KEGG   PATHWAY: cjc04014
Entry
cjc04014                    Pathway                                
Name
Ras signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04014  Ras signaling pathway
cjc04014

Other DBs
GO: 0032318
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100402888  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100392014  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118152209  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100398595  fibroblast growth factor 6-like [KO:K04358]
100405886  FGF7; fibroblast growth factor 7 [KO:K04358]
100409540  FGF4; fibroblast growth factor 4 [KO:K04358]
100401797  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100410253  FGF3; fibroblast growth factor 3 [KO:K04358]
100385862  FGF20; fibroblast growth factor 20 [KO:K04358]
100386978  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100402660  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100387695  FGF10; fibroblast growth factor 10 [KO:K04358]
100414371  FGF22; fibroblast growth factor 22 isoform X3 [KO:K04358]
100392792  FGF9; fibroblast growth factor 9 [KO:K04358]
100390531  FGF6; fibroblast growth factor 6 [KO:K04358]
100388550  FGF16; fibroblast growth factor 16 [KO:K04358]
128929061  FGF19; fibroblast growth factor 19 [KO:K22603]
100389889  FGF21; fibroblast growth factor 21 [KO:K22429]
100392707  FGF23; fibroblast growth factor 23 [KO:K22428]
100391837  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100409412  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100395962  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
100392049  NTF4; neurotrophin-4 [KO:K12457]
100393089  INS; insulin [KO:K04526]
100394985  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100393815  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
100412906  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100388628  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100393010  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100398033  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100386071  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100410844  KITLG; kit ligand isoform X1 [KO:K05461]
103790554  kit ligand-like [KO:K05461]
100411269  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X11 [KO:K05454]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100400081  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100386568  PGF; placenta growth factor isoform X1 [KO:K16859]
100395294  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100407908  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100385966  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100413870  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100404686  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100397495  ANGPT4; angiopoietin-4 [KO:K05467]
100394813  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100395416  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100395773  EFNA1; ephrin-A1 [KO:K05462]
100396146  EFNA2; ephrin-A2 [KO:K05462]
100388282  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100390192  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100393573  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
100409938  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100414348  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100392306  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
103789024  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100388984  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100403400  INSR; insulin receptor isoform X4 [KO:K04527] [EC:2.7.10.1]
100408399  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100406047  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100411615  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100413316  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100413680  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100388404  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100407045  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100408551  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103793489  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
100412970  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100406544  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
100408076  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
100390337  SHC1; SHC-transforming protein 1 isoform X5 [KO:K06279]
100415083  SHC2; SHC-transforming protein 2 [KO:K17447]
100402406  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
100392220  SHC4; SHC-transforming protein 4 [KO:K17449]
100414905  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100390905  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100896269  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100404102  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
103789934  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
100409044  T cell receptor alpha variable 8-6 [KO:K10784]
100896987  T cell receptor beta variable 7-2 [KO:K10785]
100896470  T cell receptor beta variable 7-9 [KO:K10785]
100390922  tyrosine-protein kinase ZAP-70 isoform X2 [KO:K07360] [EC:2.7.10.2]
100414442  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
100408572  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
100412968  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [KO:K04536]
100395033  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100407336  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100395633  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
100415506  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
100391372  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100397915  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100411028  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103787193  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108590740  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
108593490  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118150544  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
128930422  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100411155  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108589488  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100385281  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
108588980  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100412160  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100396640  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100394978  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108594009  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100412503  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100394732  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100408115  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100409206  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
118151333  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100413467  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100402073  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100390180  CALM1; calmodulin-1 [KO:K02183]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100406081  CALM3; calmodulin-3 [KO:K02183]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  calmodulin-1-like [KO:K02183]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100390332  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
100413772  RRAS; ras-related protein R-Ras [KO:K07829]
100401286  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100386626  ras-related protein R-Ras2-like [KO:K07830]
100400537  ras-related protein R-Ras2-like [KO:K07830]
128931276  ras-related protein R-Ras2-like [KO:K07830]
100392547  NF1; neurofibromin isoform X10 [KO:K08052]
100415187  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100413985  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100415408  RASA3; ras GTPase-activating protein 3 isoform X2 [KO:K12380]
100387192  ras GTPase-activating protein 4 isoform X1 [KO:K17630]
100401593  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
100386082  RASAL1; rasGAP-activating-like protein 1 isoform X3 [KO:K17632]
100391907  RASAL2; ras GTPase-activating protein nGAP isoform X4 [KO:K17633]
100407539  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
100407858  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100415559  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100407296  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100390844  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100400756  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100392970  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100405552  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100413676  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
100394713  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100411048  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100387874  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100401978  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100384968  FOXO4; forkhead box protein O4 [KO:K12358]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100402985  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
100387464  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
100391803  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
100409316  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
100397103  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
100385674  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
100398374  RALA; ras-related protein Ral-A [KO:K07834]
100409022  RALB; ras-related protein Ral-B [KO:K07835]
100397093  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100391217  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100391921  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100413616  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100390070  RALBP1; ralA-binding protein 1 [KO:K08773]
100404291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100398334  AFDN; afadin isoform X5 [KO:K05702]
100413840  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100391282  PLA1A; phospholipase A1 member A isoform X2 [KO:K13618] [EC:3.1.1.111]
100396610  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100394893  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X3 [KO:K01047] [EC:3.1.1.4]
100397680  PLA2G10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100395844  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100410471  PLA2G5; phospholipase A2 group V isoform X4 [KO:K01047] [EC:3.1.1.4]
100410833  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100411195  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100395483  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100411811  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100391709  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100400789  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100401154  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100402439  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
118142760  PLA2G4B; cytosolic phospholipase A2 beta isoform X6 [KO:K16342] [EC:3.1.1.4]
100415535  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
103787289  PLAAT3; phospholipase A and acyltransferase 3 isoform X5 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100393766  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100411213  ETS1; protein C-ets-1 isoform X6 [KO:K02678]
100397046  LOW QUALITY PROTEIN: protein C-ets-2-like [KO:K21932]
100397851  ETS2; protein C-ets-2 [KO:K21932]
100411316  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
100403547  KSR1; kinase suppressor of Ras 1 isoform X3 [KO:K14958]
100399468  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
100394511  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
100393183  RAP1A; ras-related protein Rap-1A [KO:K04353]
100411763  ras-related protein Rap-1b-like [KO:K07836]
100413220  RAP1B; ras-related protein Rap-1b [KO:K07836]
100385383  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100395614  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
100398414  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100388523  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
100389972  RAB5A; ras-related protein Rab-5A [KO:K07887]
100894569  ras-related protein Rab-5A-like [KO:K07887]
100408426  RAB5B; ras-related protein Rab-5B [KO:K07888]
100410452  RAB5C; ras-related protein Rab-5C [KO:K07889]
100409406  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
cjc04010  MAPK signaling pathway
cjc04015  Rap1 signaling pathway
cjc04020  Calcium signaling pathway
cjc04144  Endocytosis
cjc04151  PI3K-Akt signaling pathway
cjc04660  T cell receptor signaling pathway
cjc04720  Long-term potentiation
cjc04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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