Cytokine-cytokine receptor interaction Bcl-XL Bcl-2 c-IAP1/2 IκBα IRAK1/4 MyD88 TRAF2/5 RIP1 TRADD I... |
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map04151
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PI3K-Akt signaling pathway |
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellul... |
... (CDKN1B) K16332 (RBL2) K04389 (TNFSF6) K16341 (BCL2L11) K09408 (FOXO3) K02158 (BAD) K06643 (MDM2) K... |
PIP eIF4E 4EBPs eIF4B S6K1/2 Raptor mTOR GβL Rheb TSC2 TSC1 AKT PDK1 PI3K p53 signaling pathway mTOR... |
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map05145
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Toxoplasmosis |
Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite ... |
...06 (IL12A), K05425 (IL12B) K03156 (TNF) K02161 (BCL2), K04570 (BCL2L1) K16060 (BIRC2_3), K04725 (XIA... |
... Parasitophorus vacuole formation DNA IL12 TNFα Bcl2/XL IAP iNOS IL12 DNA Jak STAT1 CIITA LRG47 MHCI... |
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map04215
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Apoptosis - multiple species |
Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally ... |
...20106 (CED-3) K02159 (BAX) K14021 (BAK) K02161 (BCL2), K04570 (BCL2L1) K08738 (CYC) K08738 (CYC) K04... |
APOPTOSIS - MULTIPLE SPECIES Mitochondrion DIAP1 DRONC DRICE GRIM RPR HID dArk Dcp-1 DEBCL RHG fa... |
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map05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
..._B_D), K02649 (PIK3R1_2_3) K02158 (BAD) K04570 (BCL2L1) K02161 (BCL2) K02159 (BAX) K13242 (NOS3) K05... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |
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map05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
... (MIR375) K16865 (PDCD4) K17383 (SPRY2) K02161 (BCL2) K10139 (SERPINB5) K09283 (HMGA2) K09299 (ZEB1)... |
...ted miRNA) (Down-regulated miRNA) miR-133 Cdc25 BCL2L2 VEGF-A Cdk6 Let-7 K-Ras Cdk6 miR-126 CRK miR-... |
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map05169
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Epstein-Barr virus infection |
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... |
...18 (ITGAL) K06492 (CD58) K06490 (ICAM1) K02161 (BCL2) K11859 (TNFAIP3) K04427 (MAP3K7) K04430 (MAP2K... |
...TAB1/2 NFκB CD23 CD39 CD40 CD44 LFA1 LFA3 ICAM1 Bcl2 A20 TAK1 MKK4/7 MKK3/6 JNK p38 AP1 JAK3 PI3K Ak... |
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map05014
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Amyotrophic lateral sclerosis |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... |
...02187 (CASP3) K02159 (BAX) K02158 (BAD) K02161 (BCL2) K04570 (BCL2L1) K02084 (APAF1) K04399 (CASP9) ... |
SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell... |
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map05022
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Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
...5 (CSNK2B) K11518 (TOM40) K04565 (SOD1) K02161 (BCL2) K04575 (ALS2) K04392 (RAC1) K07887 (RAB5A) K05... |
PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP... |
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map05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...3853 (CAPN2) K04451 (TP53) K04728 (ATM) K02161 (BCL2) K04570 (BCL2L1) K04361 (EGFR) K04361 (EGFR) K2... |
SHIGELLOSIS Shigella dysenteria Shigella flexneri Shigella boydii Shigella sonnei TNF-R1 TNFα IκBα I... |
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map05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
...6450 (CD3D), K06453 (CD3Z) K22891 (nef) K02161 (BCL2) K04570 (BCL2L1) K19258 (tat) K22202 (vpr) K066... |
PIP S6K1/2 mTOR AKT PI3K HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION NF κB NFκB signaling pathway R... |
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map05202
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Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...6627 (CCNA) K10056 (JUP) K10051 (CEBPE) K02162 (BCL2A1) K09055 (CEBPA) K02633 (PER2) K09438 (SPI1) K... |
TRANSCRIPTIONAL MISREGULATION IN CANCER Ewing's sarcoma Clear-cell sarcoma Desmoplastic small ro... |
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map04141
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Protein processing in endoplasmic reticulum |
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of... |
...53 (SAR1) K14003 (PREB) K09487 (HSP90B) K02161 (BCL2) K02161 (BCL2) K10081 (LMAN1L) K14010 (TRAM1) K... |
...sp90 NRF2 COPII Sec13/31 SAR1 COPII Sec12 GRP94 Bcl2 Apoptosis Bcl2 ERGL TRAM CHIP Parkin NEF sHSF A... |
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map04340
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Hedgehog signaling pathway |
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue ... |
...9 (SUFU) K04503 (CCND1), K10151 (CCND2) K02161 (BCL2) K04503 (CCND1), K10151 (CCND2) K02161 (BCL2) K... |
...rget genes Activiation of Hh target genes CCND BCL2 CCND BCL2 MEGF8 MGRN1 Internalization ATTHOG Hh... |
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map05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...0 (NFKB1) K02580 (NFKB1), K04735 (RELA) K02161 (BCL2) K01403 (MMP9) K10610 (DDB1) K04390 (TNFRSF6) K... |
... ER Stress Ca PI3K Akt Bad IKK IκB p105 NF-κB Bcl2 MMP-9 Antiapoptosis PI3K-Akt signaling pathway ... |
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map05167
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Kaposi sarcoma-associated herpesvirus infection |
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most... |
...93 (IRF9) K21654 (vIRF2) K21661 (vIAP) K21660 (vBCL2) K03990 (C3) K06751 (MHC1) K06625 (CDKN1A) K020... |
...ptor signaling pathway Prosurvival genes vIAP vBcl2 MHC1 p21 CDK4/6 LANA vCyclin p53 DNA E2F DNA ... |
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map04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
... (PMAIP1) K19748 (GORAB) K22744 (SIVA1) K04570 (BCL2L1) K02161 (BCL2) K22745 (AIFM2) K26543 (ZNF385A... |
...e ARF SCYL1BP1 Cellular senescence Siva1 Bcl-xL Bcl2 AIFM2 ZNF385A Pro-arrest target genes |