Entry
Name
Herpes simplex virus 1 infection - Coregonus clupeaformis (lake whitefish)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Coregonus clupeaformis (lake whitefish) [GN:
cclu ]
Gene
121551809 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
121570376 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
121560230 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
121560511 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
121538251 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
121560512 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
123481104 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
123481844 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
121537276 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
121537798 tumor necrosis factor receptor superfamily member 14-like isoform X2 [KO:K05152 ]
121560233 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
121560509 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
121566815 nectin1b; nectin cell adhesion molecule 1b isoform X1 [KO:K06081 ]
121584063 card9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794 ]
121551332 caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
121569950 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
121555890 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
121548996 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
121552425 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404 ]
121566279 tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156 ]
121558729 sting1; stimulator of interferon genes protein isoform X1 [KO:K12654 ]
121548589 serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
121556612 eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
121538879 eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
121544302 eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237 ]
121573869 translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239 ]
121556165 translation initiation factor eIF-2B subunit beta-like [KO:K03754 ]
121552621 translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754 ]
121580917 translation initiation factor eIF-2B subunit gamma-like isoform X1 [KO:K03241 ]
121548484 eif2b4; translation initiation factor eIF-2B subunit delta [KO:K03680 ]
121535379 eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
121547808 POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364 ]
121554336 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
121566387 POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364 ]
121536565 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
121542890 POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364 ]
121586445 POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364 ]
121551541 stat1b; signal transducer and activator of transcription 1b isoform X1 [KO:K11220 ]
121536664 signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
121568070 signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
123485102 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220 ]
121562503 signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
121562466 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220 ]
123481194 signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
121562465 signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
121575263 stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
121567543 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
121542861 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
121542862 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
121554353 LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF7.1 [KO:K09228 ]
121570706 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
121533100 zinc finger and SCAN domain-containing protein 2-like isoform X1 [KO:K09228 ]
121540214 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
121571361 endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228 ]
123482108 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
121547629 LOW QUALITY PROTEIN: interferon gamma receptor 1-like [KO:K05132 ]
121571574 major histocompatibility complex class I-related gene protein [KO:K06751 ]
121586457 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
123491402 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
123491404 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
123492872 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
121565694 major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751 ]
121568348 major histocompatibility complex class I-related gene protein [KO:K06751 ]
121575337 H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752 ]
121542666 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
121542667 H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752 ]
121542668 H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752 ]
121542669 H-2 class II histocompatibility antigen, E-S beta chain isoform X1 [KO:K06752 ]
121543260 H-2 class II histocompatibility antigen, A-Q alpha chain [KO:K06752 ]
121543888 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
121537602 class II histocompatibility antigen, B-L beta chain isoform X1 [KO:K06752 ]
121543259 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
123491640 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
123491641 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
121575336 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
121538393 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121533376 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121534970 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121567694 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121557873 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
121584610 phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
121582619 phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649 ]
121581087 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
121540427 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121533661 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
121541581 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121534059 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121535055 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
121535583 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
121576870 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
121580765 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
121584889 eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205 ]
121583488 eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205 ]
121530955 eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205 ]
121541630 eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
121560048 serine/arginine-rich splicing factor 1B-like isoform X1 [KO:K12890 ]
121551111 serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891 ]
121573973 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
123480986 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
121579288 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
121539881 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
121533348 faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
121583109 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
121542980 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
121540899 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
121550363 baxb; BCL2 associated X, apoptosis regulator b isoform X1 [KO:K02159 ]
121549496 apoptotic protease-activating factor 1-like isoform X1 [KO:K02084 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
cclu04620 Toll-like receptor signaling pathway
cclu04622 RIG-I-like receptor signaling pathway
KO pathway
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