KEGG   PATHWAY: breg05132
Entry
breg05132                   Pathway                                
Name
Salmonella infection - Balearica regulorum gibbericeps (East African grey crowned-crane)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
breg05132  Salmonella infection
breg05132

Organism
Balearica regulorum gibbericeps (East African grey crowned-crane) [GN:breg]
Gene
104640812  PODXL; podocalyxin [KO:K06817]
104633731  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
104634026  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104641627  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104637959  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
104638669  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
104639484  RAB7B; ras-related protein Rab-7b [KO:K07898]
104639099  PLEKHM1; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 1 [KO:K23282]
104633934  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104640948  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104641160  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104632100  VPS39; vam6/Vps39-like protein [KO:K20183]
104632568  RILP; LOW QUALITY PROTEIN: rab-interacting lysosomal protein [KO:K13883]
104636906  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104635463  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
104637522  cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
104641973  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104636834  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104634406  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104633139  DYNC2LI1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
104636110  dynein light chain 1, cytoplasmic [KO:K10418]
104641864  dynein light chain 2, cytoplasmic-like [KO:K10418]
104642281  dynein light chain 2, cytoplasmic [KO:K10418]
104631883  dynein light chain 1, cytoplasmic-like [KO:K10418]
104631273  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
104637981  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
104631372  dynein light chain Tctex-type 1-like [KO:K10420]
104631086  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
104635965  DCTN1; dynactin subunit 1 [KO:K04648]
104629730  DCTN3; dynactin subunit 3 [KO:K10425]
104633350  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
104632594  DCTN5; dynactin subunit 5 [KO:K10427]
104634934  DCTN6; dynactin subunit 6 [KO:K10428]
104634124  ACTR1A; LOW QUALITY PROTEIN: alpha-centractin [KO:K16575]
104638948  ACTR10; actin-related protein 10 [KO:K16576]
104641522  tubulin alpha-1A chain-like [KO:K07374]
104632821  tubulin alpha-5 chain [KO:K07374]
104632956  tubulin alpha-3 chain [KO:K07374]
104638551  tubulin alpha-8 chain isoform X1 [KO:K07374]
104640112  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
104636900  tubulin beta-5 chain [KO:K07375]
104630856  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
104634764  tubulin beta chain [KO:K07375]
104635215  tubulin beta-7 chain [KO:K07375]
104635716  LOW QUALITY PROTEIN: FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
104632389  ADP-ribosylation factor-like protein 8B [KO:K07955]
104642110  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
104633374  ADP-ribosylation factor-like protein 8A [KO:K07955]
104638240  PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
104643604  KIF5B; kinesin-1 heavy chain [KO:K10396]
104639555  kinesin heavy chain isoform 5C [KO:K10396]
104636711  kinesin light chain 1-like [KO:K10407]
104640460  kinesin light chain 1-like [KO:K10407]
104642742  ACBD3; Golgi resident protein GCP60 [KO:K23935]
104641328  RHOA; transforming protein RhoA [KO:K04513]
104635145  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104631859  RAB9A; ras-related protein Rab-9A [KO:K07899]
104635751  RAB9B; ras-related protein Rab-9B [KO:K07900]
104630542  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
104630818  PFN4; profilin-4 [KO:K05759]
104632924  PFN3; profilin-3 [KO:K05759]
104640043  PFN2; profilin-2 [KO:K05759]
104642850  EXOC7; exocyst complex component 7 [KO:K07195]
104643434  EXOC5; exocyst complex component 5 [KO:K19984]
104636256  EXOC2; exocyst complex component 2 [KO:K17637]
104642543  RALA; ras-related protein Ral-A [KO:K07834]
104632918  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
104630864  ACTB; actin, cytoplasmic 1 [KO:K05692]
104631241  LOW QUALITY PROTEIN: actin, cytoplasmic 1-like [KO:K05692]
104644128  ANXA2; annexin A2 [KO:K17092]
104634850  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
104633642  rho-related GTP-binding protein RhoG-like [KO:K07863]
104634904  RHOG; rho-related GTP-binding protein RhoG isoform X1 [KO:K07863]
104641080  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
104638679  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104638047  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
104630578  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104631451  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
104635449  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104637852  FHOD1; FH1/FH2 domain-containing protein 1 [KO:K23938]
104641862  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104630597  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104632433  NCKAP1; nck-associated protein 1 [KO:K05750]
104637219  cytoplasmic FMR1-interacting protein 1-like [KO:K05749]
104639441  cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
104630735  ABI1; abl interactor 1 [KO:K23649]
104634036  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
104641105  ACTR2; actin-related protein 2 [KO:K17260]
104637129  ACTR3B; actin-related protein 3B [KO:K18584]
104638509  actin-related protein 3 [KO:K18584]
104643585  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104630434  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104639414  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104630650  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104641558  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104634174  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104634270  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104632910  MYO6; unconventional myosin-VI [KO:K10358]
104636125  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104636734  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104637393  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104635481  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104631875  PIK3C2A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
104634578  CYTH4; cytohesin-4 [KO:K18441]
104639364  CYTH3; cytohesin-3 [KO:K18441]
104631810  ARF6; ADP-ribosylation factor 6 [KO:K07941]
104644179  ARF1; ADP-ribosylation factor 1 [KO:K07937]
104642377  SNX9; sorting nexin-9 [KO:K17923]
104643232  SNX33; LOW QUALITY PROTEIN: sorting nexin-33 [KO:K17923]
104631198  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104634911  dynamin-2 [KO:K23484] [EC:3.6.5.5]
104638437  LOW QUALITY PROTEIN: toll-like receptor 10 [KO:K10169]
104633066  toll-like receptor 2 type-1 [KO:K10159]
104642331  toll-like receptor 2 type-2 [KO:K10159]
104641984  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
104633883  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104636809  TLR4; toll-like receptor 4 [KO:K10160]
104638289  LY96; lymphocyte antigen 96 [KO:K05400]
104634724  TLR5; toll-like receptor 5 [KO:K10168]
104633553  IRAK4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104641124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104642124  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104632639  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104641813  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104641034  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
104642304  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104630091  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104638129  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104643753  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104635435  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
104636905  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104637428  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
104630040  HSP90B1; endoplasmin [KO:K09487]
104644152  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
104640084  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
104642625  CSE1L; exportin-2 isoform X1 [KO:K18423]
104637014  importin subunit alpha-5 [KO:K23940]
104635909  KPNA4; importin subunit alpha-3 [KO:K23583]
104635767  KPNA3; importin subunit alpha-4 [KO:K23583]
104631064  HRAS; GTPase HRas [KO:K02833]
104632729  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
104639949  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104629471  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104641266  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
104636685  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104640593  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104636179  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104637918  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104638381  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104638505  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104638320  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104641693  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104633724  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104643707  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104636702  JUN; transcription factor AP-1 [KO:K04448]
104643280  interleukin-1 beta-like [KO:K04519]
104634214  IL6; interleukin-6 [KO:K05405]
104632443  interleukin-8-like [KO:K10030]
104631187  LOW QUALITY PROTEIN: interleukin-8-like [KO:K10030]
104636594  CTNNB1; catenin beta-1 [KO:K02105]
104643624  TCF7L2; transcription factor 7-like 2 [KO:K04491]
104637927  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
104630469  FBXO22; F-box only protein 22 [KO:K10302]
104630859  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
104630471  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104643597  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104643599  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104633402  inhibitor of apoptosis protein [KO:K16060]
104629950  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
104630467  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
104635047  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104632616  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
104632863  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
104630662  caspase-8-like [KO:K04398] [EC:3.4.22.61]
104637070  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104637035  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104639532  LOW QUALITY PROTEIN: cytochrome c, somatic-like [KO:K08738]
104640331  cytochrome c [KO:K08738]
104634110  apoptosis regulator Bcl-2-like [KO:K02161]
104641770  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104631935  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104639624  caspase-3-like [KO:K04397] [EC:3.4.22.60]
104633556  LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoB-like [KO:K07856]
104642877  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
104632555  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104635541  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104640250  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104633306  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
104640578  TXN2; thioredoxin, mitochondrial [KO:K03671]
104638485  TXN; thioredoxin [KO:K03671]
104633682  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
104634393  NACHT, LRR and PYD domains-containing protein 3-like [KO:K12800]
104631059  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
104640928  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
104640475  caspase-1-like [KO:K01370] [EC:3.4.22.36]
104630922  IL18; interleukin-18 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
breg04010  MAPK signaling pathway
breg04210  Apoptosis
breg04217  Necroptosis
breg04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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