KEGG   PATHWAY: lve05224
Entry
lve05224                    Pathway                                
Name
Breast cancer - Lipotes vexillifer (Yangtze River dolphin)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
lve05224  Breast cancer
lve05224

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103069191  ESR1; estrogen receptor [KO:K08550]
103068725  ESR2; estrogen receptor beta [KO:K08551]
103074990  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
103079443  NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48]
103084433  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
103072956  uncharacterized protein LOC103072956 [KO:K04379]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103075485  progesterone receptor-like isoform X1 [KO:K08556]
103078640  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103087836  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
103074658  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
103075672  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103090095  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103090898  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103069327  FGF5; fibroblast growth factor 5 [KO:K04358]
103077422  FGF6; fibroblast growth factor 6 [KO:K04358]
103091027  FGF20; fibroblast growth factor 20 [KO:K04358]
103088257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103086359  FGF7; fibroblast growth factor 7 [KO:K04358]
103069069  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103087751  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
103083967  FGF10; fibroblast growth factor 10 [KO:K04358]
103072981  FGF16; fibroblast growth factor 16 [KO:K04358]
103080890  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103091045  FGF9; fibroblast growth factor 9 [KO:K04358]
103090085  FGF4; fibroblast growth factor 4 [KO:K04358]
103071879  FGF18; fibroblast growth factor 18 [KO:K04358]
103081170  uncharacterized protein LOC103081170 [KO:K22603]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103074388  FGF23; fibroblast growth factor 23 [KO:K22428]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103078928  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103070834  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103090018  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103074298  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103090358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103073645  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103089749  JAG1; protein jagged-1 [KO:K06052]
103091567  JAG2; protein jagged-2 [KO:K21635]
103072496  DLL4; delta-like protein 4 [KO:K06051]
103082526  DLL1; delta-like protein 1 [KO:K06051]
103070090  DLL3; LOW QUALITY PROTEIN: delta-like protein 3 [KO:K06051]
103091390  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
103083591  NOTCH2; neurogenic locus notch homolog protein 2-like [KO:K20994]
103078398  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
103088388  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
103079775  HES1; transcription factor HES-1 [KO:K06054]
103071532  HES5; transcription factor HES-5 [KO:K06055]
103088177  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
103080810  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
103073383  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
103074358  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103076968  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103089709  WNT2B; protein Wnt-2b [KO:K00182]
103089326  WNT2; protein Wnt-2 [KO:K00182]
103087738  WNT3A; protein Wnt-3a [KO:K00312]
103081536  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103070287  WNT5A; protein Wnt-5a-like isoform X1 [KO:K00444]
103086235  WNT5B; protein Wnt-5b [KO:K00444]
103079243  WNT6; protein Wnt-6 [KO:K00445]
103083305  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
103068582  WNT7A; protein Wnt-7a [KO:K00572]
103086715  WNT8B; protein Wnt-8b [KO:K00714]
103091305  WNT8A; protein Wnt-8a [KO:K00714]
103087468  WNT9A; protein Wnt-9a [KO:K01064]
103081263  WNT9B; protein Wnt-9b [KO:K01064]
103078970  WNT10A; protein Wnt-10a [KO:K01357]
103078356  WNT10B; protein Wnt-10b [KO:K01357]
103091035  WNT11; protein Wnt-11 [KO:K01384]
103085163  WNT16; protein Wnt-16 [KO:K01558]
103091081  FZD7; frizzled-7 [KO:K02432]
103086341  FZD1; frizzled-1 [KO:K02432]
103076632  frizzled-2-like [KO:K02235]
103079251  FZD3; frizzled-3 [KO:K02329]
103086596  FZD4; frizzled-4 [KO:K02354]
103088051  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
103087849  FZD5; frizzled-5 [KO:K02375]
103074920  FZD6; frizzled-6 isoform X1 [KO:K02376]
103081501  FZD10; LOW QUALITY PROTEIN: frizzled class receptor 10 [KO:K02842]
103080648  FZD9; frizzled-9 [KO:K02842]
103090555  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103073192  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
103082466  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
103078766  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103086975  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
103084685  FRAT1; proto-oncogene FRAT1 [KO:K03069]
103072485  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103085333  AXIN1; axin-1 [KO:K02157]
103072027  AXIN2; axin-2 [KO:K04385]
103084983  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103083467  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103078301  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103073450  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
103074150  TCF7; transcription factor 7 [KO:K02620]
103069353  TCF7L1; transcription factor 7-like 1 [KO:K04490]
103068781  TCF7L2; transcription factor 7-like 2 [KO:K04491]
103068879  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103080866  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103089793  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103079241  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103069848  putative Bcl-2 homologous antagonist/killer 2-like [KO:K14021]
103079116  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103080788  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103072166  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103070408  E2F1; transcription factor E2F1 [KO:K17454]
103081780  E2F2; transcription factor E2F2 [KO:K09389]
103085882  E2F3; transcription factor E2F3 [KO:K06620]
103073470  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
103081109  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
103076579  BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
  Authors
  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
DOI:10.1186/bcr321
Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
DOI:10.1038/modpathol.2010.205
Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
lve03440  Homologous recombination
lve04010  MAPK signaling pathway
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04310  Wnt signaling pathway
lve04330  Notch signaling pathway
lve04915  Estrogen signaling pathway
KO pathway
ko05224   
LinkDB

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