KEGG   PATHWAY: chx05166
Entry
chx05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Capra hircus (goat)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
chx05166  Human T-cell leukemia virus 1 infection
chx05166

Organism
Capra hircus (goat) [GN:chx]
Gene
102174800  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
102175037  NRP1; neuropilin-1 isoform X1 [KO:K06724]
102171262  MYC; myc proto-oncogene protein [KO:K04377]
102170659  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
100861366  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
102180657  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102172115  ITGAL; integrin alpha-L precursor [KO:K05718]
100861185  ITGB2; integrin beta-2 precursor [KO:K06464]
102181113  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102170124  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
102175583  TLN2; talin-2 isoform X1 [KO:K06271]
102179669  TLN1; talin-1 isoform X1 [KO:K06271]
102191605  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
102172451  GTP-binding nuclear protein Ran-like [KO:K07936]
108637516  GTP-binding nuclear protein Ran-like [KO:K07936]
102176450  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102171837  GTP-binding nuclear protein Ran-like [KO:K07936]
108635911  GTP-binding nuclear protein Ran-like [KO:K07936]
102171795  XPO1; exportin-1 isoform X1 [KO:K14290]
102185733  CALR; calreticulin [KO:K08057]
102173831  CANX; calnexin [KO:K08054]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102188180  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102180958  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102184725  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102169656  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102171504  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102185866  signal transducer and activator of transcription 5A [KO:K11223]
102176415  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102183089  IL2; interleukin-2 precursor [KO:K05429]
102172138  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102180584  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102188814  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
102181202  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
108633459  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
108633460  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102183314  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102176782  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102170045  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102168905  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102169753  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102185917  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102181347  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
108633505  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102175817  patr class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102171703  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102168267  B2M; beta-2-microglobulin [KO:K08055]
102168547  beta-2-microglobulin [KO:K08055]
102186540  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102173075  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102178813  ADP/ATP translocase 3 [KO:K05863]
102176546  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100861351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102169457  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102191504  TSPO; translocator protein isoform X1 [KO:K05770]
102172774  TSPO2; LOW QUALITY PROTEIN: translocator protein 2 [KO:K05770]
102172568  VAC14; protein VAC14 homolog [KO:K15305]
102169615  RANBP1; ran-specific GTPase-activating protein [KO:K15306]
102170846  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
102191505  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102176047  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
102178035  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
102170324  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
102181216  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
102170548  CDC27; cell division cycle protein 27 homolog isoform X5 [KO:K03350]
102183223  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102172567  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
102178285  CDC16; cell division cycle protein 16 homolog [KO:K03353]
102175608  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
102186684  CDC23; cell division cycle protein 23 homolog [KO:K03355]
102177553  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102169049  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102170786  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102170094  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102172283  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
102175744  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102171483  CDC20; cell division cycle protein 20 homolog [KO:K03363]
102183062  PTTG1; securin isoform X1 [KO:K06635]
102177959  ESPL1; separin isoform X2 [KO:K02365] [EC:3.4.22.49]
102179856  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102172895  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
108636541  tumor suppressor ARF-like isoform X1 [KO:K06621]
102171306  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102169650  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102190470  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102179898  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102176051  CCNA1; cyclin-A1 [KO:K06627]
102190390  CCNA2; cyclin-A2 [KO:K06627]
102185672  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102184185  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100860751  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102183886  RB1; retinoblastoma-associated protein [KO:K06618]
102173018  E2F1; transcription factor E2F1 [KO:K17454]
102186169  E2F2; transcription factor E2F2 [KO:K09389]
102169535  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102190803  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102178489  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102184881  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
102184180  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102178485  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
102185891  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100861232  TNF; tumor necrosis factor [KO:K03156]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102187530  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
102175799  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102173210  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
102187231  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102186601  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
102191154  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
102190711  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102191440  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102173036  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
102189430  GPS2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
102189744  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
102183249  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102189290  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
102189617  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102171147  RELB; transcription factor RelB isoform X1 [KO:K09253]
102191581  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102183627  ZFP36; tristetraprolin [KO:K15308]
102170059  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102180957  IL15; interleukin-15 [KO:K05433]
102171722  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100861208  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
102180548  LTA; lymphotoxin-alpha [KO:K05468]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
102170035  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102191364  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
100861228  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
102189962  TGFB3; transforming growth factor beta-3 [KO:K13377]
102187767  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100861300  TGFBR2; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102188455  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102169293  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100861019  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102180724  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102171922  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102169019  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102185469  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102189798  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102169557  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102185858  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102184919  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102188104  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102182108  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
102180664  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1 [KO:K06752]
102179937  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
102187356  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102190745  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102188267  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102188986  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102187998  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102186727  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
106503481  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
102186442  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102189356  HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
100860813  HA25 [KO:K06752]
102173700  SRF; serum response factor [KO:K04378]
102171085  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102170129  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102186416  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
100860919  ETS1; protein C-ets-1 [KO:K02678]
102177477  ETS2; protein C-ets-2 [KO:K21932]
102173392  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
102176044  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
102182309  TBP; TATA-box-binding protein [KO:K03120]
102171520  FOS; proto-oncogene c-Fos [KO:K04379]
102188309  EGR1; early growth response protein 1 [KO:K09203]
102172040  FOSL1; fos-related antigen 1 [KO:K04502]
102174905  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102180221  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102174829  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102183745  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102183893  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102170199  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102180634  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102190378  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102171671  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
106502271  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
102180907  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102172203  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
102187824  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102187383  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
102184382  KAT2B; LOW QUALITY PROTEIN: histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
102184470  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
102168820  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
102177689  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
102171746  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102169723  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
102187716  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100861257  MSX2; msh homeobox 2 [KO:K09341]
102190677  MSX1; homeobox protein MSX-1 [KO:K09341]
102169797  MSX2; homeobox protein MSX-2 [KO:K09341]
108634012  LOW QUALITY PROTEIN: homeobox protein MSX-3-like [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
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Nat Rev Microbiol 6:815-26 (2008)
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Role of the cytoskeleton during leukocyte responses.
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Nat Rev Immunol 4:110-22 (2004)
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Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
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J Virol 90:7607-17 (2016)
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Shida H
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Virol J 10:182 (2013)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Oncogene 24:5952-64 (2005)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Pathogens 5:E8 (2016)
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
chx03013  Nucleocytoplasmic transport
chx04010  MAPK signaling pathway
chx04064  NF-kappa B signaling pathway
chx04110  Cell cycle
chx04115  p53 signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04350  TGF-beta signaling pathway
chx04612  Antigen processing and presentation
chx04660  T cell receptor signaling pathway
chx04668  TNF signaling pathway
KO pathway
ko05166   
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