KEGG   PATHWAY: aju05203
Entry
aju05203                    Pathway                                
Name
Viral carcinogenesis - Acinonyx jubatus (cheetah)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
aju05203  Viral carcinogenesis
aju05203

Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106974507  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
106987957  GTPase HRas isoform X1 [KO:K02833]
106968778  GTPase KRas isoform X1 [KO:K07827]
106969596  GTPase NRas [KO:K07828]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106967098  cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
106988085  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
106979942  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106981255  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
106970423  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
106987262  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
106975473  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
106978069  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
106987665  cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
106983500  cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
106977885  DNA damage-binding protein 1 isoform X1 [KO:K10610]
106973494  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
106968957  14-3-3 protein beta/alpha [KO:K16197]
106982949  14-3-3 protein theta [KO:K16197]
106989479  14-3-3 protein theta [KO:K16197]
106980045  14-3-3 protein zeta/delta [KO:K16197]
106981227  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
106983214  14-3-3 protein epsilon isoform X2 [KO:K06630]
106983312  14-3-3 protein eta [KO:K16198]
106980702  14-3-3 protein gamma [KO:K16198]
106983739  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
106972608  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
106972566  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
106972565  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
106979326  caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
106974756  serine protease hepsin isoform X3 [KO:K08665] [EC:3.4.21.106]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106971136  transcription factor p65 [KO:K04735]
106973464  proto-oncogene c-Rel [KO:K09254]
106966950  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
106984704  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106972437  cellular tumor antigen p53 [KO:K04451]
106974883  G1/S-specific cyclin-E2 [KO:K06626]
106975766  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
106986916  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
106989877  E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
106981096  early growth response protein 3 isoform X2 [KO:K12497]
106990014  voltage-dependent anion-selective channel protein 3 [KO:K15041]
106976249  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
106965448  tumor necrosis factor receptor superfamily member 3 [KO:K03159]
106972309  nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
106978574  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
106972797  cyclin-dependent kinase inhibitor 1 [KO:K06625]
106984213  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
106978970  interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106988063  histone H2B type 1-C/E/F/G/I [KO:K11252]
128313974  histone H2B type 2-E-like [KO:K11252]
128313981  histone H2B type 2-E-like [KO:K11252]
128315726  histone H2B type 1-M [KO:K11252]
128315728  histone H2B type 1-B [KO:K11252]
128315729  histone H2B type 1-C/E/F/G/I [KO:K11252]
128315730  histone H2B type 1-K-like [KO:K11252]
128315731  histone H2B type 1-C/E/F/G/I [KO:K11252]
128315732  histone H2B type 1-C/E/F/G/I [KO:K11252]
128315748  histone H2B type 1-C/E/F/G/I [KO:K11252]
106969569  histone H2B type 2-K1 [KO:K11252]
106988040  histone H2B type 1-C/E/F/G/I [KO:K11252]
106988062  histone H2B type 1-M [KO:K11252]
106988064  histone H2B type 1-K [KO:K11252]
106988066  histone H2B type 1-C/E/F/G/I [KO:K11252]
106988082  histone H2B type 1-A-like [KO:K11252]
106974815  histone H2B subacrosomal variant-like [KO:K11252]
106989350  histone H2B type 1-A [KO:K11252]
106985218  histone H2B type 3-B [KO:K11252]
106986679  histone H2B type 2-E [KO:K11252]
106982106  histone H2B type 2-F [KO:K11252]
106976313  histone H2B type 1-K [KO:K11252]
106985210  LOW QUALITY PROTEIN: uncharacterized protein LOC106985210 [KO:K11252]
113597270  histone H2B type 1-C/E/F/G/I [KO:K11252]
113592690  histone H2A.N [KO:K11252]
113593971  histone H2B type 1-C/E/F/G/I [KO:K11252]
106988080  histone H2B type 1-J [KO:K11252]
128315721  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
106965662  uncharacterized protein LOC106965662 isoform X1 [KO:K11254]
106988031  histone H4 [KO:K11254]
106988053  histone H4 [KO:K11254]
106988073  histone H4 [KO:K11254]
106988075  histone H4 [KO:K11254]
106988077  histone H4 [KO:K11254]
106982111  histone H4 [KO:K11254]
106976329  histone H4 [KO:K11254]
106988032  histone H4 [KO:K11254]
113593855  histone H4 [KO:K11254]
106988699  apoptosis regulator BAX isoform X1 [KO:K02159]
106987795  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106971422  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106989884  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106984326  TATA box-binding protein-like 2 [KO:K03120]
106976865  TATA box-binding protein-like 1 isoform X1 [KO:K03120]
106978655  TATA-box-binding protein [KO:K03120]
106971787  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
106966348  E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
106968999  recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
106975118  recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
106974389  SNW domain-containing protein 1 [KO:K06063]
106987482  general transcription factor IIH subunit 1 [KO:K03141]
106977079  general transcription factor IIH subunit 2 [KO:K03142]
106978344  general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
106966622  general transcription factor IIH subunit 4 isoform X1 [KO:K03144]
106975424  general transcription factor IIE subunit 1 [KO:K03136]
106966554  transcription initiation factor IIE subunit beta isoform X1 [KO:K03137]
106988446  staphylococcal nuclease domain-containing protein 1 isoform X1 [KO:K15979]
106979918  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
106978741  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
106968045  transcription initiation factor IIB [KO:K03124]
106971167  G1/S-specific cyclin-D1 [KO:K04503]
106965383  G1/S-specific cyclin-D2 [KO:K10151]
106974052  G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
106969949  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106977098  cyclin-A2 [KO:K06627]
106973846  cyclin-A1 isoform X1 [KO:K06627]
106979642  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
106966614  28S ribosomal protein S18b, mitochondrial [KO:K16174]
106986638  TNF receptor-associated factor 1 isoform X1 [KO:K03172]
106989490  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106975974  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
106966776  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
106969157  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
106982528  tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
106976132  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
106971657  V-type proton ATPase subunit d 1 [KO:K02146]
106977246  V-type proton ATPase subunit d 2 [KO:K02146]
106967793  ubiquitin-protein ligase E3A isoform X2 [KO:K10587] [EC:2.3.2.26]
106976354  disks large homolog 1 isoform X1 [KO:K12076]
106988832  protein scribble homolog isoform X1 [KO:K16175]
106971693  paxillin isoform X2 [KO:K05760]
106976101  bcl-2 homologous antagonist/killer [KO:K14021]
106983140  interferon regulatory factor 3 isoform X3 [KO:K05411]
106989365  26S proteasome regulatory subunit 4 [KO:K03062]
106971960  retinoblastoma-associated protein isoform X1 [KO:K06618]
106979285  retinoblastoma-like protein 1 isoform X1 [KO:K04681]
106984720  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
106965649  cyclin-dependent kinase inhibitor 1B [KO:K06624]
106983377  E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
106974986  transcription factor Jun [KO:K04448]
106965445  chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
106968918  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
106982428  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
106967267  histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
106967107  histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
106974278  histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
106989010  histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
106969353  histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
106982392  histone deacetylase 8 isoform X8 [KO:K11405] [EC:3.5.1.98]
106984149  histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
106987623  polyamine deacetylase HDAC10 isoform X3 [KO:K18671] [EC:3.5.1.98]
106978633  histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
106987855  interferon regulatory factor 9 isoform X2 [KO:K04693]
106978810  dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
106981451  histone acetyltransferase KAT2B isoform X4 [KO:K06062] [EC:2.3.1.48]
106972603  histone acetyltransferase KAT2A isoform X2 [KO:K06062] [EC:2.3.1.48]
106983580  transcription initiation factor IIA subunit 1 [KO:K03122]
106977215  TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
106973798  transcription initiation factor IIA subunit 2 [KO:K03123]
106974034  serum response factor [KO:K04378]
106988817  NF-kappa-B essential modulator isoform X1 [KO:K07210]
106965509  NF-kappa-B inhibitor alpha [KO:K04734]
106984995  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
106972835  cell division control protein 42 homolog [KO:K04393]
106977652  cell division control protein 42 homolog isoform X1 [KO:K04393]
106982604  ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
106979239  transforming protein RhoA [KO:K04513]
106983057  scinderin [KO:K05768]
106986616  gelsolin isoform X3 [KO:K05768]
106980245  alpha-actinin-4 isoform X5 [KO:K05699]
106971540  alpha-actinin-1 isoform X1 [KO:K05699]
106975871  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
106986386  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
106986385  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
106976641  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
106970210  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
106984516  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
106984356  protein VAC14 homolog isoform X1 [KO:K15305]
106983603  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
106990013  DNA polymerase beta isoform X2 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
106988905  interferon regulatory factor 7 [KO:K09447]
106975253  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
106969043  C-C chemokine receptor type 5 [KO:K04180]
106966718  C-C chemokine receptor type 8 [KO:K04183]
106969178  C-C chemokine receptor type 3 [KO:K04178]
106989283  C-C chemokine receptor type 4 [KO:K04179]
106981771  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
106987995  caspase-8 [KO:K04398] [EC:3.4.22.61]
106981699  bcl2-associated agonist of cell death [KO:K02158]
106978896  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
128314961  complement C3-like [KO:K03990]
128314963  complement C3-like isoform X1 [KO:K03990]
106975430  complement C3 [KO:K03990]
106966636  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
106984453  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
128310960  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
106969978  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
106975945  class I histocompatibility antigen, Gogo-B*0103 alpha chain [KO:K06751]
106966627  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
106975947  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
  Journal
Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
  Journal
Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
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Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
aju03022  Basal transcription factors
aju03320  PPAR signaling pathway
aju04010  MAPK signaling pathway
aju04062  Chemokine signaling pathway
aju04064  NF-kappa B signaling pathway
aju04110  Cell cycle
aju04115  p53 signaling pathway
aju04142  Lysosome
aju04151  PI3K-Akt signaling pathway
aju04210  Apoptosis
aju04630  JAK-STAT signaling pathway
aju04662  B cell receptor signaling pathway
aju04810  Regulation of actin cytoskeleton
aju05160  Hepatitis C
aju05161  Hepatitis B
aju05165  Human papillomavirus infection
aju05166  Human T-cell leukemia virus 1 infection
aju05167  Kaposi sarcoma-associated herpesvirus infection
aju05169  Epstein-Barr virus infection
KO pathway
ko05203   
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