KEGG   PATHWAY: npr04820
Entry
npr04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Nanorana parkeri (Xizang Plateau frog)
Class
Cellular Processes; Cell motility
Pathway map
npr04820  Cytoskeleton in muscle cells
npr04820

Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108790501  COL1A2; collagen alpha-2(I) chain [KO:K06236]
108784001  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108786726  COL4A3; collagen alpha-3(IV) chain [KO:K19720]
108795736  collagen alpha-1(XI) chain-like [KO:K19721]
108795740  COL5A3; collagen alpha-3(V) chain [KO:K19721]
108788524  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
108788363  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
108786719  COL5A2; collagen alpha-2(V) chain [KO:K19721]
108796216  collagen alpha-1(I) chain-like [KO:K19721]
108796813  collagen alpha-1(V) chain-like [KO:K19721]
108791362  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
108789516  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
108793880  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
108804851  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108790064  DCN; decorin [KO:K04660]
108788853  COL6A1; collagen alpha-1(VI) chain isoform X1 [KO:K06238]
108795802  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
108789838  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
108792064  collagen alpha-6(VI) chain-like [KO:K06238]
108801821  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108796832  THBS1; thrombospondin-1 [KO:K16857]
108794774  THBS3; thrombospondin-3 [KO:K04659]
108789855  THBS2; thrombospondin-2 [KO:K04659]
108796348  cartilage oligomeric matrix protein-like [KO:K04659]
108797516  THBS4; thrombospondin-4 [KO:K04659]
108792195  FBN1; fibrillin-1 isoform X1 [KO:K06825]
108792265  fibrillin-2-like [KO:K23342]
108795882  FBN2; fibrillin-2 [KO:K23342]
108787443  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108787444  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108788810  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
108788813  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108793122  FBLN1; fibulin-1 [KO:K17307]
108794411  FBLN2; fibulin-2 [KO:K17307]
108802213  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
108788587  NID2; nidogen-2 [KO:K06826]
108789839  FN1; fibronectin isoform X1 [KO:K05717]
108800902  protein eyes shut-like [KO:K06257]
108786782  SDC2; syndecan-2 [KO:K16336]
108793968  syndecan-3-like [KO:K16337]
108799664  syndecan 4-B-like [KO:K16338]
108792691  AGRN; agrin [KO:K06254]
108798380  BGN; biglycan [KO:K08118]
108785134  desmocollin-3-like [KO:K07601]
108786086  DSG2; desmoglein-2 [KO:K07597]
108786736  PKP2; plakophilin-2 isoform X1 [KO:K12642]
108787131  JUP; junction plakoglobin isoform X1 [KO:K10056]
108790136  DSP; desmoplakin isoform X1 [KO:K10381]
108793074  vimentin-4-like [KO:K07606]
108793292  vimentin-4 isoform X1 [KO:K07606]
108785809  vimentin-like [KO:K07606]
108793963  desmin-like [KO:K07610]
108785786  DES; desmin isoform X1 [KO:K07610]
108784886  LAMA1; laminin subunit alpha-1 [KO:K05637]
108786894  LAMA2; laminin subunit alpha-2 [KO:K05637]
108792940  ITGA1; integrin alpha-1 [KO:K06480]
108799979  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
108785975  integrin alpha-IIb-like [KO:K06476]
108785976  integrin alpha-IIb-like [KO:K06476]
108784022  ITGA3; integrin alpha-3 [KO:K06482]
108789472  ITGA4; integrin alpha-4 [KO:K06483]
108797346  ITGA5; integrin alpha-5 [KO:K06484]
108800541  ITGA6; integrin alpha-6 [KO:K06485]
108796489  ITGA7; integrin alpha-7 [KO:K06583]
108795077  ITGA8; integrin alpha-8 [KO:K06584]
108788067  ITGA9; integrin alpha-9 [KO:K06585]
108800102  integrin alpha-9-like [KO:K06585]
108798333  ITGA10; integrin alpha-10 [KO:K06586]
108784111  ITGA11; integrin alpha-11 [KO:K06587]
108794469  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108792462  ITGB1; integrin beta-1 [KO:K05719]
108797421  ITGB3; integrin beta-3 [KO:K06493]
108791154  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108791265  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
108799786  ITGB6; integrin beta-6 [KO:K06589]
108786823  ITGB7; integrin beta-7 [KO:K06590]
108804525  ITGB8; integrin beta-8 [KO:K06591]
108784056  TLN2; talin-2 [KO:K06271]
108803051  talin-1-like [KO:K06271]
108797655  VCL; vinculin isoform X1 [KO:K05700]
108797319  alpha-actinin-3 isoform X1 [KO:K21073]
108796718  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108799803  actin, cytoplasmic 1 [KO:K05692]
108803084  DAG1; dystroglycan [KO:K06265]
108784013  SGCA; alpha-sarcoglycan [KO:K12565]
108790496  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
108803992  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
108794325  SGCD; delta-sarcoglycan [KO:K12563]
108798034  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
108799056  SGCZ; zeta-sarcoglycan [KO:K27062]
108786722  SSPN; sarcospan [KO:K22194]
108786128  SNTA1; alpha-1-syntrophin [KO:K24063]
108787713  SNTB2; beta-2-syntrophin isoform X1 [KO:K24064]
108784495  SNTB1; beta-1-syntrophin [KO:K24064]
108792233  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
108794883  FLNC; filamin-C [KO:K27393]
108785659  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
108801111  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
108802354  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
108803618  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
108789924  ATP1B4; protein ATP1B4 [KO:K01540]
108790160  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
108787690  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
108804789  ANK3; ankyrin-3 [KO:K09259]
108794467  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
108791957  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
108793391  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
108798080  LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 1-like [KO:K23932]
108792785  CSRP1; cysteine and glycine-rich protein 1 isoform X1 [KO:K09377]
108800732  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
108784482  myosin-4-like isoform X1 [KO:K24220]
108784483  myosin-4-like isoform X1 [KO:K24220]
108788269  myosin-1B-like [KO:K24220]
108801086  myosin-1B-like [KO:K24220]
108801087  myosin-3-like isoform X1 [KO:K24220]
108803329  myosin-4-like [KO:K24220]
108803769  myosin-1B-like [KO:K24220]
108797488  MYH7B; myosin-7B [KO:K24220]
108794737  myosin-6-like [KO:K24220]
108786749  MYH7; myosin-7 [KO:K17751]
108786757  myosin-6 [KO:K17751]
108789546  myosin-10-like isoform X1 [KO:K10352]
108793304  MYH11; myosin-11 isoform X1 [KO:K10352]
108793694  MYH9; myosin-9 [KO:K10352]
108795684  MYH10; myosin-10 [KO:K10352]
108794422  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
108802637  MYL4; myosin light chain 4 [KO:K12750]
108788538  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108796071  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
108787984  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108803796  LOW QUALITY PROTEIN: myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
108787155  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
108801482  myosin-binding protein C, fast-type-like [KO:K12558]
108792370  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
108791597  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
108787350  myosin-binding protein H-like [KO:K24494]
108800760  actin, alpha cardiac muscle 1 [KO:K12314]
108793897  actin, alpha cardiac muscle 1-like isoform X1 [KO:K12314]
108794424  actin, alpha cardiac muscle 1-like [KO:K12314]
108800042  actin, alpha cardiac muscle 2-like [KO:K12314]
108793959  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
108794414  troponin C, slow skeletal and cardiac muscles [KO:K05865]
108792788  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
108792019  troponin I, slow skeletal muscle-like [KO:K10371]
108796750  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
108793376  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
108791994  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
108791992  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
108794936  TNNI3; troponin I, cardiac muscle [KO:K12044]
108804863  TNNT2; troponin T, cardiac muscle [KO:K12045]
108784053  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
108798807  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
108786385  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
108791207  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
108792753  TCAP; telethonin [KO:K19879]
108792210  SYNPO2; synaptopodin-2 [KO:K24066]
108784726  NEB; LOW QUALITY PROTEIN: nebulin [KO:K18267]
108793430  NEBL; LOW QUALITY PROTEIN: nebulette [KO:K25865]
108794873  MYOZ1; myozenin-1 [KO:K26050]
108792212  MYOZ2; myozenin-2 [KO:K26050]
108786324  MYOZ3; myozenin-3 [KO:K26050]
108792822  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
108790925  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
108792896  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
108793502  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
108802057  F-actin-capping protein subunit alpha-2-like [KO:K10364]
108802147  F-actin-capping protein subunit alpha-2 [KO:K10364]
108802221  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
108784627  xin actin-binding repeat-containing protein 1-like [KO:K27381]
108785208  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
108793510  NRAP; LOW QUALITY PROTEIN: nebulin-related-anchoring protein [KO:K24421]
108795784  MYPN; myopalladin [KO:K22028]
108783765  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
108785436  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
108798212  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
108801768  TMOD4; tropomodulin-4 [KO:K10370]
108804353  tropomodulin-2-like [KO:K10370]
108804365  tropomodulin-3-like isoform X1 [KO:K10370]
108785909  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
108784897  ZYX; zyxin [KO:K06273]
108785884  FHL1; four and a half LIM domains protein 1 [KO:K14365]
108792354  FHL2; four and a half LIM domains protein 2 [KO:K14380]
108789556  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
108788029  LMOD2; leiomodin-2 [KO:K22030]
108787369  LMOD1; leiomodin-1 [KO:K22030]
108786176  LMOD3; leiomodin-3 [KO:K22030]
108792150  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
108790699  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
108784718  FMNL2; formin-like protein 2 [KO:K23957]
108785970  FMNL1; formin-like protein 1 [KO:K23957]
108796182  FMNL3; formin-like protein 3 [KO:K23957]
108786735  inverted formin-2-like [KO:K23958]
108796017  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
108792076  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
108798735  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
108804499  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
108799904  protein diaphanous homolog 3-like [KO:K05745]
108784560  MYOM1; myomesin-1 [KO:K24495]
108803074  MYOM2; myomesin-2 [KO:K24495]
108800221  MYOM3; myomesin-3 [KO:K24495]
108800605  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
108787852  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
108798234  ANK2; ankyrin-2 [KO:K09255]
108803969  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
108804064  tripartite motif-containing protein 54-like [KO:K10653]
108804087  tripartite motif-containing protein 54-like [KO:K10653]
108785176  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
108795722  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
108799546  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
108795707  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
108786202  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
108788795  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
108797818  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
108791975  PLEC; plectin isoform X1 [KO:K10388]
108792806  SYNE3; nesprin-3 [KO:K21761]
108790127  SYNE1; nesprin-1 [KO:K19326]
108786677  SYNE2; nesprin-2 [KO:K19346]
108802253  LOW QUALITY PROTEIN: SUN domain-containing protein 2-like [KO:K19347]
108799517  SUN1; SUN domain-containing protein 1 [KO:K19347]
108795913  TMEM43; transmembrane protein 43 isoform X1 [KO:K27488]
108790452  EMD; emerin [KO:K12569]
108787063  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
108799663  LMNA; lamin [KO:K12641]
108789622  LMNB2; lamin-B2 isoform X1 [KO:K07611]
108794080  LMNB1; lamin-B1 [KO:K07611]
108804804  lamin-L(III)-like isoform X1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
npr04512  ECM-receptor interaction
npr04814  Motor proteins
KO pathway
ko04820   
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