KEGG   PATHWAY: oaa04540
Entry
oaa04540                    Pathway                                
Name
Gap junction - Ornithorhynchus anatinus (platypus)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
oaa04540  Gap junction
oaa04540

Other DBs
GO: 0005921
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100076939  GJA1; gap junction alpha-1 protein [KO:K07372]
100093241  GJD2; gap junction delta-2 protein [KO:K07373]
100073496  gap junction delta-2 protein-like [KO:K07373]
100077696  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100075665  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100089995  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100077742  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100087843  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100085895  MAP2K5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
100088657  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100079742  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100075816  tubulin alpha-8 chain [KO:K07374]
100079918  TUBA1A; tubulin alpha-1A chain [KO:K07374]
114811984  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100088515  tubulin alpha-3 chain [KO:K07374]
100085942  tubulin alpha-4A chain [KO:K07374]
100077627  tubulin alpha-8 chain isoform X2 [KO:K07374]
100079040  tubulin beta-2A chain isoform X1 [KO:K07375]
100080473  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100086969  TUBB4A; tubulin beta-4A chain [KO:K07375]
100089091  TUBB6; tubulin beta-6 chain [KO:K07375]
100080031  TUBB3; tubulin beta-3 chain [KO:K07375]
100077354  TUBB4B; tubulin beta-4B chain [KO:K07375]
100079562  tubulin beta-2B chain [KO:K07375]
107546818  TUBB; tubulin beta chain [KO:K07375]
114805411  tubulin beta-2B chain [KO:K07375]
114805389  tubulin beta-2A chain isoform X2 [KO:K07375]
100088374  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
100077655  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100078517  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
100082919  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100093565  DRD1; D(1A) dopamine receptor [KO:K04144]
100080392  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100093143  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
103168601  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100089708  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100085901  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103168714  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
114811232  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100081118  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100076221  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100077908  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100080569  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100078846  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100088079  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100083607  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100077777  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100089114  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100075372  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100080549  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100084804  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
114808753  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
100080691  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100078508  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100084272  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100081349  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100086536  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100075749  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103164954  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100088770  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100077965  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100075186  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
100082922  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100079900  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100073431  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
100082499  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
oaa04010  MAPK signaling pathway
oaa04020  Calcium signaling pathway
oaa04060  Cytokine-cytokine receptor interaction
oaa04070  Phosphatidylinositol signaling system
oaa04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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