KEGG   PATHWAY: mmur05020
Entry
mmur05020                   Pathway                                
Name
Prion disease - Microcebus murinus (gray mouse lemur)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmur05020  Prion disease
mmur05020

Disease
H00061  Prion disease
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854849  [KO:K03283]
105854855  [KO:K02264]
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105855038  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105855091  LAMC1; laminin subunit gamma-1 [KO:K05635]
105855096  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
105855129  [KO:K09047]
105855168  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105855223  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105855398  TUBB; tubulin beta chain [KO:K07375]
105855476  C9; complement component C9 [KO:K04000]
105855494  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
105855598  [KO:K21421] [EC:1.-.-.-]
105855762  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105855817  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855896  [KO:K08009]
105856433  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105856500  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
105856555  [KO:K02132]
105856893  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105856967  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105857150  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105857182  [KO:K00419]
105857205  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
105857276  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105857293  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105857620  KIF5C; kinesin heavy chain [KO:K10396]
105857636  [KO:K02138]
105857673  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105857811  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
105858099  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105858130  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105858143  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105858167  [KO:K03283]
105858168  [KO:K03283]
105858209  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105858234  ATP5C1; LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial [KO:K02136]
105858346  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105858535  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105858589  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105858681  [KO:K02264]
105858822  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105858950  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105859108  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105859190  IL1B; interleukin-1 beta [KO:K04519]
105859191  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
105859221  RYR3; ryanodine receptor 3 [KO:K04963]
105859339  [KO:K02271]
105859388  [KO:K02270]
105859618  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105859799  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105859992  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105860065  [KO:K07374]
105860083  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105860097  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105860211  [KO:K05863]
105860777  [KO:K00420]
105860785  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105860786  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105860789  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105860911  NDUFV2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105860986  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
105861075  [KO:K10407]
105861389  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105861390  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105861402  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105861500  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
105861556  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105861596  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105861623  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
105861630  PSMD12; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105861860  TUBA8; tubulin alpha-8 chain [KO:K07374]
105862473  [KO:K04741] [EC:3.4.22.-]
105862566  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
105862587  EGR1; early growth response protein 1 [KO:K09203]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105862787  [KO:K03965]
105862831  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105862943  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105862994  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105863187  [KO:K00237]
105863245  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105863295  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863327  [KO:K02267]
105863646  [KO:K02136]
105863924  [KO:K02136]
105863984  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105864015  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
105864152  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105864291  [KO:K04440] [EC:2.7.11.24]
105864304  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105864735  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105864918  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105865052  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105865079  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105865518  [KO:K02133] [EC:7.1.2.2]
105865602  BAX; apoptosis regulator BAX isoform X2 [KO:K02159]
105865636  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
105865739  [KO:K02133] [EC:7.1.2.2]
105865754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105865954  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105866025  PRNP; prion protein precursor [KO:K05634]
105866063  [KO:K02263]
105866328  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105866363  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105866929  [KO:K02266]
105866963  [KO:K02270]
105867019  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
105867259  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105867274  SEM1; 26S proteasome complex subunit DSS1 [KO:K10881]
105867420  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105867432  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105867447  KLC2; kinesin light chain 2 [KO:K10407]
105867669  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105867920  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105868254  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105868798  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105868860  [KO:K00413]
105869098  CAV3; caveolin-3 [KO:K12959]
105869365  CAV2; caveolin-2 [KO:K12958]
105869367  CAV1; caveolin-1 isoform X1 [KO:K06278]
105869379  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
105869384  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105869479  [KO:K07374]
105869496  [KO:K07374]
105869504  TUBA1C; tubulin alpha-1C chain [KO:K07374]
105869527  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105869653  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105869676  TUBB4A; tubulin beta-4A chain [KO:K07375]
105869963  [KO:K00418]
105869973  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105870127  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105870162  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105870333  [KO:K02133] [EC:7.1.2.2]
105870442  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105870472  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105870697  [KO:K04371] [EC:2.7.11.24]
105870811  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105870914  [KO:K00419]
105870975  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105871035  [KO:K02266]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105871186  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105871213  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105871362  [KO:K02263]
105871755  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
105871783  [KO:K02128]
105872092  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105872134  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105872357  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105873023  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105873036  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105873243  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105873482  [KO:K07375]
105873549  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105873557  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105873559  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105873604  [KO:K03987]
105873650  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
105873750  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105873751  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105873936  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105874077  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105874262  [KO:K03037]
105874305  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105874513  TUBB1; tubulin beta-1 chain [KO:K07375]
105874716  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105874790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105874841  [KO:K02132]
105874909  [KO:K02726] [EC:3.4.25.1]
105874931  [KO:K00414]
105875067  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105875072  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105875124  [KO:K03994]
105875126  [KO:K03994]
105875144  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105875178  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105875192  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105875650  [KO:K00417]
105875711  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105875718  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105875830  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105875882  IL6; interleukin-6 [KO:K05405]
105875906  [KO:K08738]
105876295  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
105876445  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105876466  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105876468  [KO:K08738]
105876638  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105876685  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105876779  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
105876832  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105876884  [KO:K02270]
105876919  [KO:K02267]
105877012  [KO:K00411] [EC:7.1.1.8]
105877018  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
105877076  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105877215  [KO:K02267]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105877497  [KO:K00416]
105877774  [KO:K07374]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105877917  [KO:K07375]
105877970  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1 [KO:K03948]
105877979  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
105877984  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105878143  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105878388  C6; complement component C6 isoform X1 [KO:K03995]
105878390  C7; complement component C7 [KO:K03996]
105878463  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
105878474  BAD; bcl2-associated agonist of cell death [KO:K02158]
105878912  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105879121  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X5 [KO:K03944]
105879202  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105879547  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105879726  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105879883  [KO:K03945]
105879910  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105879995  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
105880121  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105880242  EIF2S1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105880624  [KO:K02187] [EC:3.4.22.56]
105880779  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105880905  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
105881079  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105881169  [KO:K03938]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105881452  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105881706  KIF5B; kinesin-1 heavy chain [KO:K10396]
105882171  [KO:K00236]
105882219  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
105882232  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105882254  TUBB4B; tubulin beta-4B chain [KO:K07375]
105882275  CCL5; C-C motif chemokine 5 [KO:K12499]
105882283  C8G; complement component C8 gamma chain [KO:K03999]
105882326  [KO:K03955]
105882495  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105882502  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
105882578  C8A; complement component C8 alpha chain [KO:K03997]
105882579  C8B; complement component C8 beta chain [KO:K03998]
105882598  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105882907  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105883029  [KO:K08738]
105883659  [KO:K02265]
105883726  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
105883746  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105883940  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105884392  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105884600  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105884689  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105885016  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105885017  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105885081  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105885170  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105885209  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105885296  [KO:K00415]
105885383  ATP5A1; LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial [KO:K02132]
105885663  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105885820  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105885942  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109729268  [KO:K03945]
109729274  [KO:K02267]
109729382  [KO:K02268]
109729580  [KO:K02268]
109729584  [KO:K02271]
109729710  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
109729728  [KO:K02268]
109730163  [KO:K03037]
109730235  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
109730255  [KO:K02271]
109730487  [KO:K03967]
109730635  [KO:K02273]
109730662  [KO:K02268]
109730744  [KO:K02268]
109730745  [KO:K02268]
109730976  [KO:K02268]
109730981  [KO:K02268]
109731077  [KO:K02268]
109731090  [KO:K02268]
109731103  [KO:K02268]
109731114  [KO:K03945]
109731316  [KO:K02268]
109731319  [KO:K02272]
26823973  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26823976  COX2; cytochrome c oxidase subunit II [KO:K02261]
26823978  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
26823979  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
26823980  COX3; cytochrome c oxidase subunit III [KO:K02262]
26823982  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26823983  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26823987  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26823990  CYTB; cytochrome b [KO:K00412]
26823993  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
26823994  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26823995  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26823996  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
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Reference
PMID:25584786
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Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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Soto C, Satani N
  Title
The intricate mechanisms of neurodegeneration in prion diseases.
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Trends Mol Med 17:14-24 (2011)
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Reference
PMID:27060771
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The stress of prion disease.
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Brain Res 1648:553-560 (2016)
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Reference
PMID:32565065
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Neurobiol Dis 142:104973 (2020)
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Reference
PMID:18245809
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Prion diseases: from protein to cell pathology.
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Reference
PMID:15695097
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Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
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Trends Cell Biol 15:102-11 (2005)
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Reference
PMID:17051207
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  Title
Prions and their partners in crime.
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Nature 443:803-10 (2006)
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Reference
PMID:11592845
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Chiesa R, Harris DA
  Title
Prion diseases: what is the neurotoxic molecule?
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Neurobiol Dis 8:743-63 (2001)
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Reference
PMID:17085779
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Fasano C, Campana V, Zurzolo C
  Title
Prions: protein only or something more? Overview of potential prion cofactors.
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J Mol Neurosci 29:195-214 (2006)
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Reference
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Neuroprotective functions of prion protein.
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J Neurosci Res 75:153-61 (2004)
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Reference
PMID:10398674
  Authors
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Cellular biology of prion diseases.
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Reference
PMID:15890824
  Authors
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  Title
Prion biology relevant to bovine spongiform encephalopathy.
  Journal
J Anim Sci 83:1455-76 (2005)
DOI:10.2527/2005.8361455x
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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PMID:31618844
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Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
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Int J Mol Sci 20:E5107 (2019)
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Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:30710214
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Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
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Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
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Mol Neurobiol 56:6035-6045 (2019)
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Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
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Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
PMID:29194372
  Authors
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  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
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Pathogens 6:E63 (2017)
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Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Reference
PMID:29476642
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Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
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FEBS J 286:342-355 (2019)
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Reference
PMID:21722302
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
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Reference
PMID:18420416
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Ferreiro E, Oliveira CR, Pereira CM
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The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
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Neurobiol Dis 30:331-42 (2008)
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Reference
PMID:16844381
  Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
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Neurobiol Dis 23:669-78 (2006)
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Reference
PMID:21980554
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Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
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Commun Integr Biol 4:258-61 (2011)
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Reference
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
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Exp Mol Med 47:e147 (2015)
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Reference
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Disease-associated prion protein oligomers inhibit the 26S proteasome.
  Journal
Mol Cell 26:175-88 (2007)
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Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Science 284:339-43 (1999)
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Reference
PMID:14532116
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Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
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EMBO J 22:5435-45 (2003)
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Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
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Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
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Front Cell Neurosci 13:350 (2019)
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Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
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Reference
PMID:21196165
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Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
mmur00190  Oxidative phosphorylation
mmur03050  Proteasome
mmur04020  Calcium signaling pathway
mmur04140  Autophagy - animal
mmur04141  Protein processing in endoplasmic reticulum
mmur04142  Lysosome
mmur04144  Endocytosis
mmur04210  Apoptosis
mmur04330  Notch signaling pathway
mmur04610  Complement and coagulation cascades
mmur04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system