KEGG   PATHWAY: nnt04510
Entry
nnt04510                    Pathway                                
Name
Focal adhesion - Nestor notabilis (Kea)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nnt04510  Focal adhesion
nnt04510

Other DBs
GO: 0005925
Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104407698  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104409648  LOW QUALITY PROTEIN: collagen alpha-1(I) chain-like [KO:K06236]
104412532  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104413002  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104404830  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
104410227  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104411426  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
104407216  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
104410750  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104410751  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
104407274  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
104405694  collagen alpha-2(IX) chain-like [KO:K08131]
104401451  LOW QUALITY PROTEIN: collagen alpha-3(IX) chain-like [KO:K08131]
104413661  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
104405799  laminin subunit alpha-2-like [KO:K05637]
104412365  LAMA3; laminin subunit alpha-3 [KO:K06240]
104411910  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
104410555  LAMA4; laminin subunit alpha-4 [KO:K06241]
104408629  LOW QUALITY PROTEIN: laminin subunit beta-1-like [KO:K05636]
104412158  LAMB4; laminin subunit beta-4 [KO:K06245]
104402141  LAMC1; laminin subunit gamma-1 [KO:K05635]
104406707  LAMC2; laminin subunit gamma-2 [KO:K06246]
104412639  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
104409869  CHAD; chondroadherin [KO:K06248]
104399344  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
104400129  THBS1; thrombospondin-1 [KO:K16857]
104404236  LOW QUALITY PROTEIN: thrombospondin-3-like [KO:K04659]
104408884  COMP; cartilage oligomeric matrix protein [KO:K04659]
104409358  THBS2; thrombospondin-2 [KO:K04659]
104405064  THBS4; thrombospondin-4 [KO:K04659]
104408766  FN1; fibronectin [KO:K05717]
104409686  SPP1; osteopontin [KO:K06250]
104412710  VTN; vitronectin [KO:K06251]
104409772  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
104409904  TNR; tenascin-R isoform X1 [KO:K06252]
104407205  TNC; tenascin [KO:K06252]
104405586  VWF; von Willebrand factor [KO:K03900]
104411498  IBSP; bone sialoprotein 2 [KO:K06253]
104403153  ITGA1; integrin alpha-1 [KO:K06480]
104410325  ITGA2; integrin alpha-2 [KO:K06481]
104405293  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
104411070  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
104399833  ITGA6; integrin alpha-6 [KO:K06485]
104412390  ITGA8; integrin alpha-8 [KO:K06584]
104400010  ITGAV; integrin alpha-V [KO:K06487]
104400538  integrin beta-1-like [KO:K05719]
104410905  ITGB3; integrin beta-3 [KO:K06493]
104408416  ITGB4; integrin beta-4 [KO:K06525]
104399570  ITGB5; integrin beta-5 [KO:K06588]
104409466  ITGB6; integrin beta-6 [KO:K06589]
104400240  ITGB8; integrin beta-8 [KO:K06591]
104400679  EMP2; epithelial membrane protein 2 [KO:K26256]
104401729  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104404911  PDGFB; LOW QUALITY PROTEIN: platelet-derived growth factor subunit B [KO:K17386]
104408848  PDGFD; platelet-derived growth factor D [KO:K05450]
104410372  PDGFC; platelet-derived growth factor C [KO:K05450]
104412813  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
104404672  VEGFA; vascular endothelial growth factor A [KO:K05448]
104401121  PGF; placenta growth factor [KO:K16859]
104400737  VEGFC; vascular endothelial growth factor C [KO:K05449]
104402582  FIGF; vascular endothelial growth factor D [KO:K05449]
104409459  hepatocyte growth factor-like [KO:K05460]
104404822  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104413057  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104402233  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104409530  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104407420  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104411674  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104413830  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104410927  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104410484  EMP1; epithelial membrane protein 1 [KO:K26255]
104407970  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104409272  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104410564  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
104401830  RHOA; transforming protein RhoA [KO:K04513]
104403821  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
104399807  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
104410426  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104401860  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104401263  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104402613  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104400687  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
104400689  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104411482  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104408102  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
104404715  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
104412795  LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
104407141  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104407146  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104405076  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
104407458  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104404285  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104410052  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104401036  actin, cytoplasmic 1 isoform X1 [KO:K05692]
104405778  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
104413853  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104408713  LOW QUALITY PROTEIN: calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
104402220  alpha-actinin-1 isoform X1 [KO:K05699]
104403095  TLN2; talin-2 [KO:K06271]
104404092  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
104406431  FLNB; filamin-B [KO:K27392]
104402661  PXN; paxillin [KO:K05760]
104410509  ZYX; zyxin [KO:K06273]
104407370  VCL; vinculin [KO:K05700]
104412019  PARVB; beta-parvin isoform X1 [KO:K06275]
104412020  PARVG; gamma-parvin [KO:K06275]
104410562  PARVA; alpha-parvin [KO:K06275]
104399731  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104408229  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
104404908  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
104405182  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104409483  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
104404954  CTNNB1; catenin beta-1 [KO:K02105]
104408442  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104405779  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104408133  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
104408510  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104404492  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104399557  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104403579  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104413180  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
104410866  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104412283  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104408135  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104404637  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2-like [KO:K05730]
104400851  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104412405  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104402957  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104409287  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104410465  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104403158  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104405648  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104407606  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104409697  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104408939  LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1-like [KO:K05726]
104401293  CRK; adapter molecule crk [KO:K04438]
104404444  CRKL; crk-like protein [KO:K04438]
104412106  dedicator of cytokinesis protein 1-like [KO:K13708]
104413078  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
104410007  RAP1A; ras-related protein Rap-1A [KO:K04353]
104411965  ras-related protein Rap-1b-like [KO:K07836]
104408146  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104402014  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104406818  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104401428  JUN; transcription factor AP-1 [KO:K04448]
104405191  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104409696  CAV1; caveolin-1 [KO:K06278]
104402417  CAV2; caveolin-2 [KO:K12958]
104399744  CAV3; caveolin-3 [KO:K12959]
104406532  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
104401767  SHC3; SHC-transforming protein 3 [KO:K17448]
104411986  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
104407043  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104408251  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104412858  HRAS; GTPase HRas [KO:K02833]
104411647  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104408199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104408030  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
104410574  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104407973  LOW QUALITY PROTEIN: G1/S-specific cyclin-D3-like [KO:K10152]
104406446  inhibitor of apoptosis protein-like [KO:K16060]
104409037  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
104401803  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
nnt04010  MAPK signaling pathway
nnt04060  Cytokine-cytokine receptor interaction
nnt04070  Phosphatidylinositol signaling system
nnt04110  Cell cycle
nnt04310  Wnt signaling pathway
nnt04512  ECM-receptor interaction
nnt04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

DBGET integrated database retrieval system