Entry
Name
Cytokine-cytokine receptor interaction - Aquila chrysaetos chrysaetos (golden eagle)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
achc04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:
achc ]
Gene
115347215 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
115335407 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
115347943 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
115349144 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
115335409 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
115347472 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
115350784 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
115335148 tumor necrosis factor ligand superfamily member 8-like [KO:K05471 ]
115349686 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
115350597 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
115336342 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
115349026 GDF15; LOW QUALITY PROTEIN: growth/differentiation factor 15 [KO:K05504 ]
115350958 GDF11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679 ]
115339541 ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186 ]
115352724 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
115333600 IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070 ]
115335706 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
115337355 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
115341457 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
115352694 cytokine receptor common subunit beta-like isoform X1 [KO:K04738 ]
115334641 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
115334642 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
115333857 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076 ]
115351446 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
115346428 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
115337297 IL31RA; interleukin-31 receptor subunit alpha isoform X2 [KO:K22630 ]
115337293 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
115336487 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
115344457 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
115345170 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
115343515 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158 ]
115343357 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
115343425 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
115339881 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143 ]
115348644 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
115342661 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
115350118 tumor necrosis factor receptor superfamily member 10A-like isoform X3 [KO:K04722 ]
115351158 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
115334721 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
115333840 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
115344366 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
115340437 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
115353144 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
115343150 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
115338768 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
115342667 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
115343032 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
115335950 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
115335694 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
115352701 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
115353515 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
115353253 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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