KEGG   PATHWAY: mbez04014
Entry
mbez04014                   Pathway                                
Name
Ras signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mbez04014  Ras signaling pathway
mbez04014

Other DBs
GO: 0032318
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129561712  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
129539010  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
129559536  FGF1; fibroblast growth factor 1 [KO:K18496]
129542296  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129555960  FGF8; fibroblast growth factor 8 [KO:K04358]
129556389  FGF9; fibroblast growth factor 9 [KO:K04358]
129549223  FGF20; fibroblast growth factor 20 [KO:K04358]
129557346  FGF17; fibroblast growth factor 17 [KO:K04358]
129537016  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129559049  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129553142  FGF18; fibroblast growth factor 18 [KO:K04358]
129553277  FGF10; fibroblast growth factor 10 [KO:K04358]
129562082  FGF5; fibroblast growth factor 5 [KO:K04358]
129562501  FGF7; fibroblast growth factor 7 [KO:K04358]
129534906  FGF16; fibroblast growth factor 16 [KO:K04358]
129548662  FGF3; fibroblast growth factor 3 [KO:K04358]
129548663  FGF4; fibroblast growth factor 4 [KO:K04358]
129548328  FGF19; fibroblast growth factor 19 [KO:K22603]
129546182  FGF21; fibroblast growth factor 21 [KO:K22429]
129536537  FGF23; fibroblast growth factor 23 [KO:K22428]
129541318  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
129554712  BDNF; brain-derived neurotrophic factor [KO:K04355]
129536400  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
129546565  NTF4; neurotrophin-4 [KO:K12457]
129548407  INS; insulin [KO:K04526]
129535856  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129548638  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129545815  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129536369  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129542873  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129554238  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129541681  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
129535752  KITLG; kit ligand isoform X1 [KO:K05461]
129546548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129548822  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129563157  PGF; placenta growth factor isoform X1 [KO:K16859]
129549287  VEGFC; vascular endothelial growth factor C [KO:K05449]
129564310  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
129552336  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
129559853  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129549280  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
129561848  ANGPT4; angiopoietin-4 [KO:K05467]
129558723  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129559061  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
129540424  EFNA4; ephrin-A4 [KO:K05462]
129540960  EFNA3; ephrin-A3 [KO:K05462]
129541056  EFNA1; ephrin-A1 [KO:K05462]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129549407  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129555293  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129561939  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129559284  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129544277  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129540753  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129556974  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
129558099  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129550230  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129558396  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129559582  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129561998  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129556612  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129556364  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129559190  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
129561762  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129552423  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129557527  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129537851  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129544725  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129542786  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
129549043  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
129541489  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
129558379  SHC2; SHC-transforming protein 2 [KO:K17447]
129557186  SHC3; SHC-transforming protein 3 [KO:K17448]
129562932  SHC4; SHC-transforming protein 4 [KO:K17449]
129542192  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129551400  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129563552  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
129547229  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129563041  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
129548806  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
129539227  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
129546863  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
129539813  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
129545479  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
129555552  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
129551433  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129545675  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129536555  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
129562435  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129548858  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129555099  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129552025  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129550347  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
129557989  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
129539066  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
129545368  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129536255  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129562982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129563274  calmodulin-1-like [KO:K02183]
129563997  calmodulin-like [KO:K02183]
129564337  calmodulin-1-like [KO:K02183]
129550549  calmodulin-1-like [KO:K02183]
129550970  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
129551800  calmodulin-1-like [KO:K02183]
129539293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129546635  CALM3; calmodulin-3 [KO:K02183]
129554732  uncharacterized protein LOC129554732 [KO:K02183]
129555444  calmodulin-like [KO:K02183]
129562351  calmodulin-1-like [KO:K02183]
129562550  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129547251  MRAS; ras-related protein M-Ras [KO:K07831]
129546539  RRAS; ras-related protein R-Ras [KO:K07829]
129554492  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129540445  NF1; neurofibromin isoform X1 [KO:K08052]
129558112  RASA1; ras GTPase-activating protein 1 [KO:K04352]
129547049  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
129556536  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
129545645  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
129543676  SYNGAP1; ras/Rap GTPase-activating protein SynGAP [KO:K17631]
129542350  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
129551341  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
129559388  RASAL3; RAS protein activator like-3 [KO:K17634]
129547867  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
129551738  RASSF5; ras association domain-containing protein 5 [KO:K08015]
129564068  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
129552725  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129539810  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129554914  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129536787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129544591  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
129549029  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129542500  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129535252  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
129546841  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
129556249  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
129562886  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
129539448  transforming protein RhoA-like [KO:K04513]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129548767  RELA; transcription factor p65 [KO:K04735]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129538419  bcl-2-like protein 1 [KO:K04570]
129562040  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129534931  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
129551094  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129550522  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
129559155  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
129563459  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
129539155  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
129551299  RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
129543191  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
129552583  RALA; ras-related protein Ral-A [KO:K07834]
129537511  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
129535089  ras-related protein Ral-B-like [KO:K07835]
129542392  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
129551706  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129543784  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
129536260  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129539063  REL; proto-oncogene c-Rel [KO:K09254]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129549783  RALBP1; ralA-binding protein 1 [KO:K08773]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129560977  AFDN; afadin isoform X1 [KO:K05702]
129555352  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129561183  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
129542734  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129542877  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129564558  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129537646  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
129537648  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
129537649  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129537650  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
129537651  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129537652  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
129561895  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129555727  PLA2G12B; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
129563204  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
129563217  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
129563236  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
129551278  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
129562601  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
129562711  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
129536476  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
129548839  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129564305  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
129548939  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
129549365  ETS2; protein C-ets-2 [KO:K21932]
129542603  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
129540525  KSR1; kinase suppressor of Ras 1 [KO:K14958]
129542402  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
129552297  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
129541434  ras-related protein Rap-1A-like [KO:K04353]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129537257  RAP1B; ras-related protein Rap-1b [KO:K07836]
129555525  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129546400  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129548731  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
129539895  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
129551330  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
129549747  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
129536190  RAB5B; ras-related protein Rab-5B [KO:K07888]
129544418  RAB5C; ras-related protein Rab-5C [KO:K07889]
129562494  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
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pathway
mbez04010  MAPK signaling pathway
mbez04015  Rap1 signaling pathway
mbez04020  Calcium signaling pathway
mbez04144  Endocytosis
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mbez04660  T cell receptor signaling pathway
mbez04720  Long-term potentiation
mbez04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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