KEGG   PATHWAY: chx04020
Entry
chx04020                    Pathway                                
Name
Calcium signaling pathway - Capra hircus (goat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
chx04020  Calcium signaling pathway
chx04020

Other DBs
GO: 0019722
Organism
Capra hircus (goat) [GN:chx]
Gene
102177443  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
102171644  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
102181964  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
102168898  ATP2B3; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102176524  plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
102187815  ATP2B2; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
102174093  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
102187843  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108633307  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102168455  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102183812  ADORA2A; adenosine receptor A2a [KO:K04266]
102179134  ADORA2B; adenosine receptor A2b [KO:K04267]
102187558  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102179381  ADRB2; beta-2 adrenergic receptor [KO:K04142]
106503668  ADRB3; beta-3 adrenergic receptor [KO:K04143]
102168830  DRD1; D(1A) dopamine receptor [KO:K04144]
102168337  DRD5; D(1B) dopamine receptor [KO:K05840]
102168263  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
102178536  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
108637965  5-hydroxytryptamine receptor 5B [KO:K04161]
102190296  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
106503589  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102181834  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102188874  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
108633189  neuroendocrine secretory protein 55 [KO:K04632]
100861281  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
102180724  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102171922  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102169019  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102185469  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102185858  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102184919  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102188104  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102170148  PLN; cardiac phospholamban [KO:K05852]
102189693  SLN; sarcolipin [KO:K22642]
102189188  MRLN; myoregulin [KO:K22643]
108636200  C6H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
102169514  SMIM6; small integral membrane protein 6 [KO:K26468]
102180626  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102187450  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102174960  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102189986  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X2 [KO:K23450]
102189695  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
102186100  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
102171809  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
102175642  ORAI2; protein orai-2 isoform X1 [KO:K16057]
102175544  ORAI3; protein orai-3 [KO:K16058]
100861292  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102174706  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102189746  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102176151  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102168441  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
102189138  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102184834  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102187163  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102185724  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102179705  CHRNA7; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
102181789  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102189537  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108636054  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102177097  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102177187  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102191614  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
102174657  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102180347  P2RX1; P2X purinoceptor 1 [KO:K05215]
102171362  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
102180244  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
102173324  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
102179517  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
102173383  P2RX6; P2X purinoceptor 6 [KO:K05221]
102174145  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
102179229  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
102180565  RYR2; ryanodine receptor 2 [KO:K04962]
102191052  RYR3; ryanodine receptor 3 [KO:K04963]
102186691  TRDN; triadin isoform X22 [KO:K23449]
102185618  CASQ1; calsequestrin-1 [KO:K23468]
102185134  CASQ2; calsequestrin-2 [KO:K23445]
102189496  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
102184981  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102184817  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102169456  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102182788  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
102179850  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102169770  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102174163  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102174144  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
102186699  EDNRB; endothelin B receptor [KO:K04198]
102187491  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
102182568  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102177147  GRPR; gastrin-releasing peptide receptor [KO:K04169]
108633284  HRH1; histamine H1 receptor [KO:K04149]
102188025  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102182605  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102178674  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100860843  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
102184259  NTSR1; neurotensin receptor type 1 [KO:K04211]
102185124  OXTR; oxytocin receptor [KO:K04229]
102184883  AVPR1A; vasopressin V1a receptor [KO:K04226]
102174323  AVPR1B; vasopressin V1b receptor [KO:K04227]
108637010  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
102182455  PTAFR; platelet-activating factor receptor [KO:K04279]
102187936  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
102178500  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
102173625  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
108633196  BDKRB1; B1 bradykinin receptor [KO:K03915]
102187899  BDKRB2; B2 bradykinin receptor [KO:K03916]
102191055  TACR1; substance-P receptor [KO:K04222]
102190490  TACR2; substance-K receptor [KO:K04223]
102168518  TACR3; neuromedin-K receptor [KO:K04224]
102177975  TBXA2R; thromboxane A2 receptor [KO:K04264]
102187694  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102169608  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
102187794  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
102185547  CCKAR; cholecystokinin receptor type A [KO:K04194]
102186886  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
102169916  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102189950  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102177328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
106502411  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
102177052  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102185926  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102174268  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102184232  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102168651  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102168934  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102188850  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102186892  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
102171226  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
102179273  FGF16; fibroblast growth factor 16 [KO:K04358]
102178454  FGF7; fibroblast growth factor 7 [KO:K04358]
102171599  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102169384  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102180381  FGF6; fibroblast growth factor 6 [KO:K04358]
102169602  FGF9; fibroblast growth factor 9 [KO:K04358]
102178396  FGF18; fibroblast growth factor 18 [KO:K04358]
102174339  FGF10; fibroblast growth factor 10 [KO:K04358]
102179261  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108634211  FGF3; fibroblast growth factor 3 [KO:K04358]
102170206  FGF4; fibroblast growth factor 4 [KO:K04358]
102171403  FGF20; fibroblast growth factor 20 [KO:K04358]
102169942  FGF19; fibroblast growth factor 19 [KO:K22603]
102185860  FGF21; fibroblast growth factor 21 [KO:K22429]
102168896  FGF23; fibroblast growth factor 23 [KO:K22428]
100860957  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
102189099  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102185645  VEGFD; vascular endothelial growth factor D [KO:K05449]
102189826  VEGFC; vascular endothelial growth factor C [KO:K05449]
100862660  NGF; beta-nerve growth factor precursor [KO:K02582]
102183288  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102179141  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
102169798  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102181989  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102173448  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102180167  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102174007  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102184426  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102180282  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102170938  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102183685  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100860837  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102180480  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100860836  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102172584  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102180223  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102185689  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
102181186  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
102175906  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
102172412  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102169343  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
102184479  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
102190639  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
102188148  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102180505  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102169966  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102189653  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102181878  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102180337  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102178972  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102170761  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102170858  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102172881  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102189785  TPCN1; two pore calcium channel protein 1 isoform X4 [KO:K16896]
102189285  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
102169278  MCOLN1; mucolipin-1 [KO:K04992]
102186546  MCOLN2; mucolipin-2 [KO:K04993]
102189726  MCOLN3; mucolipin-3 [KO:K04994]
102168201  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
102184187  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102184878  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102169457  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102173075  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102178813  ADP/ATP translocase 3 [KO:K05863]
102176546  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100861351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102187374  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100860954  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100861317  STNC; fast twitch skeletal muscle troponin C2 [KO:K12042]
102185007  CALM1; calmodulin [KO:K02183]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102175311  calmodulin [KO:K02183]
106502751  calmodulin-like protein 3 [KO:K02183]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102169697  CALM3; calmodulin [KO:K02183]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102185139  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
100861337  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
102172049  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
102175235  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
102183305  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
102181454  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102181980  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102182147  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102190641  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102174671  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
102185318  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
102168659  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
102176762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102185715  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102185084  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102175934  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102187484  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102174171  TFEB; transcription factor EB [KO:K15590]
102188180  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102180958  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102184725  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102185490  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100860742  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102185338  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102190998  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
102185434  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102180455  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3 [KO:K13755] [EC:3.1.4.17]
102184810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102173853  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102190716  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102189152  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102172114  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102175984  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
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  Authors
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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Extracellular-signal-regulated kinase signalling in neurons.
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Mol Biol Cell 14:4003-14 (2003)
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Seikagaku 80:1123-8 (2008)
Reference
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
chx04010  MAPK signaling pathway
chx04070  Phosphatidylinositol signaling system
chx04210  Apoptosis
chx04720  Long-term potentiation
chx04730  Long-term depression
KO pathway
ko04020   
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