KEGG   PATHWAY: mpuf04820
Entry
mpuf04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Mustela putorius furo (domestic ferret)
Class
Cellular Processes; Cell motility
Pathway map
mpuf04820  Cytoskeleton in muscle cells
mpuf04820

Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101686788  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101690329  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101673325  COL3A1; collagen alpha-1(III) chain [KO:K19720]
101678452  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
101685105  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
101692687  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
101673614  COL5A2; collagen alpha-2(V) chain [KO:K19721]
101682002  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
101688728  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
101689963  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
101692568  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101671478  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101684358  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101683638  DCN; decorin [KO:K04660]
101693475  VCAN; versican core protein isoform X1 [KO:K06793]
101685544  ELN; elastin isoform X1 [KO:K14211]
101672161  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
101673012  collagen alpha-6(VI) chain [KO:K06238]
101692352  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
106003286  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
101677536  COL6A3; collagen alpha-3(VI) chain isoform X2 [KO:K06238]
101690463  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
101694197  THBS1; thrombospondin-1 [KO:K16857]
101678420  THBS4; thrombospondin-4 [KO:K04659]
101691926  THBS2; thrombospondin-2 [KO:K04659]
101673580  THBS3; thrombospondin-3 [KO:K04659]
101694423  COMP; cartilage oligomeric matrix protein [KO:K04659]
101678848  FBN1; fibrillin-1 [KO:K06825]
101688161  FBN3; fibrillin-3 isoform X1 [KO:K23342]
101676331  FBN2; fibrillin-2 [KO:K23342]
101679039  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101691865  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101692148  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101680746  COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237]
101681217  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101671302  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101679201  FBLN2; fibulin-2 isoform X1 [KO:K17307]
101693080  FBLN1; fibulin-1 isoform X1 [KO:K17307]
101681560  basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101687167  NID2; nidogen-2 isoform X1 [KO:K06826]
101689412  NID1; nidogen-1 [KO:K06826]
101692402  FN1; fibronectin isoform X2 [KO:K05717]
101680331  SDC1; syndecan-1 [KO:K06257]
101677258  SDC2; syndecan-2 [KO:K16336]
101675952  SDC3; syndecan-3 [KO:K16337]
101690222  SDC4; syndecan-4 [KO:K16338]
101686006  AGRN; agrin [KO:K06254]
101693568  BGN; biglycan [KO:K08118]
101687080  DSC2; desmocollin-2 [KO:K07601]
101687650  DSG2; desmoglein-2 [KO:K07597]
101679436  PKP2; plakophilin-2 [KO:K12642]
101677365  JUP; junction plakoglobin [KO:K10056]
101676103  DSP; desmoplakin isoform X1 [KO:K10381]
101671433  VIM; vimentin isoform X1 [KO:K07606]
101682328  DES; desmin [KO:K07610]
101673993  LAMA1; laminin subunit alpha-1 [KO:K05637]
101687362  LAMA2; laminin subunit alpha-2 [KO:K05637]
101677795  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
101676920  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101678224  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
101684180  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101681396  ITGA4; integrin alpha-4 [KO:K06483]
101686447  ITGA5; integrin alpha-5 [KO:K06484]
101682530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101692696  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101692829  ITGA8; integrin alpha-8 [KO:K06584]
101669936  ITGA9; integrin alpha-9 [KO:K06585]
101686096  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
101672159  ITGA11; integrin alpha-11 [KO:K06587]
101681626  ITGAV; integrin alpha-V [KO:K06487]
101690880  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
101685180  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101683751  ITGB3; integrin beta-3 [KO:K06493]
101675802  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101671893  ITGB5; integrin beta-5 [KO:K06588]
101690894  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101685685  ITGB7; integrin beta-7 [KO:K06590]
101675667  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101682257  TLN1; talin-1 isoform X2 [KO:K06271]
101689432  TLN2; talin-2 isoform X1 [KO:K06271]
101679725  VCL; vinculin isoform X1 [KO:K05700]
101678589  ACTN3; alpha-actinin-3 [KO:K21073]
101674315  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
101679540  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101686268  ACTB; actin, cytoplasmic 1 [KO:K05692]
101693150  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
101677695  DAG1; dystroglycan [KO:K06265]
101686508  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
101689363  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
101676646  SGCB; beta-sarcoglycan [KO:K12566]
101684263  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
101676694  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
101671937  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
101683259  SSPN; sarcospan isoform X1 [KO:K22194]
101672364  DMD; dystrophin [KO:K10366]
101685154  SNTA1; alpha-1-syntrophin [KO:K24063]
106003342  SNTB1; beta-1-syntrophin [KO:K24064]
101676330  beta-1-syntrophin [KO:K24064]
101676859  beta-2-syntrophin [KO:K24064]
101674122  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
101692958  FLNC; filamin-C isoform X1 [KO:K27393]
101678857  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
101689482  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X2 [KO:K01539] [EC:7.2.2.13]
101677161  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
101678357  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101679289  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101693106  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
101681278  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
101677205  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101673234  ANK3; ankyrin-3 isoform X1 [KO:K09259]
101679779  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
101672975  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
101675903  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
101670914  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
101687155  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
101692703  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
101692822  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
101688845  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
101678392  myosin-2 isoform X1 [KO:K24220]
101678693  myosin-8 [KO:K24220]
101679197  myosin-1 [KO:K24220]
101679495  MYH13; myosin-13 [KO:K24220]
101693038  myosin-4 [KO:K24220]
101671087  MYH7B; myosin-7B isoform X1 [KO:K24220]
101678085  MYH3; myosin-3 [KO:K24220]
101673577  myosin-7 [KO:K17751]
101673860  myosin-6 [KO:K17751]
101684930  MYH10; myosin-10 [KO:K10352]
101692760  myosin-9 [KO:K10352]
101688519  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
101682467  MYH11; myosin-11 [KO:K10352]
101675867  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
101686212  MYL3; myosin light chain 3 [KO:K12749]
101677363  MYL4; myosin light chain 4 [KO:K12750]
101670913  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101690344  MYL5; myosin light chain 5 [KO:K12753]
101686312  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101679631  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101692429  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101676458  MYBPC1; myosin-binding protein C, slow-type isoform X2 [KO:K12557]
101674967  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
101690976  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
101686717  MYBPHL; myosin-binding protein H-like [KO:K24494]
101683480  MYBPH; myosin-binding protein H isoform X1 [KO:K24494]
101690850  ACTA1; actin, alpha skeletal muscle [KO:K10354]
101684977  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
101680196  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101692253  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
101678058  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
101683134  TNNC2; troponin C, skeletal muscle [KO:K12042]
101690111  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
101686671  TNNT3; troponin T, fast skeletal muscle isoform X8 [KO:K12046]
106003394  TNNI3; troponin I, cardiac muscle [KO:K12044]
101690457  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
101686383  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
101678214  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
101681825  TPM3; tropomyosin alpha-3 chain [KO:K09290]
101688400  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
101687481  TTN; titin [KO:K12567] [EC:2.7.11.1]
101685261  MYOT; myotilin isoform X1 [KO:K19875]
101671461  TCAP; telethonin [KO:K19879]
101682755  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
101669885  NEB; nebulin isoform X1 [KO:K18267]
101676718  NEBL; nebulette isoform X10 [KO:K25865]
101692492  MYOZ1; myozenin-1 [KO:K26050]
101681587  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
101678789  MYOZ3; myozenin-3 isoform X1 [KO:K26050]
101674455  PDZ and LIM domain protein 2 [KO:K23353]
101687312  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
101690053  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
101677399  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
101686910  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101693564  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101675355  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101681850  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
101676032  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
101687943  xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
101684561  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
101686559  MYPN; myopalladin [KO:K22028]
101681939  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
101682204  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
101684657  LDB3; LIM domain-binding protein 3 isoform X6 [KO:K19867]
101685066  TMOD1; tropomodulin-1 [KO:K10370]
101673761  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
101683474  TMOD3; tropomodulin-3 isoform X1 [KO:K10370]
101684142  TMOD2; tropomodulin-2 [KO:K10370]
101676685  ZYX; zyxin isoform X1 [KO:K06273]
101683449  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
101687366  FHL2; four and a half LIM domains protein 2 [KO:K14380]
101688983  FHL3; four and a half LIM domains protein 3 [KO:K24414]
101685035  LMOD2; leiomodin-2 [KO:K22030]
101679896  LMOD3; leiomodin-3 [KO:K22030]
101671129  LMOD1; leiomodin-1 [KO:K22030]
101674884  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
101693364  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
101688550  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
101674763  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
101688533  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
101688947  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
101678570  INF2; inverted formin-2 isoform X1 [KO:K23958]
101680408  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
101684732  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
101674562  DIAPH1; protein diaphanous homolog 1 isoform X5 [KO:K05740]
101690551  DIAPH2; protein diaphanous homolog 2 isoform X5 [KO:K05741]
101676288  DIAPH3; protein diaphanous homolog 3 isoform X3 [KO:K05745]
101683173  FMN2; formin-2 [KO:K02184]
101672184  MYOM3; myomesin-3 [KO:K24495]
101687935  MYOM1; myomesin-1 isoform X2 [KO:K24495]
101689554  MYOM2; myomesin-2 [KO:K24495]
101679228  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
101680330  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
101674624  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
101671186  ANK2; ankyrin-2 isoform X7 [KO:K09255]
101694559  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
101686231  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
101691395  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
101682637  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
101692777  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
101681682  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101678350  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
106004496  obscurin-like [KO:K17531] [EC:2.7.11.1]
101690467  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
101675191  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
101694502  PLEC; plectin [KO:K10388]
101670733  SYNE3; nesprin-3 isoform X1 [KO:K21761]
101692147  SYNE1; nesprin-1 isoform X1 [KO:K19326]
101673979  SYNE2; nesprin-2 isoform X5 [KO:K19346]
101672489  SUN2; SUN domain-containing protein 2 [KO:K19347]
101687026  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
101678396  TMEM43; transmembrane protein 43 [KO:K27488]
101689231  EMD; emerin [KO:K12569]
101681647  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
101685893  LMNA; lamin [KO:K12641]
101679686  LMNB1; lamin-B1 [KO:K07611]
101671833  LMNB2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
mpuf04512  ECM-receptor interaction
mpuf04814  Motor proteins
KO pathway
ko04820   
LinkDB

DBGET integrated database retrieval system