KEGG   PATHWAY: oor05168
Entry
oor05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Orcinus orca (killer whale)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
oor05168  Herpes simplex virus 1 infection
oor05168

Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101270123  LTA; lymphotoxin-alpha [KO:K05468]
101280766  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
101281303  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101280074  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101285763  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101281072  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101272428  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101289477  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101276394  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101276649  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101289706  C-C motif chemokine 2 [KO:K14624]
101289082  NECTIN1; nectin-1 isoform X1 [KO:K06081]
101271022  NECTIN2; nectin-2 isoform X2 [KO:K06531]
101281966  paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
101288182  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X5 [KO:K07293] [EC:3.1.3.48]
101275353  ITGA5; integrin alpha-5 [KO:K06484]
101275188  ITGB3; integrin beta-3 [KO:K06493]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101281971  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101284636  CARD9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
101272168  IRF3; interferon regulatory factor 3 [KO:K05411]
101289058  IFNB1; interferon beta [KO:K05415]
101285670  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
101281425  C3; complement C3 [KO:K03990]
101279383  C5; complement C5 isoform X1 [KO:K03994]
101272896  CFP; properdin [KO:K15412]
101276053  TLR2; toll-like receptor 2 [KO:K10159]
101289148  toll-like receptor 9 isoform X3 [KO:K10161]
101278425  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101277458  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101278583  TLR3; toll-like receptor 3 [KO:K05401]
101271374  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101283238  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101280639  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
101277553  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101283961  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101282675  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
101284365  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101284892  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
101273776  C-C motif chemokine 5 isoform X2 [KO:K12499]
101281783  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
101269870  TNF; tumor necrosis factor [KO:K03156]
101279088  IL12A; interleukin-12 subunit alpha [KO:K05406]
101272835  IL12B; interleukin-12 subunit beta [KO:K05425]
101277446  RIGI; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
101271323  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X2 [KO:K12647] [EC:5.6.2.6]
101284556  MAVS; mitochondrial antiviral-signaling protein isoform X4 [KO:K12648]
101288184  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101273673  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
101290315  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101274041  interferon alpha-1-like [KO:K05414]
101275016  interferon alpha-1-like [KO:K05414]
101275275  interferon alpha-1-like [KO:K05414]
101287367  interferon alpha-3-like [KO:K05414]
125964698  interferon alpha-1-like [KO:K05414]
125964699  interferon alpha-1-like [KO:K05414]
125964701  interferon alpha-3-like [KO:K05414]
125964702  interferon alpha-3-like [KO:K05414]
125964703  interferon alpha-3-like [KO:K05414]
101289557  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
101275872  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
101285623  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101280558  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101286983  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101272505  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3 [KO:K16194] [EC:2.7.11.1]
101270256  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101282451  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101288996  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
101281288  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101289826  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
101284780  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
101280970  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
101273610  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
101279236  LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta-like [KO:K03680]
101270312  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
101289192  2'-5'-oligoadenylate synthase 1 isoform X2 [KO:K14216] [EC:2.7.7.84]
101277868  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101286130  RNASEL; 2-5A-dependent ribonuclease isoform X2 [KO:K01165]
101282458  HCFC1; host cell factor 1 isoform X7 [KO:K14966]
101289068  HCFC2; host cell factor 2 isoform X3 [KO:K27390]
101281331  POU2F2; POU domain, class 2, transcription factor 2 isoform X9 [KO:K09364]
101280171  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101280569  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101284215  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101283958  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101284843  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101275383  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101278346  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
101272458  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
101281591  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101272815  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101285758  ZNF34; zinc finger protein 34 [KO:K09228]
101276779  ZNF658; zinc finger protein 658 isoform X2 [KO:K09228]
101273649  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
101284626  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
105748721  zinc finger protein 883-like isoform X1 [KO:K09228]
101279356  zinc finger protein 160-like isoform X1 [KO:K09228]
105747728  ZNF487; LOW QUALITY PROTEIN: putative zinc finger protein 487 [KO:K09228]
101290171  KRBOX4; KRAB domain-containing protein 4 isoform X1 [KO:K09228]
101285314  ZNF425; LOW QUALITY PROTEIN: zinc finger protein 425 [KO:K09228]
101285829  ZNF212; zinc finger protein 212 [KO:K09228]
105747734  zinc finger protein 677-like isoform X1 [KO:K09228]
101280890  LOW QUALITY PROTEIN: zinc finger protein 578-like [KO:K09228]
101278490  ZNF26; zinc finger protein 26 isoform X2 [KO:K09228]
101278091  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
101278913  ZNF140; zinc finger protein 140 isoform X4 [KO:K09228]
101279156  ZNF891; zinc finger protein 891 [KO:K09228]
101272182  ZNF180; zinc finger protein 180 isoform X1 [KO:K09228]
101272604  zinc finger protein 112 [KO:K09228]
101273273  ZNF283; zinc finger protein 283 [KO:K09228]
101273775  ZNF233; LOW QUALITY PROTEIN: zinc finger protein 233 [KO:K09228]
101288640  ZNF624; zinc finger protein 624 isoform X1 [KO:K09228]
101288888  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
101274670  ZNF285; LOW QUALITY PROTEIN: zinc finger protein 285 [KO:K09228]
101282523  ZNF777; zinc finger protein 777 isoform X1 [KO:K09228]
101285047  ZNF786; zinc finger protein 786 isoform X1 [KO:K09228]
101273417  ZNF81; zinc finger protein 81 isoform X1 [KO:K09228]
101273908  ZNF157; zinc finger protein 157 isoform X1 [KO:K09228]
101285899  zinc finger protein 501 [KO:K09228]
101288593  ZNF74; LOW QUALITY PROTEIN: zinc finger protein 74 [KO:K09228]
101276194  zinc finger protein 791 isoform X1 [KO:K09228]
101285207  ZNF619; LOW QUALITY PROTEIN: zinc finger protein 619 [KO:K09228]
101285466  ZNF620; LOW QUALITY PROTEIN: zinc finger protein 620 [KO:K09228]
105748414  ZNF621; zinc finger protein 621 isoform X1 [KO:K09228]
101286080  ZNF783; zinc finger protein 783 [KO:K09228]
101271215  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
101285397  zinc finger protein 773 isoform X1 [KO:K09228]
101272375  zinc finger protein 177-like isoform X2 [KO:K09228]
101275840  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
101276246  ZNF12; zinc finger protein 12 isoform X1 [KO:K09228]
105748583  zinc finger protein 239-like [KO:K09228]
101288692  zinc finger protein 705A [KO:K09228]
105748926  ZFP92; zinc finger protein 92 homolog isoform X1 [KO:K09228]
101281723  ZNF275; zinc finger protein 275 [KO:K09228]
105748931  zinc finger protein 84-like isoform X3 [KO:K09228]
101277417  zinc finger protein 577 isoform X2 [KO:K09228]
105747729  zinc finger protein 350 isoform X3 [KO:K09228]
101276424  ZNF175; zinc finger protein 175 [KO:K09228]
101277179  zinc finger protein 268-like [KO:K09228]
105748930  zinc finger protein 84-like [KO:K09228]
101281373  ZNF782; zinc finger protein 782 [KO:K09228]
101281624  ZNF510; zinc finger protein 510 isoform X1 [KO:K09228]
101277660  ZNF473; zinc finger protein 473 isoform X1 [KO:K09228]
101273860  ZSCAN32; LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32 [KO:K09228]
101283004  zinc finger protein 77-like isoform X2 [KO:K09228]
101283253  zinc finger protein 77-like [KO:K09228]
101284520  zinc finger protein 555 isoform X1 [KO:K09228]
105748381  zinc finger protein 699 isoform X1 [KO:K09228]
101272961  zinc finger protein 14-like [KO:K09228]
101276708  zinc finger protein 709-like [KO:K09228]
101276959  LOW QUALITY PROTEIN: zinc finger protein 627 [KO:K09228]
101277213  zinc finger protein 709-like [KO:K09228]
101281293  LOW QUALITY PROTEIN: zinc finger protein 665 [KO:K09228]
101279864  zinc finger protein 665-like isoform X2 [KO:K09228]
105747740  zinc finger protein 836-like [KO:K09228]
101280108  zinc finger protein 665-like [KO:K09228]
105747735  zinc finger protein 836-like [KO:K09228]
101280614  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
105748726  zinc finger protein 132-like isoform X1 [KO:K09228]
105747737  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
101283130  LOW QUALITY PROTEIN: zinc finger protein 154-like [KO:K09228]
101283627  ZNF671; zinc finger protein 671 isoform X1 [KO:K09228]
105748732  zinc finger protein 256-like [KO:K09228]
105748733  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
105748734  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
101285138  zinc finger protein interacting with ribonucleoprotein K-like isoform X1 [KO:K09228]
105748736  zinc finger protein 304-like [KO:K09228]
101286412  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
105747723  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
101288200  zinc finger protein 28 homolog isoform X1 [KO:K09228]
101281044  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
105747725  ZNF324; zinc finger protein 324A isoform X1 [KO:K09228]
101288707  zinc finger protein 471 isoform X1 [KO:K09228]
105748777  ZNF25; zinc finger protein 25 [KO:K09228]
101287816  ZFP90; zinc finger protein 90 homolog [KO:K09228]
101279657  zinc finger protein 883-like [KO:K09228]
101283883  ZNF454; zinc finger protein 454 [KO:K09228]
101284137  ZNF879; zinc finger protein 879 [KO:K09228]
101283323  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
101270706  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
101282124  ZNF398; zinc finger protein 398 isoform X2 [KO:K09228]
101282779  ZNF746; zinc finger protein 746 isoform X4 [KO:K09228]
101285572  ZNF282; zinc finger protein 282 isoform X1 [KO:K09228]
101287519  zinc finger protein 33B isoform X1 [KO:K09228]
101277200  ZNF23; zinc finger protein 23 isoform X2 [KO:K09228]
101285007  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
101271378  ZNF2; zinc finger protein 2 isoform X2 [KO:K09228]
101271622  ZNF514; zinc finger protein 514 isoform X2 [KO:K09228]
101281277  ZNF214; zinc finger protein 214 isoform X2 [KO:K09228]
101286171  ZNF436; zinc finger protein 436 isoform X2 [KO:K09228]
101280732  zinc finger protein 160-like [KO:K09228]
101280982  zinc finger protein 83-like [KO:K09228]
101271732  ZNF354A; zinc finger protein 354A isoform X2 [KO:K09228]
101272396  ZNF41; zinc finger protein 41 [KO:K09228]
101273155  ZNF182; zinc finger protein 182 [KO:K09228]
101272848  uncharacterized protein LOC101272848 [KO:K09228]
101284319  ZNF853; zinc finger protein 853 [KO:K09228]
105747952  ZNF316; zinc finger protein 316 isoform X1 [KO:K09228]
101280794  ZNF132; zinc finger protein 132 [KO:K09228]
101283876  zinc finger protein 665 isoform X1 [KO:K09228]
101285396  zinc finger protein 772 isoform X1 [KO:K09228]
101286153  zinc finger protein 304-like isoform X1 [KO:K09228]
101286411  ZNF304; zinc finger protein 304 isoform X1 [KO:K09228]
101286931  uncharacterized protein LOC101286931 [KO:K09228]
101287695  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
101288199  ZNF583; zinc finger protein 583 isoform X2 [KO:K09228]
101277903  ZNF613; LOW QUALITY PROTEIN: zinc finger protein 613 [KO:K09228]
101278150  zinc finger protein 432 isoform X5 [KO:K09228]
101274735  ZNF684; zinc finger protein 684 isoform X3 [KO:K09228]
101274603  ZNF641; zinc finger protein 641 isoform X1 [KO:K09228]
101285879  ZNF317; zinc finger protein 317 isoform X1 [KO:K09228]
101273534  zinc finger protein 227 isoform X1 [KO:K09228]
101274919  zinc finger protein 235 isoform X3 [KO:K09228]
105748075  ZNF404; zinc finger protein 404 [KO:K09228]
101270920  LOW QUALITY PROTEIN: zinc finger protein 354B [KO:K09228]
101282625  zinc finger protein 607-like [KO:K09228]
101271475  ZNF875; zinc finger protein 875 isoform X1 [KO:K09228]
101281636  zinc finger protein 181 isoform X2 [KO:K09228]
101273502  zinc finger protein 585A isoform X5 [KO:K09228]
101289429  zinc finger protein 501-like [KO:K09228]
101285118  zinc finger protein 300 isoform X2 [KO:K09228]
101290281  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
101290025  ZNF184; zinc finger protein 184 isoform X1 [KO:K09228]
101289547  ZFP57; zinc finger protein 57 homolog [KO:K09228]
105748907  ZNF311; zinc finger protein 311 isoform X1 [KO:K09228]
101270446  ZFP37; zinc finger protein 37 homolog isoform X1 [KO:K09228]
101269545  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
101277937  zinc finger protein 709-like [KO:K09228]
101278423  zinc finger protein 14-like [KO:K09228]
101286474  LOW QUALITY PROTEIN: zinc finger protein 709 [KO:K09228]
101290321  ZNF558; zinc finger protein 558 isoform X2 [KO:K09228]
101285621  zinc finger protein 709-like [KO:K09228]
101277456  zinc finger protein 709-like [KO:K09228]
101290224  ZNF333; zinc finger protein 333 isoform X2 [KO:K09228]
101282872  zinc finger protein 256-like [KO:K09228]
101284875  LOW QUALITY PROTEIN: zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
101284625  zinc finger protein 211-like [KO:K09228]
101286154  LOW QUALITY PROTEIN: zinc finger protein 548-like [KO:K09228]
101284368  zinc finger protein 211-like isoform X6 [KO:K09228]
101290200  ZNF713; zinc finger protein 713 [KO:K09228]
101283909  ZNF205; zinc finger protein 205 isoform X2 [KO:K09228]
101285263  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
101279128  ZNF768; zinc finger protein 768 [KO:K09228]
101279382  ZNF764; zinc finger protein 764 isoform X2 [KO:K09228]
101289214  ZNF484; zinc finger protein 484 isoform X3 [KO:K09228]
101289453  ZNF169; zinc finger protein 169 isoform X2 [KO:K09228]
101277014  ZNF334; LOW QUALITY PROTEIN: zinc finger protein 334 [KO:K09228]
101290112  zinc finger protein 786-like [KO:K09228]
101280621  ZNF567; zinc finger protein 567 isoform X1 [KO:K09228]
101281050  ZNF599; zinc finger protein 599 isoform X1 [KO:K09228]
101280379  zinc finger protein 665 [KO:K09228]
101279883  ZNF331; zinc finger protein 331 isoform X1 [KO:K09228]
101290352  zinc finger protein 345 isoform X1 [KO:K09228]
101271227  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
101277416  zinc finger protein 883 isoform X1 [KO:K09228]
101285684  ZNF3; zinc finger protein 3 [KO:K09228]
101273621  ZNF597; LOW QUALITY PROTEIN: zinc finger protein 597 [KO:K09228]
101276947  ZNF19; zinc finger protein 19 isoform X1 [KO:K09228]
101289189  zinc finger protein 239-like [KO:K09228]
101281716  ZFP69; zinc finger protein 69 homolog isoform X3 [KO:K09228]
105748074  zinc finger protein 546 isoform X1 [KO:K09228]
101281382  ZNF589; LOW QUALITY PROTEIN: zinc finger protein 589 [KO:K09228]
101288435  putative zinc finger protein 705EP [KO:K09228]
101284857  zinc finger protein 569-like isoform X1 [KO:K09228]
101279612  zinc finger protein 345-like [KO:K09228]
101270594  zinc finger protein 461 isoform X1 [KO:K09228]
101273654  ZNF662; LOW QUALITY PROTEIN: zinc finger protein 662 [KO:K09228]
101285340  zinc finger protein OZF-like isoform X1 [KO:K09228]
117195353  ZNF8; zinc finger protein 8 [KO:K09228]
117195355  ZNF135; zinc finger protein 135 [KO:K09228]
117195360  ZNF565; zinc finger protein 565 isoform X2 [KO:K09228]
117195362  ZFP30; zinc finger protein 30 homolog isoform X2 [KO:K09228]
117195375  ZNF569; zinc finger protein 569 isoform X1 [KO:K09228]
117195377  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
117195385  zinc finger protein 615-like isoform X1 [KO:K09228]
117195386  zinc finger protein 154-like [KO:K09228]
117197921  ZNF544; LOW QUALITY PROTEIN: zinc finger protein 544 [KO:K09228]
117197932  zinc finger protein 549-like isoform X3 [KO:K09228]
117197933  zinc finger protein 211-like [KO:K09228]
117197934  zinc finger protein 550 [KO:K09228]
117197938  zinc finger protein OZF-like [KO:K09228]
117198134  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
117198222  zinc finger protein 790 isoform X1 [KO:K09228]
117198223  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
117198224  ZNF570; zinc finger protein 570 isoform X1 [KO:K09228]
117198225  ZNF829; zinc finger protein 829 [KO:K09228]
117198237  ZNF566; zinc finger protein 566 isoform X1 [KO:K09228]
117198238  ZFP14; zinc finger protein 14 homolog isoform X1 [KO:K09228]
117198241  ZNF792; zinc finger protein 792 isoform X1 [KO:K09228]
117199139  zinc finger protein 677-like isoform X1 [KO:K09228]
117199251  LOW QUALITY PROTEIN: zinc finger protein 791-like [KO:K09228]
117199624  zinc finger protein 252-like isoform X1 [KO:K09228]
117199626  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
117199682  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
117199683  ZNF623; zinc finger protein 623 [KO:K09228]
117200145  ZFP69B; zinc finger protein 69 homolog B isoform X1 [KO:K09228]
117201522  ZNF133; zinc finger protein 133 isoform X3 [KO:K09228]
125960246  zinc finger protein 77-like [KO:K09228]
125960255  ZNF793; zinc finger protein 793 isoform X1 [KO:K09228]
125960256  zinc finger protein 420 isoform X1 [KO:K09228]
125960258  ZNF571; zinc finger protein 571 isoform X2 [KO:K09228]
125962660  ZNF260; zinc finger protein 260 isoform X1 [KO:K09228]
125963075  ZNF674; zinc finger protein 674 [KO:K09228]
125960265  LOW QUALITY PROTEIN: zinc finger protein 568-like [KO:K09228]
101282672  BST2; bone marrow stromal antigen 2 [KO:K06731]
101282933  IFNG; interferon gamma [KO:K04687]
101276054  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101279441  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
101283649  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101276381  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
101283102  PML; protein PML isoform X2 [KO:K10054] [EC:2.3.2.-]
101289708  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101290371  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101284313  TAPBP; tapasin isoform X2 [KO:K08058]
101282830  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
101279584  CALR; calreticulin [KO:K08057]
101271749  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
101276578  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X8 [KO:K06751]
105748394  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
125965560  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
101278678  B2M; beta-2-microglobulin [KO:K08055]
101275177  beta-2-microglobulin-like [KO:K08055]
125963661  beta-2-microglobulin [KO:K08055]
101275987  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X2 [KO:K06752]
101287624  HLA class II histocompatibility antigen, DM beta chain isoform X3 [KO:K06752]
101287882  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101277081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101276823  DLA class II histocompatibility antigen, DR-1 beta chain isoform X3 [KO:K06752]
101288385  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101289225  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101270971  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101275677  TSC1; hamartin isoform X1 [KO:K07206]
101276336  TSC2; tuberin isoform X9 [KO:K07207]
101286490  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101284249  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101277165  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101270273  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
101270874  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
101281675  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
101288810  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
101285243  serine/arginine-rich splicing factor 3-like [KO:K12892]
101281391  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
101283089  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
101287933  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101270820  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893]
101287781  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101281360  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101286095  nuclear RNA export factor 3 isoform X1 [KO:K14284]
101287280  LOW QUALITY PROTEIN: nuclear RNA export factor 2 [KO:K14284]
101284211  NXF1; nuclear RNA export factor 1 isoform X4 [KO:K14284]
101287516  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
101275531  ALYREF; THO complex subunit 4 [KO:K12881]
101272436  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101284022  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
101282502  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101271709  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101272962  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
101281780  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101277745  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101285349  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101281395  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101276750  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101288063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105747906  cytochrome c-like [KO:K08738]
101283052  cytochrome c [KO:K08738]
101275631  cytochrome c-like [KO:K08738]
105747703  cytochrome c 2 [KO:K08738]
101272869  cytochrome c-like [KO:K08738]
117203203  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101280303  APAF1; apoptotic protease-activating factor 1 isoform X4 [KO:K02084]
101271677  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101289847  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
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Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
PMID:15163721
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Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
oor03040  Spliceosome
oor03050  Proteasome
oor04115  p53 signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04210  Apoptosis
oor04610  Complement and coagulation cascades
oor04612  Antigen processing and presentation
oor04620  Toll-like receptor signaling pathway
oor04622  RIG-I-like receptor signaling pathway
oor04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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