KEGG   PATHWAY: cge05166
Entry
cge05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Cricetulus griseus (Chinese hamster)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
cge05166  Human T-cell leukemia virus 1 infection
cge05166

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100753506  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100763324  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
100773301  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
100763987  Trrap; LOW QUALITY PROTEIN: transformation/transcription domain-associated protein isoform X2 [KO:K08874]
100761603  Kat5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
100771544  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100770691  Itgal; integrin alpha-L isoform X2 [KO:K05718]
100756135  Itgb2; integrin beta-2 [KO:K06464]
100689428  Icam1; intercellular adhesion molecule 1 precursor [KO:K06490]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100766761  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
100755764  Tln1; talin-1 isoform X2 [KO:K06271]
100770331  Tln2; talin-2 isoform X1 [KO:K06271]
100771967  Ranbp3; ran-binding protein 3 isoform X2 [KO:K15304]
100771164  GTP-binding nuclear protein Ran [KO:K07936]
100769066  Ran; GTP-binding nuclear protein Ran isoform X2 [KO:K07936]
100770067  GTP-binding nuclear protein Ran [KO:K07936]
100770879  Xpo1; exportin-1 [KO:K14290]
100760153  calreticulin [KO:K08057]
100689096  Calr; calreticulin precursor [KO:K08057]
100689345  Canx; calnexin precursor [KO:K08054]
100751412  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6 [KO:K04348] [EC:3.1.3.16]
100752571  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100764987  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100754314  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100773706  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100764851  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100762227  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100760989  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100768420  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
113832088  interleukin-2 receptor subunit beta-like isoform X2 [KO:K05069]
100756284  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
100754824  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100773497  Jak3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100755571  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100750571  signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
100755773  Il2; interleukin-2 [KO:K05429]
100689010  MHC class I antigen Hm1-C2 precursor [KO:K06751]
100689011  MHC class I antigen Hm1-C3 precursor [KO:K06751]
103162117  H-2 class I histocompatibility antigen, K-D alpha chain [KO:K06751]
100751667  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100771128  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X2 [KO:K06751]
100751953  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
113832472  class I histocompatibility antigen, Gogo-A*0101 alpha chain-like [KO:K06751]
113832473  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
100772658  HLA class I histocompatibility antigen, alpha chain F [KO:K06751]
100772949  saoe class I histocompatibility antigen, A alpha chain isoform X2 [KO:K06751]
100757234  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
100757524  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
100758961  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100758095  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
100753528  RT1 class I histocompatibility antigen, AA alpha chain isoform X2 [KO:K06751]
100762763  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
100762478  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100757615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
100759246  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
100751378  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
100689009  MHC class I antigen Hm1-C4 precursor [KO:K06751]
100689008  MHC class I antigen Hm1-C5 isoform X1 [KO:K06751]
103158895  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
100761901  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
113831254  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X4 [KO:K06751]
100773242  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
118237718  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
100689409  B2m; beta-2-microglobulin precursor [KO:K08055]
100754883  Fdps; farnesyl pyrophosphate synthase isoform X4 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100765792  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
100750613  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
100769087  Slc25a5; ADP/ATP translocase 2 isoform X2 [KO:K05863]
100751779  Slc25a4; ADP/ATP translocase 1 isoform X2 [KO:K05863]
100773145  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
100761654  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like isoform X2 [KO:K05863]
100761812  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100774187  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100768847  Tspo; translocator protein [KO:K05770]
100756965  Tspo2; translocator protein 2 [KO:K05770]
100753800  Vac14; protein VAC14 homolog isoform X1 [KO:K15305]
100770912  Ranbp1; ran-specific GTPase-activating protein isoform X2 [KO:K15306]
100689352  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
100753081  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100754771  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X4 [KO:K06637] [EC:2.7.11.1]
100767122  Bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
100770891  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
100774636  Anapc2; anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
100770539  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
100763196  LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
100767504  Anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100766376  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100759495  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100765036  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
100752608  Cdc23; cell division cycle protein 23 homolog isoform X2 [KO:K03355]
100772439  Anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100767345  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
100753813  Cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100766682  anaphase-promoting complex subunit CDC26-like [KO:K03359]
100770713  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
100752128  anaphase-promoting complex subunit 15 [KO:K25228]
100759455  Anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
100767761  Cdc20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
100765630  Pttg1; securin [KO:K06635]
100768842  Espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
100773656  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
113833995  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100764983  tumor suppressor ARF isoform X2 [KO:K06621]
100760122  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100766025  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100759649  Ccna2; cyclin-A2 isoform X2 [KO:K06627]
100769969  Ccna1; cyclin-A1 isoform X2 [KO:K06627]
100760464  Ccne2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100753358  Ccne1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100752928  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X2 [KO:K06618]
100758556  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 isoform X2 [KO:K17454]
100754522  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
100754647  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
100754226  serine-protein kinase ATM isoform X6 [KO:K04728] [EC:2.7.11.1]
100766256  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100751099  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100769280  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100774630  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
100764294  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100764780  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
100765017  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
100770540  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
100770977  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100771734  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100754361  mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100764964  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113834001  transcription factor AP-1 [KO:K04448]
100760540  Mmp7; matrilysin isoform X2 [KO:K01397] [EC:3.4.24.23]
100758740  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
100759030  Il1r2; interleukin-1 receptor type 2 [KO:K04387]
100757609  T-cell receptor beta-2 chain C region [KO:K10785]
100756906  Cd3d; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
100757488  Cd3e; T-cell surface glycoprotein CD3 epsilon chain isoform X2 [KO:K06451]
100757196  Cd3g; T-cell surface glycoprotein CD3 gamma chain isoform X2 [KO:K06452]
100753508  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X4 [KO:K04421] [EC:2.7.11.25]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100754153  Nfkbia; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100766072  Gps2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
100751411  Ltbr; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
100770242  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
100762567  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
100766459  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X3 [KO:K04466] [EC:2.7.11.25]
100752828  Relb; transcription factor RelB isoform X3 [KO:K09253]
113837283  transcription factor RelB-like isoform X1 [KO:K09253]
100774604  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100772937  Zfp36; mRNA decay activator protein ZFP36 isoform X2 [KO:K15308]
100764797  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
100772160  Il15; interleukin-15 isoform X1 [KO:K05433]
100755321  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
100689186  Il6; interleukin-6 [KO:K05405]
100765221  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100765068  Lta; lymphotoxin-alpha [KO:K05468]
100689371  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
100689374  Xiap; baculoviral IAP repeat-containing protein 4 [KO:K04725] [EC:2.3.2.27]
100773359  Tgfb1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100774918  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100756831  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100772727  Tgfbr1; TGF-beta receptor type-1 isoform X3 [KO:K04674] [EC:2.7.11.30]
100773953  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100771578  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100759220  Smad3; mothers against decapentaplegic homolog 3 isoform X3 [KO:K23605]
100770737  Smad4; mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
100764561  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100773811  Adcy2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100770498  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100768998  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100765958  Adcy5; LOW QUALITY PROTEIN: adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
100768368  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100756132  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
113837458  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100751372  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
103162651  LOW QUALITY PROTEIN: nuclear transcription factor Y subunit beta-like isoform X2 [KO:K08065]
100765985  Nfyb; nuclear transcription factor Y subunit beta isoform X3 [KO:K08065]
100750512  H-2 class II histocompatibility antigen, E-S beta chain isoform X2 [KO:K06752]
100759913  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
100760208  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100759342  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100760794  class II histocompatibility antigen, M alpha chain [KO:K06752]
103161518  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100761373  rano class II histocompatibility antigen, A beta chain isoform X2 [KO:K06752]
100752328  H-2 class II histocompatibility antigen, I-E alpha chain [KO:K06752]
100761951  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
100766775  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, E-S beta chain-like isoform X2 [KO:K06752]
100767068  H-2 class II histocompatibility antigen, E-D beta chain [KO:K06752]
100762240  H-2 class II histocompatibility antigen, E-D beta chain-like isoform X2 [KO:K06752]
100767639  H-2 class II histocompatibility antigen, E-U alpha chain isoform X2 [KO:K06752]
100774703  LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
100761082  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
100756170  Srf; serum response factor isoform X3 [KO:K04378]
100755459  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
100763890  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
100763362  Spi1; transcription factor PU.1 isoform X4 [KO:K09438]
100767456  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
100774407  Ets2; protein C-ets-2 [KO:K21932]
100751579  Tbp; TATA-box-binding protein isoform X1 [KO:K03120]
100768754  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
100689418  Fos; proto-oncogene c-Fos [KO:K04379]
100755852  Egr1; early growth response protein 1 isoform X2 [KO:K09203]
103159499  Fosl1; fos-related antigen 1 [KO:K04502]
100770422  Egr2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100761582  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100762192  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
100771872  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100766300  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100774488  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100772940  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100754663  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100689386  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100764159  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
100767112  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
100766676  Crtc1; CREB-regulated transcription coactivator 1 isoform X4 [KO:K15309]
100751848  Crtc2; CREB-regulated transcription coactivator 2 isoform X7 [KO:K16333]
100751622  Crtc3; CREB-regulated transcription coactivator 3 isoform X2 [KO:K16334]
100762260  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100770451  histone lysine acetyltransferase CREBBP isoform X3 [KO:K04498] [EC:2.3.1.48]
100774478  Kat2a; LOW QUALITY PROTEIN: histone acetyltransferase KAT2A isoform X2 [KO:K06062] [EC:2.3.1.48]
100772054  Kat2b; histone acetyltransferase KAT2B isoform X2 [KO:K06062] [EC:2.3.1.48]
100768423  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
100774965  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100759316  Lck; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
100689032  Bax; apoptosis regulator BAX [KO:K02159]
100774733  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100774541  Tert; telomerase reverse transcriptase isoform X4 [KO:K11126] [EC:2.7.7.49]
100752378  Msx1; homeobox protein MSX-1 isoform X2 [KO:K09341]
100761249  Msx2; homeobox protein MSX-2 [KO:K09341]
100771818  Ventx; homeobox protein VENTX isoform X1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
cge03013  Nucleocytoplasmic transport
cge04010  MAPK signaling pathway
cge04064  NF-kappa B signaling pathway
cge04110  Cell cycle
cge04115  p53 signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04210  Apoptosis
cge04350  TGF-beta signaling pathway
cge04612  Antigen processing and presentation
cge04660  T cell receptor signaling pathway
cge04668  TNF signaling pathway
KO pathway
ko05166   
LinkDB

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