KEGG   PATHWAY: cdk05206
Entry
cdk05206                    Pathway                                
Name
MicroRNAs in cancer - Camelus dromedarius (Arabian camel)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
cdk05206  MicroRNAs in cancer
cdk05206

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105088956  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105094245  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105101079  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105088747  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
105103857  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
105096018  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105090655  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
116156380  HMGA2; high mobility group protein HMGI-C [KO:K09283]
105104393  CCND1; LOW QUALITY PROTEIN: G1/S-specific cyclin-D1 [KO:K04503]
105091327  CCND2; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2 [KO:K10151]
105085741  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105096784  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105088123  CRK; adapter molecule crk isoform X1 [KO:K04438]
105095221  CRKL; crk-like protein [KO:K04438]
105101051  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
105103240  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
105095267  FOXP1; forkhead box protein P1 isoform X1 [KO:K23582]
105087031  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
105085321  hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105100034  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X3 [KO:K17398] [EC:2.1.1.37]
105090549  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
105103187  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105096987  bcl-2-like protein 2 [KO:K02163]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105088633  VEGFA; vascular endothelial growth factor A [KO:K05448]
105086868  ZEB1; LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1 [KO:K09299]
105100091  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
105103128  EZR; ezrin isoform X1 [KO:K08007]
105091702  PDCD4; programmed cell death protein 4 [KO:K16865]
105091909  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105099829  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105095823  TPM1; tropomyosin alpha-1 chain isoform X4 [KO:K10373]
105103275  SPRY2; protein sprouty homolog 2 [KO:K17383]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105089003  SERPINB5; serpin B5 isoform X1 [KO:K10139]
105094280  ST14; suppressor of tumorigenicity 14 protein isoform X1 [KO:K08670] [EC:3.4.21.109]
105103641  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105106263  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105098859  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
105099069  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105086379  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105092528  ABL1; tyrosine-protein kinase ABL1 isoform X4 [KO:K06619] [EC:2.7.10.2]
105097542  TP63; tumor protein 63 isoform X1 [KO:K10149]
105084593  ZEB2; zinc finger E-box-binding homeobox 2 [KO:K23560]
105104253  FSCN1; LOW QUALITY PROTEIN: fascin [KO:K23551]
105090617  LOW QUALITY PROTEIN: fascin-like [KO:K23551]
105087424  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105098423  HOXD10; homeobox protein Hox-D10 [KO:K09295]
105092482  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105096889  BMF; bcl-2-modifying factor [KO:K17460]
105093311  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105087845  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105086588  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
105097690  CCNG1; cyclin-G1 [KO:K10145]
105097386  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
105100671  STMN1; stathmin [KO:K04381]
105090458  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105096445  MYC; myc proto-oncogene protein [KO:K04377]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105089630  NRAS; GTPase NRas [KO:K07828]
105087645  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
105095381  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
105104128  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
105088301  IRS1; insulin receptor substrate 1 [KO:K16172]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105100603  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105100478  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
105102276  RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461]
105089193  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
116157131  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
105105795  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105089487  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
105105157  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
105090858  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
105084911  BMI1; polycomb complex protein BMI-1 [KO:K11459]
105089491  MMP16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
105096603  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105089066  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
105106811  CD44; CD44 antigen isoform X7 [KO:K06256]
105095547  DICER1; endoribonuclease Dicer isoform X1 [KO:K11592] [EC:3.1.26.-]
105102079  FZD3; frizzled-3 [KO:K02329]
105101003  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
105096591  RDX; radixin isoform X1 [KO:K05762]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105092451  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
105101376  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105090566  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105099753  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
105089194  SOX4; LOW QUALITY PROTEIN: transcription factor SOX-4 [KO:K23581]
105103745  TNC; tenascin isoform X7 [KO:K06252]
105099963  TNR; tenascin-R [KO:K06252]
105099990  TNN; tenascin-N isoform X1 [KO:K06252]
105090860  TNXB; tenascin-X isoform X1 [KO:K06252]
105087358  ABCB1; ATP-dependent translocase ABCB1 isoform X1 [KO:K05658] [EC:7.6.2.2]
105091152  ABCC1; multidrug resistance-associated protein 1 isoform X2 [KO:K05665] [EC:7.6.2.3]
105090493  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105101330  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
105088931  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105089638  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105104131  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
105095397  EFNA5; ephrin-A5 [KO:K05462]
116148121  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105096896  THBS1; thrombospondin-1 [KO:K16857]
105095771  IGF2BP1; LOW QUALITY PROTEIN: insulin-like growth factor 2 mRNA-binding protein 1 [KO:K17391]
105090719  TRIM71; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105099289  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105094833  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105103265  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105104642  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105100875  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105095956  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105101086  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105098644  MDM4; protein Mdm4 isoform X1 [KO:K10127]
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105085024  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105089440  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105091467  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105103654  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105089005  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105102061  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105104832  SHC4; SHC-transforming protein 4 [KO:K17449]
105091934  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105098486  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105092872  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
105092697  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
105088895  E2F2; transcription factor E2F2 [KO:K09389]
105092985  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
105099220  LOW QUALITY PROTEIN: myristoylated alanine-rich C-kinase substrate [KO:K12561]
105098972  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
105085792  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
105099222  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
105085196  EZH2; histone-lysine N-methyltransferase EZH2 isoform X3 [KO:K11430] [EC:2.1.1.356]
105088784  GLS; glutaminase kidney isoform, mitochondrial isoform X4 [KO:K01425] [EC:3.5.1.2]
105086356  GLS2; glutaminase liver isoform, mitochondrial isoform X2 [KO:K01425] [EC:3.5.1.2]
105093901  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
105094160  WNT3A; protein Wnt-3a [KO:K00312]
105090437  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
105102619  sororin [KO:K17390]
105087306  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
105086272  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105103566  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
105098625  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
105099235  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
cdk05210  Colorectal cancer
cdk05214  Glioma
cdk05215  Prostate cancer
cdk05219  Bladder cancer
cdk05222  Small cell lung cancer
cdk05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

DBGET integrated database retrieval system