KEGG   PATHWAY: oas05171
Entry
oas05171                    Pathway                                
Name
Coronavirus disease - COVID-19 - Ovis aries (sheep)
Description
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by  interleukin-6 (IL-6) production. SARS-CoV-2 also activates the innate immune system; macrophage stimulation triggers the overproduction of pro-inflammatory cytokines, including IL-6, and the "cytokine storm", which results in systemic inflammatory response syndrome and multiple organ failure. The combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19.
Class
Human Diseases; Infectious disease: viral
Pathway map
oas05171  Coronavirus disease - COVID-19
oas05171

Organism
Ovis aries (sheep) [GN:oas]
Gene
101120216  TMPRSS2; transmembrane protease serine 2 isoform X2 [KO:K09633] [EC:3.4.21.122]
101103622  ACE2; angiotensin-converting enzyme 2 isoform X2 [KO:K09708] [EC:3.4.17.23]
101123225  NRP1; neuropilin-1 isoform X1 [KO:K06724]
554335  ACE; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
105613829  angiotensin-converting enzyme-like protein Ace3 isoform X1 [KO:K01283] [EC:3.4.15.1]
101112233  MAS1; proto-oncogene Mas [KO:K04303]
443107  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100036757  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101108228  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101102191  RELA; transcription factor p65 [KO:K04735]
443540  TNF; tumor necrosis factor [KO:K03156]
443406  IL6; interleukin-6 precursor [KO:K05405]
443539  IL1B; interleukin-1 beta precursor [KO:K04519]
443064  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
443472  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
101118895  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101120355  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101120093  C-C motif chemokine 2 [KO:K14624]
443418  CXCL8; interleukin-8 precursor [KO:K10030]
101116815  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
100135698  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
780520  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101113618  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
101118185  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
780479  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101103369  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
101113174  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101110716  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101117248  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100294659  STAT3; signal transducer and activator of transcription 3 isoform X10 [KO:K04692]
443401  IL2; interleukin-2 precursor [KO:K05429]
443523  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
443400  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
442997  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
101109132  LOW QUALITY PROTEIN: small ribosomal subunit protein uS5 [KO:K02981]
780524  RPS2; small ribosomal subunit protein uS5 isoform X1 [KO:K02981]
101109646  small ribosomal subunit protein uS5-like [KO:K02981]
101121379  small ribosomal subunit protein uS5-like [KO:K02981]
101108684  RPS3; small ribosomal subunit protein uS3 [KO:K02985]
101106110  RPS3A; small ribosomal subunit protein eS1 [KO:K02984]
101102285  small ribosomal subunit protein eS1-like [KO:K02984]
101108561  small ribosomal subunit protein eS1-like [KO:K02984]
101116252  small ribosomal subunit protein eS1-like [KO:K02984]
106990950  small ribosomal subunit protein eS1-like [KO:K02984]
114113024  small ribosomal subunit protein eS1-like [KO:K02984]
101117053  small ribosomal subunit protein eS4, X isoform-like [KO:K02987]
101109246  RPS4X; small ribosomal subunit protein eS4, X isoform [KO:K02987]
101121718  small ribosomal subunit protein eS4, X isoform [KO:K02987]
101122834  small ribosomal subunit protein eS4, X isoform-like [KO:K02987]
101102787  small ribosomal subunit protein eS4, X isoform-like [KO:K02987]
101111994  RPS5; small ribosomal subunit protein uS7 [KO:K02989]
100037665  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
106991797  small ribosomal subunit protein eS6-like [KO:K02991]
101105666  small ribosomal subunit protein eS6-like [KO:K02991]
101116863  small ribosomal subunit protein eS6-like [KO:K02991]
105602663  small ribosomal subunit protein eS6-like [KO:K02991]
114116599  small ribosomal subunit protein eS6-like [KO:K02991]
114118688  small ribosomal subunit protein eS6-like [KO:K02991]
121819715  small ribosomal subunit protein eS6-like [KO:K02991]
101114496  RPS7; small ribosomal subunit protein eS7 [KO:K02993]
101106223  small ribosomal subunit protein eS7-like [KO:K02993]
101117800  RPS8; small ribosomal subunit protein eS8 [KO:K02995]
101102330  RPS9; small ribosomal subunit protein uS4 [KO:K02997]
101115487  RPS10; small ribosomal subunit protein eS10 isoform X2 [KO:K02947]
101113072  small ribosomal subunit protein eS10-like [KO:K02947]
100037666  RPS11; small ribosomal subunit protein uS17 [KO:K02949]
100037667  RPS12; small ribosomal subunit protein eS12 [KO:K02951]
106990434  small ribosomal subunit protein eS12 [KO:K02951]
101115399  RPS13; small ribosomal subunit protein uS15 [KO:K02953]
101112774  small ribosomal subunit protein uS15-like [KO:K02953]
101112973  small ribosomal subunit protein uS15-like [KO:K02953]
105606498  small ribosomal subunit protein uS15-like [KO:K02953]
101120300  LOW QUALITY PROTEIN: small ribosomal subunit protein uS15-like [KO:K02953]
101102145  RPS14; small ribosomal subunit protein uS11 isoform X1 [KO:K02955]
105603688  small ribosomal subunit protein uS11-like [KO:K02955]
541599  RPS15; small ribosomal subunit protein uS19 [KO:K02958]
101105635  uncharacterized protein LOC101105635 [KO:K02958]
101109655  small ribosomal subunit protein uS19-like [KO:K02958]
101112339  small ribosomal subunit protein uS8 [KO:K02957]
101117120  LOW QUALITY PROTEIN: small ribosomal subunit protein uS8 [KO:K02957]
101115173  RPS15A; small ribosomal subunit protein uS8 [KO:K02957]
101116302  small ribosomal subunit protein uS8 [KO:K02957]
100037668  small ribosomal subunit protein uS8 [KO:K02957]
114112986  small ribosomal subunit protein uS8 [KO:K02957]
101107776  small ribosomal subunit protein uS8-like [KO:K02957]
101108400  small ribosomal subunit protein uS8-like [KO:K02957]
101109556  small ribosomal subunit protein uS8-like [KO:K02957]
101109575  small ribosomal subunit protein uS8-like [KO:K02957]
101112592  small ribosomal subunit protein uS8-like [KO:K02957]
105613234  small ribosomal subunit protein uS8-like [KO:K02957]
105615745  small ribosomal subunit protein uS8-like [KO:K02957]
114116976  small ribosomal subunit protein uS8-like [KO:K02957]
101116931  RPS16; small ribosomal subunit protein uS9 [KO:K02960]
101109830  RPS17; small ribosomal subunit protein eS17 [KO:K02962]
114110784  small ribosomal subunit protein eS17-like [KO:K02962]
114114478  small ribosomal subunit protein eS17-like [KO:K02962]
100036761  RPS18; small ribosomal subunit protein uS13 [KO:K02964]
101106101  RPS19; small ribosomal subunit protein eS19 isoform X1 [KO:K02966]
101107920  small ribosomal subunit protein eS19-like [KO:K02966]
100135683  RPS20; small ribosomal subunit protein uS10 [KO:K02969]
105604852  small ribosomal subunit protein uS10-like [KO:K02969]
101112152  RPS21; small ribosomal subunit protein eS21 [KO:K02971]
101123208  RPS23; small ribosomal subunit protein uS12 [KO:K02973]
114113983  LOW QUALITY PROTEIN: small ribosomal subunit protein uS12 [KO:K02973]
101107331  small ribosomal subunit protein uS12-like [KO:K02973]
101104961  RPS24; small ribosomal subunit protein eS24 isoform X2 [KO:K02974]
101112316  small ribosomal subunit protein eS24-like [KO:K02974]
101106881  small ribosomal subunit protein eS24-like [KO:K02974]
101109850  small ribosomal subunit protein eS24-like [KO:K02974]
114111301  small ribosomal subunit protein eS24-like [KO:K02974]
121816498  small ribosomal subunit protein eS24-like [KO:K02974]
443521  RPS25; 40S ribosomal protein S25 [KO:K02975]
101110758  small ribosomal subunit protein eS25 [KO:K02975]
114110611  small ribosomal subunit protein eS25 [KO:K02975]
114117259  small ribosomal subunit protein eS25 [KO:K02975]
114118459  small ribosomal subunit protein eS25 [KO:K02975]
114114914  small ribosomal subunit protein eS25-like [KO:K02975]
114116453  small ribosomal subunit protein eS25-like [KO:K02975]
443468  RPS26; 40S ribosomal protein S26 [KO:K02976]
105607745  small ribosomal subunit protein eS26-like [KO:K02976]
105613145  small ribosomal subunit protein eS26-like [KO:K02976]
105609307  small ribosomal subunit protein eS26-like [KO:K02976]
101116885  small ribosomal subunit protein eS26-like [KO:K02976]
114110653  small ribosomal subunit protein eS26-like [KO:K02976]
121815980  small ribosomal subunit protein eS26 [KO:K02976]
105613572  small ribosomal subunit protein eS27-like [KO:K02978]
101119090  small ribosomal subunit protein eS27-like [KO:K02978]
101108004  RPS27; small ribosomal subunit protein eS27 isoform X2 [KO:K02978]
101120721  small ribosomal subunit protein eS27-like [KO:K02978]
101110035  small ribosomal subunit protein eS27-like [KO:K02978]
101112227  RPS27L; ribosomal protein eS27-like [KO:K02978]
101112481  small ribosomal subunit protein eS27-like [KO:K02978]
105603504  small ribosomal subunit protein eS27-like [KO:K02978]
105605666  small ribosomal subunit protein eS27-like [KO:K02978]
114114908  small ribosomal subunit protein eS27 [KO:K02978]
443297  ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
100135694  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
105614945  ubiquitin-like [KO:K02977]
101112274  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
101122127  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
114109129  small ribosomal subunit protein eS28-like [KO:K02979]
114110985  small ribosomal subunit protein eS28-like [KO:K02979]
101121859  RPS29; small ribosomal subunit protein uS14 isoform X2 [KO:K02980]
114114794  small ribosomal subunit protein uS14-like [KO:K02980]
114117795  small ribosomal subunit protein uS14-like [KO:K02980]
114118103  small ribosomal subunit protein uS14 [KO:K02980]
114109006  small ribosomal subunit protein uS14-like [KO:K02980]
114115340  small ribosomal subunit protein uS14-like [KO:K02980]
114116467  small ribosomal subunit protein uS14-like [KO:K02980]
101106472  FAU; ubiquitin-like FUBI-ribosomal protein eS30 fusion protein isoform X2 [KO:K02983]
101104797  ubiquitin-like protein FUBI [KO:K02983]
114114864  ubiquitin-like protein FUBI [KO:K02983]
100125628  RPSA; small ribosomal subunit protein uS2 [KO:K02998]
101102096  LOW QUALITY PROTEIN: small ribosomal subunit protein uS2 [KO:K02998]
114110433  small ribosomal subunit protein uS2-like [KO:K02998]
101112108  RPL3L; ribosomal protein uL3-like isoform X2 [KO:K02925]
101106836  RPL3; large ribosomal subunit protein uL3 [KO:K02925]
105606693  LOW QUALITY PROTEIN: large ribosomal subunit protein uL4 [KO:K02930]
780462  RPL4; large ribosomal subunit protein uL4 [KO:K02930]
114114491  large ribosomal subunit protein uL4-like [KO:K02930]
101104192  RPL5; large ribosomal subunit protein uL18 [KO:K02932]
101104787  large ribosomal subunit protein uL18 [KO:K02932]
101118481  large ribosomal subunit protein uL18 [KO:K02932]
101103964  large ribosomal subunit protein uL18-like [KO:K02932]
101113750  large ribosomal subunit protein uL18-like [KO:K02932]
101116922  large ribosomal subunit protein uL18-like [KO:K02932]
106991582  large ribosomal subunit protein uL18-like [KO:K02932]
114109112  large ribosomal subunit protein uL18-like [KO:K02932]
101102541  large ribosomal subunit protein eL6 [KO:K02934]
100135440  RPL6; large ribosomal subunit protein eL6 [KO:K02934]
101109212  large ribosomal subunit protein eL6 [KO:K02934]
114116368  large ribosomal subunit protein eL6 [KO:K02934]
101102687  large ribosomal subunit protein eL6-like [KO:K02934]
101106344  large ribosomal subunit protein eL6-like [KO:K02934]
101107072  large ribosomal subunit protein eL6-like [KO:K02934]
106991885  large ribosomal subunit protein eL6-like [KO:K02934]
114118401  large ribosomal subunit protein eL6-like [KO:K02934]
101106854  RPL7; large ribosomal subunit protein uL30 [KO:K02937]
101106362  large ribosomal subunit protein uL30-like [KO:K02937]
101110112  large ribosomal subunit protein uL30-like [KO:K02937]
101112892  large ribosomal subunit protein uL30-like [KO:K02937]
101117979  large ribosomal subunit protein uL30-like [KO:K02937]
105609749  large ribosomal subunit protein uL30-like [KO:K02937]
105610637  large ribosomal subunit protein uL30-like [KO:K02937]
121819493  large ribosomal subunit protein uL30 [KO:K02937]
101110647  LOW QUALITY PROTEIN: large ribosomal subunit protein uL30 [KO:K02937]
101110132  RPL7A; large ribosomal subunit protein eL8 [KO:K02936]
101112474  large ribosomal subunit protein eL8-like [KO:K02936]
101116334  large ribosomal subunit protein eL8-like [KO:K02936]
101111556  RPL8; large ribosomal subunit protein uL2 [KO:K02938]
101105336  large ribosomal subunit protein uL6 [KO:K02940]
101120489  large ribosomal subunit protein uL6 [KO:K02940]
101107098  large ribosomal subunit protein uL6 [KO:K02940]
101113592  RPL9; large ribosomal subunit protein uL6 [KO:K02940]
114116830  large ribosomal subunit protein uL6 [KO:K02940]
101110567  large ribosomal subunit protein uL6-like [KO:K02940]
101118374  large ribosomal subunit protein uL6-like [KO:K02940]
114117927  large ribosomal subunit protein uL6-like [KO:K02940]
121817852  large ribosomal subunit protein uL6-like [KO:K02940]
105601845  large ribosomal subunit protein uL16-like [KO:K02866]
106991444  large ribosomal subunit protein uL16-like [KO:K02866]
101110719  large ribosomal subunit protein uL16-like [KO:K02866]
100127215  RPL10; 60S ribosomal protein L10 [KO:K02866]
101120838  RPL10L; ribosomal protein uL16-like isoform X1 [KO:K02866]
101114528  large ribosomal subunit protein uL16-like isoform X1 [KO:K02866]
101118727  large ribosomal subunit protein uL16-like [KO:K02866]
114108601  large ribosomal subunit protein uL16-like [KO:K02866]
121817095  large ribosomal subunit protein uL16-like [KO:K02866]
101106166  LOW QUALITY PROTEIN: large ribosomal subunit protein uL1 [KO:K02865]
106990094  RPL10A; large ribosomal subunit protein uL1 isoform X1 [KO:K02865]
101117539  large ribosomal subunit protein uL1-like [KO:K02865]
101120019  large ribosomal subunit protein uL1-like [KO:K02865]
101120737  large ribosomal subunit protein uL1-like [KO:K02865]
105605079  large ribosomal subunit protein uL1-like [KO:K02865]
114114996  large ribosomal subunit protein uL1-like [KO:K02865]
101107597  large ribosomal subunit protein uL1 [KO:K02865]
101120638  RPL11; large ribosomal subunit protein uL5 [KO:K02868]
101111087  RPL12; large ribosomal subunit protein uL11 isoform X2 [KO:K02870]
105608827  LOW QUALITY PROTEIN: superkiller complex protein 8 [KO:K02870]
105611038  large ribosomal subunit protein uL11-like [KO:K02870]
101113344  large ribosomal subunit protein eL13 [KO:K02873]
443072  RPL13; large ribosomal subunit protein eL13 [KO:K02873]
105607128  large ribosomal subunit protein eL13-like [KO:K02873]
101109545  large ribosomal subunit protein uL13 [KO:K02872]
100036760  RPL13A; large ribosomal subunit protein uL13 isoform X2 [KO:K02872]
100135452  RPL14; large ribosomal subunit protein eL14 [KO:K02875]
121816084  LOW QUALITY PROTEIN: large ribosomal subunit protein eL14-like [KO:K02875]
101103783  RPL15; large ribosomal subunit protein eL15 [KO:K02877]
101109701  large ribosomal subunit protein eL15 [KO:K02877]
101114033  large ribosomal subunit protein uL22 [KO:K02880]
101115926  C23H18orf32; UPF0729 protein C18orf32 homolog isoform X1 [KO:K02880]
106991069  LOW QUALITY PROTEIN: large ribosomal subunit protein uL22 [KO:K02880]
106990881  large ribosomal subunit protein uL22 [KO:K02880]
101109676  large ribosomal subunit protein uL22 [KO:K02880]
106991327  LOW QUALITY PROTEIN: large ribosomal subunit protein uL22 [KO:K02880]
101110649  large ribosomal subunit protein uL22 [KO:K02880]
105610137  large ribosomal subunit protein uL22 [KO:K02880]
105610402  large ribosomal subunit protein uL22 [KO:K02880]
105606943  large ribosomal subunit protein uL22 [KO:K02880]
114108766  large ribosomal subunit protein uL22 [KO:K02880]
101104815  large ribosomal subunit protein uL22-like [KO:K02880]
101114013  large ribosomal subunit protein uL22-like [KO:K02880]
101118825  large ribosomal subunit protein uL22-like [KO:K02880]
101120269  large ribosomal subunit protein uL22-like [KO:K02880]
101123128  large ribosomal subunit protein uL22-like [KO:K02880]
106991051  large ribosomal subunit protein uL22-like [KO:K02880]
114110661  large ribosomal subunit protein uL22-like [KO:K02880]
114110970  large ribosomal subunit protein uL22-like [KO:K02880]
114115421  large ribosomal subunit protein uL22-like [KO:K02880]
114116720  large ribosomal subunit protein uL22-like [KO:K02880]
121818306  large ribosomal subunit protein uL22 [KO:K02880]
101112058  large ribosomal subunit protein uL22-like [KO:K02880]
101122808  RPL18; large ribosomal subunit protein eL18 [KO:K02883]
101112566  RPL18A; large ribosomal subunit protein eL20 [KO:K02882]
100270789  RPL19; large ribosomal subunit protein eL19 isoform X1 [KO:K02885]
114108769  large ribosomal subunit protein eL19-like [KO:K02885]
101115288  RPL21; large ribosomal subunit protein eL21 [KO:K02889]
105616394  large ribosomal subunit protein eL21-like [KO:K02889]
101119878  large ribosomal subunit protein eL21-like [KO:K02889]
101116638  large ribosomal subunit protein eL21-like [KO:K02889]
101103401  large ribosomal subunit protein eL21-like [KO:K02889]
101102357  large ribosomal subunit protein eL21-like [KO:K02889]
101117395  large ribosomal subunit protein eL21 [KO:K02889]
114115304  large ribosomal subunit protein eL21-like [KO:K02889]
106991020  large ribosomal subunit protein eL21-like [KO:K02889]
101122293  RPL22; large ribosomal subunit protein eL22 [KO:K02891]
106991603  ribosomal protein eL22-like [KO:K02891]
101117207  RPL22L1; ribosomal protein eL22-like [KO:K02891]
106991728  ribosomal protein eL22-like [KO:K02891]
114117294  ribosomal protein eL22-like [KO:K02891]
101121710  ribosomal protein eL22-like [KO:K02891]
114117016  large ribosomal subunit protein eL22-like [KO:K02891]
101121360  RPL23; large ribosomal subunit protein uL14 [KO:K02894]
101103150  large ribosomal subunit protein uL14-like [KO:K02894]
114112955  large ribosomal subunit protein uL14-like [KO:K02894]
105614819  large ribosomal subunit protein uL14-like [KO:K02894]
100415774  RPL23A; large ribosomal subunit protein uL23 [KO:K02893]
106991767  large ribosomal subunit protein uL23 [KO:K02893]
101123112  large ribosomal subunit protein uL23 [KO:K02893]
101114092  large ribosomal subunit protein uL23-like [KO:K02893]
101114879  large ribosomal subunit protein uL23-like [KO:K02893]
101115106  large ribosomal subunit protein uL23-like [KO:K02893]
101122224  large ribosomal subunit protein uL23-like [KO:K02893]
121817232  large ribosomal subunit protein uL23-like [KO:K02893]
121818183  large ribosomal subunit protein uL23 [KO:K02893]
101112181  RPL24; large ribosomal subunit protein eL24 [KO:K02896]
101123214  RSL24D1; probable ribosome biogenesis protein RLP24 [KO:K02896]
101108162  RPL26L1; ribosomal protein uL24-like [KO:K02898]
101104237  large ribosomal subunit protein uL24-like [KO:K02898]
101113347  RPL27; large ribosomal subunit protein eL27 [KO:K02901]
101102690  large ribosomal subunit protein eL27 [KO:K02901]
121820186  large ribosomal subunit protein eL27-like [KO:K02901]
101123279  RPL27A; large ribosomal subunit protein uL15 [KO:K02900]
101120598  RPL28; large ribosomal subunit protein eL28 [KO:K02903]
101113539  RPL29; large ribosomal subunit protein eL29 [KO:K02905]
106990098  RPL30; large ribosomal subunit protein eL30 [KO:K02908]
101106855  large ribosomal subunit protein eL30 [KO:K02908]
101103352  large ribosomal subunit protein eL30-like [KO:K02908]
101110546  large ribosomal subunit protein eL30 [KO:K02908]
114112992  large ribosomal subunit protein eL30-like [KO:K02908]
114112563  large ribosomal subunit protein eL30-like [KO:K02908]
101104219  RPL31; large ribosomal subunit protein eL31 [KO:K02910]
114111689  large ribosomal subunit protein eL31-like [KO:K02910]
114115362  large ribosomal subunit protein eL31-like [KO:K02910]
443070  RPL32; large ribosomal subunit protein eL32 [KO:K02912]
780467  RPL34; large ribosomal subunit protein eL34 [KO:K02915]
101103412  large ribosomal subunit protein eL34-like [KO:K02915]
101113502  large ribosomal subunit protein eL34-like [KO:K02915]
114108994  large ribosomal subunit protein eL34-like [KO:K02915]
101112126  RPL35; large ribosomal subunit protein uL29 [KO:K02918]
114114915  large ribosomal subunit protein uL29-like [KO:K02918]
100037664  large ribosomal subunit protein eL33 [KO:K02917]
106990090  RPL35A; large ribosomal subunit protein eL33 isoform X6 [KO:K02917]
101102537  large ribosomal subunit protein eL33-like [KO:K02917]
101107369  large ribosomal subunit protein eL33-like [KO:K02917]
101112471  large ribosomal subunit protein eL33-like [KO:K02917]
101112702  large ribosomal subunit protein eL33-like [KO:K02917]
101114892  large ribosomal subunit protein eL33-like [KO:K02917]
101115593  large ribosomal subunit protein eL33-like [KO:K02917]
101103002  large ribosomal subunit protein eL33-like [KO:K02917]
101103232  large ribosomal subunit protein eL36 [KO:K02920]
101109011  RPL36; large ribosomal subunit protein eL36 [KO:K02920]
105605472  large ribosomal subunit protein eL36-like [KO:K02920]
101103841  RPL37; large ribosomal subunit protein eL37 [KO:K02922]
114115299  large ribosomal subunit protein eL37-like [KO:K02922]
114115333  LOW QUALITY PROTEIN: large ribosomal subunit protein eL37-like [KO:K02922]
101123533  large ribosomal subunit protein eL43 [KO:K02921]
101121371  large ribosomal subunit protein eL43 [KO:K02921]
114117284  large ribosomal subunit protein eL43-like [KO:K02921]
101109155  RPL37A; large ribosomal subunit protein eL43 [KO:K02921]
114109518  large ribosomal subunit protein eL43 [KO:K02921]
101106700  RPL38; large ribosomal subunit protein eL38 [KO:K02923]
105606567  large ribosomal subunit protein eL39 [KO:K02924]
106990819  large ribosomal subunit protein eL39-like [KO:K02924]
114113931  large ribosomal subunit protein eL39-like [KO:K02924]
121818182  RPL39; large ribosomal subunit protein eL39 [KO:K02924]
443296  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
101110438  ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
101105982  RPL36A; large ribosomal subunit protein eL42 [KO:K02929]
105609873  large ribosomal subunit protein eL42-like [KO:K02929]
101117063  large ribosomal subunit protein eL42-like [KO:K02929]
101122112  RPL36AL; ribosomal protein eL42-like [KO:K02929]
101122812  large ribosomal subunit protein eL42-like [KO:K02929]
114112903  large ribosomal subunit protein eL42-like [KO:K02929]
100036764  RPLP0; large ribosomal subunit protein uL10 [KO:K02941]
101106848  RPLP1; large ribosomal subunit protein P1 isoform X1 [KO:K02942]
114117842  large ribosomal subunit protein P1-like [KO:K02942]
101102122  large ribosomal subunit protein P1-like [KO:K02942]
106991226  large ribosomal subunit protein P1-like [KO:K02942]
114111014  large ribosomal subunit protein P1-like [KO:K02942]
101122828  large ribosomal subunit protein P2-like [KO:K02943]
101103196  RPLP2; large ribosomal subunit protein P2 [KO:K02943]
101113211  Ig mu chain C region membrane-bound form [KO:K06856]
101106730  low affinity immunoglobulin gamma Fc region receptor II-like isoform X3 [KO:K06472]
101105303  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101103341  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101122126  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101110074  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101118410  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101116423  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100194428  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100217411  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101116223  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
101115956  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
554262  TLR2; toll-like receptor 2 precursor [KO:K10159]
554263  TLR4; toll-like receptor 4 precursor [KO:K10160]
678682  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
554254  TLR7; toll-like receptor 7 precursor [KO:K05404]
554259  TLR8; toll-like receptor 8 precursor [KO:K10170]
100216438  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101121405  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
101107132  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
101108056  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X4 [KO:K04427] [EC:2.7.11.25]
114118284  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
101122114  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
443218  FOS; protein c-Fos [KO:K04379]
443219  JUN; transcription factor Jun [KO:K04448]
101111143  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
780484  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101107332  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
101107699  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101117013  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
554258  TLR3; toll-like receptor 3 precursor [KO:K05401]
101107257  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
443057  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
101106234  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101119838  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100036758  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101116923  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101110830  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
780485  IRF3; interferon regulatory factor 3 [KO:K05411]
114116050  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
101116050  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
101111435  interferon alpha-H-like [KO:K05414]
105601948  interferon alpha-H-like [KO:K05414]
492823  IFN1; interferon alpha-1 [KO:K05414]
101102963  interferon alpha-H-like [KO:K05414]
101105135  interferon alpha-H [KO:K05414]
101103872  interferon alpha-2-like [KO:K05414]
114113084  interferon alpha-14-like [KO:K05414]
114113089  interferon alpha-2-like [KO:K05414]
114113090  interferon alpha-H-like [KO:K05414]
114112827  interferon alpha-3-like [KO:K05414]
101105632  interferon alpha-H-like [KO:K05414]
121818512  interferon alpha-2-like [KO:K05414]
101103702  interferon beta-2-like [KO:K05415]
101103376  interferon beta-2-like [KO:K05415]
101103623  interferon beta-2 [KO:K05415]
114113004  interferon beta-2-like [KO:K05415]
114113016  interferon beta-2-like [KO:K05415]
114113206  interferon beta-2-like [KO:K05415]
114112819  interferon beta-2-like [KO:K05415]
114112835  interferon beta-2-like [KO:K05415]
114112840  interferon beta-2-like [KO:K05415]
114112883  interferon beta-2 [KO:K05415]
114112830  interferon beta-2-like [KO:K05415]
121818657  interferon beta-2-like [KO:K05415]
443126  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
443363  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
100307049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101108211  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101116656  IRF9; interferon regulatory factor 9 isoform X3 [KO:K04693]
105602911  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
101109915  2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
101112122  2'-5'-oligoadenylate synthase 3-like isoform X2 [KO:K14216] [EC:2.7.7.84]
443146  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
780441  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
101121673  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101118296  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
101104226  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
101108131  C3; complement C3 [KO:K03990]
114114921  complement C3-like isoform X1 [KO:K03990]
101115072  CFB; complement factor B isoform X2 [KO:K01335] [EC:3.4.21.47]
101115705  CFD; complement factor D [KO:K01334] [EC:3.4.21.46]
101121825  C5; complement C5 [KO:K03994]
101102674  C6; complement component C6 [KO:K03995]
101102931  C7; complement component C7 [KO:K03996]
101102273  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
101102522  C8B; complement component C8 beta chain [KO:K03998]
114113848  C8G; complement component C8 gamma chain [KO:K03999]
101105026  C9; complement component C9 [KO:K04000]
443305  SELP; P-selectin precursor [KO:K06496]
101110931  VWF; von Willebrand factor [KO:K03900]
101102126  C1QA; complement C1q subcomponent subunit A isoform X1 [KO:K03986]
121818782  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101123189  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
101107430  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
101107688  C1S; complement C1s subcomponent [KO:K01331] [EC:3.4.21.42]
101115321  C2; complement C2 isoform X3 [KO:K01332] [EC:3.4.21.43]
101112891  complement C4-like isoform X1 [KO:K03989]
101123672  complement C4 isoform X1 [KO:K03989]
101123419  LOW QUALITY PROTEIN: complement C4-A [KO:K03989]
101107498  MBLA; LOW QUALITY PROTEIN: mannose-binding protein A [KO:K03991]
101116362  MBL2; mannose-binding protein C [KO:K03991]
101111065  MASP1; mannan-binding lectin serine protease 1 isoform X1 [KO:K03992] [EC:3.4.21.-]
100307041  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
101108612  F13A1; coagulation factor XIII A chain [KO:K03917] [EC:2.3.2.13]
101122712  F13B; coagulation factor XIII B chain isoform X4 [KO:K03906]
101102090  FGA; fibrinogen alpha chain [KO:K03903]
101102336  FGB; fibrinogen beta chain [KO:K03904]
101123664  FGG; fibrinogen gamma chain isoform X2 [KO:K03905]
Compound
C00027  Hydrogen peroxide
C00046  RNA
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00704  Superoxide
C00873  Angiotensin I
C02135  Angiotensin II
C15850  Angiotensin (1-7)
C20640  Cyclic GMP-AMP
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Trends Immunol S1471-4906(20)30233-7 (2020)
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PMID:33077917
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COVID-19 cytokine storm: The anger of inflammation.
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Complement as a target in COVID-19?
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COVID-19: the vasculature unleashed.
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Tackling COVID-19 infection through complement-targeted immunotherapy.
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COVID-19: A collision of complement, coagulation and inflammatory pathways.
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J Thromb Haemost 18:2110-2117 (2020)
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The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
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SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
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PMID:32405269
  Authors
Omarjee L, Janin A, Perrot F, Laviolle B, Meilhac O, Mahe G
  Title
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
  Journal
Clin Immunol 216:108464 (2020)
DOI:10.1016/j.clim.2020.108464
Reference
PMID:32337664
  Authors
Zhang S, Li L, Shen A, Chen Y, Qi Z
  Title
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia.
  Journal
Clin Drug Investig 40:511-518 (2020)
DOI:10.1007/s40261-020-00917-3
Related
pathway
oas03015  mRNA surveillance pathway
oas04144  Endocytosis
oas04270  Vascular smooth muscle contraction
oas04610  Complement and coagulation cascades
oas04611  Platelet activation
oas04613  Neutrophil extracellular trap formation
oas04614  Renin-angiotensin system
oas04620  Toll-like receptor signaling pathway
oas04621  NOD-like receptor signaling pathway
oas04622  RIG-I-like receptor signaling pathway
oas04623  Cytosolic DNA-sensing pathway
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04666  Fc gamma R-mediated phagocytosis
oas04668  TNF signaling pathway
oas04670  Leukocyte transendothelial migration
KO pathway
ko05171   
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