[ Network menu | Network entry | Help ]

ENTRY	nt06542
Name	HIF signaling
Category	Pathway view; Signal transduction
Pathway	hsa04066 HIF-1 signaling pathway
Disease	H00021 Renal cell carcinoma H00559 von Hippel-Lindau syndrome
Display	drug-target relation   disease type

N00079            HIF1A = ARNT ⇒ (SLC2A1,VEGFA,TGFB..           D1  |         N01870            EPAS1 = ARNT ⇒ (VEGFA,CXCL8,GLUT1..     ECYT4         EPAS1*↗     ECYT5                 EPO*↗   D1  |       D1  | N01871    (HIF1A,EPAS1) − EGLN → (HIF1A-OH,EPAS1-OH..     ECYT3     EGLN1*           D1  | N01872        (VHL+RBX1+ELOC+ELO.. ⊣ (HIF1A-OH,EPAS1-OH.. N00080    RCC     (VHL*+RBX1+ELOC+EL.. ⌿ HIF1A = ARNT ⇒ (SLC2A1,VEGFA,TGFB.. N00081    RCC     (VHL*+RBX1+ELOC+EL.. ⌿ HIF1A = ARNT ⇒ (SLC2A1,VEGFA,TGFB..           D1  |         N01873    RCC/VHLS/ECYT2     (VHL*+RBX1+ELOC+EL.. ⌿ EPAS1 = ARNT ⇒ (VEGFA,CXCL8,GLUT1..

		Disease name	Disease category
ECYT4	H00236	Congenital polycythemia	Hematologic disease
ECYT5	H00236	Congenital polycythemia	Hematologic disease
ECYT3	H00236	Congenital polycythemia	Hematologic disease
RCC	H00021	Renal cell carcinoma	Cancer
RCC/VHLS/ECYT2	H00021	Renal cell carcinoma	Cancer
	H00559	von Hippel-Lindau syndrome	Congenital malformation
	H00236	Congenital polycythemia	Hematologic disease

		Drug name
D1	D11954	Belzutifan (JAN/USAN/INN)