KEGG   PATHWAY: mmyo05169
Entry
mmyo05169                   Pathway                                
Name
Epstein-Barr virus infection - Myotis myotis (greater mouse-eared bat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmyo05169  Epstein-Barr virus infection
mmyo05169

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118673476  CR2; complement receptor type 2 isoform X1 [KO:K04012]
118652937  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
118679500  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
118679523  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
118679525  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118679591  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118679613  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
118679614  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
118679619  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118679624  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679625  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
118679626  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679627  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
118679628  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
118679633  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118679640  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118660487  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118658736  TLR2; toll-like receptor 2 [KO:K10159]
118668344  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118649743  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118654047  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118665127  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118650066  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118659738  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118659996  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118653690  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118677878  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118665292  RELA; transcription factor p65 [KO:K04735]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118666134  IL6; interleukin-6 [KO:K05405]
118667402  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
118663001  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
118655021  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118651925  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118672786  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118648972  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118655420  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118667586  interferon omega-1-like [KO:K05414]
118666805  IFNB1; interferon beta [KO:K05415]
118676057  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118676213  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118675339  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118658254  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118661220  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118651142  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118678839  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118669450  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118673356  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118678496  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
118678600  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
118670106  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118655585  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118669989  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118665178  FADD; FAS-associated death domain protein [KO:K02373]
118661495  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118652071  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118655230  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118663765  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118655437  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118679638  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118666111  cytochrome c [KO:K08738]
118679308  cytochrome c-like [KO:K08738]
118654943  cytochrome c-like [KO:K08738]
118650180  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118677148  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118650210  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118679427  T cell receptor alpha chain MC.7.G5-like [KO:K10784]
118664241  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
118664239  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118664240  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
118673501  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
118666031  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118659186  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118674451  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118655396  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
118665053  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118671610  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118676255  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
118662263  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118671666  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118649948  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
118671823  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118671770  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
118667921  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
118674324  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118656347  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
118648967  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
118673745  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118662250  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
118674093  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118663710  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118665674  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
118679553  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118679593  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
118679520  tapasin [KO:K08058]
118650961  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118652589  CALR; calreticulin [KO:K08057]
118658369  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118679578  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
118652788  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118659954  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659955  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659956  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118659957  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118662409  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118655123  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118655161  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118655171  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
118651123  B2M; beta-2-microglobulin [KO:K08055]
118658683  SNW1; SNW domain-containing protein 1 [KO:K06063]
118660281  SNW domain-containing protein 1-like [KO:K06063]
118676090  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
118665982  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
118660079  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118676336  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118664991  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
118655481  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
118658119  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
118658920  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
118661713  CIR1; corepressor interacting with RBPJ 1 isoform X1 [KO:K06066]
118667398  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
118663233  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
118676420  HES1; transcription factor HES-1 [KO:K06054]
118658600  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
118676760  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
118670599  MYC; myc proto-oncogene protein [KO:K04377]
118656774  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
118650326  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118672084  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118659964  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118658909  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118652529  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
118676452  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
118665064  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118656304  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
118672932  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118671685  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118674827  RELB; transcription factor RelB isoform X1 [KO:K09253]
118669805  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118674287  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118674217  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
118659880  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
118672164  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118659182  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118657754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118652068  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
118679322  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118670993  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118655263  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118675368  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
118662418  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
118672023  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118660246  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118660247  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118657384  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118676104  JUN; transcription factor AP-1 [KO:K04448]
118668367  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
118669925  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
118655283  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
118663560  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118665138  CD44; CD44 antigen isoform X1 [KO:K06256]
118656453  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
118672973  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
118658133  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
118674298  VIM; vimentin [KO:K07606]
118659998  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
118658721  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118671501  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118670849  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118652511  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
118652463  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118657696  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118654418  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
118669920  BLNK; B-cell linker protein isoform X1 [KO:K07371]
118674206  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118655860  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118650327  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118665181  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118650032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118660354  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118651037  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118666224  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118651324  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
118658224  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118653038  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118670629  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118651193  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118651068  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118663841  E2F1; transcription factor E2F1 [KO:K17454]
118676426  E2F2; transcription factor E2F2 [KO:K09389]
118676306  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
mmyo03050  Proteasome
mmyo04010  MAPK signaling pathway
mmyo04020  Calcium signaling pathway
mmyo04064  NF-kappa B signaling pathway
mmyo04110  Cell cycle
mmyo04115  p53 signaling pathway
mmyo04210  Apoptosis
mmyo04612  Antigen processing and presentation
mmyo04620  Toll-like receptor signaling pathway
mmyo04622  RIG-I-like receptor signaling pathway
mmyo04630  JAK-STAT signaling pathway
mmyo04662  B cell receptor signaling pathway
KO pathway
ko05169   
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