KEGG   PATHWAY: bbub05166
Entry
bbub05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Bubalus bubalis (water buffalo)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
bbub05166  Human T-cell leukemia virus 1 infection
bbub05166

Disease
H00009  Adult T-cell leukemia
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102388922  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102388955  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
102388997  [KO:K10784]
102389005  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
102389065  [KO:K06752]
102389341  TSPO; translocator protein [KO:K05770]
102389408  ETS1; protein C-ets-1 isoform X5 [KO:K02678]
102389416  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102389605  [KO:K06752]
102389770  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
102389863  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
102389936  [KO:K06752]
102390133  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
102390270  [KO:K06752]
102390435  [KO:K06751]
102390438  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102390460  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102390629  TGFB2; transforming growth factor beta-2 proprotein isoform X3 [KO:K13376]
102390834  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102390852  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102391217  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102391778  LTA; lymphotoxin-alpha [KO:K05468]
102391873  [KO:K05069]
102391970  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102392078  FOSL1; fos-related antigen 1 [KO:K04502]
102392112  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102392192  [KO:K05069]
102392246  RELB; transcription factor RelB isoform X3 [KO:K09253]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102392377  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
102392555  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
102392615  [KO:K06751]
102392759  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
102392808  [KO:K06752]
102392963  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102393133  [KO:K06752]
102393344  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102393434  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102393627  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102393680  [KO:K06751]
102393791  FOS; proto-oncogene C-Fos [KO:K04379]
102394072  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
102394197  EP300; histone acetyltransferase p300 isoform X4 [KO:K04498] [EC:2.3.1.48]
102394305  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102394310  TBPL2; TATA box-binding protein-like 2 isoform X1 [KO:K03120]
102394332  [KO:K06751]
102394352  ETS2; protein C-ets-2 [KO:K21932]
102394631  [KO:K06752]
102394706  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
102394968  [KO:K06751]
102395032  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102395178  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
102395302  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
102395333  TLN1; talin-1 isoform X4 [KO:K06271]
102395384  [KO:K02649]
102395421  IL2; interleukin-2 precursor [KO:K05429]
102395512  [KO:K03120]
102395805  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102396473  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
102396508  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
102396572  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
102396612  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 [KO:K17332]
102396812  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102396861  DLG1; disks large homolog 1 isoform X6 [KO:K12076]
102396976  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
102396979  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
102397007  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102397136  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
102397525  [KO:K07936]
102397540  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102397735  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102397755  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102397938  RELA; transcription factor P65 [KO:K04735]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398044  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
102398125  [KO:K06751]
102398200  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102398229  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
102398301  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
102398457  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102398478  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
102398705  [KO:K08057]
102398715  CCNA2; cyclin-A2 [KO:K06627]
102398757  EGR1; early growth response protein 1 [KO:K09203]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102398886  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102399207  ATM; serine-protein kinase ATM isoform X2 [KO:K04728] [EC:2.7.11.1]
102399213  POLB; DNA polymerase beta isoform X2 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
102399327  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
102399346  [KO:K08057]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102399613  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
102400064  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102400076  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102400092  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
102400120  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
102400134  RB1; retinoblastoma-associated protein [KO:K06618]
102400333  BUB3; mitotic checkpoint protein BUB3 isoform X3 [KO:K02180]
102400457  NRP1; neuropilin-1 isoform X4 [KO:K06724]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102400684  LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
102400710  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102400750  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
102400784  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102400804  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102400858  [KO:K11224]
102400864  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
102400898  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102401072  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
102401163  MMP7; matrilysin isoform X2 [KO:K01397] [EC:3.4.24.23]
102401483  CDC16; cell division cycle protein 16 homolog [KO:K03353]
102401554  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
102401594  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102401906  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102401972  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102401997  SRF; serum response factor [KO:K04378]
102402069  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
102402346  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102402466  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
102402481  [KO:K06751]
102402566  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102402664  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
102403077  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102403332  E2F2; transcription factor E2F2 [KO:K09389]
102403452  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
102403750  [KO:K04498] [EC:2.3.1.48]
102403895  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102403930  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102404023  [KO:K04725] [EC:2.3.2.27]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102404282  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102404283  MSX2; homeobox protein MSX-2 [KO:K09341]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102404650  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
102404816  [KO:K12456]
102405003  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102405012  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102405130  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
102405224  JUN; transcription factor AP-1 [KO:K04448]
102405285  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102405361  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102405387  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102406078  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102406192  [KO:K08874]
102406311  [KO:K06621]
102406564  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102406719  [KO:K06751]
102406784  LCK; tyrosine-protein kinase Lck isoform X3 [KO:K05856] [EC:2.7.10.2]
102406954  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
102407125  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
102407360  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
102407579  MSX1; homeobox protein MSX-1 isoform X1 [KO:K09341]
102407601  [KO:K06752]
102407637  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102407976  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
102408087  CCNA1; cyclin-A1 [KO:K06627]
102408103  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
102408122  XPO1; exportin-1 isoform X1 [KO:K14290]
102408345  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102408905  [KO:K06752]
102408938  [KO:K03120]
102409200  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
102409438  [KO:K06752]
102409445  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
102409656  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102409778  [KO:K06752]
102409889  CDC20; cell division cycle protein 20 homolog [KO:K03363]
102410004  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102410456  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102410577  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102410834  GPS2; G protein pathway suppressor 2 [KO:K15307]
102410916  [KO:K06751]
102411013  [KO:K04570]
102411133  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102411220  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
102411932  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
102412005  KAT2B; histone acetyltransferase KAT2B isoform X2 [KO:K06062] [EC:2.3.1.48]
102412107  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102412126  [KO:K06751]
102412430  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102412516  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
102412622  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102412626  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102412769  [KO:K06751]
102412787  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102413480  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
102413568  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
102413610  CALR; calreticulin [KO:K08057]
102413611  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X4 [KO:K04421] [EC:2.7.11.25]
102413631  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
102413660  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
102413723  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
102413761  [KO:K05863]
102413768  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102413795  CANX; calnexin [KO:K08054]
102413969  [KO:K06751]
102414534  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
102415084  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102415101  IL6; interleukin-6 isoform X1 [KO:K05405]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102415303  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102415323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102415423  PTTG1; securin isoform X2 [KO:K06635]
102415442  [KO:K11223]
102415498  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102415631  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102415632  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
102415657  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102415730  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
102416012  TLN2; talin-2 isoform X1 [KO:K06271]
102416300  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
102416566  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102416581  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102416630  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112577626  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112578753  [KO:K06752]
112580290  [KO:K04374]
112586263  MAD2L1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
112587129  [KO:K02833]
112587745  [KO:K08055]
112587746  [KO:K08055]
112587779  [KO:K07936]
123331302  [KO:K09341]
123335143  RANBP3; ran-binding protein 3 isoform X9 [KO:K15304]
123464883  E2F1; transcription factor E2F1 [KO:K17454]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
bbub03013  Nucleocytoplasmic transport
bbub04010  MAPK signaling pathway
bbub04064  NF-kappa B signaling pathway
bbub04110  Cell cycle
bbub04115  p53 signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04210  Apoptosis
bbub04350  TGF-beta signaling pathway
bbub04612  Antigen processing and presentation
bbub04660  T cell receptor signaling pathway
bbub04668  TNF signaling pathway
KO pathway
ko05166   

DBGET integrated database retrieval system