KEGG   PATHWAY: oki04270
Entry
oki04270                    Pathway                                
Name
Vascular smooth muscle contraction - Oncorhynchus kisutch (coho salmon)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
oki04270  Vascular smooth muscle contraction
oki04270

Other DBs
GO: 0014829
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109868578  alpha-1A adrenergic receptor-like [KO:K04135]
109871907  alpha-1A adrenergic receptor-like [KO:K04135]
109873616  alpha-1A adrenergic receptor-like [KO:K04135]
109895108  alpha-1A adrenergic receptor-like [KO:K04135]
109892185  alpha-1A adrenergic receptor [KO:K04136]
109864813  alpha-1A adrenergic receptor isoform X1 [KO:K04136]
109880662  alpha-1A adrenergic receptor [KO:K04136]
109873385  alpha-1A adrenergic receptor-like [KO:K04136]
109901067  alpha-1D adrenergic receptor [KO:K04137]
109894190  alpha-1D adrenergic receptor-like [KO:K04137]
109870483  agt; angiotensinogen [KO:K09821]
109877912  type-1 angiotensin II receptor-like [KO:K04166]
109908507  endothelin-1-like [KO:K16366]
109904673  endothelin-1 [KO:K16366]
109901628  endothelin-2-like [KO:K16367]
109902273  endothelin-2-like [KO:K16367]
109866202  endothelin-1-like [KO:K16367]
109903509  endothelin-2 [KO:K16367]
109908631  endothelin-2-like [KO:K16367]
116374128  uncharacterized protein LOC116374128 [KO:K05227]
109885651  ednra; endothelin-1 receptor [KO:K04197]
109881007  endothelin receptor type B-like [KO:K04197]
109901296  endothelin receptor type B [KO:K04197]
109867984  vasotocin-neurophysin VT 1 [KO:K05242]
109872415  vasotocin-neurophysin VT 2 [KO:K05242]
109874079  vasotocin-neurophysin VT 1 [KO:K05242]
109896402  arg8-vasotocin receptor [KO:K04226]
109897463  arg8-vasotocin receptor [KO:K04226]
109864696  arg8-vasotocin receptor-like [KO:K04226]
109867512  arg8-vasotocin receptor-like [KO:K04226]
109868066  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
109876572  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
109892404  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
109902532  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04634]
109895676  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
109897876  guanine nucleotide-binding protein subunit alpha-11 isoform X3 [KO:K04635]
109890384  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
109879717  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
109909428  uncharacterized protein LOC109909428 [KO:K01047] [EC:3.1.1.4]
109877064  LOW QUALITY PROTEIN: group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
109878424  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
109878434  phospholipase A2, minor isoenzyme [KO:K01047] [EC:3.1.1.4]
109889298  group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
109897603  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
116358891  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
109891715  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
109892249  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
109879864  uncharacterized protein LOC109879864 isoform X3 [KO:K01047] [EC:3.1.1.4]
109865954  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
109881937  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
109895093  phospholipase A2, minor isoenzyme [KO:K01047] [EC:3.1.1.4]
109882801  uncharacterized protein LOC109882801 isoform X1 [KO:K01047] [EC:3.1.1.4]
116364344  LOW QUALITY PROTEIN: group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
109904849  mediator of DNA damage checkpoint protein 1-like [KO:K01047] [EC:3.1.1.4]
109902883  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109889895  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109898161  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109899096  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109906823  cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
116354066  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
109871574  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109884205  LOW QUALITY PROTEIN: 85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
116352991  85/88 kDa calcium-independent phospholipase A2-like isoform X1 [KO:K16343] [EC:3.1.1.4]
109882135  calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
109890060  calcium-activated potassium channel subunit alpha-1-like isoform X1 [KO:K04936]
109899946  calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
109899813  calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
109898788  calcium-activated potassium channel subunit beta-2-like [KO:K04938]
109875397  calcium-activated potassium channel subunit beta-2-like [KO:K04938]
109872304  calcium-activated potassium channel subunit beta-2-like [KO:K04938]
109902647  calcium-activated potassium channel subunit beta-2 [KO:K04938]
109875396  calcium-activated potassium channel subunit beta-3-like [KO:K04939]
109885031  calcium-activated potassium channel subunit beta-4-like [KO:K04941]
116360540  calcium-activated potassium channel subunit beta-4-like [KO:K04941]
109882530  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
109869746  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
109891346  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
109907825  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
109892681  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
109869700  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
109869670  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 isoform X1 [KO:K04857]
109891316  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
109885052  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04857]
109899957  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
109908833  calmodulin [KO:K02183]
109905418  calmodulin [KO:K02183]
109889822  calm2; calmodulin-2 isoform X2 [KO:K02183]
109904758  calmodulin-alpha-like [KO:K02183]
109899635  calmodulin [KO:K02183]
109900879  calmodulin [KO:K02183]
109872803  calmodulin [KO:K02183]
109873760  calmodulin isoform X2 [KO:K02183]
109894368  calmodulin [KO:K02183]
116363551  calmodulin-like protein 4 [KO:K02183]
116365188  calmodulin-like protein 4 [KO:K02183]
109908374  calmodulin [KO:K02183]
109867329  calmodulin-like protein 4 [KO:K02183]
109885140  calmodulin-like protein 4 [KO:K02183]
109904201  calm1; calmodulin-1 [KO:K02183]
109869410  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109898432  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109870693  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109871935  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109893329  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
109898091  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
109865875  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109881317  myosin light chain kinase family member 4-like isoform X2 [KO:K00907] [EC:2.7.11.18]
109874826  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109895488  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109886180  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
109865537  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
109868957  myosin light polypeptide 6 isoform X1 [KO:K12751]
109891129  myosin light polypeptide 6 isoform X1 [KO:K12751]
109908313  myosin light polypeptide 6-like isoform X2 [KO:K12751]
109895803  myosin light polypeptide 6 isoform X1 [KO:K12751]
109891383  myosin regulatory light polypeptide 9-like [KO:K12755]
109891943  myosin regulatory light polypeptide 9 [KO:K12755]
109888419  myosin-9-like isoform X1 [KO:K10352]
116352994  LOW QUALITY PROTEIN: myosin-11-like [KO:K10352]
109891959  myosin-10 isoform X1 [KO:K10352]
109887921  myosin-9-like isoform X1 [KO:K10352]
109865030  myosin-10-like isoform X1 [KO:K10352]
109886934  myosin-11-like isoform X1 [KO:K10352]
109885559  myosin-11-like isoform X1 [KO:K10352]
109898615  myosin-10-like isoform X1 [KO:K10352]
109893502  myosin-9 isoform X1 [KO:K10352]
109865816  myosin-9 isoform X1 [KO:K10352]
109865302  myosin-10 isoform X1 [KO:K10352]
109885251  myosin-11-like isoform X1 [KO:K10352]
109896842  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
109904135  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
109903173  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109893726  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109886387  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
109900969  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109884894  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
109866240  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
109900392  plcb4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
109898016  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
109891520  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109891193  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
109895256  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109889517  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
109866991  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
109869089  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
109907995  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109889555  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116359989  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
109865703  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
109876162  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
116366449  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
109886787  protein kinase C beta type-like [KO:K19663] [EC:2.7.11.13]
109897123  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
109891002  protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
109891155  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
109895618  protein kinase C delta type isoform X2 [KO:K06068] [EC:2.7.11.13]
109870171  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
109869986  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
109898971  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
109893741  protein kinase C eta type isoform X1 [KO:K18051] [EC:2.7.11.13]
109904112  protein kinase C eta type isoform X1 [KO:K18051] [EC:2.7.11.13]
109910350  protein kinase C theta type-like [KO:K18052] [EC:2.7.11.13]
109910344  protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
109882485  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
109896112  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
109886565  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116366651  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
109869276  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109907765  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109883542  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109897850  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
109872320  dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
109902503  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109874662  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
109898211  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109882760  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
109893105  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109881705  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109876812  non-muscle caldesmon-like isoform X1 [KO:K12327]
109896765  non-muscle caldesmon isoform X1 [KO:K12327]
109888920  caldesmon isoform X1 [KO:K12327]
109897798  non-muscle caldesmon-like isoform X1 [KO:K12327]
116359648  non-muscle caldesmon-like isoform X1 [KO:K12327]
109879111  non-muscle caldesmon-like isoform X1 [KO:K12327]
109867390  non-muscle caldesmon isoform X1 [KO:K12327]
109870177  actin, aortic smooth muscle [KO:K12313]
109865359  actin, aortic smooth muscle [KO:K12313]
109908935  protein phosphatase 1 regulatory subunit 14A-like [KO:K12328]
109905493  protein phosphatase 1 regulatory subunit 14A isoform X2 [KO:K12328]
109892890  protein phosphatase 1 regulatory subunit 14A-like [KO:K12328]
109872973  protein phosphatase 1 regulatory subunit 14A [KO:K12328]
109897095  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
109878257  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116374489  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
109906577  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
109900911  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
109865607  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
109878667  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
109866344  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109895786  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
109896632  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
109910297  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
109881399  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
109882082  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
109908122  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
109889359  protein phosphatase 1 regulatory subunit 12C-like isoform X1 [KO:K17457]
109865734  protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
109885709  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109876168  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109870070  guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
109886145  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109865520  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
109905382  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109892921  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
109872638  rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
109908863  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
109906608  rho guanine nucleotide exchange factor 1-like [KO:K12330]
109881774  rho guanine nucleotide exchange factor 1-like isoform X1 [KO:K12330]
109896906  rho guanine nucleotide exchange factor 11 isoform X3 [KO:K12331]
109906396  rho guanine nucleotide exchange factor 11-like isoform X1 [KO:K12331]
109868954  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
109869057  rho-related GTP-binding protein RhoA-C [KO:K04513]
109890848  rho-related GTP-binding protein RhoA-D [KO:K04513]
109891336  transforming protein RhoA [KO:K04513]
109892807  transforming protein RhoA-like [KO:K04513]
109881405  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
109907845  rho-related GTP-binding protein RhoA-B [KO:K04513]
109908045  rho-related GTP-binding protein RhoA-C-like isoform X2 [KO:K04513]
109875460  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109871603  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109866154  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
109894400  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
109901330  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
109904161  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
109868612  adenosine receptor A2b-like [KO:K04266]
109871728  adenosine receptor A2b-like [KO:K04266]
109873705  adenosine receptor A2b [KO:K04266]
109895776  adora2a; adenosine receptor A2a [KO:K04266]
109892130  adora2b; adenosine receptor A2b [KO:K04267]
109872643  adenosine receptor A2b-like [KO:K04267]
109905419  prostacyclin receptor-like [KO:K04263]
109909706  prostacyclin receptor-like [KO:K04263]
109897746  calcitonin gene-related peptide-like isoform X1 [KO:K12332]
109873175  calcitonin-1-like isoform X1 [KO:K12332]
109894985  calcitonin-1 isoform X1 [KO:K12332]
109867829  calcitonin-1-like isoform X1 [KO:K12332]
109887277  ADM-like [KO:K12333]
109895417  ADM [KO:K12333]
116356333  ADM-like [KO:K12333]
109897736  ADM [KO:K12333]
109867633  protein ADM2 [KO:K25343]
109896698  protein ADM2-like [KO:K25343]
109910339  protein ADM2 [KO:K25343]
109877228  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
116374132  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
109869535  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
109871401  calcitonin gene-related peptide type 1 receptor isoform X1 [KO:K04577]
109908094  calcitonin gene-related peptide type 1 receptor [KO:K04577]
109870737  calcitonin gene-related peptide type 1 receptor-like [KO:K04577]
116370492  receptor activity-modifying protein 1-like [KO:K08447]
109867578  receptor activity-modifying protein 1-like isoform X2 [KO:K08447]
109870971  uncharacterized protein LOC109870971 [KO:K08447]
109871411  receptor activity-modifying protein 1 [KO:K08447]
109885189  receptor activity-modifying protein 1 isoform X1 [KO:K08447]
109865941  receptor activity-modifying protein 1 [KO:K08447]
109897600  receptor activity-modifying protein 1-like [KO:K08448]
109893335  receptor activity-modifying protein 1 isoform X1 [KO:K08448]
109909865  receptor activity-modifying protein 3-like [KO:K08449]
109899014  receptor activity-modifying protein 3-like isoform X1 [KO:K08449]
109869198  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
109889525  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
109907814  guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
109875168  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
109886998  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
109872139  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109875142  adenylate cyclase type 1-like isoform X2 [KO:K08041] [EC:4.6.1.1]
109881128  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
109908625  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
109902225  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
109864829  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
109866597  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
109870742  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
109868074  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
109869150  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
109869860  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
109907076  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
109907793  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
109881364  adenylate cyclase type 2 isoform X1 [KO:K08047] [EC:4.6.1.1]
109881656  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
109881906  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
109875096  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109878239  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109880859  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109880861  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
109886804  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
109880753  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109871709  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109898739  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109866517  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109874831  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109869470  natriuretic peptides A [KO:K12334]
109869588  ventricular natriuretic peptide [KO:K12334]
109908537  ventricular natriuretic peptide-like [KO:K12334]
109875808  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
109901951  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
109907461  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
109908026  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
109888568  nppc; C-type natriuretic peptide [KO:K12336]
109901460  C-type natriuretic peptide 1 [KO:K12336]
109901516  C-type natriuretic peptide 4-like [KO:K12336]
109883112  C-type natriuretic peptide 1 [KO:K12336]
109867948  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
109873703  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
109866679  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
109889943  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
109870242  cGMP-dependent protein kinase 1 isoform X2 [KO:K07376] [EC:2.7.11.12]
109865573  cGMP-dependent protein kinase 1 isoform X2 [KO:K07376] [EC:2.7.11.12]
109899108  cGMP-dependent protein kinase 1-like isoform X1 [KO:K07376] [EC:2.7.11.12]
109906120  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
109900331  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
109909489  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
109893862  guanylate cyclase soluble subunit alpha-1-like [KO:K12318] [EC:4.6.1.2]
109909340  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
109879657  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
109901045  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
oki00590  Arachidonic acid metabolism
oki04020  Calcium signaling pathway
KO pathway
ko04270   
LinkDB

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