KEGG   PATHWAY: lve04014
Entry
lve04014                    Pathway                                
Name
Ras signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
lve04014  Ras signaling pathway
lve04014

Other DBs
GO: 0032318
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103076982  TGFA; protransforming growth factor alpha [KO:K08774]
103090095  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103090898  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103069327  FGF5; fibroblast growth factor 5 [KO:K04358]
103077422  FGF6; fibroblast growth factor 6 [KO:K04358]
103091027  FGF20; fibroblast growth factor 20 [KO:K04358]
103088257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103086359  FGF7; fibroblast growth factor 7 [KO:K04358]
103069069  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103087751  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
103083967  FGF10; fibroblast growth factor 10 [KO:K04358]
103072981  FGF16; fibroblast growth factor 16 [KO:K04358]
103080890  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103091045  FGF9; fibroblast growth factor 9 [KO:K04358]
103090085  FGF4; fibroblast growth factor 4 [KO:K04358]
103071879  FGF18; fibroblast growth factor 18 [KO:K04358]
103081170  uncharacterized protein LOC103081170 [KO:K22603]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103074388  FGF23; fibroblast growth factor 23 [KO:K22428]
103084220  NGF; beta-nerve growth factor [KO:K02582]
103085069  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103075247  NTF3; neurotrophin-3 [KO:K04356]
103086387  NTF4; neurotrophin-4 [KO:K12457]
103085742  INS; insulin [KO:K04526]
103078928  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103084737  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103077876  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103080643  KITLG; kit ligand isoform X1 [KO:K05461]
103091506  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103085446  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103082053  PGF; placenta growth factor isoform X1 [KO:K16859]
103074827  VEGFC; vascular endothelial growth factor C [KO:K05449]
103087133  FIGF; vascular endothelial growth factor D [KO:K05449]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103072433  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103075969  ANGPT2; angiopoietin-2 [KO:K05466]
103090694  ANGPT4; angiopoietin-4 [KO:K05467]
103080206  EFNA5; ephrin-A5 [KO:K05462]
103069563  EFNA2; ephrin-A2 [KO:K05462]
103070557  EFNA1; ephrin-A1 [KO:K05462]
103071477  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
103071944  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103090812  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103086424  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103078406  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103076750  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103071756  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103069787  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
103085622  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103070834  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103080479  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103079754  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103074358  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103087802  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103068442  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
103082417  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103085000  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
103079396  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103088783  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103068930  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103070997  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103080961  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
103078201  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
103070705  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
103069074  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
103074297  ZAP70; tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
103084123  LAT; linker for activation of T-cells family member 1 [KO:K07362]
103075673  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
103069235  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
103072092  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103089752  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103084472  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103088923  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103068747  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103075748  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103082839  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103069500  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103075492  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103091114  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103089745  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103068686  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103077256  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103068413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103089724  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103084885  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
103070268  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103085162  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103091670  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
103082207  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103091655  CALM3; calmodulin [KO:K02183]
103079915  CALML6; calmodulin-like protein 6 [KO:K02183]
103080762  CALM1; calmodulin isoform X1 [KO:K02183]
103087479  CALM2; calmodulin [KO:K02183]
103072156  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103074541  LOW QUALITY PROTEIN: calmodulin-like protein 1-like [KO:K02183]
103074817  CALML5; calmodulin-like protein 5 [KO:K02183]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103087313  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103070662  RRAS; ras-related protein R-Ras [KO:K07829]
103069562  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103072653  NF1; neurofibromin isoform X1 [KO:K08052]
103070068  RASA1; ras GTPase-activating protein 1 [KO:K04352]
103085645  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103070877  RASA3; ras GTPase-activating protein 3 [KO:K12380]
103086781  RASA4; ras GTPase-activating protein 4 isoform X1 [KO:K17630]
103069296  SYNGAP1; ras/Rap GTPase-activating protein SynGAP [KO:K17631]
103084835  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
103076505  RASAL2; ras GTPase-activating protein nGAP [KO:K17633]
103088564  RASAL3; RAS protein activator like-3 [KO:K17634]
103073757  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
103081394  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
103079150  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103073449  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103072869  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103082256  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103077310  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103077393  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103077706  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
103078952  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103080887  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103088082  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103069588  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
103075066  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
103091426  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
103086535  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
103069800  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
103090236  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
103072770  RALA; ras-related protein Ral-A [KO:K07834]
103077787  RALB; ras-related protein Ral-B [KO:K07835]
103069742  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103084538  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103070242  EXOC2; exocyst complex component 2 [KO:K17637]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082973  REL; proto-oncogene c-Rel [KO:K09254]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103076643  RALBP1; ralA-binding protein 1 [KO:K08773]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103080521  MLLT4; LOW QUALITY PROTEIN: afadin [KO:K05702]
103086236  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103086697  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
103088816  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103069738  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
103072495  PLA2G2C; LOW QUALITY PROTEIN: phospholipase A2, group IIC [KO:K01047] [EC:3.1.1.4]
103072760  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103073038  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103071759  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103072041  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103079728  phospholipase A2, major isoenzyme-like [KO:K01047] [EC:3.1.1.4]
103075665  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103079421  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
103075223  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
103090681  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103090934  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103089071  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103083510  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103083784  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103091644  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
103091503  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103079793  ETS1; transforming protein p68/c-ets-1 isoform X1 [KO:K02678]
103079282  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
103085554  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
103073577  KSR1; kinase suppressor of Ras 1 [KO:K14958]
103089866  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
103081274  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
103069239  RAP1A; ras-related protein Rap-1A [KO:K04353]
103088976  ras-related protein Rap-1b-like isoform X1 [KO:K07836]
103083426  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
103080930  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103077560  RIN1; ras and Rab interactor 1 [KO:K17638]
103076172  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
103079814  ABL2; Abelson tyrosine-protein kinase 2 [KO:K08887] [EC:2.7.10.2]
103075981  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
103088513  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
103080992  RAB5C; ras-related protein Rab-5C [KO:K07889]
103082078  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
lve04010  MAPK signaling pathway
lve04015  Rap1 signaling pathway
lve04020  Calcium signaling pathway
lve04144  Endocytosis
lve04151  PI3K-Akt signaling pathway
lve04660  T cell receptor signaling pathway
lve04720  Long-term potentiation
lve04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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