KEGG   PATHWAY: apla04020
Entry
apla04020                   Pathway                                
Name
Calcium signaling pathway - Anas platyrhynchos (mallard)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
apla04020  Calcium signaling pathway
apla04020

Other DBs
GO: 0019722
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101799858  SLC8A1; LOW QUALITY PROTEIN: sodium/calcium exchanger 1 [KO:K05849]
101798929  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101798634  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101803323  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
113839940  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101791742  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
101805433  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101801586  ADORA2A; adenosine receptor A2a [KO:K04266]
101800579  ADORA2B; adenosine receptor A2b [KO:K04267]
101790405  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101800857  beta-2 adrenergic receptor [KO:K04142]
101801679  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101797733  DRD1; D(1A) dopamine receptor [KO:K04144]
101799912  D(1)-like dopamine receptor [KO:K05840]
101790596  DRD5; D(1B) dopamine receptor [KO:K05840]
119713451  D(1) dopamine receptor-like [KO:K05840]
101802707  HRH2; histamine H2 receptor [KO:K04150]
106018247  octopamine receptor [KO:K04150]
101801752  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101795278  5-hydroxytryptamine receptor 5A-like [KO:K04161]
101789607  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101793522  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101799166  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101791695  5-hydroxytryptamine receptor 7 [KO:K04163]
101791631  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X3 [KO:K04632]
101803485  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
101804073  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101803512  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101791112  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101794076  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101794043  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101800617  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101791856  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
101790025  PLN; cardiac phospholamban [KO:K05852]
101803718  SLN; sarcolipin [KO:K22642]
101805261  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
101790551  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101801715  LOW QUALITY PROTEIN: stromal interaction molecule 1 [KO:K16059]
119713004  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
101801709  STIM2; stromal interaction molecule 2 isoform X3 [KO:K18196]
101802702  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
101804005  ORAI2; protein orai-2 isoform X2 [KO:K16057]
101790062  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X12 [KO:K04850]
101803307  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101801311  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101794161  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101795250  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101800038  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101803209  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101803794  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
101795859  CHRFAM7A; CHRNA7-FAM7A fusion protein isoform X1 [KO:K04809]
101793841  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101789524  GRIN1; glutamate receptor ionotropic, NMDA 1 precursor [KO:K05208]
101804769  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X3 [KO:K05209]
101801248  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101800611  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101797705  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101798799  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
101804477  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
101790466  P2X purinoceptor 2 [KO:K05216]
119718472  P2X purinoceptor 2-like [KO:K05216]
119717133  P2RX3; LOW QUALITY PROTEIN: P2X purinoceptor 3 [KO:K05217]
101791189  P2RX4; P2X purinoceptor 4 [KO:K05218]
101797369  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101790078  P2RX6; P2X purinoceptor 6 [KO:K05221]
101801281  P2RX7; P2X purinoceptor 7 [KO:K05220]
101793907  RYR2; ryanodine receptor 2 isoform X4 [KO:K04962]
101789513  RYR3; ryanodine receptor 3 isoform X2 [KO:K04963]
101796027  triadin [KO:K23449]
106016351  TRDN; triadin isoform X1 [KO:K23449]
101794422  CASQ2; LOW QUALITY PROTEIN: calsequestrin-2 [KO:K23445]
101796017  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
119717859  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101805449  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
101792126  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
119713527  ADRA1A; LOW QUALITY PROTEIN: alpha-1A adrenergic receptor [KO:K04135]
101800019  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101789627  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101804939  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101796799  EDNRA; endothelin-1 receptor [KO:K04197]
101790262  EDNRB; endothelin receptor type B [KO:K04198]
101805249  endothelin B receptor-like precursor [KO:K04198]
119714597  F2R; proteinase-activated receptor 1 [KO:K03914]
101803914  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101805339  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101790718  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101794475  HRH1; histamine H1 receptor [KO:K04149]
101792508  5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
101799400  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101797990  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101803098  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101801363  NTSR1; LOW QUALITY PROTEIN: neurotensin receptor type 1 [KO:K04211]
101795636  OXTR; oxytocin receptor [KO:K04229]
101796503  AVPR1A; vasopressin V1a receptor [KO:K04226]
101799416  AVPR1B; LOW QUALITY PROTEIN: vasopressin V1b receptor [KO:K04227]
101792728  PTAFR; platelet-activating factor receptor [KO:K04279]
101795912  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101804306  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
101793101  BDKRB1; B1 bradykinin receptor [KO:K03915]
101790477  BDKRB2; B2 bradykinin receptor [KO:K03916]
119713505  TACR1; substance-P receptor [KO:K04222]
101798587  TACR2; substance-K receptor isoform X1 [KO:K04223]
101797865  TACR3; neuromedin-K receptor [KO:K04224]
101790923  TBXA2R; thromboxane A2 receptor [KO:K04264]
101800830  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101791646  thyrotropin-releasing hormone receptor-like [KO:K04282]
101802176  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
101790257  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
101800439  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101794123  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101790479  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101802177  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101793706  guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
101795002  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
119713550  TGFA; protransforming growth factor alpha [KO:K08774]
101803502  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101794895  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101789650  PDGFC; platelet-derived growth factor C [KO:K05450]
101798843  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101794210  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
101798064  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
101801536  FGF20; fibroblast growth factor 20 [KO:K04358]
101795878  FGF17; fibroblast growth factor 17 [KO:K04358]
101793257  FGF9; fibroblast growth factor 9 isoform X2 [KO:K04358]
101797915  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101795837  FGF7; fibroblast growth factor 7 isoform X2 [KO:K04358]
101798153  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
101790873  FGF3; fibroblast growth factor 3 [KO:K04358]
101803036  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
101800554  FGF16; fibroblast growth factor 16 [KO:K04358]
106014914  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
113845652  FGF22; fibroblast growth factor 22 isoform X7 [KO:K04358]
113840147  FGF10; fibroblast growth factor 10 [KO:K04358]
113843807  FGF4; fibroblast growth factor 4 [KO:K04358]
101790481  FGF19; fibroblast growth factor 19 [KO:K22603]
101802843  FGF23; fibroblast growth factor 23 [KO:K22428]
101805258  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
101794827  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
101791715  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101792805  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
101793664  HGF; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
101789735  MST1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
101802438  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101797830  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101791759  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101801144  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101797285  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101799587  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
119713481  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101791540  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101804995  FGFR3; fibroblast growth factor receptor 3 isoform X7 [KO:K05094] [EC:2.7.10.1]
110354206  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101795331  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101797327  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
101790164  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101797579  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101797842  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101790659  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101801559  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101805281  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
101803164  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
101791674  uncharacterized LOC101791674 precursor [KO:K06856]
119712955  LOW QUALITY PROTEIN: immunoglobulin gamma-1 heavy chain-like [KO:K06856]
101796325  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
101804382  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
101796880  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101804447  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101805172  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
101790966  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101798692  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101792010  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
101799246  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101794187  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101801909  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101791594  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X6 [KO:K04958]
101791934  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101792202  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101795362  TPCN1; two pore calcium channel protein 1 isoform X2 [KO:K16896]
101790097  TPCN2; two pore calcium channel protein 2 [KO:K14077]
119714243  LOW QUALITY PROTEIN: mucolipin-1-like [KO:K04992]
119714244  mucolipin-1-like isoform X1 [KO:K04992]
101794497  MCOLN2; mucolipin-2 isoform X3 [KO:K04993]
101794809  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101798369  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101790944  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101803948  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101791585  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
113840724  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
113841418  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
119716487  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
101789930  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101794225  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101799034  ADP/ATP translocase 3 [KO:K05863]
101791414  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
119716478  ADP/ATP translocase 3-like [KO:K05863]
101802609  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101799009  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101802822  TNNC2; troponin C, skeletal muscle [KO:K12042]
101805317  calmodulin, striated muscle [KO:K02183]
101804276  CALML4; calmodulin-like protein 4 [KO:K02183]
101790182  CALM1; calmodulin [KO:K02183]
101799716  CALM2; calmodulin-2 [KO:K02183]
101793068  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
101794281  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101794322  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
101802849  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101800032  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
101803931  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101793167  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101794935  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101799935  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101792047  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
101802855  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
113845028  CAMK1; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101804017  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101801648  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101802786  CAMK2A; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
101804940  calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101802471  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101792272  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101800684  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101794308  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101791746  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
101792969  TFEB; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
101793899  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X4 [KO:K04446]
101798786  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101802637  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101798766  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101804455  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101802160  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101800233  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101793366  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101791659  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101802546  PRKCA; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
101799551  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
apla04010  MAPK signaling pathway
apla04070  Phosphatidylinositol signaling system
apla04210  Apoptosis
KO pathway
ko04020   
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