KEGG   PATHWAY: csyr05161
Entry
csyr05161                   Pathway                                
Name
Hepatitis B - Carlito syrichta (Philippine tarsier)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05161  Hepatitis B
csyr05161

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103265029  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
103254252  SLC10A1; LOW QUALITY PROTEIN: sodium/bile acid cotransporter [KO:K14341]
103254633  TGFB1; transforming growth factor beta-1 [KO:K13375]
103254860  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103260508  TGFB3; transforming growth factor beta-3 [KO:K13377]
103253382  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103261716  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103267025  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
103266974  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103252280  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103272968  MAPK8; mitogen-activated protein kinase 8 isoform X5 [KO:K04440] [EC:2.7.11.24]
103255312  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103264057  MYC; myc proto-oncogene protein [KO:K04377]
103272751  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
103265912  EGR3; early growth response protein 3 [KO:K12497]
103271980  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103273679  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103273211  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
103249427  DDB1; DNA damage-binding protein 1 [KO:K10610]
103261208  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103277203  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103269337  YWHAB; 14-3-3 protein beta/alpha isoform X2 [KO:K16197]
103261347  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
103273751  YWHAQ; 14-3-3 protein theta [KO:K16197]
103274589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103252103  RELA; transcription factor p65 [KO:K04735]
103260266  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
103274703  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103273364  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
103274231  BID; BH3-interacting domain death agonist [KO:K04726]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103251017  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103255326  cytochrome c 2 [KO:K08738]
110596190  cytochrome c, somatic-like [KO:K08738]
103274909  cytochrome c, somatic [KO:K08738]
103260483  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103257846  caspase-3 [KO:K02187] [EC:3.4.22.56]
103267234  caspase-12-like [KO:K04741] [EC:3.4.22.-]
103262808  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103270886  CCNA2; cyclin-A2 [KO:K06627]
103262730  CCNA1; cyclin-A1 [KO:K06627]
103266414  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103267956  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103277250  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103259274  RB1; retinoblastoma-associated protein [KO:K06618]
103253965  E2F1; transcription factor E2F1 [KO:K17454]
103264171  E2F2; transcription factor E2F2 [KO:K09389]
103260979  E2F3; transcription factor E2F3 [KO:K06620]
103274664  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
103269994  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103251444  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103276479  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103266669  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103276035  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103268196  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103272225  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103270149  TNF; tumor necrosis factor [KO:K03156]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103250706  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103273032  signal transducer and activator of transcription 3 [KO:K04692]
103267743  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
103277171  LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like [KO:K04692]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103258295  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
103255989  signal transducer and activator of transcription 4 [KO:K11222]
103277170  signal transducer and activator of transcription 5A [KO:K11223]
103276756  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
103267652  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
103257263  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103251411  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103274529  JUN; transcription factor AP-1 [KO:K04448]
103257913  SMAD4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
103264952  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103252293  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103249547  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103252136  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
103263755  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103265465  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103257302  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103267309  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
103273492  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
103271306  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
103266387  interleukin-8-like [KO:K10030]
103259317  CXCL8; interleukin-8 [KO:K10030]
103262609  LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like [KO:K04802]
103265090  PCNA; proliferating cell nuclear antigen isoform X1 [KO:K04802]
103270865  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103271179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103266527  FOS; proto-oncogene c-Fos [KO:K04379]
103270864  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103274468  TLR2; toll-like receptor 2 [KO:K10159]
103270832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103270561  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
103255573  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
103276369  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103274081  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103263671  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103254079  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103259721  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103268608  IL6; interleukin-6 [KO:K05405]
103264569  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103254297  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103251143  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103275027  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
103258420  TLR3; toll-like receptor 3 [KO:K05401]
103263504  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
103256184  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103268983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103262174  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
103267796  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103260907  interferon alpha-5-like [KO:K05414]
103260908  interferon alpha-5-like [KO:K05414]
103260910  interferon alpha-5-like [KO:K05414]
103274154  interferon alpha-5-like [KO:K05414]
103274155  interferon alpha-5-like [KO:K05414]
103274156  interferon alpha-10-like [KO:K05414]
103274157  interferon alpha-17-like [KO:K05414]
103274161  interferon alpha-5-like [KO:K05414]
103274163  interferon alpha-17-like [KO:K05414]
103274165  interferon alpha-5-like [KO:K05414]
103274168  interferon alpha-5-like [KO:K05414]
103260915  IFNB1; interferon beta [KO:K05415]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
csyr04010  MAPK signaling pathway
csyr04064  NF-kappa B signaling pathway
csyr04110  Cell cycle
csyr04115  p53 signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04620  Toll-like receptor signaling pathway
csyr04622  RIG-I-like receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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