KEGG   PATHWAY: cabi04060
Entry
cabi04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cabi04060  Cytokine-cytokine receptor interaction
cabi04060

Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116830181  interleukin-8-like [KO:K05514]
116830264  C-C motif chemokine 3-like [KO:K05514]
116818234  C-C motif chemokine 19-like [KO:K05512]
116818232  C-C motif chemokine 21b-like [KO:K16062]
116830182  C-C motif chemokine 3-like [KO:K05408]
116830183  C-C motif chemokine 3-like [KO:K05408]
116830188  C-C motif chemokine 5-like [KO:K05408]
116830186  C-C motif chemokine 4-like [KO:K12964]
116830187  C-C motif chemokine 4-like [KO:K12964]
116830267  C-C motif chemokine 4-like [KO:K12964]
116823877  C-C motif chemokine 17-like [KO:K21083]
116830185  C-C motif chemokine 5-like [KO:K12499]
116821130  C-C motif chemokine 17-like [KO:K16596]
116825102  CCL28; LOW QUALITY PROTEIN: C-C motif chemokine 28 [KO:K05513]
116816687  C-C motif chemokine 20-like [KO:K14625]
116816688  C-C motif chemokine 20-like [KO:K14625]
116837766  alveolar macrophage chemotactic factor-like [KO:K10030]
116834615  LOW QUALITY PROTEIN: interleukin-8-like [KO:K10030]
116814586  interleukin-8-like isoform X1 [KO:K10030]
116817706  LOW QUALITY PROTEIN: C-X-C motif chemokine 10-like [KO:K12671]
116817707  C-X-C motif chemokine 10-like [KO:K12671]
116817708  C-X-C motif chemokine 10-like [KO:K12671]
116817717  C-X-C motif chemokine 11-like [KO:K12672]
116827163  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
116827164  C-X-C motif chemokine 13-like [KO:K10032]
116816959  CXCL12; stromal cell-derived factor 1 [KO:K10031]
116826490  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
116831199  lymphotactin-like [KO:K05507]
116821129  fractalkine-like isoform X1 [KO:K05508]
116838149  IL7; interleukin-7 isoform X1 [KO:K05431]
116818230  IL15; interleukin-15 isoform X1 [KO:K05433]
116814977  EPO; erythropoietin [KO:K05437]
116817881  somatotropin [KO:K05438]
116818046  PRL; LOW QUALITY PROTEIN: prolactin [KO:K05439]
116821697  prolactin-like [KO:K05439]
116838575  THPO; thrombopoietin [KO:K06854]
116829868  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
116832980  LEP; leptin [KO:K05424]
116831337  IL6; interleukin-6 [KO:K05405]
116832333  IL11; interleukin-11 [KO:K05417]
116815969  IL12A; interleukin-12 subunit alpha [KO:K05406]
116833140  IL12B; interleukin-12 subunit beta [KO:K05425]
116820195  EBI3; interleukin-27 subunit beta [KO:K24476]
116833431  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
116822216  CNTF; ciliary neurotrophic factor [KO:K05420]
116816163  CTF1; cardiotrophin-1 [KO:K05422]
116816164  cardiotrophin-2-like [KO:K24382]
116821250  LIF; leukemia inhibitory factor [KO:K05419]
116821252  leukemia inhibitory factor-like [KO:K05419]
116832096  IL10; interleukin-10 [KO:K05443]
116832046  interleukin-20-like [KO:K22667]
116832047  interleukin-20-like [KO:K22667]
116834458  IL22; interleukin-22 [KO:K05445]
116823548  IL26; interleukin-26 [KO:K05446]
116839413  interferon lambda-3-like [KO:K22669]
116824507  interferon kappa-like [KO:K05414]
116825810  interferon beta-like [KO:K05414]
116825951  interferon tau-like [KO:K05414]
116826477  interferon beta-like [KO:K05414]
116826478  interferon beta-like [KO:K05414]
116820753  interferon beta-like [KO:K05414]
116835077  interferon beta-like [KO:K05414]
116835091  interferon beta-like [KO:K05414]
116835092  interferon beta-like [KO:K05414]
116835093  interferon epsilon-like [KO:K05414]
116835094  interferon kappa-like [KO:K05414]
116823551  IFNG; interferon gamma [KO:K04687]
116830711  interleukin-1 beta-like [KO:K04519]
116830722  interleukin-1 beta-like [KO:K04519]
116830683  interleukin-1 receptor antagonist protein-like isoform X1 [KO:K05481]
116830682  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
116819404  interleukin-36 receptor antagonist protein-like [KO:K05483]
116819405  interleukin-36 receptor antagonist protein-like [KO:K05483]
116829290  IL18; interleukin-18 isoform X1 [KO:K05482]
116834530  interleukin-17F-like [KO:K05494]
116834536  interleukin-17F-like [KO:K05494]
116833129  IL17B; interleukin-17B [KO:K05490]
116815673  IL17C; interleukin-17C [KO:K05491]
116816475  IL17D; interleukin-17D [KO:K05492]
116819856  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
116833708  IL34; interleukin-34 [KO:K22633]
116833832  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116822853  TNF; tumor necrosis factor isoform X1 [KO:K03156]
116822864  lymphotoxin-alpha-like [KO:K05468]
116830882  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
116822232  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116835215  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
116826739  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
116834724  ectodysplasin-A isoform X1 [KO:K05480]
116826036  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
116817999  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
116839654  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
116835222  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
116820588  CD40LG; CD40 ligand [KO:K03161]
116830877  uncharacterized protein LOC116830877 [KO:K05472]
116822227  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
116839653  TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
116833096  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
116833884  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
116828212  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
116837512  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
116826198  GDF15; growth/differentiation factor 15 [KO:K05504]
116834965  GDF2; growth/differentiation factor 2 [KO:K05503]
116828511  BMP10; bone morphogenetic protein 10 [KO:K22670]
116823971  INHA; inhibin alpha chain [KO:K05500]
116834628  BMP3; bone morphogenetic protein 3 [KO:K05496]
116834957  GDF10; growth/differentiation factor 10 [KO:K22674]
116827816  GDF11; growth/differentiation factor 11 [KO:K22679]
116837840  MSTN; growth/differentiation factor 8 [KO:K05497]
116832643  INHBA; inhibin beta A chain [KO:K04667]
116834017  INHBB; inhibin beta B chain [KO:K22687]
116826210  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
116826173  NODAL; nodal homolog [KO:K04666]
116821423  nodal homolog 2-A-like [KO:K04666]
116818355  GDF9; growth/differentiation factor 9 [KO:K22673]
116818851  inhibin beta C chain-like [KO:K22688]
116818853  inhibin beta C chain-like [KO:K22688]
116824477  AMH; muellerian-inhibiting factor [KO:K04665]
116816947  bone morphogenetic protein 2-like [KO:K21283]
116824056  BMP2; bone morphogenetic protein 2 [KO:K21283]
116825838  bone morphogenetic protein 2-like [KO:K21283]
116819607  BMP4; bone morphogenetic protein 4 [KO:K04662]
116816914  GDF5; growth/differentiation factor 5 [KO:K04664]
116815485  GDF6; growth/differentiation factor 6 [KO:K20012]
116818816  GDF7; growth/differentiation factor 7 [KO:K20013]
116831525  BMP15; bone morphogenetic protein 15 [KO:K05498]
116819415  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
116818025  BMP6; bone morphogenetic protein 6 [KO:K16620]
116826076  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
116830240  bone morphogenetic protein 8A-like [KO:K16622]
116838168  C-C chemokine receptor type 8-like [KO:K04183]
116838176  C-C chemokine receptor type 8-like [KO:K04183]
116825609  C-C chemokine receptor type 8-like [KO:K04183]
116838157  LOW QUALITY PROTEIN: C-C chemokine receptor type 9-like [KO:K04184]
116838180  C-C chemokine receptor type 9-like [KO:K04184]
116839735  ACKR4; atypical chemokine receptor 4 isoform X1 [KO:K04186]
116829894  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
116825564  CCR4; C-C chemokine receptor type 4 [KO:K04179]
116838175  C-C chemokine receptor type 5-like [KO:K04180]
116838177  LOW QUALITY PROTEIN: C-C chemokine receptor type 5-like [KO:K04180]
116820375  CCR10; LOW QUALITY PROTEIN: C-C chemokine receptor type 10 [KO:K04185]
116825471  C-C chemokine receptor type 6-like [KO:K04181]
116825490  C-C chemokine receptor type 6-like [KO:K04181]
116815802  C-X-C chemokine receptor type 2-like [KO:K05050]
116819089  C-X-C chemokine receptor type 3-2-like [KO:K04188]
116819097  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
116822938  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
116825876  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
116836454  ACKR3; atypical chemokine receptor 3 [KO:K04304]
116838181  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
116838166  XCR1; chemokine XC receptor 1 [KO:K04193]
116825618  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
116823520  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
116824117  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
116833382  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
116830029  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
116824571  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
116830033  interleukin-9 receptor-like isoform X1 [KO:K05073]
116835047  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
116830028  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
116820674  cytokine receptor-like factor 2 [KO:K05078]
116824102  cytokine receptor common subunit beta-like [KO:K04738]
116824126  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
116827037  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
116820672  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
116829729  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
116822531  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
116822524  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
116830658  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
116825106  GHR; growth hormone receptor [KO:K05080]
116833369  PRLR; prolactin receptor [KO:K05081]
116833032  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
116817035  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
116819890  LEPR; leptin receptor isoform X1 [KO:K05062]
116832734  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
116838490  interleukin-6 receptor subunit beta-like [KO:K05060]
116818241  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
116818236  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
116826233  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
116819880  IL12RB2; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2 [KO:K05064]
116819895  interleukin-23 receptor-like [KO:K05065]
116824808  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
116818251  IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630]
116825131  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
116815704  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
116820519  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
116822949  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
116820909  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
116818809  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
116833263  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
116830213  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
116830209  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
116829956  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
116820908  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116818785  IFNGR1; interferon gamma receptor 1 [KO:K05132]
116829957  IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133]
116832859  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
116832861  interleukin-1 receptor-like 2 isoform X1 [KO:K04386]
116823029  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116832866  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
116832867  interleukin-1 receptor type 1-like [KO:K05172]
116832863  interleukin-18 receptor 1-like [KO:K05173]
116832845  IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174]
116832862  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
116834348  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
116830416  IL17RC; interleukin-17 receptor C [KO:K05166]
116833083  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
116830417  IL17RE; interleukin-17 receptor E [KO:K05168]
116837532  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
116820002  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
116820865  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116821901  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
116815397  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
116816882  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143]
116818982  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116815424  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
116836889  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
116816362  tumor necrosis factor receptor superfamily member 6-like [KO:K04722]
116823194  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
116819875  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
116816567  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
116831464  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116819136  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
116822982  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
116829418  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
116821902  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
116833810  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
116815436  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
116824601  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
116824583  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
116821116  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
116814811  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]
116828743  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
116819329  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
116834379  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
116820886  RELL2; RELT-like protein 2 [KO:K26541]
116819742  RELL1; RELT-like protein 1 [KO:K26541]
116832884  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
116827024  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116827805  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
116831627  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
116821880  bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
116829938  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
116827804  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
116830036  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
116829952  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
116828478  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
116825005  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
116830587  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
116830588  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
116814759  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
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KO pathway
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