KEGG   PATHWAY: mcf04014
Entry
mcf04014                    Pathway                                
Name
Ras signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcf04014  Ras signaling pathway
mcf04014

Other DBs
GO: 0032318
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102145541  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102134593  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102133679  FGF2; fibroblast growth factor 2 [KO:K18497]
102127718  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102141473  FGF18; fibroblast growth factor 18 [KO:K04358]
102131922  FGF7; fibroblast growth factor 7 [KO:K04358]
102146180  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102137925  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102120710  FGF6; fibroblast growth factor 6 [KO:K04358]
102140602  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102138682  FGF20; fibroblast growth factor 20 [KO:K04358]
102134212  FGF3; fibroblast growth factor 3 [KO:K04358]
102134588  FGF4; fibroblast growth factor 4 [KO:K04358]
102121261  FGF16; fibroblast growth factor 16 [KO:K04358]
102143550  FGF10; fibroblast growth factor 10 [KO:K04358]
102140725  FGF9; fibroblast growth factor 9 [KO:K04358]
102134957  FGF19; fibroblast growth factor 19 [KO:K22603]
102126624  FGF21; fibroblast growth factor 21 [KO:K22429]
102120346  FGF23; fibroblast growth factor 23 [KO:K22428]
102132327  NGF; beta-nerve growth factor [KO:K02582]
102126294  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102128547  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
102139472  neurotrophin-4 [KO:K12457]
102133184  INS; insulin [KO:K04526]
102128018  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102126663  IGF2; insulin-like growth factor II isoform X4 [KO:K13769]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102132043  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101925936  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102141631  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102136326  KITLG; kit ligand isoform X1 [KO:K05461]
102125470  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X14 [KO:K05454]
102140241  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102127655  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102134620  PGF; placenta growth factor isoform X3 [KO:K16859]
102117741  VEGFC; vascular endothelial growth factor C [KO:K05449]
107126428  VEGFD; vascular endothelial growth factor D [KO:K05449]
102133907  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102123994  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101925495  ANGPT2; angiopoietin-2 isoform X3 [KO:K05466]
102121734  ANGPT4; angiopoietin-4 [KO:K05467]
102133074  EFNA1; ephrin-A1 [KO:K05462]
102137539  EFNA4; ephrin-A4 [KO:K05462]
102133712  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102141609  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102129165  EFNA2; ephrin-A2 [KO:K05462]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102144714  FGFR1; fibroblast growth factor receptor 1 isoform X31 [KO:K04362] [EC:2.7.10.1]
102143086  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102128947  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102118990  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102115306  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102129364  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102132446  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102139081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102138392  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101867161  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102124214  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102137242  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102144988  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X4 [KO:K05092] [EC:2.7.10.1]
102115442  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102123168  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102136227  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102123512  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102122204  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102146108  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101865745  GAB1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
102121794  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
102142777  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102125325  SHC2; SHC-transforming protein 2 [KO:K17447]
102130150  SHC3; SHC-transforming protein 3 [KO:K17448]
102130383  SHC4; SHC-transforming protein 4 [KO:K17449]
102129572  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102138313  SOS2; son of sevenless homolog 2 [KO:K03099]
102138726  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102117471  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
102124752  RASGRP1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
102139509  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
102136095  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102120963  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
102135442  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
102143768  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
102118538  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
102120049  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101867297  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102125334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102125173  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101866657  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
101925341  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101925867  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102146209  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102141053  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102145967  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123568653  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123572350  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
107128232  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
102125944  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like isoform X1 [KO:K04545]
107127614  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102133905  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102126944  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123570590  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102134312  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102142284  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102117414  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
102142443  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101926461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102116296  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
102138771  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102115033  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
102123126  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101866879  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102119159  CALML6; calmodulin-like protein 6 [KO:K02183]
102114795  CALML3; calmodulin-like protein 3 [KO:K02183]
102146976  CALML5; calmodulin-like protein 5 [KO:K02183]
102131162  CALM1; calmodulin-1 [KO:K02183]
101866377  CALM3; calmodulin-3 [KO:K02183]
101865168  CALM2; calmodulin-2 [KO:K02183]
102122343  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102144138  calmodulin-1 [KO:K02183]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
101865297  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102131991  RRAS; ras-related protein R-Ras [KO:K07829]
102143296  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101867475  NF1; neurofibromin isoform X1 [KO:K08052]
102130897  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101926820  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102136941  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
102133900  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
102117970  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
102133538  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
101925083  RASAL2; ras GTPase-activating protein nGAP isoform X2 [KO:K17633]
102128902  RASAL3; RAS protein activator like-3 [KO:K17634]
102144868  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
102127304  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
102115733  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101865530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102137056  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102143597  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101866132  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102115437  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101866329  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102136180  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101926721  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101926308  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101865630  RHOA; transforming protein RhoA [KO:K04513]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102140222  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102144289  FOXO4; forkhead box protein O4 [KO:K12358]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102141084  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X7 [KO:K25768]
102140348  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
102126497  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
102121408  RALGDS; ral guanine nucleotide dissociation stimulator isoform X3 [KO:K08732]
102124288  ral-GDS-related protein-like isoform X1 [KO:K08732]
102125458  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
102125141  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
102126524  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
102124292  RALA; ras-related protein Ral-A [KO:K07834]
101925782  RALB; ras-related protein Ral-B [KO:K07835]
102132109  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
102130012  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102130619  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102116653  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102128258  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102125726  cell division control protein 42 homolog [KO:K04393]
102124817  cell division control protein 42 homolog [KO:K04393]
102124166  AFDN; afadin isoform X1 [KO:K05702]
102140457  SHOC2; leucine-rich repeat protein SHOC-2 isoform X2 [KO:K19613]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102138086  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
102130154  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102131708  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102132091  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102132454  PLA2G5; phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
102133993  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102140858  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102131194  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
102118348  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102139488  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102120351  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123572971  LOW QUALITY PROTEIN: group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
102143026  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
102143695  PLA2G4A; cytosolic phospholipase A2 isoform X2 [KO:K16342] [EC:3.1.1.4]
102143812  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
102146081  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102142596  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
101926332  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
102116906  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123566748  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102146168  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102131144  ETS domain-containing protein Elk-1-like [KO:K04375]
102137357  ETS domain-containing protein Elk-1-like [KO:K04375]
102131296  ETS1; protein C-ets-1 isoform X6 [KO:K02678]
102121723  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
102119836  BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
102118522  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
102124172  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
102140481  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
102144586  RAP1A; ras-related protein Rap-1A isoform X3 [KO:K04353]
102133022  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
102142941  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102135875  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101865773  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102132424  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
102115803  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
102119266  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
102144117  RAB5A; ras-related protein Rab-5A [KO:K07887]
101865961  RAB5B; ras-related protein Rab-5B [KO:K07888]
102116190  RAB5C; ras-related protein Rab-5C [KO:K07889]
102133230  ras-related protein Rab-5C-like [KO:K07889]
102132075  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mcf04010  MAPK signaling pathway
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04144  Endocytosis
mcf04151  PI3K-Akt signaling pathway
mcf04660  T cell receptor signaling pathway
mcf04720  Long-term potentiation
mcf04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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