KEGG   PATHWAY: oaa04020
Entry
oaa04020                    Pathway                                
Name
Calcium signaling pathway - Ornithorhynchus anatinus (platypus)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
oaa04020  Calcium signaling pathway
oaa04020

Other DBs
GO: 0019722
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100092005  SLC8A2; LOW QUALITY PROTEIN: sodium/calcium exchanger 2 [KO:K05849]
100074200  SLC8A1; sodium/calcium exchanger 1 isoform X7 [KO:K05849]
100088707  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
100089144  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X2 [KO:K05850] [EC:7.2.2.10]
100078819  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100074008  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100074053  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100077867  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
100086064  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114815970  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04129]
100084007  CHRM3; muscarinic acetylcholine receptor M3 isoform X2 [KO:K04131]
103166702  ADORA2A; adenosine receptor A2a [KO:K04266]
100078270  ADORA2B; adenosine receptor A2b [KO:K04267]
100082919  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100086303  ADRB2; beta-2 adrenergic receptor [KO:K04142]
107547780  nucleoplasmin [KO:K04143]
100093565  DRD1; D(1A) dopamine receptor [KO:K04144]
100092962  DRD5; D(1B) dopamine receptor [KO:K05840]
114812185  D(1B) dopamine receptor-like [KO:K05840]
100084788  HRH2; histamine H2 receptor isoform X2 [KO:K04150]
100075879  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
114815978  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100085417  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100081612  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100080392  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100077658  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
103168601  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100089708  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100085901  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103168714  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100076221  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100077908  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100080569  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100078846  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100088079  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100093363  PLN; cardiac phospholamban [KO:K05852]
100077110  SLN; sarcolipin [KO:K22642]
100092580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100073740  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
100086258  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
103166796  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100073721  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
100083707  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
100079447  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100086419  ORAI2; protein orai-2 isoform X1 [KO:K16057]
100082960  ORAI3; protein orai-3 [KO:K16058]
100082618  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100077296  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100075939  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100093447  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100078981  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2 [KO:K04344]
100681261  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100081909  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100089403  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X8 [KO:K04854]
103165526  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100075872  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100087588  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100082705  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100074436  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100090612  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100681823  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100084653  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100080844  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
100092855  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100087194  P2RX1; P2X purinoceptor 1 [KO:K05215]
100080197  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
100086691  P2RX3; P2X purinoceptor 3 [KO:K05217]
100090378  P2RX4; P2X purinoceptor 4 [KO:K05218]
100077854  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
100084240  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
100090720  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100681936  RYR1; ryanodine receptor 1 [KO:K04961]
100084273  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
100089020  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
100074885  TRDN; triadin isoform X1 [KO:K23449]
114808165  CASQ1; calsequestrin-1 [KO:K23468]
100092801  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
100082566  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
100680980  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100083474  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
100075952  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100680572  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
100074819  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
103169047  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100077014  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100079418  EDNRA; endothelin-1 receptor [KO:K04197]
100084359  endothelin receptor type B-like [KO:K04198]
103170233  EDNRB; endothelin receptor type B [KO:K04198]
114813183  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
100075372  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100080549  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100083607  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100077777  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100089114  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100083183  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100074791  NTSR1; neurotensin receptor type 1 [KO:K04211]
100089486  OXTR; oxytocin receptor [KO:K04229]
100091927  AVPR1A; vasopressin V1a receptor [KO:K04226]
100080825  AVPR1B; vasopressin V1b receptor [KO:K04227]
100089784  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100077915  PTAFR; platelet-activating factor receptor [KO:K04279]
100086373  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
103165753  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100081185  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100081162  BDKRB1; B1 bradykinin receptor [KO:K03915]
100081132  BDKRB2; B2 bradykinin receptor [KO:K03916]
100082941  TACR1; substance-P receptor [KO:K04222]
100085449  TACR2; substance-K receptor [KO:K04223]
107547134  TACR3; neuromedin-K receptor [KO:K04224]
100090815  TBXA2R; thromboxane A2 receptor [KO:K04264]
100078234  thyrotropin-releasing hormone receptor-like [KO:K04282]
107547268  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
114813764  thyrotropin-releasing hormone receptor-like [KO:K04282]
107547241  CCKAR; cholecystokinin receptor type A [KO:K04194]
100088108  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
100079713  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100080691  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100084804  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
114808753  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
100088891  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100085240  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100074960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100090413  TGFA; protransforming growth factor alpha [KO:K08774]
100081033  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100085757  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100079757  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100078558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100078822  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100075228  FGF4; fibroblast growth factor 4 [KO:K04358]
100075300  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
100089319  FGF9; fibroblast growth factor 9 [KO:K04358]
100073730  FGF5; fibroblast growth factor 5 [KO:K04358]
100093377  FGF18; fibroblast growth factor 18 [KO:K04358]
100089414  FGF22; fibroblast growth factor 22 [KO:K04358]
100088500  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100089135  FGF20; fibroblast growth factor 20 [KO:K04358]
100080372  FGF8; fibroblast growth factor 8 [KO:K04358]
100075757  FGF10; fibroblast growth factor 10 [KO:K04358]
103165700  FGF6; fibroblast growth factor 6 [KO:K04358]
100084373  FGF16; fibroblast growth factor 16 [KO:K04358]
114813732  FGF7; fibroblast growth factor 7 [KO:K04358]
100075189  FGF19; fibroblast growth factor 19 [KO:K22603]
114807786  FGF23; fibroblast growth factor 23 [KO:K22428]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100082290  VEGFD; vascular endothelial growth factor D [KO:K05449]
100084886  VEGFC; vascular endothelial growth factor C [KO:K05449]
100074403  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100091473  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100081598  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100091139  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100079793  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100077353  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100084432  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100079459  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100084641  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100084071  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100081967  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100090501  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100090796  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100087557  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
103167743  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100080080  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100078146  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100077130  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
100076319  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103166634  Ig heavy chain Mem5 [KO:K06856]
100083809  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
103168316  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
103169159  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
100078508  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100084272  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100081349  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100086536  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103169567  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103167538  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
100075749  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103164954  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100088770  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100074315  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100090887  TPCN1; LOW QUALITY PROTEIN: two pore calcium channel protein 1 [KO:K16896]
100074753  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
100092020  MCOLN1; mucolipin-1 [KO:K04992]
100079299  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
100092028  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
100076678  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100077394  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100079428  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100075011  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100076584  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100080434  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100087351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
114812883  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100073904  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100074254  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
114806035  TNNC2; troponin C, skeletal muscle [KO:K12042]
100075369  CALM1; calmodulin-1 [KO:K02183]
100083509  CALM2; calmodulin-2 [KO:K02183]
100085837  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103165382  calmodulin-A-like [KO:K02183]
114812128  CALM3; calmodulin-3 [KO:K02183]
114816270  CALML3; calmodulin-like protein 3 [KO:K02183]
100088260  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
100093441  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100092559  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100075998  PHKB; phosphorylase b kinase regulatory subunit beta isoform X3 [KO:K07190]
100083592  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100092442  MYLK3; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100091283  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100079091  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100075278  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
100078245  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100085379  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100089453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100079279  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100074083  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100089905  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100082421  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100076517  calcium/calmodulin-dependent protein kinase type IV-like isoform X1 [KO:K05869] [EC:2.7.11.17]
100087467  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083890  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100073776  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100083665  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
100088254  TFEB; transcription factor EB [KO:K15590]
100078396  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100077893  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100073470  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114815911  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100093259  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100075386  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100091599  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100085441  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
100086657  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100091748  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
100085161  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100082453  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100086923  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100092615  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
oaa04010  MAPK signaling pathway
oaa04070  Phosphatidylinositol signaling system
oaa04210  Apoptosis
oaa04720  Long-term potentiation
oaa04730  Long-term depression
KO pathway
ko04020   
LinkDB

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