Entry
Name
Cytokine-cytokine receptor interaction - Carlito syrichta (Philippine tarsier)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
csyr04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Carlito syrichta (Philippine tarsier) [GN:
csyr ]
Gene
103270135 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103271792 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
103251198 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
103263108 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
103273211 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
103258317 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
103264833 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
103258316 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
103257547 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
103258432 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
103258780 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
103264626 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
103264867 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476 ]
103273482 CXCR3; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3 [KO:K04188 ]
103250262 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
103262364 CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061 ]
103269306 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
103268243 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
103273409 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
103269358 IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135 ]
103270923 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
103267176 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
103250566 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
103276043 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
103271633 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
103267574 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
103277316 TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
103273943 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
103250874 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
103260813 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
103250631 tumor necrosis factor receptor superfamily member EDAR-like [KO:K05162 ]
103257695 tumor necrosis factor receptor superfamily member EDAR-like [KO:K05162 ]
103256827 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X2 [KO:K05163 ]
103266350 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
103275806 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
103276223 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
103252044 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
103276036 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
103260263 CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160 ]
103260861 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
103251481 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
103251482 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
103268648 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
103274553 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
103264355 TNFRSF13C; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
103262395 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
103277186 RELT; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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