KEGG   PATHWAY: eee05132
Entry
eee05132                    Pathway                                
Name
Salmonella infection - Electrophorus electricus (electric eel)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
eee05132  Salmonella infection
eee05132

Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113583753  podxl; podocalyxin isoform X1 [KO:K06817]
113568600  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
113588725  ras-related protein Rab-5A [KO:K07887]
113578813  ras-related protein Rab-5A-like [KO:K07887]
113567539  ras-related protein Rab-5B-like [KO:K07888]
113581775  ras-related protein Rab-5C-like [KO:K07889]
113591521  ras-related protein Rab-5C-like [KO:K07889]
113578319  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
113576002  rab7a; ras-related protein Rab-7a [KO:K07897]
113589948  ras-related protein rab7 [KO:K07897]
113572358  ras-related protein rab7-like [KO:K07897]
113578160  ras-related protein rab7-like [KO:K07897]
113588314  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
113579043  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
113584066  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
113570769  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
113576944  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
113567749  vps39; vam6/Vps39-like protein [KO:K20183]
113573806  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
113589400  RILP-like protein 1 [KO:K13883]
113587268  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
113578673  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
113575675  cytoplasmic dynein 1 intermediate chain 1-like isoform X1 [KO:K10415]
113570388  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
113588397  dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
113588461  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
113580410  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
113578356  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
113590674  dynein light chain 1, cytoplasmic [KO:K10418]
113583304  dynein light chain 2, cytoplasmic [KO:K10418]
113589340  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
113573151  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
113578254  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
113576570  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
113585836  dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
113585867  dynactin subunit 1-like isoform X1 [KO:K04648]
113571561  dynactin subunit 2-like isoform X1 [KO:K10424]
113572880  dctn3; dynactin subunit 3 [KO:K10425]
113588229  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
113582214  dctn5; dynactin subunit 5 [KO:K10427]
113585884  dctn6; dynactin subunit 6 isoform X1 [KO:K10428]
113589264  beta-centractin [KO:K16575]
113569801  actr10; actin-related protein 10 [KO:K16576]
113588693  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
113588694  tubulin alpha-1B chain [KO:K07374]
113572092  tubulin alpha chain, testis-specific-like [KO:K07374]
113578577  tubulin alpha-1C chain isoform X1 [KO:K07374]
113578583  tubulin alpha-1A chain [KO:K07374]
113583891  tubulin alpha chain, testis-specific-like [KO:K07374]
113580047  tubulin alpha chain isoform X1 [KO:K07374]
113584283  tubulin alpha chain-like [KO:K07374]
113584284  tubulin alpha chain-like [KO:K07374]
113579196  tubulin alpha chain-like [KO:K07374]
113590646  tubulin alpha chain-like isoform X1 [KO:K07374]
113577863  tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
113586197  tubulin beta-1 chain isoform X1 [KO:K07375]
113568359  tubulin beta chain-like [KO:K07375]
113570868  tubb3; tubulin beta-3 chain [KO:K07375]
113579381  tubulin beta-5 chain [KO:K07375]
113578529  tubulin beta-4 chain-like isoform X1 [KO:K07375]
113581365  tubulin beta-4B chain-like [KO:K07375]
113591923  tubulin beta-4B chain-like [KO:K07375]
113567646  tubulin beta-4 chain-like [KO:K07375]
113587855  tubulin beta-1 chain-like [KO:K07375]
113570238  tubb4b; tubulin beta-4B chain [KO:K07375]
113584355  FYVE and coiled-coil domain-containing protein 1-like isoform X1 [KO:K21954]
113589308  LOW QUALITY PROTEIN: FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
113586642  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
113571560  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
113586967  arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
113580159  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
113577421  kinesin heavy chain-like isoform X1 [KO:K10396]
113576454  kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
113584083  kinesin heavy chain-like [KO:K10396]
113568233  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
113571651  kinesin heavy chain-like [KO:K10396]
113577280  kinesin heavy chain-like [KO:K10396]
113583449  kinesin light chain 1-like isoform X1 [KO:K10407]
113583833  klc1; kinesin light chain 1 isoform X1 [KO:K10407]
113585164  klc2; kinesin light chain 2 [KO:K10407]
113568495  klc4; kinesin light chain 4 [KO:K10407]
113570524  acbd3; Golgi resident protein GCP60 [KO:K23935]
113583672  Golgi resident protein GCP60-like [KO:K23935]
113575836  rho-related GTP-binding protein RhoA-B [KO:K04513]
113582797  transforming protein RhoA-like [KO:K04513]
113587089  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
113587285  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
113583072  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
113572085  rho-related GTP-binding protein RhoA-D [KO:K04513]
113575279  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
113590726  ras-related protein Rab-9A-like [KO:K07899]
113588857  rab9a; ras-related protein Rab-9A [KO:K07899]
113576520  ras-related protein Rab-9B-like [KO:K07900]
113574626  gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
113568278  syntaxin-10-like [KO:K23937]
113575389  profilin-2-like isoform X1 [KO:K05759]
113579855  pfn4; profilin-4 isoform X1 [KO:K05759]
113590710  profilin-2-like [KO:K05759]
113568058  profilin-1-like [KO:K05759]
113570037  filamin-A-like isoform X1 [KO:K04437]
113591266  exoc7; exocyst complex component 7 [KO:K07195]
113583331  exoc5; exocyst complex component 5 [KO:K19984]
113587057  exocyst complex component 4-like [KO:K06111]
113570529  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
113574769  ras-related protein Ral-A [KO:K07834]
113572010  ras-related protein Ral-A-like [KO:K07834]
113580904  actin, cytoplasmic 1 [KO:K05692]
113585569  actb; actin, cytoplasmic 1 [KO:K05692]
113572575  protein S100-A1-like [KO:K17274]
113591707  protein S100-A1-like [KO:K17274]
113573178  anxa2; annexin A2 [KO:K17092]
113584707  annexin A2-A-like isoform X1 [KO:K17092]
113584867  annexin A2-like [KO:K17092]
113581476  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
113581880  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
113572976  rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
113589485  arhgef26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744]
113574183  rho-related GTP-binding protein RhoG-like [KO:K07863]
113586757  rho-related GTP-binding protein RhoG-like [KO:K07863]
113592141  rho-related GTP-binding protein RhoG-like isoform X1 [KO:K07863]
113573636  rhog; rho-related GTP-binding protein RhoG [KO:K07863]
113575632  engulfment and cell motility protein 1-like [KO:K12366]
113578666  engulfment and cell motility protein 1-like [KO:K12366]
113590031  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
113572437  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
113588491  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
113576241  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113583613  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113571031  LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
113570755  myosin light chain 5-like [KO:K12753]
113588676  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
113582345  myosin regulatory light polypeptide 9-like [KO:K12755]
113569661  myosin regulatory light polypeptide 9 [KO:K12755]
113583039  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
113592196  myosin regulatory light chain 2B, cardiac muscle isoform-like isoform X1 [KO:K12756]
113579317  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
113579113  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
113576872  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
113580868  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
113582727  fhod1; FH1/FH2 domain-containing protein 1 [KO:K23938]
113575458  cell division control protein 42 homolog [KO:K04393]
113586656  cell division control protein 42 homolog isoform X1 [KO:K04393]
113572585  cell division control protein 42 homolog [KO:K04393]
113584625  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113575309  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113584720  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
113581447  nckap1l; nck-associated protein 1-like [KO:K05750]
113574607  cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
113586139  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
113582137  abi1; abl interactor 1 isoform X1 [KO:K23649]
113570139  abl interactor 1-like isoform X1 [KO:K23649]
113578896  brk1; protein BRICK1 [KO:K05752]
113582312  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
113576131  wasf3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
113591976  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
113579657  actr2; actin-related protein 2 [KO:K17260]
113585161  actin-related protein 2-A-like [KO:K17260]
113572712  actin-related protein 2-A isoform X1 [KO:K17260]
113578559  actr3; actin-related protein 3 [KO:K18584]
113580267  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
113582006  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113569982  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113583705  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113585138  actin-related protein 2/3 complex subunit 2-A-like [KO:K05758]
113573735  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113576019  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
113589954  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
113583609  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588486  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
113567915  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588345  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
113576959  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113586857  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
113587403  unconventional myosin-VI-like isoform X1 [KO:K10358]
113586553  unconventional myosin-VI-like [KO:K10358]
113568728  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113584997  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113581289  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
113575802  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
113570029  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
113576605  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
113576623  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
113589083  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
113579504  cyth3; cytohesin-3 [KO:K18441]
113577647  cytohesin-1 isoform X1 [KO:K18441]
113580096  cytohesin-4-like [KO:K18441]
113573023  cytohesin-2-like [KO:K18441]
113571409  cytohesin-1-like isoform X1 [KO:K18441]
113575325  cytohesin-3 isoform X1 [KO:K18441]
113572881  cytohesin-2-like [KO:K18441]
113571372  ADP-ribosylation factor 6 [KO:K07941]
113569719  ADP-ribosylation factor 6 [KO:K07941]
113580260  ADP-ribosylation factor 1-like [KO:K07937]
113583772  ADP-ribosylation factor 1 [KO:K07937]
113587159  arf1; ADP-ribosylation factor 1 [KO:K07937]
113575863  sorting nexin-18-like [KO:K17923]
113583681  sorting nexin-9-like isoform X1 [KO:K17923]
113589634  snx18; sorting nexin-18 [KO:K17923]
113573648  snx33; sorting nexin-33 [KO:K17923]
113570063  snx9; sorting nexin-9 isoform X1 [KO:K17923]
113582930  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
113575817  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
113582844  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
113587305  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
113583650  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
113589619  toll-like receptor 2 type-1 [KO:K10159]
113585082  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113571833  tlr5; toll-like receptor 5 [KO:K10168]
113578876  toll-like receptor 9 [KO:K10161]
113575834  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
113571874  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113579696  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113579878  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
113579727  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113589932  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
113587553  LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793]
113587986  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113582078  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113584916  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113571703  NF-kappa-B inhibitor alpha-like [KO:K04734]
113571141  nfkbia; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
113588037  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113584194  putative transcription factor p65 homolog isoform X1 [KO:K04735]
113571929  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
113569657  heat shock protein HSP 90-alpha 1 [KO:K04079]
113569531  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
113580649  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
113582687  hsp90b1; endoplasmin [KO:K09487]
113570106  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
113586917  receptor-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K08846] [EC:2.7.11.1]
113568302  cse1l; exportin-2 [KO:K18423]
113581226  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
113588289  kpna4; importin subunit alpha-3 [KO:K23583]
113568126  importin subunit alpha-4-like [KO:K23583]
113577482  kpna3; importin subunit alpha-4 [KO:K23583]
113576969  rps3; 40S ribosomal protein S3 [KO:K02985]
113579694  GTPase HRas [KO:K02833]
113581312  hras; GTPase HRas [KO:K02833]
113580611  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
113572287  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
113588584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113588939  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113584672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113585589  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
113592047  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
113585643  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113585541  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
113575356  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113575357  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113576377  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
113577382  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113586186  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113590096  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
113591405  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
113570943  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
113580330  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113578033  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
113574265  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113586292  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
113586306  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
113571260  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
113585922  proto-oncogene c-Fos-like [KO:K04379]
113590125  proto-oncogene c-Fos-like [KO:K04379]
113590136  proto-oncogene c-Fos-like [KO:K04379]
113589106  transcription factor AP-1-like [KO:K04448]
113582834  transcription factor AP-1-like [KO:K04448]
113568701  transcription factor AP-1-like [KO:K04448]
113586401  tumor necrosis factor-like [KO:K03156]
113584063  interleukin-1 beta-like [KO:K04519]
113585165  interleukin-8-like [KO:K10030]
113587340  interleukin-8-like isoform X1 [KO:K10030]
113580088  LOW QUALITY PROTEIN: catenin beta-1-like [KO:K02105]
113585629  catenin beta-1 isoform X1 [KO:K02105]
113578029  tcf7; transcription factor 7 isoform X1 [KO:K02620]
113589257  transcription factor 7-like 1-A isoform X1 [KO:K04490]
113586207  transcription factor 7-like 1-B [KO:K04490]
113577640  transcription factor 7-like 2 [KO:K04491]
113568617  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
113589820  LOW QUALITY PROTEIN: transcriptional regulator Myc-B-like [KO:K04377]
113573843  transcriptional regulator Myc-2-like [KO:K04377]
113584844  serine/threonine-protein kinase N1-like [KO:K06071] [EC:2.7.11.13]
113580329  LOW QUALITY PROTEIN: serine/threonine-protein kinase N1-like [KO:K06071] [EC:2.7.11.13]
113584700  fbxo22; F-box only protein 22 [KO:K10302]
113578037  skp1; S-phase kinase-associated protein 1 [KO:K03094]
113575300  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113569968  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113588078  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
113577947  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
113579129  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113573611  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
113582984  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
113575253  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
113567706  lymphotoxin-alpha-like [KO:K04721]
113576103  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
113576923  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
113568408  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
113578454  fadd; FAS-associated death domain protein isoform X1 [KO:K02373]
113588302  caspase-8-like [KO:K04398] [EC:3.4.22.61]
113574024  caspase-8-like [KO:K04398] [EC:3.4.22.61]
113582334  caspase-8-like [KO:K04398] [EC:3.4.22.61]
113581408  receptor-interacting serine/threonine-protein kinase 4-like isoform X1 [KO:K08847] [EC:2.7.11.1]
113580268  apoptosis regulator BAX-like [KO:K02159]
113578802  apoptosis regulator BAX-like [KO:K02159]
113589910  bax; apoptosis regulator BAX [KO:K02159]
113582741  cytochrome c [KO:K08738]
113573821  apoptosis regulator Bcl-2-like [KO:K02161]
113570065  bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113586537  caspase-3-like [KO:K02187] [EC:3.4.22.56]
113581517  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113586620  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
113580651  rho-related GTP-binding protein RhoB [KO:K07856]
113579956  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
113571342  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113578378  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113568414  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113579639  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113585312  mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
113578317  thioredoxin-like [KO:K03671]
113584868  txn2; thioredoxin, mitochondrial [KO:K03671]
113591977  thioredoxin-like [KO:K03671]
113569060  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
113574405  caspase-4-like [KO:K01370] [EC:3.4.22.36]
113573520  caspase-1-like [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
eee04010  MAPK signaling pathway
eee04210  Apoptosis
eee04217  Necroptosis
eee04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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