KEGG   PATHWAY: hsp04910
Entry
hsp04910                    Pathway                                
Name
Insulin signaling pathway - Hippoglossus stenolepis (Pacific halibut)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
hsp04910  Insulin signaling pathway
hsp04910

Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118112388  insulin [KO:K04526]
118122248  ins; insulin [KO:K04526]
118118019  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
118120869  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
118102283  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X2 [KO:K16172]
124854838  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
118102549  insulin receptor substrate 2-B [KO:K07187]
118103209  insulin receptor substrate 2 isoform X1 [KO:K07187]
118119877  irs2b; insulin receptor substrate 2 [KO:K07187]
118114686  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118117905  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118117936  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118120979  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118125392  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118120902  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118106261  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118117868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118111369  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118121033  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118102955  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118100245  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
118106240  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118098902  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118121900  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118116209  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118118965  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118119791  gsk3ba; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
118101580  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
118123856  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
118114879  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
118123457  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
118099407  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118116488  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118100486  serine/threonine-protein phosphatase alpha-2 isoform isoform X1 [KO:K06269] [EC:3.1.3.16]
118102789  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118115119  ppp1r3c2b; protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
118110556  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
118111608  si:ch211-167b20.8; protein phosphatase 1 regulatory subunit 3A isoform X1 [KO:K07189]
118112301  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
118119236  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
118104758  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
118101884  ppp1r3aa; uncharacterized protein ppp1r3aa [KO:K07189]
118125889  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
118100551  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
118105810  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
118111451  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118102811  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118104524  phkb; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
118106082  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
118099217  calm1b; calmodulin-1b [KO:K02183]
118115889  calm1a; calmodulin-1a [KO:K02183]
118109799  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
118111614  calml4a; calmodulin-like protein 4a [KO:K02183]
118118820  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
118105150  calglandulin [KO:K02183]
118121829  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
118116327  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
118102247  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
118105480  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
118123348  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118123233  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118117870  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118121305  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118100630  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
118123198  prkar1aa; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a isoform X1 [KO:K04739]
118110770  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
118123906  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
118104655  cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
118113590  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
118125101  lipea; lipase, hormone-sensitive a isoform X1 [KO:K07188] [EC:3.1.1.79]
118111455  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118117258  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118102310  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
118106491  flot2b; flotillin-2b [KO:K07192]
118121843  flotillin-2a isoform X1 [KO:K07192]
118103784  flot1a; flotillin-1a isoform X1 [KO:K07192]
118113210  flot1b; flotillin-1b isoform X1 [KO:K07192]
118106320  SH2B adapter protein 2 isoform X1 [KO:K07193]
118118580  sorbin and SH3 domain-containing protein 1 [KO:K06086]
118106564  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
118122095  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
118122658  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
118106304  crk; adapter molecule crk isoform X1 [KO:K04438]
118121874  adapter molecule crk [KO:K04438]
118125678  crkl; crk-like protein [KO:K04438]
118125467  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
118118682  rho-related GTP-binding protein RhoQ [KO:K07194]
118100498  exoc7; exocyst complex component 7 isoform X3 [KO:K07195]
118116347  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
118123236  trip10a; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
118123399  srebf1; sterol regulatory element-binding protein 1 isoform X3 [KO:K07197]
118122026  acaca; acetyl-CoA carboxylase 1 isoform X3 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
118114652  acacb; acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
118100276  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
118098368  hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
118106106  hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
118106128  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
118115011  hk2; hexokinase-2 isoform X1 [KO:K00844] [EC:2.7.1.1]
118122591  hexokinase-4 [KO:K00844] [EC:2.7.1.1]
118115140  gck; hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
118120708  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118125713  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
118115377  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
118117356  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
118125489  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
118117188  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118103337  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118119692  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
118105476  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
118098708  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
118106156  foxo1a; forkhead box protein O1-A [KO:K07201]
124854860  forkhead box protein O1-A-like [KO:K07201]
118102638  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
118100390  g6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
118100650  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
118100683  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
118120147  glucose-6-phosphatase 2-like [KO:K01084] [EC:3.1.3.9]
118115539  fbp1a; fructose-1,6-bisphosphatase 1a [KO:K03841] [EC:3.1.3.11]
118114578  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
118125787  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
118098793  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
118101924  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
118110357  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118125634  rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
118105952  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
118122079  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118121192  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118123543  rps6; 40S ribosomal protein S6 [KO:K02991]
118115008  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
118125727  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118116198  eif4eb; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4eb [KO:K03259]
118117994  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118111847  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
118102841  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 isoform X1 [KO:K03259]
118119063  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
118114670  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
118125796  tsc1b; TSC complex subunit 1b [KO:K07206]
118118306  tsc2; tuberin isoform X1 [KO:K07207]
118118332  rheb; GTP-binding protein Rheb [KO:K07208]
118105477  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
118102525  badb; BCL2 associated agonist of cell death b [KO:K02158]
118113543  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118120944  shc2; SHC-transforming protein 2 [KO:K17447]
118098019  shc3; SHC-transforming protein 3 [KO:K17448]
118121798  SHC-transforming protein 4 [KO:K17449]
118123567  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
118116998  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118120279  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
118109904  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
118109259  kras; GTPase KRas isoform X1 [KO:K07827]
118123859  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
118114645  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118101548  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118111456  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118109512  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124854736  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118114727  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118122982  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118120705  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
124854779  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
118111080  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
118101128  suppressor of cytokine signaling 1-like [KO:K04694]
118123914  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
118101316  socs2; suppressor of cytokine signaling 2 [KO:K04695]
118100795  suppressor of cytokine signaling 3 [KO:K04696]
118123896  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
118110616  socs4; suppressor of cytokine signaling 4 [KO:K04697]
118111558  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
118121396  ptprfa; protein tyrosine phosphatase receptor type Fa [KO:K05695] [EC:3.1.3.48]
118117990  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
118100088  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118118847  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118112070  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118098029  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118114623  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118105914  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
118112055  inppl1b; inositol polyphosphate phosphatase-like 1b isoform X1 [KO:K15909] [EC:3.1.3.86]
118119362  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
hsp00010  Glycolysis / Gluconeogenesis
hsp00061  Fatty acid biosynthesis
hsp00500  Starch and sucrose metabolism
hsp04010  MAPK signaling pathway
hsp04070  Phosphatidylinositol signaling system
hsp04210  Apoptosis
KO pathway
ko04910   
LinkDB

DBGET integrated database retrieval system