KEGG   PATHWAY: mze05132
Entry
mze05132                    Pathway                                
Name
Salmonella infection - Maylandia zebra (zebra mbuna)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mze05132  Salmonella infection
mze05132

Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101482397  podxl; podocalyxin [KO:K06817]
101480305  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
101481330  ras-related protein Rab-5A [KO:K07887]
101476881  ras-related protein Rab-5A [KO:K07887]
101475520  ras-related protein Rab-5B [KO:K07888]
101465912  ras-related protein Rab-5C [KO:K07889]
101481749  rab5c; ras-related protein Rab-5C [KO:K07889]
101485817  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
101486296  ras-related protein rab7 [KO:K07897]
101464763  ras-related protein rab7 [KO:K07897]
101469527  ras-related protein rab7 [KO:K07897]
101468851  ras-related protein rab7 [KO:K07897]
101486039  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
101488021  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
101464321  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
101470063  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101476005  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
101464928  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
101476720  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
101478553  RILP-like protein 1 [KO:K13883]
101466185  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
101469517  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
101481244  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
101480119  cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
101472883  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
101475530  cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
101468647  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
101487066  dynein light chain 2, cytoplasmic [KO:K10418]
101475127  dynein light chain 2, cytoplasmic [KO:K10418]
101475762  dynein light chain 2, cytoplasmic [KO:K10418]
105940937  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
101473633  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
101486243  dynein light chain Tctex-type 1 [KO:K10420]
101486477  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
101476234  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
101467871  dynactin subunit 1 isoform X5 [KO:K04648]
101464740  dynactin subunit 1 isoform X7 [KO:K04648]
101474281  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
101483504  dctn3; dynactin subunit 3 [KO:K10425]
101475783  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
101467016  dctn5; dynactin subunit 5 [KO:K10427]
101486450  dynactin subunit 6 isoform X1 [KO:K10428]
101469849  dynactin subunit 6 [KO:K10428]
101468410  beta-centractin [KO:K16575]
101480251  actr10; actin-related protein 10 [KO:K16576]
101475061  tubulin alpha chain-like [KO:K07374]
101471801  tubulin alpha chain isoform X2 [KO:K07374]
101480465  tubulin alpha chain [KO:K07374]
101486701  tubulin alpha-1C chain [KO:K07374]
105941124  tubulin alpha-1C chain isoform X4 [KO:K07374]
101471595  tubulin alpha-1B chain [KO:K07374]
101484757  tubulin alpha-8 chain [KO:K07374]
106674879  tubulin alpha chain [KO:K07374]
106676044  tubulin alpha chain [KO:K07374]
101472165  tubulin alpha-1B chain [KO:K07374]
101475575  tubulin alpha chain isoform X1 [KO:K07374]
106674509  tubulin alpha-1D chain-like [KO:K07374]
112435909  tubulin alpha chain [KO:K07374]
101478022  tubulin beta-5 chain [KO:K07375]
101486495  tubulin beta chain [KO:K07375]
101473957  tubulin beta chain isoform X1 [KO:K07375]
101480422  tubulin beta-4B chain [KO:K07375]
101469831  tubulin beta chain isoform X2 [KO:K07375]
101468168  tubulin beta chain [KO:K07375]
101465389  tubulin beta-1 chain [KO:K07375]
101481081  tubulin beta-4B chain [KO:K07375]
101469005  tubulin beta-4B chain [KO:K07375]
101469042  FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
101473040  FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
101481818  ADP-ribosylation factor-like protein 8A [KO:K07955]
101468561  ADP-ribosylation factor-like protein 8B [KO:K07955]
101467984  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
101487243  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
101484518  kinesin heavy chain [KO:K10396]
101483513  kinesin heavy chain [KO:K10396]
101470268  LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
101464413  kinesin heavy chain [KO:K10396]
101487918  kinesin-1 heavy chain [KO:K10396]
101474744  kinesin heavy chain isoform X1 [KO:K10396]
101479034  klc2; kinesin light chain 2 [KO:K10407]
101486855  kinesin light chain 1 [KO:K10407]
101468719  kinesin light chain 1 isoform X1 [KO:K10407]
101485744  klc1; kinesin light chain 1 isoform X4 [KO:K10407]
101472387  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
101485690  rho-related GTP-binding protein RhoA-B [KO:K04513]
101478838  rho-related GTP-binding protein RhoA-C [KO:K04513]
101472412  rho-related GTP-binding protein RhoA-D [KO:K04513]
101464339  rho-related GTP-binding protein RhoA-C [KO:K04513]
101465971  rho-related GTP-binding protein RhoA-B [KO:K04513]
101468482  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101466890  ras-related protein Rab-9A [KO:K07899]
101486526  rab9a; ras-related protein Rab-9A [KO:K07899]
101481201  ras-related protein Rab-9B [KO:K07900]
101468995  gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
101485448  stx10; syntaxin-10 [KO:K23937]
101481969  pfn2; profilin-2 isoform X1 [KO:K05759]
101471541  profilin-2 isoform X1 [KO:K05759]
101465745  profilin-1 [KO:K05759]
101465053  LOW QUALITY PROTEIN: filamin-A [KO:K04437]
101476189  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
101480142  exoc5; exocyst complex component 5 [KO:K19984]
101477545  exoc4; exocyst complex component 4 [KO:K06111]
101470494  exoc2; exocyst complex component 2 [KO:K17637]
101477841  ras-related protein Ral-A [KO:K07834]
101487522  actin, cytoplasmic 1 [KO:K05692]
101470738  actb; actin, cytoplasmic 1 [KO:K05692]
101464190  actin, cytoplasmic 2 [KO:K05692]
101487996  actin, cytoplasmic 2-like [KO:K05692]
101469546  protein S100-A10 [KO:K17274]
101477134  protein S100-P [KO:K17274]
101477800  annexin A2 [KO:K17092]
101481057  annexin A2-A [KO:K17092]
112429814  annexin A2-like isoform X1 [KO:K17092]
101466970  LOW QUALITY PROTEIN: annexin A2 [KO:K17092]
112429726  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
106674558  LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934]
101467856  ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
101469570  ahnak2; protein AHNAK2 [KO:K23934]
106674550  neuroblast differentiation-associated protein AHNAK [KO:K23934]
105940457  neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
101464946  arhgef26; rho guanine nucleotide exchange factor 26 [KO:K13744]
101478812  rho-related GTP-binding protein RhoG [KO:K07863]
101479556  rho-related GTP-binding protein RhoG [KO:K07863]
101480652  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
101468934  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
101475967  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101470679  rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
101478915  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101482094  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
106677009  myosin regulatory light chain 2, atrial isoform [KO:K12754]
101480470  myosin regulatory light chain 2, atrial isoform [KO:K12754]
101473299  myosin regulatory light polypeptide 9 [KO:K12755]
101476290  myosin regulatory light polypeptide 9 [KO:K12757]
101484951  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
101482131  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101470913  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101473869  FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
101478153  FH1/FH2 domain-containing protein 1 [KO:K23938]
101465436  cell division control protein 42 homolog [KO:K04393]
101466111  cell division control protein 42 homolog [KO:K04393]
101466863  cell division control protein 42 homolog [KO:K04393]
101480754  cell division control protein 42 homolog isoform X2 [KO:K04393]
101479607  cell division control protein 42 homolog [KO:K04393]
101472760  cell division control protein 42 homolog [KO:K04393]
112430189  cdc42 homolog [KO:K04393]
101483895  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105941067  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101485378  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101485652  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101482301  nckap1l; nck-associated protein 1-like [KO:K05750]
101482438  nckap1; nck-associated protein 1 isoform X3 [KO:K05750]
101468528  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
101465754  cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
112433858  LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
101472048  abi1; LOW QUALITY PROTEIN: abl interactor 1 [KO:K23649]
101470874  abl interactor 1 [KO:K23649]
112430093  abl interactor 1-like [KO:K23649]
101472224  brk1; protein BRICK1 [KO:K05752]
101467939  wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
101469879  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
101469375  wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
101484478  wasf3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
101481337  actin-related protein 2-A [KO:K17260]
101465187  actr2; actin-related protein 2 [KO:K17260]
101476876  actin-related protein 3B isoform X1 [KO:K18584]
101467416  actin-related protein 3 [KO:K18584]
101475383  actin-related protein 3 [KO:K18584]
101468635  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101469153  actin-related protein 2/3 complex subunit 1B [KO:K05757]
101471957  actin-related protein 2/3 complex subunit 1A [KO:K05757]
101487555  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101476469  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101475148  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101468546  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101474410  actin-related protein 2/3 complex subunit 5 [KO:K05754]
101472838  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101483196  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101484450  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101482346  myo6; unconventional myosin-VI [KO:K10358]
101466186  unconventional myosin-VI isoform X2 [KO:K10358]
101466374  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101473981  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101474114  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101469095  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101487871  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101471620  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101474181  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101488075  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
101481785  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
101464810  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
112434824  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta-like [KO:K00923] [EC:2.7.1.154]
101468222  cytohesin-1 isoform X1 [KO:K18441]
101475579  cytohesin-3 [KO:K18441]
101480312  cytohesin-1 isoform X1 [KO:K18441]
101482068  cyth2; cytohesin-2 [KO:K18441]
101483598  cyth3; cytohesin-3 [KO:K18441]
101486233  cytohesin-3 [KO:K18441]
101487734  cytohesin-4 [KO:K18441]
101478443  arf6; ADP-ribosylation factor 6 [KO:K07941]
101476180  ADP-ribosylation factor 6 [KO:K07941]
101469037  ADP-ribosylation factor 1 [KO:K07937]
101471922  arf1; ADP-ribosylation factor 1 [KO:K07937]
101471187  ADP-ribosylation factor 1 [KO:K07937]
101465854  sorting nexin-9 isoform X1 [KO:K17923]
101469622  snx33; sorting nexin-33 isoform X1 [KO:K17923]
101477122  sorting nexin-18 [KO:K17923]
101478075  sorting nexin-9 isoform X1 [KO:K17923]
101487053  snx18; sorting nexin-18 [KO:K17923]
112432817  sorting nexin-9-like [KO:K17923]
101477761  neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
101478754  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein [KO:K23612]
101466950  neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
101484724  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
101473937  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
101475856  toll-like receptor 1 [KO:K10169]
101470585  toll-like receptor 2 [KO:K10159]
101463793  toll-like receptor 2 [KO:K10159]
106675704  toll-like receptor 2 type-2 [KO:K10159]
106675443  toll-like receptor 2 [KO:K10159]
101484533  LOW QUALITY PROTEIN: toll-like receptor 2 type-1 [KO:K10159]
101483841  tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101476408  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101486268  toll-like receptor 5 [KO:K10168]
101475838  toll-like receptor 5 [KO:K10168]
101465239  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101482950  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101469001  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101484924  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101475992  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
101484781  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101482482  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101477256  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
101466977  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101486267  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101487089  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101472803  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101464752  NF-kappa-B inhibitor alpha [KO:K04734]
101484153  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
101479063  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101487989  rela; transcription factor p65 isoform X1 [KO:K04735]
101466792  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
101474541  heat shock protein HSP 90-alpha [KO:K04079]
101475013  heat shock protein HSP 90-alpha 1 [KO:K04079]
101486975  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
101467243  hsp90b1; endoplasmin [KO:K09487]
101478382  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
101481223  cse1l; exportin-2 [KO:K18423]
101468860  kpna1; importin subunit alpha-5 [KO:K23940]
101470873  kpna4; importin subunit alpha-3 [KO:K23583]
101479238  kpna3; importin subunit alpha-4 [KO:K23583]
101470901  rps3; 40S ribosomal protein S3 [KO:K02985]
101474892  hras; GTPase HRas [KO:K02833]
101470685  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101465184  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101484555  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101478402  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101486997  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101474234  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101479195  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101473145  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101485680  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
101463712  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101484752  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101485563  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
101484250  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101484517  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101474406  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101478377  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101483027  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101475777  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101480702  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101486303  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101477577  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101476882  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101487312  proto-oncogene c-Fos [KO:K04379]
101487601  proto-oncogene c-Fos [KO:K04379]
101467033  proto-oncogene c-Fos [KO:K04379]
101463670  transcription factor AP-1 [KO:K04448]
101486839  jun; transcription factor AP-1 [KO:K04448]
101472459  transcription factor AP-1 [KO:K04448]
101469924  tumor necrosis factor [KO:K03156]
101467886  lymphotoxin-alpha [KO:K03156]
101472170  tumor necrosis factor [KO:K03156]
101472948  interleukin-1 beta-like [KO:K04519]
101473431  interleukin-1 beta-like [KO:K04519]
101485031  interleukin-1 beta isoform X1 [KO:K04519]
101481848  interleukin-1 beta [KO:K04519]
101476515  interleukin-6-like [KO:K05405]
101487440  interleukin-8 [KO:K10030]
101463610  growth-regulated alpha protein isoform X1 [KO:K10030]
106676095  interleukin-8-like [KO:K10030]
111501281  C-X-C motif chemokine 3-like [KO:K10030]
112431585  growth-regulated alpha protein-like [KO:K10030]
112431586  C-X-C motif chemokine 3-like [KO:K10030]
112431587  C-X-C motif chemokine 3-like [KO:K10030]
111501391  C-X-C motif chemokine 3-like [KO:K10030]
101468246  permeability factor 2 isoform X1 [KO:K10030]
101486082  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
101475823  catenin beta-1 [KO:K02105]
101469770  tcf7; transcription factor 7 isoform X1 [KO:K02620]
101481605  tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
101466461  transcription factor 7-like 1-B isoform X1 [KO:K04490]
101473558  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101472434  transcription factor 7-like 2 [KO:K04491]
101464688  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101464606  transcriptional regulator Myc-2 isoform X1 [KO:K04377]
101479046  transcriptional regulator Myc-A [KO:K04377]
101474120  myc; myc proto-oncogene protein [KO:K04377]
101476563  pkn1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
101475594  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
101471506  fbxo22; F-box only protein 22 [KO:K10302]
101469121  skp1; S-phase kinase-associated protein 1 [KO:K03094]
101476032  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K03158]
101479156  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
101467121  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101473415  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101472424  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101483832  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101484124  inhibitor of apoptosis protein isoform X1 [KO:K16060]
101477700  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101468360  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101474674  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101478620  tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
101470019  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101466428  tumor necrosis factor receptor superfamily member 10A [KO:K04722]
101465040  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
101483780  fadd; FAS-associated death domain protein [KO:K02373]
106676518  caspase-8 [KO:K04398] [EC:3.4.22.61]
101481407  caspase-8 [KO:K04398] [EC:3.4.22.61]
101478827  caspase-8 [KO:K04398] [EC:3.4.22.61]
106674852  caspase-8 [KO:K04398] [EC:3.4.22.61]
101475706  caspase-8 [KO:K04398] [EC:3.4.22.61]
112430088  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
112430089  caspase-8-like [KO:K04398] [EC:3.4.22.61]
101470036  caspase-8 [KO:K04398] [EC:3.4.22.61]
101480907  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
106674752  receptor-interacting serine/threonine-protein kinase 3 isoform X2 [KO:K08847] [EC:2.7.11.1]
101484052  apoptosis regulator BAX [KO:K02159]
101475737  apoptosis regulator BAX [KO:K02159]
101468197  bax; apoptosis regulator BAX [KO:K02159]
112432380  apoptosis regulator BAX-like [KO:K02159]
101472417  cytochrome c iso-1/iso-2-like [KO:K08738]
101468594  cytochrome c-b [KO:K08738]
101481166  cytochrome c [KO:K08738]
101477921  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101466853  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101464077  caspase-3 [KO:K02187] [EC:3.4.22.56]
101463771  caspase-3 [KO:K02187] [EC:3.4.22.56]
101478576  caspase-3 [KO:K02187] [EC:3.4.22.56]
101466737  caspase-3-like [KO:K04397] [EC:3.4.22.60]
101468707  caspase-7-like [KO:K04397] [EC:3.4.22.60]
101473187  casp7; caspase-7 isoform X3 [KO:K04397] [EC:3.4.22.60]
101468761  rho-related GTP-binding protein RhoB [KO:K07856]
101480731  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
101467814  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101480630  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101469973  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101476427  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101466452  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101483735  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
101466611  mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
101486616  mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
101478257  txn2; LOW QUALITY PROTEIN: thioredoxin, mitochondrial [KO:K03671]
101481447  thioredoxin [KO:K03671]
101481929  thioredoxin [KO:K03671]
101483363  thioredoxin [KO:K03671]
112430797  thioredoxin-like [KO:K03671]
101475740  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
112431240  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112432183  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112429886  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
101463887  caspase-1-like [KO:K01370] [EC:3.4.22.36]
101464464  caspase-1-A [KO:K01370] [EC:3.4.22.36]
101481357  caspase-1-like [KO:K01370] [EC:3.4.22.36]
112432409  caspase-1-like [KO:K01370] [EC:3.4.22.36]
112429920  caspase-1-like [KO:K01370] [EC:3.4.22.36]
112431722  caspase-13-like [KO:K01370] [EC:3.4.22.36]
101468196  caspase-1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
mze04010  MAPK signaling pathway
mze04210  Apoptosis
mze04217  Necroptosis
mze04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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