KEGG   PATHWAY: myb04062
Entry
myb04062                    Pathway                                
Name
Chemokine signaling pathway - Myotis brandtii (Brandt's bat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
myb04062  Chemokine signaling pathway
myb04062

Other DBs
GO: 0070098
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102242586  growth-regulated protein homolog gamma-like [KO:K05505]
102241767  growth-regulated protein homolog gamma-like [KO:K05505]
102242280  growth-regulated protein homolog gamma [KO:K05505]
102246776  CXCL6; C-X-C motif chemokine ligand 6 [KO:K05506]
102246461  PPBP; platelet basic protein [KO:K10029]
102243203  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
102239629  CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
102242383  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
102242087  CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
102247013  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102238609  CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
102262866  CXCL16; C-X-C motif chemokine ligand 16 [KO:K10035]
102242897  PF4; platelet factor 4 [KO:K05407]
102258216  CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]
102246603  XCL1; lymphotactin [KO:K05507]
102250746  CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
106726430  uncharacterized LOC106726430 [KO:K05514]
102258649  CCL2; C-C motif chemokine 2 [KO:K14624]
102246598  C-C motif chemokine 3 [KO:K05408]
102246902  C-C motif chemokine 4 [KO:K12964]
102244179  C-C motif chemokine 4-like [KO:K12964]
102245368  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
102257853  C-C motif chemokine 8 [KO:K16596]
102258156  eotaxin [KO:K16597]
102257542  CCL13; C-C motif chemokine 13 [KO:K16595]
106725102  C-C motif chemokine 15-like [KO:K05511]
102245668  CCL16; C-C motif chemokine ligand 16 [KO:K21093]
102250449  CCL17; C-C motif chemokine ligand 17 [KO:K21083]
102254342  CCL19; C-C motif chemokine ligand 19 [KO:K05512]
102260179  CCL20; C-C motif chemokine ligand 20 [KO:K14625]
102241671  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
102250032  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
102247008  CCL26; C-C motif chemokine 26 [KO:K21096]
102254930  CCL27; C-C motif chemokine ligand 27 [KO:K16598]
102248646  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
102246524  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
102255166  C-X-C chemokine receptor type 2-like [KO:K04175]
102246363  CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
102263583  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
106726152  CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
102263744  CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
102250158  XCR1; X-C motif chemokine receptor 1 [KO:K04193]
102258485  CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
102258177  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
106726667  uncharacterized LOC106726667 [KO:K04181]
102248860  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
102261709  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
102259466  CCR7; C-C motif chemokine receptor 7 [KO:K04182]
102252432  CCR2; C-C motif chemokine receptor 2 [KO:K04177]
102252723  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102251645  CCR1; C-C motif chemokine receptor 1 [KO:K04176]
102252140  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
102260033  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
102253056  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
102241153  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
102243651  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102240965  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102239853  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102241062  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
102249318  GNAI2; G protein subunit alpha i2 [KO:K04630]
102239557  GNAI3; G protein subunit alpha i3 [KO:K04630]
102256872  GNAI1; G protein subunit alpha i1 [KO:K04630]
102257679  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102260356  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102261014  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102247996  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102257731  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102248773  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102253549  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102249345  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102248953  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102244919  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102252927  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102262917  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
102256952  HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
102256827  FGR; FGR proto-oncogene, Src family tyrosine kinase [KO:K08891] [EC:2.7.10.2]
102247553  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102245916  SHC1; SHC adaptor protein 1 [KO:K06279]
102251506  SHC2; SHC adaptor protein 2 [KO:K17447]
102245983  SHC3; SHC adaptor protein 3 [KO:K17448]
102239285  SHC4; SHC adaptor protein 4 [KO:K17449]
102241832  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102252301  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102259408  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102260644  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102241723  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
102246489  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
102246179  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
102238785  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
106726938  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102250265  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102246728  FOXO3; forkhead box O3 [KO:K09408]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102252013  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102256580  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102261181  NFKBIB; NFKB inhibitor beta [KO:K02581]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102239479  BAD; BCL2 associated agonist of cell death [KO:K02158]
102250707  GSK3A; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102245625  ITK; IL2 inducible T-cell kinase [KO:K07363] [EC:2.7.10.2]
102242321  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102253658  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102263523  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102249503  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102240321  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102257260  CDC42; cell division cycle 42 [KO:K04393]
102239987  cell division control protein 42 homolog [KO:K04393]
102242874  WAS; Wiskott-Aldrich syndrome [KO:K05747]
102244315  RHOA; ras homolog family member A [KO:K04513]
102252747  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102254781  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102257321  GNB1; G protein subunit beta 1 [KO:K04536]
102257762  GNB2; G protein subunit beta 2 [KO:K04537]
102262102  GNB3; G protein subunit beta 3 [KO:K07825]
102263696  GNB4; G protein subunit beta 4 [KO:K04538]
102252218  guanine nucleotide-binding protein subunit beta-4-like [KO:K04538]
102242731  GNB5; G protein subunit beta 5 [KO:K04539]
102253997  GNG2; G protein subunit gamma 2 [KO:K07826]
102259768  GNG4; G protein subunit gamma 4 [KO:K04541]
102250530  GNG5; G protein subunit gamma 5 [KO:K04542]
102258952  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102263275  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102238618  GNG7; G protein subunit gamma 7 [KO:K04543]
102250013  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102263426  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102254808  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102242875  GNG12; G protein subunit gamma 12 [KO:K04347]
102240295  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102257413  GNG13; G protein subunit gamma 13 [KO:K04547]
102252604  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102238904  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [KO:K12365]
102248431  ELMO1; engulfment and cell motility 1 [KO:K12366]
102241503  DOCK2; dedicator of cytokinesis 2 [KO:K12367]
102245460  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102253973  PXN; paxillin [KO:K05760]
102256265  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102248665  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102252934  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102253195  adapter molecule crk [KO:K04438]
102256791  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
102247263  GNAQ; G protein subunit alpha q [KO:K04634]
102238655  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102254054  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102241255  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102240650  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102248243  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102261553  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102242639  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102258771  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102254910  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102256516  PARD3; par-3 family cell polarity regulator [KO:K04237]
102243136  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102256501  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
102252724  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
102242883  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
102257754  GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
102243341  GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
102248143  GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
102255277  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
102260906  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
102246592  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
102264231  ARRB1; arrestin beta 1 [KO:K04439]
102246094  ARRB2; arrestin beta 2 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
myb04010  MAPK signaling pathway
myb04060  Cytokine-cytokine receptor interaction
myb04120  Ubiquitin mediated proteolysis
myb04630  JAK-STAT signaling pathway
myb04670  Leukocyte transendothelial migration
myb04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
LinkDB

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