KEGG   PATHWAY: cdk04015
Entry
cdk04015                    Pathway                                
Name
Rap1 signaling pathway - Camelus dromedarius (Arabian camel)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
cdk04015  Rap1 signaling pathway
cdk04015

Other DBs
GO: 0007264
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105102039  RAP1A; ras-related protein Rap-1A [KO:K04353]
105101089  RAP1B; ras-related protein Rap-1b [KO:K07836]
105086302  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105092902  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
105085302  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
105106183  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105089056  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105096536  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105096001  CALM1; calmodulin-1 [KO:K02183]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105104026  CALM3; calmodulin-3 [KO:K02183]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105092364  CALM2; calmodulin-2 [KO:K02183]
116147086  calmodulin-like [KO:K02183]
105084810  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
105101898  F2RL3; proteinase-activated receptor 4 [KO:K04236]
105094987  P2RY1; P2Y purinoceptor 1 [KO:K04270]
105096434  lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105103737  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105095047  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105090092  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105098214  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105095191  ADORA2A; adenosine receptor A2a [KO:K04266]
105085087  ADORA2B; adenosine receptor A2b [KO:K04267]
105095656  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
105095655  neuroendocrine secretory protein 55 [KO:K04632]
105095715  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105094039  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105100030  ADCY3; adenylate cyclase type 3 isoform X5 [KO:K08043] [EC:4.6.1.1]
105102432  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105090284  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105103816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105097528  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105096450  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
105099828  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105103807  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
105091096  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X5 [KO:K04351]
105087414  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
105101292  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101500  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
105096910  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105095517  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105101557  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105089905  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105090819  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105093669  FGF2; fibroblast growth factor 2 [KO:K18497]
105089379  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105104761  FGF7; fibroblast growth factor 7 [KO:K04358]
105084385  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105091789  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105102821  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105107148  FGF10; fibroblast growth factor 10 [KO:K04358]
105096404  FGF9; LOW QUALITY PROTEIN: fibroblast growth factor 9 [KO:K04358]
105091325  FGF6; fibroblast growth factor 6 [KO:K04358]
105095567  FGF16; fibroblast growth factor 16 [KO:K04358]
105102396  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105093420  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105104468  FGF4; fibroblast growth factor 4 [KO:K04358]
116157091  fibroblast growth factor 9 [KO:K04358]
105104469  FGF19; fibroblast growth factor 19 [KO:K22603]
105102899  FGF21; fibroblast growth factor 21 [KO:K22429]
105091333  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
105089623  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
116152037  INS; insulin [KO:K04526]
105097468  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105102061  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105091934  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105101177  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
116155424  PDGFD; platelet-derived growth factor D [KO:K05450]
105085658  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
105094866  KITLG; kit ligand isoform X1 [KO:K05461]
105088633  VEGFA; vascular endothelial growth factor A [KO:K05448]
105101542  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105086095  PGF; placenta growth factor isoform X5 [KO:K16859]
105084416  VEGFC; vascular endothelial growth factor C [KO:K05449]
105100399  VEGFD; vascular endothelial growth factor D [KO:K05449]
105100369  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105090509  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105084403  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105104308  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105088931  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105089638  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105104131  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
105095397  EFNA5; ephrin-A5 [KO:K05462]
116148121  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105105270  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105104060  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
105100875  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105099582  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105104837  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105087555  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105093441  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105098486  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105098488  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105091541  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105086584  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105100622  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105091598  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105085321  hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105093613  TEK; angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
105107071  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105088123  CRK; adapter molecule crk isoform X1 [KO:K04438]
105095221  CRKL; crk-like protein [KO:K04438]
105085169  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X16 [KO:K06277]
105085072  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105088409  CDH1; cadherin-1 isoform X2 [KO:K05689]
105084622  CTNNB1; catenin beta-1 [KO:K02105]
105095246  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4 [KO:K05631]
105093004  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
105085910  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X3 [KO:K06112]
105094767  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
105089950  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
105102785  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
105106853  FYB1; FYN-binding protein 1 isoform X3 [KO:K17698]
105089386  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
105106974  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
105085024  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105094833  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105103265  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105104042  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
105103635  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
105094205  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
105091720  DRD2; D(2) dopamine receptor isoform X2 [KO:K04145]
105095542  CNR1; cannabinoid receptor 1 [KO:K04277]
105087520  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105085647  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
105100375  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105096168  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105088864  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
105086138  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 [KO:K17701]
105102637  SIPA1; LOW QUALITY PROTEIN: signal-induced proliferation-associated protein 1 [KO:K08013]
105102157  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 [KO:K17702]
105096953  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
105100819  ID1; DNA-binding protein inhibitor ID-1 isoform X2 [KO:K04680]
105096896  THBS1; thrombospondin-1 [KO:K16857]
105085184  RALGDS; LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator [KO:K08732]
105088273  RALA; ras-related protein Ral-A [KO:K07834]
105088329  RALB; ras-related protein Ral-B isoform X2 [KO:K07835]
105101582  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105102215  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105102342  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
105102295  TLN1; talin-1 isoform X1 [KO:K06271]
105095822  TLN2; talin-2 isoform X1 [KO:K06271]
105094425  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105107141  profilin-2-like [KO:K05759]
105101469  PFN1; profilin-1 [KO:K05759]
105099591  PFN3; profilin-3 [KO:K05759]
105100025  PFN4; profilin-4 [KO:K05759]
105089494  PFN2; profilin-2 isoform X1 [KO:K05759]
105095447  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
105099759  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
105095385  EVL; LOW QUALITY PROTEIN: ena/VASP-like protein [KO:K23487]
105105716  actin, cytoplasmic 2 [KO:K05692]
105104247  ACTB; actin, cytoplasmic 1 [KO:K05692]
116150665  actin, cytoplasmic 1-like [KO:K05692]
105104077  actin-like [KO:K05692]
105090802  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105084996  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105096204  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
105088868  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105085620  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105102810  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
105087660  VAV1; proto-oncogene vav [KO:K05730]
105086777  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105099564  LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
105087881  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105088438  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105103858  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
105105552  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105085957  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105091826  AFDN; afadin [KO:K05702]
105101219  CTNND1; catenin delta-1 isoform X2 [KO:K05690]
105087383  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
105099589  RGS14; regulator of G-protein signaling 14 [KO:K17706]
116148489  LOW QUALITY PROTEIN: regulator of G-protein signaling 14-like [KO:K17706]
105098663  RASSF5; LOW QUALITY PROTEIN: ras association domain-containing protein 5 [KO:K08015]
105102736  ITGAL; integrin alpha-L isoform X4 [KO:K05718]
105089721  ITGAM; integrin alpha-M [KO:K06461]
105101515  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105100650  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105091663  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105100607  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
105085694  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105101337  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
105101338  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105090355  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105090356  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105084245  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105089630  NRAS; GTPase NRas [KO:K07828]
105100199  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
cdk04010  MAPK signaling pathway
cdk04014  Ras signaling pathway
cdk04020  Calcium signaling pathway
cdk04151  PI3K-Akt signaling pathway
cdk04510  Focal adhesion
cdk04520  Adherens junction
cdk04660  T cell receptor signaling pathway
cdk04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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