KEGG   PATHWAY: nmel04020
Entry
nmel04020                   Pathway                                
Name
Calcium signaling pathway - Numida meleagris (helmeted guineafowl)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
nmel04020  Calcium signaling pathway
nmel04020

Other DBs
GO: 0019722
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110396043  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
110391923  sodium/calcium exchanger 2-like [KO:K05849]
110401740  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
110395170  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110404987  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110388176  plasma membrane calcium-transporting ATPase 4-like isoform X1 [KO:K05850] [EC:7.2.2.10]
110396674  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
110401754  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
110406400  ADORA2A; adenosine receptor A2a [KO:K04266]
110407643  ADORA2B; adenosine receptor A2b [KO:K04267]
110400444  ADRB1; beta-1 adrenergic receptor [KO:K04141]
110405300  ADRB2; beta-2 adrenergic receptor [KO:K04142]
110387052  ADRB3; beta-3 adrenergic receptor [KO:K04143]
110405443  DRD1; D(1A) dopamine receptor [KO:K04144]
110400203  D(1)-like dopamine receptor [KO:K05840]
110398506  DRD5; D(1B) dopamine receptor [KO:K05840]
110397824  octopamine receptor-like [KO:K04150]
110405452  HRH2; histamine H2 receptor [KO:K04150]
110405268  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
110393009  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
110408495  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110398647  5-hydroxytryptamine receptor 7-like [KO:K04163]
110400279  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
110408305  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
110394740  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
110390836  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110394300  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110395965  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
110404374  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110394336  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110405807  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110402971  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110393706  SLN; sarcolipin [KO:K22642]
110406283  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110407860  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
110392109  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
110397564  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
110406589  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
110407626  ORAI2; protein orai-2 [KO:K16057]
110395457  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110404743  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110388201  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
110407048  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
110402713  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
110407349  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110405734  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
110397901  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110390224  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
110403957  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
110406928  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110405936  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110388345  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
110407430  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
110390274  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
110389090  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110407862  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
110406225  P2RX2; P2X purinoceptor 2 [KO:K05216]
110401622  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
110406319  P2RX4; P2X purinoceptor 4 [KO:K05218]
110407638  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
110406412  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
110406317  P2RX7; P2X purinoceptor 7 [KO:K05220]
110395962  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
110401310  RYR3; ryanodine receptor 3 [KO:K04963]
110396377  TRDN; triadin [KO:K23449]
110399374  CASQ2; calsequestrin-2 [KO:K23445]
110394980  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
110403242  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
110387746  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
110394649  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
110387180  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
110405475  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
110398889  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
110398297  AGTR1; type-1 angiotensin II receptor [KO:K04166]
110397510  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
110408339  EDNRB; endothelin B receptor [KO:K04198]
110403465  endothelin B receptor-like [KO:K04198]
110390007  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
110396806  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
110392735  GRPR; gastrin-releasing peptide receptor [KO:K04169]
110404910  HRH1; histamine H1 receptor [KO:K04149]
110387688  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
110398996  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
110403168  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
110396821  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
110408292  NTSR1; neurotensin receptor type 1 [KO:K04211]
110405000  OXTR; oxytocin receptor [KO:K04229]
110392666  AVPR1A; vasopressin V1a receptor [KO:K04226]
110388318  AVPR1B; vasopressin V1b receptor [KO:K04227]
110387246  PTAFR; platelet-activating factor receptor [KO:K04279]
110402647  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
110402586  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
110401891  BDKRB1; B1 bradykinin receptor [KO:K03915]
110401472  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
110387181  TACR1; substance-P receptor isoform X1 [KO:K04222]
110399275  TACR2; substance-K receptor isoform X1 [KO:K04223]
110398979  TACR3; neuromedin-K receptor [KO:K04224]
110388880  TBXA2R; thromboxane A2 receptor [KO:K04264]
110408355  thyrotropin-releasing hormone receptor-like [KO:K04282]
110394371  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
110399075  CCKAR; cholecystokinin receptor type A [KO:K04194]
110394966  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
110400376  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
110389577  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
110388935  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
110399042  EGF; pro-epidermal growth factor [KO:K04357]
110387213  TGFA; protransforming growth factor alpha [KO:K08774]
110405632  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110392622  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
110397304  PDGFC; platelet-derived growth factor C [KO:K05450]
110389823  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110405391  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110398111  FGF2; fibroblast growth factor 2 [KO:K18497]
110398386  FGF5; fibroblast growth factor 5 [KO:K04358]
110398266  FGF20; fibroblast growth factor 20 [KO:K04358]
110390665  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
110399995  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110389087  FGF22; fibroblast growth factor 22 [KO:K04358]
110402192  FGF3; fibroblast growth factor 3 [KO:K04358]
110401571  FGF4; fibroblast growth factor 4 [KO:K04358]
110402985  FGF16; fibroblast growth factor 16 [KO:K04358]
110405399  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
110389317  FGF9; fibroblast growth factor 9 [KO:K04358]
110404057  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110400908  FGF19; fibroblast growth factor 19 [KO:K22603]
110391341  fibroblast growth factor 21-like [KO:K22429]
110390661  FGF23; fibroblast growth factor 23 [KO:K22428]
110395890  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110404988  VEGFD; vascular endothelial growth factor D [KO:K05449]
110398494  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
110388196  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
110392449  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110405051  MST1; hepatocyte growth factor-like protein [KO:K23441]
110390044  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110393050  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110388649  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110389140  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110399647  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110397725  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110405265  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110387131  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110399304  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110398027  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110405535  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110403438  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
110388861  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
110405266  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110398187  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
110388022  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
110389852  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110403788  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
110392601  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110404754  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
110399502  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110391511  immunoglobulin delta heavy chain-like [KO:K06856]
110394675  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
110388519  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
110400529  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110396662  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110395536  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110401183  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110408143  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110393955  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
110404260  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110399282  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
110395900  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
110404652  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110396437  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110388144  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110398571  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
110406532  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
110401008  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
110391134  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
110391061  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
110391066  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
110407457  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
110400250  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
110405202  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110399852  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
110387188  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110405908  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
110398592  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
110403250  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
110399523  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110404770  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
110408341  TNNC2; troponin C, skeletal muscle [KO:K12042]
110403952  CALML4; calmodulin-like protein 4 [KO:K02183]
110396315  CALM2; calmodulin-2 [KO:K02183]
110401188  CALM1; calmodulin-1 [KO:K02183]
110392216  calmodulin, striated muscle [KO:K02183]
110407838  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
110403030  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
110404225  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
110404712  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110388525  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
110393482  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110400604  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110408280  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110404229  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110388298  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
110392267  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
110405097  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
110387161  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110397346  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110405364  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110399309  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110388918  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
110389600  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
110391318  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
110397833  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110400477  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110396552  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
110388230  TFEB; transcription factor EB isoform X1 [KO:K15590]
110393567  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110407983  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110404601  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110406170  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
110407551  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110390423  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
110399623  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
110393085  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
110395785  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110402029  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
110395321  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
110407228  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110405777  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
nmel04010  MAPK signaling pathway
nmel04070  Phosphatidylinositol signaling system
nmel04210  Apoptosis
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system