KEGG   PATHWAY: mlk05224
Entry
mlk05224                    Pathway                                
Name
Breast cancer - Mustela lutreola (European mink)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
mlk05224  Breast cancer
mlk05224

Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131833450  ESR1; estrogen receptor [KO:K08550]
131836671  ESR2; estrogen receptor beta [KO:K08551]
131807294  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
131807502  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
131836857  FOS; protein c-Fos [KO:K04379]
131809019  JUN; transcription factor Jun [KO:K04448]
131838694  SP1; transcription factor Sp1 [KO:K04684]
131817001  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
131826401  MYC; myc proto-oncogene protein [KO:K04377]
131838919  PGR; progesterone receptor [KO:K08556]
131837931  WNT1; proto-oncogene Wnt-1 [KO:K03209]
131809216  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
131813956  TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473]
131815770  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131832196  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
131828225  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
131836265  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131839915  FGF6; fibroblast growth factor 6 [KO:K04358]
131834291  FGF17; fibroblast growth factor 17 [KO:K04358]
131819956  FGF5; fibroblast growth factor 5 [KO:K04358]
131820615  FGF20; fibroblast growth factor 20 [KO:K04358]
131813822  FGF9; fibroblast growth factor 9 [KO:K04358]
131821509  FGF16; fibroblast growth factor 16 [KO:K04358]
131822740  FGF4; fibroblast growth factor 4 [KO:K04358]
131822741  FGF3; fibroblast growth factor 3 [KO:K04358]
131823154  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
131830281  FGF8; fibroblast growth factor 8 [KO:K04358]
131831722  FGF10; fibroblast growth factor 10 [KO:K04358]
131831909  FGF18; fibroblast growth factor 18 [KO:K04358]
131822739  FGF19; fibroblast growth factor 19 [KO:K22603]
131818352  FGF21; fibroblast growth factor 21 [KO:K22429]
131838416  FGF23; fibroblast growth factor 23 [KO:K22428]
131820646  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
131839335  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
131835676  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
131829316  EGF; pro-epidermal growth factor [KO:K04357]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131824017  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
131814353  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
131823143  SHC2; SHC-transforming protein 2 [KO:K17447]
131812476  SHC3; SHC-transforming protein 3 [KO:K17448]
131836254  SHC4; SHC-transforming protein 4 [KO:K17449]
131816784  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
131836536  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
131840500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131838926  KRAS; GTPase KRas isoform X1 [KO:K07827]
131810307  NRAS; GTPase NRas isoform X1 [KO:K07828]
131810524  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
131821130  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
131829849  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
131824239  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131835957  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
131823312  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
131811758  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131820131  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131809015  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824589  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131824847  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131823754  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131832309  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131810162  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
131828969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828977  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131828978  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131829020  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131837056  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131815063  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131817507  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131810411  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
131816533  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
131816894  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
131808092  JAG1; protein jagged-1 isoform X1 [KO:K06052]
131837067  JAG2; protein jagged-2 isoform X1 [KO:K21635]
131836131  DLL4; delta-like protein 4 [KO:K06051]
131818041  DLL3; delta-like protein 3 [KO:K06051]
131833331  DLL1; delta-like protein 1 isoform X1 [KO:K06051]
131812256  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
131810237  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
131823672  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
131834308  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
131824711  HES1; transcription factor HES-1 [KO:K06054]
131809689  HES5; transcription factor HES-5 [KO:K06055]
131826678  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
131833831  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
131809513  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
131832669  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131833891  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
131828505  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
131829661  WNT2; protein Wnt-2 [KO:K00182]
131810097  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
131816623  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
131832728  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
131838371  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
131824047  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
131827444  WNT6; protein Wnt-6 [KO:K00445]
131839614  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
131824267  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
131830087  WNT8B; protein Wnt-8b [KO:K00714]
131831373  WNT8A; protein Wnt-8a [KO:K00714]
131816404  WNT9B; protein Wnt-9b [KO:K01064]
131832729  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
131838813  WNT10B; protein Wnt-10b [KO:K01357]
131827443  WNT10A; protein Wnt-10a [KO:K01357]
131840515  WNT11; protein Wnt-11 [KO:K01384]
131829677  WNT16; protein Wnt-16 [KO:K01558]
131827565  FZD7; frizzled-7 [KO:K02432]
131829356  FZD1; frizzled-1 [KO:K02432]
131816463  FZD2; frizzled-2 [KO:K02235]
131833459  FZD3; frizzled-3 isoform X1 [KO:K02329]
131839511  FZD4; frizzled-4 [KO:K02354]
131838318  FZD8; frizzled-8 [KO:K02375]
131827515  FZD5; frizzled-5 [KO:K02375]
131826518  FZD6; frizzled-6 [KO:K02376]
131811657  FZD10; frizzled-10 [KO:K02842]
131819986  FZD9; frizzled-9 [KO:K02842]
131839032  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
131816811  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
131815751  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
131809301  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
131824796  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
131828593  FRAT1; proto-oncogene FRAT1 [KO:K03069]
131828592  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
131825080  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131820017  AXIN1; axin-1 isoform X1 [KO:K02157]
131816023  AXIN2; axin-2 isoform X1 [KO:K04385]
131823200  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
131832532  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
131824424  CTNNB1; catenin beta-1 [KO:K02105]
131831752  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
131832039  TCF7; transcription factor 7 isoform X1 [KO:K02620]
131840380  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
131830678  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
131829467  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
131815809  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131812894  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
131823251  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
131809793  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
131817775  BAX; apoptosis regulator BAX [KO:K02159]
131834235  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
131812400  DDB2; DNA damage-binding protein 2 [KO:K10140]
131832361  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
131838541  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
131829369  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
131813843  RB1; retinoblastoma-associated protein [KO:K06618]
131807833  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
131809711  E2F2; transcription factor E2F2 [KO:K09389]
131834799  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
131816810  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
131813490  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
  Authors
  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
DOI:10.1186/bcr321
Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
DOI:10.1038/modpathol.2010.205
Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
mlk03440  Homologous recombination
mlk04010  MAPK signaling pathway
mlk04110  Cell cycle
mlk04115  p53 signaling pathway
mlk04151  PI3K-Akt signaling pathway
mlk04310  Wnt signaling pathway
mlk04330  Notch signaling pathway
mlk04915  Estrogen signaling pathway
KO pathway
ko05224   
LinkDB

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